Putative phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative

Species:

Leishmania braziliensis

UniProt:

A4HP35_LEIBR

TriTrypDb:

LbrM.35.1900 , LBRM2903_350025300

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	1
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HP35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP35

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008194	UDP-glycosyltransferase activity	4	7
GO:0008375	acetylglucosaminyltransferase activity	5	7
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016758	hexosyltransferase activity	4	7
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.703
CLV_NRD_NRD_1	70	72	PF00675	0.261
CLV_PCSK_SKI1_1	22	26	PF00082	0.351
CLV_PCSK_SKI1_1	61	65	PF00082	0.479
CLV_PCSK_SKI1_1	71	75	PF00082	0.202
CLV_PCSK_SKI1_1	98	102	PF00082	0.334
DOC_CDC14_PxL_1	325	333	PF14671	0.308
DOC_MAPK_gen_1	101	110	PF00069	0.458
DOC_MAPK_MEF2A_6	139	147	PF00069	0.315
DOC_MAPK_MEF2A_6	254	263	PF00069	0.537
DOC_PP4_FxxP_1	344	347	PF00568	0.388
DOC_USP7_MATH_1	175	179	PF00917	0.472
DOC_USP7_MATH_1	278	282	PF00917	0.371
DOC_USP7_MATH_1	370	374	PF00917	0.586
DOC_WW_Pin1_4	180	185	PF00397	0.500
DOC_WW_Pin1_4	210	215	PF00397	0.303
DOC_WW_Pin1_4	292	297	PF00397	0.254
DOC_WW_Pin1_4	64	69	PF00397	0.679
LIG_14-3-3_CanoR_1	180	184	PF00244	0.492
LIG_14-3-3_CanoR_1	200	206	PF00244	0.503
LIG_14-3-3_CanoR_1	274	278	PF00244	0.309
LIG_14-3-3_CanoR_1	303	308	PF00244	0.408
LIG_14-3-3_CanoR_1	352	358	PF00244	0.537
LIG_14-3-3_CanoR_1	41	48	PF00244	0.642
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BRCT_BRCA1_1	1	5	PF00533	0.757
LIG_Clathr_ClatBox_1	142	146	PF01394	0.423
LIG_deltaCOP1_diTrp_1	378	384	PF00928	0.650
LIG_EH1_1	334	342	PF00400	0.423
LIG_eIF4E_1	335	341	PF01652	0.450
LIG_FHA_1	110	116	PF00498	0.434
LIG_FHA_1	132	138	PF00498	0.238
LIG_FHA_1	216	222	PF00498	0.338
LIG_FHA_1	228	234	PF00498	0.338
LIG_FHA_1	306	312	PF00498	0.457
LIG_FHA_1	334	340	PF00498	0.450
LIG_FHA_2	220	226	PF00498	0.337
LIG_FHA_2	23	29	PF00498	0.684
LIG_FHA_2	4	10	PF00498	0.576
LIG_IRF3_LxIS_1	337	343	PF10401	0.425
LIG_LIR_Apic_2	343	347	PF02991	0.423
LIG_LIR_Apic_2	81	87	PF02991	0.451
LIG_LIR_Gen_1	102	113	PF02991	0.456
LIG_LIR_Gen_1	243	250	PF02991	0.477
LIG_LIR_LC3C_4	141	144	PF02991	0.197
LIG_LIR_Nem_3	102	108	PF02991	0.446
LIG_LIR_Nem_3	243	248	PF02991	0.463
LIG_LIR_Nem_3	313	318	PF02991	0.439
LIG_LIR_Nem_3	67	73	PF02991	0.537
LIG_NRBOX	237	243	PF00104	0.388
LIG_PDZ_Class_2	381	386	PF00595	0.662
LIG_Pex14_2	125	129	PF04695	0.333
LIG_Pex14_2	344	348	PF04695	0.423
LIG_SH2_CRK	105	109	PF00017	0.475
LIG_SH2_CRK	140	144	PF00017	0.332
LIG_SH2_CRK	245	249	PF00017	0.451
LIG_SH2_GRB2like	247	250	PF00017	0.451
LIG_SH2_PTP2	84	87	PF00017	0.451
LIG_SH2_SRC	247	250	PF00017	0.511
LIG_SH2_SRC	84	87	PF00017	0.451
LIG_SH2_STAP1	105	109	PF00017	0.511
LIG_SH2_STAP1	140	144	PF00017	0.388
LIG_SH2_STAP1	305	309	PF00017	0.537
LIG_SH2_STAP1	335	339	PF00017	0.423
LIG_SH2_STAP1	48	52	PF00017	0.572
LIG_SH2_STAT3	75	78	PF00017	0.451
LIG_SH2_STAT5	157	160	PF00017	0.375
LIG_SH2_STAT5	247	250	PF00017	0.441
LIG_SH2_STAT5	266	269	PF00017	0.396
LIG_SH2_STAT5	335	338	PF00017	0.353
LIG_SH2_STAT5	84	87	PF00017	0.455
LIG_SH3_3	181	187	PF00018	0.529
LIG_SUMO_SIM_anti_2	118	123	PF11976	0.423
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.426
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.390
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.450
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.450
LIG_SUMO_SIM_par_1	111	116	PF11976	0.504
LIG_SUMO_SIM_par_1	141	146	PF11976	0.372
LIG_SUMO_SIM_par_1	201	207	PF11976	0.327
LIG_SUMO_SIM_par_1	217	222	PF11976	0.203
LIG_SUMO_SIM_par_1	224	232	PF11976	0.310
LIG_SUMO_SIM_par_1	338	343	PF11976	0.320
LIG_TRAF2_1	26	29	PF00917	0.736
LIG_TRFH_1	292	296	PF08558	0.303
LIG_UBA3_1	349	358	PF00899	0.423
LIG_WRC_WIRS_1	341	346	PF05994	0.423
MOD_CDC14_SPxK_1	183	186	PF00782	0.375
MOD_CDK_SPxK_1	180	186	PF00069	0.375
MOD_CDK_SPxxK_3	292	299	PF00069	0.303
MOD_CDK_SPxxK_3	64	71	PF00069	0.683
MOD_CK1_1	176	182	PF00069	0.556
MOD_CK1_1	204	210	PF00069	0.423
MOD_CK1_1	217	223	PF00069	0.222
MOD_CK1_1	224	230	PF00069	0.120
MOD_CK1_1	232	238	PF00069	0.232
MOD_CK1_1	273	279	PF00069	0.314
MOD_CK1_1	30	36	PF00069	0.631
MOD_CK1_1	356	362	PF00069	0.537
MOD_CK2_1	22	28	PF00069	0.681
MOD_CK2_1	3	9	PF00069	0.751
MOD_CK2_1	40	46	PF00069	0.703
MOD_GlcNHglycan	280	283	PF01048	0.338
MOD_GlcNHglycan	372	375	PF01048	0.383
MOD_GlcNHglycan	381	384	PF01048	0.379
MOD_GSK3_1	109	116	PF00069	0.496
MOD_GSK3_1	175	182	PF00069	0.556
MOD_GSK3_1	210	217	PF00069	0.325
MOD_GSK3_1	23	30	PF00069	0.671
MOD_GSK3_1	266	273	PF00069	0.351
MOD_GSK3_1	352	359	PF00069	0.482
MOD_GSK3_1	57	64	PF00069	0.661
MOD_LATS_1	55	61	PF00433	0.569
MOD_N-GLC_1	257	262	PF02516	0.360
MOD_N-GLC_2	249	251	PF02516	0.175
MOD_NEK2_1	11	16	PF00069	0.680
MOD_NEK2_1	133	138	PF00069	0.299
MOD_NEK2_1	219	224	PF00069	0.272
MOD_NEK2_1	234	239	PF00069	0.319
MOD_NEK2_1	270	275	PF00069	0.292
MOD_NEK2_1	290	295	PF00069	0.120
MOD_NEK2_1	340	345	PF00069	0.376
MOD_NEK2_1	353	358	PF00069	0.406
MOD_PIKK_1	11	17	PF00454	0.717
MOD_PIKK_1	113	119	PF00454	0.408
MOD_PIKK_1	131	137	PF00454	0.233
MOD_PIKK_1	186	192	PF00454	0.375
MOD_PIKK_1	249	255	PF00454	0.537
MOD_PIKK_1	323	329	PF00454	0.360
MOD_PIKK_1	356	362	PF00454	0.537
MOD_PKA_2	167	173	PF00069	0.375
MOD_PKA_2	176	182	PF00069	0.350
MOD_PKA_2	273	279	PF00069	0.315
MOD_PKA_2	40	46	PF00069	0.677
MOD_Plk_1	117	123	PF00069	0.423
MOD_Plk_1	224	230	PF00069	0.244
MOD_Plk_1	243	249	PF00069	0.511
MOD_Plk_1	257	263	PF00069	0.360
MOD_Plk_4	138	144	PF00069	0.258
MOD_Plk_4	146	152	PF00069	0.278
MOD_Plk_4	201	207	PF00069	0.405
MOD_Plk_4	224	230	PF00069	0.253
MOD_Plk_4	243	249	PF00069	0.500
MOD_Plk_4	266	272	PF00069	0.322
MOD_Plk_4	335	341	PF00069	0.381
MOD_ProDKin_1	180	186	PF00069	0.500
MOD_ProDKin_1	210	216	PF00069	0.303
MOD_ProDKin_1	292	298	PF00069	0.254
MOD_ProDKin_1	64	70	PF00069	0.667
MOD_SUMO_rev_2	366	371	PF00179	0.582
MOD_SUMO_rev_2	93	102	PF00179	0.375
TRG_ENDOCYTIC_2	105	108	PF00928	0.462
TRG_ENDOCYTIC_2	140	143	PF00928	0.372
TRG_ENDOCYTIC_2	245	248	PF00928	0.451
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE33	Leptomonas seymouri	70%	97%
A0A0S4IX12	Bodo saltans	46%	100%
A0A1X0P843	Trypanosomatidae	52%	100%
A0A3R7MPS8	Trypanosoma rangeli	50%	100%
A0A3S7XAV4	Leishmania donovani	87%	100%
A4IDE2	Leishmania infantum	87%	100%
D0A318	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ASU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O59802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q3ZBX1	Bos taurus	30%	100%
Q4Q1Q3	Leishmania major	86%	100%
Q54M40	Dictyostelium discoideum	31%	100%
Q5PQQ4	Rattus norvegicus	31%	100%
Q92535	Homo sapiens	30%	100%
Q9CXR4	Mus musculus	31%	100%
V5BU34	Trypanosoma cruzi	47%	100%