Mucin-5AC

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Mucin-5AC

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP34_LEIBR

TriTrypDb:

LbrM.35.1890 , LBRM2903_350025200

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.742
CLV_C14_Caspase3-7	514	518	PF00656	0.550
CLV_NRD_NRD_1	446	448	PF00675	0.631
CLV_NRD_NRD_1	484	486	PF00675	0.626
CLV_PCSK_KEX2_1	446	448	PF00082	0.703
CLV_PCSK_KEX2_1	484	486	PF00082	0.595
CLV_PCSK_SKI1_1	217	221	PF00082	0.542
CLV_PCSK_SKI1_1	273	277	PF00082	0.726
CLV_PCSK_SKI1_1	281	285	PF00082	0.727
CLV_PCSK_SKI1_1	322	326	PF00082	0.565
CLV_PCSK_SKI1_1	383	387	PF00082	0.611
CLV_PCSK_SKI1_1	89	93	PF00082	0.660
DEG_Nend_Nbox_1	1	3	PF02207	0.782
DEG_SCF_FBW7_1	328	335	PF00400	0.726
DEG_SCF_FBW7_1	522	529	PF00400	0.545
DOC_CKS1_1	130	135	PF01111	0.783
DOC_CKS1_1	329	334	PF01111	0.692
DOC_CKS1_1	80	85	PF01111	0.577
DOC_CYCLIN_RxL_1	214	223	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.748
DOC_MAPK_DCC_7	58	66	PF00069	0.561
DOC_MAPK_DCC_7	67	76	PF00069	0.510
DOC_MAPK_gen_1	482	489	PF00069	0.623
DOC_MAPK_gen_1	88	94	PF00069	0.510
DOC_MAPK_MEF2A_6	304	313	PF00069	0.728
DOC_MAPK_MEF2A_6	482	491	PF00069	0.625
DOC_PP1_RVXF_1	215	222	PF00149	0.542
DOC_PP2B_LxvP_1	197	200	PF13499	0.704
DOC_PP2B_LxvP_1	74	77	PF13499	0.762
DOC_PP4_FxxP_1	130	133	PF00568	0.783
DOC_PP4_FxxP_1	338	341	PF00568	0.569
DOC_PP4_FxxP_1	9	12	PF00568	0.679
DOC_SPAK_OSR1_1	8	12	PF12202	0.528
DOC_USP7_MATH_1	102	106	PF00917	0.638
DOC_USP7_MATH_1	172	176	PF00917	0.680
DOC_USP7_MATH_1	180	184	PF00917	0.682
DOC_USP7_MATH_1	242	246	PF00917	0.704
DOC_USP7_MATH_1	451	455	PF00917	0.809
DOC_USP7_MATH_1	526	530	PF00917	0.699
DOC_USP7_MATH_1	87	91	PF00917	0.663
DOC_USP7_MATH_2	145	151	PF00917	0.523
DOC_USP7_UBL2_3	322	326	PF12436	0.561
DOC_USP7_UBL2_3	383	387	PF12436	0.564
DOC_WW_Pin1_4	129	134	PF00397	0.671
DOC_WW_Pin1_4	210	215	PF00397	0.667
DOC_WW_Pin1_4	244	249	PF00397	0.768
DOC_WW_Pin1_4	275	280	PF00397	0.725
DOC_WW_Pin1_4	314	319	PF00397	0.743
DOC_WW_Pin1_4	328	333	PF00397	0.707
DOC_WW_Pin1_4	347	352	PF00397	0.710
DOC_WW_Pin1_4	376	381	PF00397	0.681
DOC_WW_Pin1_4	522	527	PF00397	0.550
DOC_WW_Pin1_4	57	62	PF00397	0.669
DOC_WW_Pin1_4	79	84	PF00397	0.582
LIG_14-3-3_CanoR_1	244	248	PF00244	0.802
LIG_14-3-3_CanoR_1	97	104	PF00244	0.586
LIG_AP2alpha_1	91	95	PF02296	0.510
LIG_BRCT_BRCA1_1	113	117	PF00533	0.647
LIG_BRCT_BRCA1_1	221	225	PF00533	0.539
LIG_BRCT_BRCA1_1	334	338	PF00533	0.573
LIG_BRCT_BRCA1_1	412	416	PF00533	0.653
LIG_BRCT_BRCA1_1	459	463	PF00533	0.691
LIG_CSL_BTD_1	368	371	PF09270	0.567
LIG_CtBP_PxDLS_1	357	361	PF00389	0.843
LIG_deltaCOP1_diTrp_1	547	553	PF00928	0.688
LIG_FHA_1	130	136	PF00498	0.532
LIG_FHA_1	258	264	PF00498	0.824
LIG_FHA_1	315	321	PF00498	0.741
LIG_FHA_1	329	335	PF00498	0.641
LIG_FHA_1	384	390	PF00498	0.559
LIG_FHA_1	517	523	PF00498	0.551
LIG_FHA_2	359	365	PF00498	0.585
LIG_LIR_Apic_2	128	133	PF02991	0.782
LIG_LIR_Apic_2	335	341	PF02991	0.570
LIG_LIR_Apic_2	6	12	PF02991	0.672
LIG_LIR_Gen_1	114	124	PF02991	0.533
LIG_LIR_Gen_1	175	186	PF02991	0.682
LIG_LIR_Gen_1	28	36	PF02991	0.789
LIG_LIR_Gen_1	435	444	PF02991	0.682
LIG_LIR_Gen_1	458	467	PF02991	0.768
LIG_LIR_Gen_1	529	538	PF02991	0.697
LIG_LIR_Gen_1	90	96	PF02991	0.761
LIG_LIR_Nem_3	175	181	PF02991	0.677
LIG_LIR_Nem_3	213	219	PF02991	0.531
LIG_LIR_Nem_3	435	440	PF02991	0.678
LIG_LIR_Nem_3	458	462	PF02991	0.774
LIG_LIR_Nem_3	529	534	PF02991	0.628
LIG_LIR_Nem_3	547	553	PF02991	0.691
LIG_LIR_Nem_3	90	94	PF02991	0.508
LIG_MLH1_MIPbox_1	459	463	PF16413	0.772
LIG_MYND_1	196	200	PF01753	0.552
LIG_Pex14_1	216	220	PF04695	0.538
LIG_Pex14_2	221	225	PF04695	0.690
LIG_Pex14_2	463	467	PF04695	0.509
LIG_Pex14_2	91	95	PF04695	0.661
LIG_PTAP_UEV_1	67	72	PF05743	0.683
LIG_REV1ctd_RIR_1	218	228	PF16727	0.538
LIG_SH2_PTP2	10	13	PF00017	0.530
LIG_SH2_SRC	10	13	PF00017	0.530
LIG_SH2_STAP1	459	463	PF00017	0.670
LIG_SH2_STAT5	10	13	PF00017	0.530
LIG_SH2_STAT5	148	151	PF00017	0.523
LIG_SH2_STAT5	531	534	PF00017	0.689
LIG_SH3_1	164	170	PF00018	0.692
LIG_SH3_2	239	244	PF14604	0.580
LIG_SH3_3	164	170	PF00018	0.702
LIG_SH3_3	181	187	PF00018	0.689
LIG_SH3_3	236	242	PF00018	0.721
LIG_SH3_3	245	251	PF00018	0.741
LIG_SH3_3	266	272	PF00018	0.720
LIG_SH3_3	303	309	PF00018	0.722
LIG_SH3_3	321	327	PF00018	0.700
LIG_SH3_3	33	39	PF00018	0.675
LIG_SH3_3	365	371	PF00018	0.619
LIG_SH3_3	499	505	PF00018	0.803
LIG_SH3_3	65	71	PF00018	0.712
LIG_SH3_4	326	333	PF00018	0.551
LIG_SUMO_SIM_par_1	200	205	PF11976	0.590
LIG_SUMO_SIM_par_1	356	361	PF11976	0.727
LIG_SUMO_SIM_par_1	519	525	PF11976	0.760
LIG_SUMO_SIM_par_1	76	82	PF11976	0.621
LIG_WRC_WIRS_1	459	464	PF05994	0.670
LIG_WW_3	166	170	PF00397	0.667
MOD_CDC14_SPxK_1	278	281	PF00782	0.724
MOD_CDC14_SPxK_1	350	353	PF00782	0.590
MOD_CDK_SPK_2	210	215	PF00069	0.536
MOD_CDK_SPxK_1	275	281	PF00069	0.725
MOD_CDK_SPxK_1	347	353	PF00069	0.591
MOD_CDK_SPxxK_3	129	136	PF00069	0.681
MOD_CDK_SPxxK_3	210	217	PF00069	0.535
MOD_CDK_SPxxK_3	376	383	PF00069	0.558
MOD_CK1_1	22	28	PF00069	0.717
MOD_CK1_1	247	253	PF00069	0.836
MOD_CK1_1	259	265	PF00069	0.777
MOD_CK1_1	347	353	PF00069	0.692
MOD_CK1_1	426	432	PF00069	0.699
MOD_CK1_1	43	49	PF00069	0.623
MOD_CK1_1	461	467	PF00069	0.573
MOD_CK1_1	529	535	PF00069	0.789
MOD_CK1_1	537	543	PF00069	0.674
MOD_CK1_1	98	104	PF00069	0.662
MOD_CK2_1	358	364	PF00069	0.696
MOD_CK2_1	424	430	PF00069	0.672
MOD_CK2_1	435	441	PF00069	0.485
MOD_CK2_1	498	504	PF00069	0.548
MOD_DYRK1A_RPxSP_1	244	248	PF00069	0.587
MOD_GlcNHglycan	113	116	PF01048	0.804
MOD_GlcNHglycan	159	162	PF01048	0.742
MOD_GlcNHglycan	208	211	PF01048	0.804
MOD_GlcNHglycan	27	30	PF01048	0.604
MOD_GlcNHglycan	346	349	PF01048	0.802
MOD_GlcNHglycan	416	419	PF01048	0.727
MOD_GlcNHglycan	437	440	PF01048	0.569
MOD_GlcNHglycan	45	48	PF01048	0.589
MOD_GlcNHglycan	492	495	PF01048	0.655
MOD_GlcNHglycan	533	537	PF01048	0.700
MOD_GlcNHglycan	68	71	PF01048	0.665
MOD_GSK3_1	106	113	PF00069	0.710
MOD_GSK3_1	16	23	PF00069	0.569
MOD_GSK3_1	206	213	PF00069	0.694
MOD_GSK3_1	243	250	PF00069	0.842
MOD_GSK3_1	253	260	PF00069	0.663
MOD_GSK3_1	328	335	PF00069	0.744
MOD_GSK3_1	410	417	PF00069	0.623
MOD_GSK3_1	421	428	PF00069	0.636
MOD_GSK3_1	457	464	PF00069	0.631
MOD_GSK3_1	500	507	PF00069	0.671
MOD_GSK3_1	516	523	PF00069	0.684
MOD_GSK3_1	534	541	PF00069	0.801
MOD_GSK3_1	98	105	PF00069	0.688
MOD_N-GLC_1	25	30	PF02516	0.539
MOD_NEK2_1	219	224	PF00069	0.713
MOD_NEK2_1	225	230	PF00069	0.661
MOD_NEK2_1	358	363	PF00069	0.592
MOD_NEK2_1	385	390	PF00069	0.712
MOD_NEK2_1	411	416	PF00069	0.651
MOD_NEK2_1	462	467	PF00069	0.681
MOD_NEK2_1	534	539	PF00069	0.708
MOD_NEK2_1	95	100	PF00069	0.525
MOD_PIKK_1	106	112	PF00454	0.565
MOD_PIKK_1	446	452	PF00454	0.711
MOD_PIKK_1	504	510	PF00454	0.696
MOD_PK_1	485	491	PF00069	0.505
MOD_PKA_1	446	452	PF00069	0.554
MOD_PKA_2	225	231	PF00069	0.599
MOD_PKA_2	243	249	PF00069	0.739
MOD_PKA_2	446	452	PF00069	0.584
MOD_PKA_2	66	72	PF00069	0.565
MOD_PKA_2	96	102	PF00069	0.680
MOD_Plk_1	155	161	PF00069	0.697
MOD_Plk_1	19	25	PF00069	0.719
MOD_Plk_1	281	287	PF00069	0.578
MOD_Plk_1	374	380	PF00069	0.618
MOD_Plk_1	457	463	PF00069	0.776
MOD_Plk_2-3	473	479	PF00069	0.581
MOD_Plk_2-3	498	504	PF00069	0.548
MOD_Plk_4	320	326	PF00069	0.563
MOD_Plk_4	333	339	PF00069	0.521
MOD_Plk_4	411	417	PF00069	0.656
MOD_Plk_4	458	464	PF00069	0.774
MOD_Plk_4	87	93	PF00069	0.761
MOD_ProDKin_1	129	135	PF00069	0.673
MOD_ProDKin_1	210	216	PF00069	0.666
MOD_ProDKin_1	244	250	PF00069	0.769
MOD_ProDKin_1	275	281	PF00069	0.725
MOD_ProDKin_1	314	320	PF00069	0.744
MOD_ProDKin_1	328	334	PF00069	0.709
MOD_ProDKin_1	347	353	PF00069	0.713
MOD_ProDKin_1	376	382	PF00069	0.679
MOD_ProDKin_1	522	528	PF00069	0.548
MOD_ProDKin_1	57	63	PF00069	0.670
MOD_ProDKin_1	79	85	PF00069	0.579
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.809
TRG_ENDOCYTIC_2	459	462	PF00928	0.669
TRG_ENDOCYTIC_2	531	534	PF00928	0.630
TRG_ER_diArg_1	483	485	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.784

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH7	Leptomonas seymouri	45%	100%
A0A3S7XAN3	Leishmania donovani	68%	100%
A4IDE1	Leishmania infantum	68%	100%
E9ASU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q1Q4	Leishmania major	65%	98%