Mitochondrial inner membrane protease ATP23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase M76 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HP33_LEIBR

TriTrypDb:

LbrM.35.1880 , LBRM2903_350025100

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0019898	extrinsic component of membrane	2	1
GO:0031312	extrinsic component of organelle membrane	3	1
GO:0031314	extrinsic component of mitochondrial inner membrane	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP33

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016485	protein processing	5	1
GO:0022607	cellular component assembly	4	1
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	8	1
GO:0034982	mitochondrial protein processing	6	1
GO:0043461	proton-transporting ATP synthase complex assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0051604	protein maturation	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004222	metalloendopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.642
CLV_C14_Caspase3-7	137	141	PF00656	0.408
CLV_NRD_NRD_1	232	234	PF00675	0.303
CLV_NRD_NRD_1	249	251	PF00675	0.164
CLV_NRD_NRD_1	26	28	PF00675	0.476
CLV_NRD_NRD_1	273	275	PF00675	0.341
CLV_PCSK_KEX2_1	248	250	PF00082	0.312
CLV_PCSK_KEX2_1	26	28	PF00082	0.627
CLV_PCSK_SKI1_1	65	69	PF00082	0.380
CLV_PCSK_SKI1_1	89	93	PF00082	0.174
DOC_MAPK_gen_1	245	255	PF00069	0.276
DOC_MAPK_gen_1	69	77	PF00069	0.264
DOC_PP4_FxxP_1	283	286	PF00568	0.343
DOC_USP7_MATH_1	148	152	PF00917	0.391
DOC_USP7_MATH_1	156	160	PF00917	0.346
DOC_USP7_MATH_1	84	88	PF00917	0.308
DOC_USP7_MATH_1	9	13	PF00917	0.606
DOC_WW_Pin1_4	144	149	PF00397	0.376
DOC_WW_Pin1_4	157	162	PF00397	0.419
DOC_WW_Pin1_4	163	168	PF00397	0.150
DOC_WW_Pin1_4	30	35	PF00397	0.340
DOC_WW_Pin1_4	89	94	PF00397	0.386
LIG_14-3-3_CanoR_1	262	269	PF00244	0.280
LIG_14-3-3_CanoR_1	274	283	PF00244	0.290
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BIR_III_2	14	18	PF00653	0.471
LIG_BIR_III_4	199	203	PF00653	0.268
LIG_FHA_1	86	92	PF00498	0.263
LIG_FHA_2	9	15	PF00498	0.478
LIG_LIR_Apic_2	281	286	PF02991	0.256
LIG_LIR_Nem_3	278	283	PF02991	0.252
LIG_LIR_Nem_3	94	100	PF02991	0.262
LIG_MYND_3	179	183	PF01753	0.342
LIG_NRBOX	169	175	PF00104	0.396
LIG_SH2_STAP1	206	210	PF00017	0.167
LIG_SH2_STAT3	54	57	PF00017	0.342
LIG_SH2_STAT5	100	103	PF00017	0.224
LIG_SH2_STAT5	44	47	PF00017	0.312
LIG_SH3_1	73	79	PF00018	0.406
LIG_SH3_3	73	79	PF00018	0.367
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.268
LIG_SUMO_SIM_par_1	113	119	PF11976	0.268
LIG_SUMO_SIM_par_1	251	256	PF11976	0.196
LIG_TRAF2_1	17	20	PF00917	0.452
LIG_TRAF2_1	58	61	PF00917	0.268
LIG_WRC_WIRS_1	1	6	PF05994	0.421
MOD_CDK_SPxK_1	89	95	PF00069	0.392
MOD_CK1_1	104	110	PF00069	0.421
MOD_CK1_1	147	153	PF00069	0.398
MOD_CK1_1	159	165	PF00069	0.424
MOD_CK1_1	289	295	PF00069	0.534
MOD_CK1_1	3	9	PF00069	0.564
MOD_CK1_1	30	36	PF00069	0.452
MOD_CK2_1	275	281	PF00069	0.252
MOD_CK2_1	55	61	PF00069	0.268
MOD_GlcNHglycan	103	106	PF01048	0.335
MOD_GlcNHglycan	222	225	PF01048	0.255
MOD_GSK3_1	144	151	PF00069	0.394
MOD_GSK3_1	156	163	PF00069	0.285
MOD_GSK3_1	4	11	PF00069	0.703
MOD_GSK3_1	85	92	PF00069	0.332
MOD_N-GLC_1	299	304	PF02516	0.576
MOD_N-GLC_2	141	143	PF02516	0.167
MOD_NEK2_1	124	129	PF00069	0.352
MOD_NEK2_1	174	179	PF00069	0.392
MOD_NEK2_1	4	9	PF00069	0.610
MOD_NEK2_2	268	273	PF00069	0.342
MOD_NEK2_2	299	304	PF00069	0.576
MOD_PIKK_1	174	180	PF00454	0.392
MOD_PKA_2	220	226	PF00069	0.252
MOD_Plk_1	141	147	PF00069	0.368
MOD_Plk_1	185	191	PF00069	0.282
MOD_Plk_4	129	135	PF00069	0.310
MOD_Plk_4	141	147	PF00069	0.392
MOD_Plk_4	268	274	PF00069	0.392
MOD_Plk_4	27	33	PF00069	0.514
MOD_ProDKin_1	144	150	PF00069	0.376
MOD_ProDKin_1	157	163	PF00069	0.419
MOD_ProDKin_1	30	36	PF00069	0.339
MOD_ProDKin_1	89	95	PF00069	0.386
MOD_SUMO_for_1	134	137	PF00179	0.167
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.342
TRG_ENDOCYTIC_2	280	283	PF00928	0.252
TRG_ER_diArg_1	247	250	PF00400	0.306
TRG_ER_diArg_1	25	27	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.167
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.167

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ07	Leptomonas seymouri	70%	100%
A0A0S4IYE0	Bodo saltans	38%	100%
A0A1X0P8Q9	Trypanosomatidae	46%	100%
A0A3Q8IJ83	Leishmania donovani	83%	98%
A0A422MWT3	Trypanosoma rangeli	49%	100%
A4IDE0	Leishmania infantum	83%	98%
D0A316	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ASU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q1Q5	Leishmania major	81%	100%
Q6CTY3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
Q75EL5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	33%	100%
V5B4E2	Trypanosoma cruzi	49%	100%