Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP32_LEIBR

TriTrypDb:

LbrM.35.1870 , LBRM2903_350025000

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.566
CLV_C14_Caspase3-7	27	31	PF00656	0.617
CLV_C14_Caspase3-7	303	307	PF00656	0.561
CLV_C14_Caspase3-7	768	772	PF00656	0.468
CLV_NRD_NRD_1	126	128	PF00675	0.468
CLV_NRD_NRD_1	144	146	PF00675	0.350
CLV_NRD_NRD_1	173	175	PF00675	0.665
CLV_NRD_NRD_1	205	207	PF00675	0.560
CLV_NRD_NRD_1	260	262	PF00675	0.581
CLV_NRD_NRD_1	354	356	PF00675	0.741
CLV_NRD_NRD_1	407	409	PF00675	0.473
CLV_NRD_NRD_1	416	418	PF00675	0.460
CLV_NRD_NRD_1	48	50	PF00675	0.605
CLV_NRD_NRD_1	496	498	PF00675	0.498
CLV_NRD_NRD_1	596	598	PF00675	0.543
CLV_NRD_NRD_1	611	613	PF00675	0.616
CLV_NRD_NRD_1	640	642	PF00675	0.605
CLV_NRD_NRD_1	670	672	PF00675	0.644
CLV_NRD_NRD_1	76	78	PF00675	0.444
CLV_NRD_NRD_1	774	776	PF00675	0.519
CLV_PCSK_FUR_1	668	672	PF00082	0.753
CLV_PCSK_KEX2_1	126	128	PF00082	0.468
CLV_PCSK_KEX2_1	144	146	PF00082	0.373
CLV_PCSK_KEX2_1	173	175	PF00082	0.665
CLV_PCSK_KEX2_1	205	207	PF00082	0.560
CLV_PCSK_KEX2_1	260	262	PF00082	0.581
CLV_PCSK_KEX2_1	354	356	PF00082	0.783
CLV_PCSK_KEX2_1	407	409	PF00082	0.473
CLV_PCSK_KEX2_1	416	418	PF00082	0.460
CLV_PCSK_KEX2_1	496	498	PF00082	0.498
CLV_PCSK_KEX2_1	596	598	PF00082	0.543
CLV_PCSK_KEX2_1	611	613	PF00082	0.616
CLV_PCSK_KEX2_1	62	64	PF00082	0.512
CLV_PCSK_KEX2_1	667	669	PF00082	0.636
CLV_PCSK_KEX2_1	670	672	PF00082	0.641
CLV_PCSK_KEX2_1	76	78	PF00082	0.578
CLV_PCSK_KEX2_1	774	776	PF00082	0.519
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.432
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.552
CLV_PCSK_SKI1_1	126	130	PF00082	0.478
CLV_PCSK_SKI1_1	162	166	PF00082	0.597
CLV_PCSK_SKI1_1	174	178	PF00082	0.487
CLV_PCSK_SKI1_1	179	183	PF00082	0.479
CLV_PCSK_SKI1_1	321	325	PF00082	0.565
CLV_PCSK_SKI1_1	329	333	PF00082	0.566
CLV_PCSK_SKI1_1	535	539	PF00082	0.651
CLV_PCSK_SKI1_1	611	615	PF00082	0.560
CLV_PCSK_SKI1_1	625	629	PF00082	0.376
CLV_PCSK_SKI1_1	63	67	PF00082	0.434
CLV_PCSK_SKI1_1	687	691	PF00082	0.516
CLV_PCSK_SKI1_1	747	751	PF00082	0.674
CLV_PCSK_SKI1_1	76	80	PF00082	0.502
CLV_PCSK_SKI1_1	774	778	PF00082	0.511
CLV_Separin_Metazoa	758	762	PF03568	0.474
DEG_APCC_DBOX_1	178	186	PF00400	0.377
DEG_APCC_DBOX_1	328	336	PF00400	0.476
DEG_APCC_DBOX_1	534	542	PF00400	0.528
DEG_SPOP_SBC_1	721	725	PF00917	0.648
DOC_CYCLIN_RxL_1	744	754	PF00134	0.599
DOC_CYCLIN_RxL_1	76	88	PF00134	0.433
DOC_MAPK_gen_1	596	603	PF00069	0.491
DOC_MAPK_MEF2A_6	596	605	PF00069	0.653
DOC_MAPK_RevD_3	112	127	PF00069	0.482
DOC_PP1_RVXF_1	177	184	PF00149	0.408
DOC_PP1_RVXF_1	319	325	PF00149	0.556
DOC_PP2B_LxvP_1	232	235	PF13499	0.503
DOC_PP2B_LxvP_1	447	450	PF13499	0.417
DOC_PP2B_LxvP_1	661	664	PF13499	0.549
DOC_PP2B_LxvP_1	728	731	PF13499	0.547
DOC_PP4_FxxP_1	192	195	PF00568	0.557
DOC_PP4_FxxP_1	562	565	PF00568	0.592
DOC_PP4_MxPP_1	776	779	PF00568	0.495
DOC_USP7_MATH_1	106	110	PF00917	0.621
DOC_USP7_MATH_1	273	277	PF00917	0.626
DOC_USP7_MATH_1	283	287	PF00917	0.621
DOC_USP7_MATH_1	398	402	PF00917	0.558
DOC_USP7_MATH_1	587	591	PF00917	0.518
DOC_USP7_MATH_1	607	611	PF00917	0.400
DOC_USP7_MATH_1	679	683	PF00917	0.570
DOC_USP7_MATH_1	721	725	PF00917	0.615
DOC_USP7_UBL2_3	62	66	PF12436	0.438
DOC_WW_Pin1_4	143	148	PF00397	0.424
DOC_WW_Pin1_4	255	260	PF00397	0.799
DOC_WW_Pin1_4	262	267	PF00397	0.752
DOC_WW_Pin1_4	279	284	PF00397	0.564
DOC_WW_Pin1_4	322	327	PF00397	0.564
DOC_WW_Pin1_4	341	346	PF00397	0.545
DOC_WW_Pin1_4	371	376	PF00397	0.530
DOC_WW_Pin1_4	542	547	PF00397	0.588
DOC_WW_Pin1_4	659	664	PF00397	0.667
DOC_WW_Pin1_4	687	692	PF00397	0.567
DOC_WW_Pin1_4	774	779	PF00397	0.496
LIG_14-3-3_CanoR_1	416	421	PF00244	0.709
LIG_14-3-3_CanoR_1	427	432	PF00244	0.534
LIG_14-3-3_CanoR_1	611	620	PF00244	0.660
LIG_14-3-3_CanoR_1	81	86	PF00244	0.432
LIG_Actin_WH2_2	440	455	PF00022	0.443
LIG_Actin_WH2_2	534	552	PF00022	0.537
LIG_BIR_III_2	30	34	PF00653	0.674
LIG_BRCT_BRCA1_1	22	26	PF00533	0.494
LIG_BRCT_BRCA1_1	343	347	PF00533	0.684
LIG_CtBP_PxDLS_1	15	19	PF00389	0.537
LIG_DLG_GKlike_1	81	89	PF00625	0.433
LIG_eIF4E_1	117	123	PF01652	0.394
LIG_eIF4E_1	210	216	PF01652	0.590
LIG_eIF4E_1	341	347	PF01652	0.518
LIG_eIF4E_1	442	448	PF01652	0.439
LIG_eIF4E_1	623	629	PF01652	0.409
LIG_FHA_1	262	268	PF00498	0.720
LIG_FHA_1	341	347	PF00498	0.620
LIG_FHA_1	358	364	PF00498	0.479
LIG_FHA_1	552	558	PF00498	0.685
LIG_FHA_1	565	571	PF00498	0.560
LIG_FHA_1	576	582	PF00498	0.621
LIG_FHA_1	6	12	PF00498	0.672
LIG_FHA_1	600	606	PF00498	0.599
LIG_FHA_1	615	621	PF00498	0.409
LIG_FHA_1	688	694	PF00498	0.535
LIG_FHA_1	709	715	PF00498	0.625
LIG_FHA_1	755	761	PF00498	0.518
LIG_FHA_2	25	31	PF00498	0.494
LIG_FHA_2	543	549	PF00498	0.543
LIG_FHA_2	613	619	PF00498	0.502
LIG_Integrin_RGD_1	463	465	PF01839	0.659
LIG_LIR_Apic_2	190	195	PF02991	0.389
LIG_LIR_Apic_2	277	283	PF02991	0.554
LIG_LIR_Apic_2	560	565	PF02991	0.600
LIG_LIR_Gen_1	740	750	PF02991	0.515
LIG_LIR_Gen_1	780	788	PF02991	0.515
LIG_LIR_Gen_1	84	92	PF02991	0.483
LIG_LIR_Nem_3	319	323	PF02991	0.608
LIG_LIR_Nem_3	780	785	PF02991	0.508
LIG_LIR_Nem_3	84	89	PF02991	0.514
LIG_LIR_Nem_3	94	98	PF02991	0.561
LIG_NRBOX	177	183	PF00104	0.391
LIG_SH2_CRK	320	324	PF00017	0.757
LIG_SH2_CRK	458	462	PF00017	0.552
LIG_SH2_CRK	86	90	PF00017	0.482
LIG_SH2_NCK_1	395	399	PF00017	0.536
LIG_SH2_NCK_1	782	786	PF00017	0.518
LIG_SH2_STAP1	149	153	PF00017	0.398
LIG_SH2_STAP1	395	399	PF00017	0.536
LIG_SH2_STAP1	782	786	PF00017	0.518
LIG_SH2_STAT5	210	213	PF00017	0.540
LIG_SH2_STAT5	4	7	PF00017	0.637
LIG_SH2_STAT5	442	445	PF00017	0.500
LIG_SH2_STAT5	753	756	PF00017	0.673
LIG_SH3_2	663	668	PF14604	0.631
LIG_SH3_3	227	233	PF00018	0.511
LIG_SH3_3	256	262	PF00018	0.653
LIG_SH3_3	320	326	PF00018	0.484
LIG_SH3_3	339	345	PF00018	0.544
LIG_SH3_3	616	622	PF00018	0.427
LIG_SH3_3	660	666	PF00018	0.681
LIG_SUMO_SIM_anti_2	602	608	PF11976	0.472
LIG_SUMO_SIM_par_1	514	520	PF11976	0.657
LIG_TRAF2_1	250	253	PF00917	0.551
LIG_TRAF2_1	325	328	PF00917	0.668
LIG_TYR_ITIM	456	461	PF00017	0.452
LIG_WW_2	663	666	PF00397	0.588
MOD_CDC14_SPxK_1	258	261	PF00782	0.577
MOD_CDK_SPK_2	255	260	PF00069	0.573
MOD_CDK_SPxK_1	255	261	PF00069	0.576
MOD_CDK_SPxxK_3	322	329	PF00069	0.464
MOD_CK1_1	20	26	PF00069	0.637
MOD_CK1_1	265	271	PF00069	0.795
MOD_CK1_1	286	292	PF00069	0.567
MOD_CK1_1	382	388	PF00069	0.545
MOD_CK1_1	391	397	PF00069	0.527
MOD_CK1_1	401	407	PF00069	0.623
MOD_CK1_1	469	475	PF00069	0.650
MOD_CK1_1	544	550	PF00069	0.808
MOD_CK1_1	590	596	PF00069	0.655
MOD_CK1_1	599	605	PF00069	0.731
MOD_CK1_1	659	665	PF00069	0.637
MOD_CK1_1	726	732	PF00069	0.669
MOD_CK1_1	733	739	PF00069	0.673
MOD_CK1_1	84	90	PF00069	0.643
MOD_CK2_1	322	328	PF00069	0.677
MOD_CK2_1	346	352	PF00069	0.527
MOD_CK2_1	371	377	PF00069	0.558
MOD_CK2_1	542	548	PF00069	0.541
MOD_CK2_1	777	783	PF00069	0.707
MOD_CK2_1	88	94	PF00069	0.454
MOD_GlcNHglycan	22	25	PF01048	0.547
MOD_GlcNHglycan	267	270	PF01048	0.802
MOD_GlcNHglycan	277	280	PF01048	0.643
MOD_GlcNHglycan	381	384	PF01048	0.614
MOD_GlcNHglycan	400	403	PF01048	0.564
MOD_GlcNHglycan	443	446	PF01048	0.442
MOD_GlcNHglycan	598	601	PF01048	0.585
MOD_GlcNHglycan	90	93	PF01048	0.459
MOD_GSK3_1	106	113	PF00069	0.606
MOD_GSK3_1	16	23	PF00069	0.692
MOD_GSK3_1	214	221	PF00069	0.530
MOD_GSK3_1	261	268	PF00069	0.672
MOD_GSK3_1	275	282	PF00069	0.679
MOD_GSK3_1	341	348	PF00069	0.684
MOD_GSK3_1	382	389	PF00069	0.514
MOD_GSK3_1	412	419	PF00069	0.671
MOD_GSK3_1	466	473	PF00069	0.645
MOD_GSK3_1	540	547	PF00069	0.622
MOD_GSK3_1	588	595	PF00069	0.587
MOD_GSK3_1	607	614	PF00069	0.445
MOD_GSK3_1	653	660	PF00069	0.609
MOD_GSK3_1	722	729	PF00069	0.763
MOD_GSK3_1	777	784	PF00069	0.597
MOD_GSK3_1	81	88	PF00069	0.647
MOD_N-GLC_1	16	21	PF02516	0.664
MOD_N-GLC_1	273	278	PF02516	0.556
MOD_NEK2_1	116	121	PF00069	0.560
MOD_NEK2_1	131	136	PF00069	0.375
MOD_NEK2_1	16	21	PF00069	0.682
MOD_NEK2_1	34	39	PF00069	0.537
MOD_NEK2_1	412	417	PF00069	0.467
MOD_NEK2_1	471	476	PF00069	0.541
MOD_NEK2_1	5	10	PF00069	0.763
MOD_NEK2_1	541	546	PF00069	0.559
MOD_NEK2_1	85	90	PF00069	0.439
MOD_NEK2_2	149	154	PF00069	0.585
MOD_NEK2_2	187	192	PF00069	0.418
MOD_NEK2_2	476	481	PF00069	0.519
MOD_PIKK_1	208	214	PF00454	0.495
MOD_PIKK_1	575	581	PF00454	0.528
MOD_PKA_1	416	422	PF00069	0.479
MOD_PKA_1	596	602	PF00069	0.491
MOD_PKA_1	611	617	PF00069	0.419
MOD_PKA_2	286	292	PF00069	0.563
MOD_PKA_2	416	422	PF00069	0.714
MOD_PKA_2	587	593	PF00069	0.566
MOD_PKA_2	596	602	PF00069	0.561
MOD_PKA_2	611	617	PF00069	0.419
MOD_Plk_1	389	395	PF00069	0.526
MOD_Plk_1	466	472	PF00069	0.641
MOD_Plk_1	656	662	PF00069	0.549
MOD_Plk_4	187	193	PF00069	0.449
MOD_Plk_4	286	292	PF00069	0.723
MOD_Plk_4	335	341	PF00069	0.550
MOD_Plk_4	401	407	PF00069	0.688
MOD_Plk_4	509	515	PF00069	0.680
MOD_Plk_4	680	686	PF00069	0.719
MOD_Plk_4	689	695	PF00069	0.582
MOD_Plk_4	723	729	PF00069	0.549
MOD_Plk_4	777	783	PF00069	0.663
MOD_Plk_4	81	87	PF00069	0.475
MOD_ProDKin_1	143	149	PF00069	0.421
MOD_ProDKin_1	255	261	PF00069	0.801
MOD_ProDKin_1	262	268	PF00069	0.751
MOD_ProDKin_1	279	285	PF00069	0.562
MOD_ProDKin_1	322	328	PF00069	0.561
MOD_ProDKin_1	341	347	PF00069	0.549
MOD_ProDKin_1	371	377	PF00069	0.532
MOD_ProDKin_1	542	548	PF00069	0.590
MOD_ProDKin_1	659	665	PF00069	0.667
MOD_ProDKin_1	687	693	PF00069	0.567
MOD_ProDKin_1	774	780	PF00069	0.496
MOD_SUMO_rev_2	328	338	PF00179	0.579
TRG_DiLeu_BaEn_1	172	177	PF01217	0.669
TRG_DiLeu_BaEn_1	327	332	PF01217	0.679
TRG_DiLeu_BaEn_4	327	333	PF01217	0.679
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.504
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.549
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.518
TRG_DiLeu_BaLyEn_6	673	678	PF01217	0.536
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.599
TRG_DiLeu_BaLyEn_6	744	749	PF01217	0.554
TRG_ENDOCYTIC_2	320	323	PF00928	0.585
TRG_ENDOCYTIC_2	458	461	PF00928	0.551
TRG_ENDOCYTIC_2	782	785	PF00928	0.515
TRG_ENDOCYTIC_2	86	89	PF00928	0.479
TRG_ER_diArg_1	143	145	PF00400	0.411
TRG_ER_diArg_1	204	206	PF00400	0.554
TRG_ER_diArg_1	259	261	PF00400	0.577
TRG_ER_diArg_1	353	355	PF00400	0.577
TRG_ER_diArg_1	406	408	PF00400	0.470
TRG_ER_diArg_1	495	497	PF00400	0.518
TRG_ER_diArg_1	533	536	PF00400	0.514
TRG_ER_diArg_1	611	613	PF00400	0.662
TRG_ER_diArg_1	668	671	PF00400	0.640
TRG_ER_diArg_1	76	78	PF00400	0.662
TRG_ER_diArg_1	773	775	PF00400	0.492
TRG_NLS_MonoExtC_3	666	671	PF00514	0.553
TRG_NLS_MonoExtN_4	664	671	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF83	Leptomonas seymouri	33%	88%
A0A3S7XAQ0	Leishmania donovani	62%	100%
A4IDD9	Leishmania infantum	62%	100%
E9ASU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q1Q6	Leishmania major	62%	99%