Queuosine salvage protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2419), putative

Species:

Leishmania braziliensis

UniProt:

A4HP31_LEIBR

TriTrypDb:

LbrM.35.1860 , LBRM2903_350024900

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP31

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0101030	tRNA-guanine transglycosylation	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.474
CLV_NRD_NRD_1	123	125	PF00675	0.450
CLV_NRD_NRD_1	204	206	PF00675	0.427
CLV_NRD_NRD_1	271	273	PF00675	0.315
CLV_NRD_NRD_1	532	534	PF00675	0.240
CLV_PCSK_KEX2_1	123	125	PF00082	0.658
CLV_PCSK_KEX2_1	204	206	PF00082	0.421
CLV_PCSK_KEX2_1	271	273	PF00082	0.315
CLV_PCSK_SKI1_1	451	455	PF00082	0.492
CLV_PCSK_SKI1_1	466	470	PF00082	0.438
CLV_PCSK_SKI1_1	486	490	PF00082	0.240
CLV_PCSK_SKI1_1	528	532	PF00082	0.503
DEG_SPOP_SBC_1	369	373	PF00917	0.478
DOC_ANK_TNKS_1	316	323	PF00023	0.582
DOC_CKS1_1	480	485	PF01111	0.492
DOC_CYCLIN_RxL_1	472	482	PF00134	0.492
DOC_MAPK_DCC_7	242	251	PF00069	0.464
DOC_MAPK_DCC_7	336	345	PF00069	0.297
DOC_MAPK_gen_1	255	264	PF00069	0.436
DOC_MAPK_gen_1	336	345	PF00069	0.492
DOC_MAPK_gen_1	431	440	PF00069	0.433
DOC_MAPK_gen_1	511	519	PF00069	0.492
DOC_MAPK_MEF2A_6	25	32	PF00069	0.532
DOC_MAPK_MEF2A_6	255	264	PF00069	0.406
DOC_MAPK_MEF2A_6	311	320	PF00069	0.292
DOC_MAPK_MEF2A_6	336	345	PF00069	0.297
DOC_MAPK_NFAT4_5	257	265	PF00069	0.422
DOC_PP1_RVXF_1	473	480	PF00149	0.393
DOC_PP2B_LxvP_1	179	182	PF13499	0.527
DOC_PP2B_LxvP_1	249	252	PF13499	0.540
DOC_PP2B_LxvP_1	454	457	PF13499	0.438
DOC_PP2B_LxvP_1	87	90	PF13499	0.430
DOC_PP4_FxxP_1	168	171	PF00568	0.638
DOC_USP7_MATH_1	229	233	PF00917	0.545
DOC_USP7_MATH_1	267	271	PF00917	0.515
DOC_USP7_MATH_1	295	299	PF00917	0.498
DOC_USP7_MATH_1	383	387	PF00917	0.496
DOC_USP7_MATH_1	75	79	PF00917	0.629
DOC_WW_Pin1_4	244	249	PF00397	0.496
DOC_WW_Pin1_4	365	370	PF00397	0.492
DOC_WW_Pin1_4	479	484	PF00397	0.475
LIG_14-3-3_CanoR_1	123	130	PF00244	0.514
LIG_14-3-3_CanoR_1	156	164	PF00244	0.464
LIG_14-3-3_CanoR_1	271	276	PF00244	0.484
LIG_14-3-3_CanoR_1	374	379	PF00244	0.670
LIG_14-3-3_CanoR_1	466	471	PF00244	0.438
LIG_APCC_ABBA_1	438	443	PF00400	0.492
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BRCT_BRCA1_1	234	238	PF00533	0.283
LIG_BRCT_BRCA1_1	297	301	PF00533	0.429
LIG_BRCT_BRCA1_1	411	415	PF00533	0.486
LIG_Clathr_ClatBox_1	107	111	PF01394	0.266
LIG_CSL_BTD_1	249	252	PF09270	0.458
LIG_CtBP_PxDLS_1	90	94	PF00389	0.407
LIG_DLG_GKlike_1	271	278	PF00625	0.498
LIG_FHA_1	125	131	PF00498	0.627
LIG_FHA_1	159	165	PF00498	0.653
LIG_FHA_1	187	193	PF00498	0.507
LIG_FHA_1	370	376	PF00498	0.548
LIG_FHA_1	39	45	PF00498	0.390
LIG_FHA_1	402	408	PF00498	0.477
LIG_Integrin_isoDGR_2	121	123	PF01839	0.431
LIG_Integrin_RGD_1	224	226	PF01839	0.592
LIG_LIR_Apic_2	166	171	PF02991	0.646
LIG_LIR_Apic_2	426	430	PF02991	0.357
LIG_LIR_Gen_1	273	283	PF02991	0.401
LIG_LIR_Gen_1	314	323	PF02991	0.601
LIG_LIR_Gen_1	50	59	PF02991	0.438
LIG_LIR_Nem_3	135	140	PF02991	0.497
LIG_LIR_Nem_3	17	22	PF02991	0.307
LIG_LIR_Nem_3	273	279	PF02991	0.382
LIG_LIR_Nem_3	314	318	PF02991	0.540
LIG_LIR_Nem_3	50	55	PF02991	0.387
LIG_PAM2_1	378	390	PF00658	0.681
LIG_Pex14_2	215	219	PF04695	0.506
LIG_PTAP_UEV_1	379	384	PF05743	0.744
LIG_Rb_LxCxE_1	235	256	PF01857	0.338
LIG_RPA_C_Fungi	266	278	PF08784	0.500
LIG_SH2_CRK	276	280	PF00017	0.442
LIG_SH2_CRK	427	431	PF00017	0.357
LIG_SH2_CRK	529	533	PF00017	0.438
LIG_SH2_NCK_1	141	145	PF00017	0.534
LIG_SH2_SRC	427	430	PF00017	0.391
LIG_SH2_SRC	441	444	PF00017	0.391
LIG_SH2_STAP1	441	445	PF00017	0.438
LIG_SH2_STAP1	521	525	PF00017	0.438
LIG_SH2_STAT5	103	106	PF00017	0.349
LIG_SH2_STAT5	201	204	PF00017	0.450
LIG_SH2_STAT5	312	315	PF00017	0.267
LIG_SH2_STAT5	525	528	PF00017	0.401
LIG_SH2_STAT5	64	67	PF00017	0.488
LIG_SH2_STAT5	9	12	PF00017	0.575
LIG_SH3_3	141	147	PF00018	0.534
LIG_SH3_3	313	319	PF00018	0.462
LIG_SH3_3	377	383	PF00018	0.733
LIG_SH3_3	503	509	PF00018	0.442
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.482
LIG_SUMO_SIM_par_1	106	111	PF11976	0.379
LIG_SUMO_SIM_par_1	259	266	PF11976	0.430
LIG_SUMO_SIM_par_1	85	92	PF11976	0.393
LIG_TRAF2_1	459	462	PF00917	0.438
LIG_UBA3_1	339	344	PF00899	0.272
MOD_CDK_SPxxK_3	479	486	PF00069	0.454
MOD_CK1_1	148	154	PF00069	0.667
MOD_CK1_1	232	238	PF00069	0.293
MOD_CK1_1	270	276	PF00069	0.294
MOD_CK1_1	346	352	PF00069	0.455
MOD_CK1_1	368	374	PF00069	0.670
MOD_CK1_1	402	408	PF00069	0.741
MOD_CK1_1	409	415	PF00069	0.385
MOD_CK1_1	7	13	PF00069	0.496
MOD_CK1_1	79	85	PF00069	0.529
MOD_CK2_1	456	462	PF00069	0.492
MOD_CK2_1	85	91	PF00069	0.463
MOD_Cter_Amidation	121	124	PF01082	0.435
MOD_GlcNHglycan	147	150	PF01048	0.636
MOD_GlcNHglycan	195	198	PF01048	0.490
MOD_GlcNHglycan	231	234	PF01048	0.547
MOD_GlcNHglycan	380	383	PF01048	0.682
MOD_GlcNHglycan	411	414	PF01048	0.410
MOD_GlcNHglycan	417	420	PF01048	0.382
MOD_GlcNHglycan	67	70	PF01048	0.666
MOD_GSK3_1	1	8	PF00069	0.630
MOD_GSK3_1	10	17	PF00069	0.443
MOD_GSK3_1	184	191	PF00069	0.481
MOD_GSK3_1	267	274	PF00069	0.420
MOD_GSK3_1	365	372	PF00069	0.580
MOD_GSK3_1	374	381	PF00069	0.659
MOD_GSK3_1	402	409	PF00069	0.654
MOD_GSK3_1	415	422	PF00069	0.203
MOD_GSK3_1	65	72	PF00069	0.609
MOD_GSK3_1	75	82	PF00069	0.533
MOD_GSK3_1	85	92	PF00069	0.376
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	193	198	PF00069	0.450
MOD_NEK2_1	260	265	PF00069	0.419
MOD_NEK2_1	33	38	PF00069	0.521
MOD_NEK2_1	343	348	PF00069	0.451
MOD_NEK2_1	400	405	PF00069	0.521
MOD_NEK2_1	407	412	PF00069	0.544
MOD_NEK2_1	415	420	PF00069	0.395
MOD_NEK2_1	539	544	PF00069	0.350
MOD_NEK2_1	63	68	PF00069	0.483
MOD_PIKK_1	343	349	PF00454	0.458
MOD_PKA_1	123	129	PF00069	0.621
MOD_PKA_1	271	277	PF00069	0.288
MOD_PKA_2	123	129	PF00069	0.639
MOD_PKA_2	14	20	PF00069	0.426
MOD_PKA_2	155	161	PF00069	0.485
MOD_PKA_2	193	199	PF00069	0.412
MOD_PKA_2	270	276	PF00069	0.489
MOD_PKA_2	373	379	PF00069	0.521
MOD_Plk_1	461	467	PF00069	0.393
MOD_Plk_4	14	20	PF00069	0.395
MOD_Plk_4	181	187	PF00069	0.722
MOD_Plk_4	188	194	PF00069	0.573
MOD_Plk_4	271	277	PF00069	0.405
MOD_Plk_4	28	34	PF00069	0.515
MOD_Plk_4	383	389	PF00069	0.631
MOD_Plk_4	40	46	PF00069	0.481
MOD_Plk_4	466	472	PF00069	0.430
MOD_Plk_4	76	82	PF00069	0.501
MOD_ProDKin_1	244	250	PF00069	0.496
MOD_ProDKin_1	365	371	PF00069	0.508
MOD_ProDKin_1	479	485	PF00069	0.475
MOD_SUMO_rev_2	478	488	PF00179	0.240
MOD_SUMO_rev_2	91	100	PF00179	0.311
TRG_DiLeu_BaEn_1	256	261	PF01217	0.480
TRG_DiLeu_BaEn_2	280	286	PF01217	0.286
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.438
TRG_ENDOCYTIC_2	103	106	PF00928	0.349
TRG_ENDOCYTIC_2	141	144	PF00928	0.446
TRG_ENDOCYTIC_2	275	278	PF00928	0.444
TRG_ENDOCYTIC_2	312	315	PF00928	0.384
TRG_ER_diArg_1	203	205	PF00400	0.427
TRG_ER_diArg_1	336	339	PF00400	0.347
TRG_NLS_MonoExtN_4	532	537	PF00514	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P722	Leptomonas seymouri	50%	100%
A0A1X0P849	Trypanosomatidae	33%	100%
A0A3Q8INL6	Leishmania donovani	75%	100%
A4IDD8	Leishmania infantum	76%	100%
D0A314	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AST9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q1Q7	Leishmania major	74%	100%