Putative tRNA pseudouridine synthase A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA pseudouridine synthase A, putative

Species:

Leishmania braziliensis

UniProt:

A4HP30_LEIBR

TriTrypDb:

LbrM.35.1850 , LBRM2903_350024800

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP30

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	3
GO:0006396	RNA processing	6	3
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016072	rRNA metabolic process	7	3
GO:0034470	ncRNA processing	7	3
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	3
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0001522	pseudouridine synthesis	6	4
GO:0009451	RNA modification	5	4
GO:0043412	macromolecule modification	4	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004730	pseudouridylate synthase activity	5	8
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	602	606	PF00656	0.479
CLV_NRD_NRD_1	108	110	PF00675	0.711
CLV_NRD_NRD_1	214	216	PF00675	0.822
CLV_NRD_NRD_1	295	297	PF00675	0.665
CLV_NRD_NRD_1	31	33	PF00675	0.587
CLV_NRD_NRD_1	344	346	PF00675	0.276
CLV_NRD_NRD_1	489	491	PF00675	0.344
CLV_NRD_NRD_1	56	58	PF00675	0.652
CLV_NRD_NRD_1	580	582	PF00675	0.475
CLV_NRD_NRD_1	588	590	PF00675	0.461
CLV_PCSK_FUR_1	29	33	PF00082	0.607
CLV_PCSK_FUR_1	54	58	PF00082	0.696
CLV_PCSK_FUR_1	586	590	PF00082	0.467
CLV_PCSK_KEX2_1	108	110	PF00082	0.711
CLV_PCSK_KEX2_1	295	297	PF00082	0.671
CLV_PCSK_KEX2_1	31	33	PF00082	0.579
CLV_PCSK_KEX2_1	344	346	PF00082	0.276
CLV_PCSK_KEX2_1	489	491	PF00082	0.385
CLV_PCSK_KEX2_1	50	52	PF00082	0.671
CLV_PCSK_KEX2_1	56	58	PF00082	0.607
CLV_PCSK_KEX2_1	580	582	PF00082	0.475
CLV_PCSK_KEX2_1	588	590	PF00082	0.461
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.671
CLV_PCSK_SKI1_1	259	263	PF00082	0.651
CLV_PCSK_SKI1_1	468	472	PF00082	0.560
CLV_PCSK_SKI1_1	552	556	PF00082	0.432
CLV_PCSK_SKI1_1	594	598	PF00082	0.477
CLV_PCSK_SKI1_1	613	617	PF00082	0.388
DEG_APCC_DBOX_1	152	160	PF00400	0.630
DEG_SCF_FBW7_2	668	674	PF00400	0.502
DEG_SPOP_SBC_1	225	229	PF00917	0.533
DOC_CKS1_1	45	50	PF01111	0.680
DOC_CKS1_1	668	673	PF01111	0.500
DOC_MAPK_DCC_7	205	213	PF00069	0.668
DOC_MAPK_DCC_7	384	394	PF00069	0.450
DOC_MAPK_gen_1	108	115	PF00069	0.734
DOC_MAPK_gen_1	503	512	PF00069	0.475
DOC_MAPK_MEF2A_6	386	394	PF00069	0.447
DOC_MAPK_MEF2A_6	503	512	PF00069	0.438
DOC_MAPK_RevD_3	474	490	PF00069	0.336
DOC_MIT_MIM_1	150	160	PF04212	0.511
DOC_PP1_RVXF_1	382	388	PF00149	0.482
DOC_PP1_RVXF_1	533	539	PF00149	0.407
DOC_PP2B_LxvP_1	645	648	PF13499	0.658
DOC_PP4_FxxP_1	387	390	PF00568	0.458
DOC_PP4_FxxP_1	497	500	PF00568	0.498
DOC_USP7_MATH_1	217	221	PF00917	0.722
DOC_USP7_MATH_1	248	252	PF00917	0.752
DOC_USP7_MATH_1	25	29	PF00917	0.538
DOC_USP7_MATH_1	286	290	PF00917	0.561
DOC_USP7_MATH_1	310	314	PF00917	0.708
DOC_USP7_MATH_1	317	321	PF00917	0.729
DOC_USP7_MATH_1	428	432	PF00917	0.402
DOC_USP7_MATH_1	501	505	PF00917	0.520
DOC_USP7_MATH_1	547	551	PF00917	0.440
DOC_USP7_MATH_1	652	656	PF00917	0.741
DOC_USP7_MATH_1	84	88	PF00917	0.732
DOC_WW_Pin1_4	141	146	PF00397	0.564
DOC_WW_Pin1_4	264	269	PF00397	0.688
DOC_WW_Pin1_4	44	49	PF00397	0.687
DOC_WW_Pin1_4	451	456	PF00397	0.546
DOC_WW_Pin1_4	594	599	PF00397	0.484
DOC_WW_Pin1_4	667	672	PF00397	0.500
DOC_WW_Pin1_4	93	98	PF00397	0.628
LIG_14-3-3_CanoR_1	180	188	PF00244	0.482
LIG_14-3-3_CanoR_1	254	262	PF00244	0.730
LIG_14-3-3_CanoR_1	490	500	PF00244	0.501
LIG_14-3-3_CanoR_1	505	509	PF00244	0.438
LIG_14-3-3_CanoR_1	535	539	PF00244	0.395
LIG_14-3-3_CanoR_1	635	644	PF00244	0.503
LIG_Actin_WH2_2	619	637	PF00022	0.604
LIG_BRCT_BRCA1_1	168	172	PF00533	0.725
LIG_deltaCOP1_diTrp_1	573	579	PF00928	0.497
LIG_EH_1	364	368	PF12763	0.476
LIG_FHA_1	147	153	PF00498	0.525
LIG_FHA_1	225	231	PF00498	0.542
LIG_FHA_1	35	41	PF00498	0.594
LIG_FHA_1	460	466	PF00498	0.413
LIG_FHA_1	479	485	PF00498	0.320
LIG_FHA_2	227	233	PF00498	0.673
LIG_FHA_2	595	601	PF00498	0.476
LIG_FHA_2	606	612	PF00498	0.469
LIG_Integrin_isoDGR_2	487	489	PF01839	0.608
LIG_Integrin_RGD_1	132	134	PF01839	0.745
LIG_LIR_Apic_2	494	500	PF02991	0.474
LIG_LIR_Gen_1	608	616	PF02991	0.497
LIG_LIR_Gen_1	670	679	PF02991	0.503
LIG_LIR_Nem_3	537	541	PF02991	0.414
LIG_LIR_Nem_3	573	579	PF02991	0.503
LIG_LIR_Nem_3	608	612	PF02991	0.539
LIG_LIR_Nem_3	670	675	PF02991	0.504
LIG_PCNA_PIPBox_1	1	10	PF02747	0.570
LIG_PCNA_yPIPBox_3	355	368	PF02747	0.404
LIG_PTB_Apo_2	490	497	PF02174	0.487
LIG_PTB_Apo_2	603	610	PF02174	0.512
LIG_PTB_Phospho_1	603	609	PF10480	0.510
LIG_RPA_C_Fungi	340	352	PF08784	0.449
LIG_SH2_CRK	395	399	PF00017	0.389
LIG_SH2_NCK_1	395	399	PF00017	0.283
LIG_SH2_SRC	609	612	PF00017	0.556
LIG_SH2_STAP1	506	510	PF00017	0.503
LIG_SH2_STAP1	560	564	PF00017	0.580
LIG_SH2_STAT5	578	581	PF00017	0.591
LIG_SH2_STAT5	607	610	PF00017	0.600
LIG_SH2_STAT5	7	10	PF00017	0.692
LIG_SH3_3	551	557	PF00018	0.427
LIG_SH3_3	665	671	PF00018	0.631
LIG_SUMO_SIM_par_1	183	190	PF11976	0.430
LIG_SUMO_SIM_par_1	438	443	PF11976	0.372
LIG_SUMO_SIM_par_1	614	622	PF11976	0.384
LIG_TRAF2_1	608	611	PF00917	0.506
LIG_TRAF2_2	145	150	PF00917	0.552
LIG_UBA3_1	156	163	PF00899	0.509
LIG_WRC_WIRS_1	61	66	PF05994	0.726
LIG_WRPW_2	568	571	PF00400	0.506
LIG_WW_1	557	560	PF00397	0.452
LIG_WW_3	388	392	PF00397	0.448
MOD_CDK_SPK_2	451	456	PF00069	0.330
MOD_CDK_SPK_2	594	599	PF00069	0.484
MOD_CDK_SPxK_1	44	50	PF00069	0.683
MOD_CDK_SPxxK_3	44	51	PF00069	0.685
MOD_CK1_1	116	122	PF00069	0.539
MOD_CK1_1	454	460	PF00069	0.325
MOD_CK1_1	504	510	PF00069	0.436
MOD_CK2_1	178	184	PF00069	0.465
MOD_CK2_1	192	198	PF00069	0.468
MOD_CK2_1	340	346	PF00069	0.328
MOD_CK2_1	547	553	PF00069	0.447
MOD_CK2_1	594	600	PF00069	0.473
MOD_CK2_1	605	611	PF00069	0.468
MOD_Cter_Amidation	487	490	PF01082	0.417
MOD_GlcNHglycan	180	183	PF01048	0.436
MOD_GlcNHglycan	193	197	PF01048	0.410
MOD_GlcNHglycan	20	23	PF01048	0.630
MOD_GlcNHglycan	221	224	PF01048	0.687
MOD_GlcNHglycan	272	275	PF01048	0.593
MOD_GlcNHglycan	308	311	PF01048	0.693
MOD_GlcNHglycan	312	315	PF01048	0.712
MOD_GlcNHglycan	319	322	PF01048	0.695
MOD_GlcNHglycan	352	355	PF01048	0.339
MOD_GlcNHglycan	58	61	PF01048	0.659
MOD_GlcNHglycan	81	84	PF01048	0.618
MOD_GlcNHglycan	86	89	PF01048	0.631
MOD_GSK3_1	306	313	PF00069	0.700
MOD_GSK3_1	56	63	PF00069	0.672
MOD_GSK3_1	652	659	PF00069	0.714
MOD_GSK3_1	84	91	PF00069	0.513
MOD_N-GLC_1	605	610	PF02516	0.519
MOD_N-GLC_1	652	657	PF02516	0.493
MOD_NEK2_1	100	105	PF00069	0.617
MOD_NEK2_1	253	258	PF00069	0.567
MOD_NEK2_1	332	337	PF00069	0.482
MOD_NEK2_1	541	546	PF00069	0.440
MOD_NEK2_2	547	552	PF00069	0.445
MOD_NEK2_2	60	65	PF00069	0.638
MOD_NEK2_2	652	657	PF00069	0.746
MOD_PIKK_1	286	292	PF00454	0.628
MOD_PIKK_1	558	564	PF00454	0.587
MOD_PKA_1	56	62	PF00069	0.713
MOD_PKA_2	201	207	PF00069	0.523
MOD_PKA_2	248	254	PF00069	0.746
MOD_PKA_2	491	497	PF00069	0.471
MOD_PKA_2	504	510	PF00069	0.435
MOD_PKA_2	534	540	PF00069	0.399
MOD_PKA_2	56	62	PF00069	0.719
MOD_PKA_2	582	588	PF00069	0.458
MOD_PKA_2	656	662	PF00069	0.733
MOD_PKA_2	88	94	PF00069	0.585
MOD_PKB_1	54	62	PF00069	0.706
MOD_Plk_1	124	130	PF00069	0.705
MOD_Plk_1	192	198	PF00069	0.646
MOD_Plk_1	238	244	PF00069	0.542
MOD_Plk_1	281	287	PF00069	0.738
MOD_Plk_1	446	452	PF00069	0.432
MOD_Plk_1	552	558	PF00069	0.433
MOD_Plk_1	605	611	PF00069	0.519
MOD_Plk_2-3	605	611	PF00069	0.484
MOD_Plk_2-3	66	72	PF00069	0.587
MOD_Plk_4	168	174	PF00069	0.581
MOD_Plk_4	248	254	PF00069	0.584
MOD_Plk_4	454	460	PF00069	0.451
MOD_Plk_4	60	66	PF00069	0.595
MOD_ProDKin_1	141	147	PF00069	0.560
MOD_ProDKin_1	264	270	PF00069	0.686
MOD_ProDKin_1	44	50	PF00069	0.683
MOD_ProDKin_1	451	457	PF00069	0.542
MOD_ProDKin_1	594	600	PF00069	0.480
MOD_ProDKin_1	667	673	PF00069	0.500
MOD_ProDKin_1	93	99	PF00069	0.630
MOD_SUMO_for_1	159	162	PF00179	0.408
MOD_SUMO_rev_2	154	161	PF00179	0.469
MOD_SUMO_rev_2	605	615	PF00179	0.490
TRG_DiLeu_BaEn_2	446	452	PF01217	0.474
TRG_DiLeu_BaEn_3	324	330	PF01217	0.412
TRG_DiLeu_BaEn_4	238	244	PF01217	0.542
TRG_DiLeu_BaEn_4	642	648	PF01217	0.438
TRG_ENDOCYTIC_2	138	141	PF00928	0.755
TRG_ENDOCYTIC_2	609	612	PF00928	0.619
TRG_ER_diArg_1	200	203	PF00400	0.732
TRG_ER_diArg_1	29	32	PF00400	0.633
TRG_ER_diArg_1	294	296	PF00400	0.678
TRG_ER_diArg_1	384	387	PF00400	0.477
TRG_ER_diArg_1	465	468	PF00400	0.420
TRG_ER_diArg_1	489	491	PF00400	0.559
TRG_ER_diArg_1	579	581	PF00400	0.488
TRG_ER_diArg_1	586	589	PF00400	0.470
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.753
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W9	Leptomonas seymouri	69%	85%
A0A0S4IST3	Bodo saltans	40%	100%
A0A1X0P7U6	Trypanosomatidae	53%	100%
A0A3R7R867	Trypanosoma rangeli	54%	100%
A0A3S7XAP2	Leishmania donovani	84%	79%
A4IDD7	Leishmania infantum	84%	79%
D0A313	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AST8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q1Q8	Leishmania major	84%	100%
V5BPI0	Trypanosoma cruzi	56%	100%