Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome subunit beta type-5, putative

Species:

Leishmania braziliensis

UniProt:

A4HP29_LEIBR

TriTrypDb:

LbrM.35.1840 , LBRM2903_350024700

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:0019774	proteasome core complex, beta-subunit complex	2	1

Expansion

Sequence features

A4HP29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP29

PDB structure(s): 6qm7_L , 6qm7_Z , 6qm8_L , 6qm8_Z , 6tcz_l , 6td5_l

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004298	threonine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0070003	threonine-type peptidase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.461
CLV_NRD_NRD_1	242	244	PF00675	0.278
CLV_NRD_NRD_1	256	258	PF00675	0.227
CLV_NRD_NRD_1	44	46	PF00675	0.712
CLV_PCSK_KEX2_1	256	258	PF00082	0.261
CLV_PCSK_KEX2_1	44	46	PF00082	0.744
CLV_PCSK_SKI1_1	257	261	PF00082	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.565
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.625
DOC_MAPK_gen_1	97	105	PF00069	0.461
DOC_MAPK_HePTP_8	103	115	PF00069	0.565
DOC_MAPK_MEF2A_6	106	115	PF00069	0.461
DOC_MAPK_MEF2A_6	89	96	PF00069	0.506
DOC_USP7_MATH_1	114	118	PF00917	0.461
DOC_USP7_MATH_1	176	180	PF00917	0.484
DOC_USP7_MATH_1	255	259	PF00917	0.462
DOC_USP7_MATH_1	65	69	PF00917	0.693
DOC_USP7_UBL2_3	93	97	PF12436	0.512
DOC_WW_Pin1_4	51	56	PF00397	0.729
LIG_14-3-3_CanoR_1	118	125	PF00244	0.461
LIG_14-3-3_CanoR_1	172	176	PF00244	0.480
LIG_14-3-3_CanoR_1	77	82	PF00244	0.634
LIG_Actin_WH2_2	153	170	PF00022	0.565
LIG_APCC_Cbox_2	296	302	PF00515	0.481
LIG_FHA_1	98	104	PF00498	0.482
LIG_FHA_2	1	7	PF00498	0.504
LIG_FHA_2	12	18	PF00498	0.531
LIG_FHA_2	261	267	PF00498	0.495
LIG_FHA_2	31	37	PF00498	0.615
LIG_LIR_Gen_1	25	34	PF02991	0.605
LIG_LIR_Gen_1	3	13	PF02991	0.526
LIG_LIR_Nem_3	25	29	PF02991	0.590
LIG_LIR_Nem_3	292	298	PF02991	0.358
LIG_LIR_Nem_3	3	8	PF02991	0.525
LIG_PTB_Apo_2	181	188	PF02174	0.461
LIG_PTB_Phospho_1	181	187	PF10480	0.461
LIG_SH2_CRK	26	30	PF00017	0.488
LIG_SH2_GRB2like	26	29	PF00017	0.709
LIG_SH2_SRC	233	236	PF00017	0.461
LIG_SH2_STAP1	295	299	PF00017	0.444
LIG_SH2_STAT5	124	127	PF00017	0.461
LIG_SH2_STAT5	139	142	PF00017	0.472
LIG_SH2_STAT5	212	215	PF00017	0.461
LIG_SH2_STAT5	298	301	PF00017	0.552
LIG_SUMO_SIM_par_1	111	117	PF11976	0.461
LIG_SUMO_SIM_par_1	132	138	PF11976	0.461
LIG_SUMO_SIM_par_1	35	42	PF11976	0.683
MOD_CK1_1	117	123	PF00069	0.476
MOD_CK1_1	171	177	PF00069	0.528
MOD_CK1_1	195	201	PF00069	0.480
MOD_CK1_1	226	232	PF00069	0.461
MOD_CK1_1	39	45	PF00069	0.658
MOD_CK1_1	54	60	PF00069	0.694
MOD_CK1_1	7	13	PF00069	0.593
MOD_CK2_1	30	36	PF00069	0.620
MOD_GlcNHglycan	228	231	PF01048	0.266
MOD_GlcNHglycan	268	271	PF01048	0.261
MOD_GSK3_1	114	121	PF00069	0.461
MOD_GSK3_1	4	11	PF00069	0.522
MOD_GSK3_1	47	54	PF00069	0.760
MOD_GSK3_1	77	84	PF00069	0.704
MOD_N-GLC_1	11	16	PF02516	0.647
MOD_N-GLC_1	168	173	PF02516	0.328
MOD_N-GLC_1	183	188	PF02516	0.276
MOD_N-GLC_2	76	78	PF02516	0.604
MOD_NEK2_1	140	145	PF00069	0.482
MOD_NEK2_1	260	265	PF00069	0.461
MOD_NEK2_1	66	71	PF00069	0.591
MOD_NEK2_1	81	86	PF00069	0.441
MOD_NEK2_2	228	233	PF00069	0.461
MOD_NEK2_2	255	260	PF00069	0.461
MOD_NEK2_2	271	276	PF00069	0.461
MOD_OFUCOSY	78	85	PF10250	0.595
MOD_PIKK_1	124	130	PF00454	0.461
MOD_PK_1	244	250	PF00069	0.565
MOD_PKA_1	97	103	PF00069	0.461
MOD_PKA_2	117	123	PF00069	0.461
MOD_PKA_2	171	177	PF00069	0.461
MOD_PKA_2	255	261	PF00069	0.461
MOD_Plk_1	11	17	PF00069	0.536
MOD_Plk_1	183	189	PF00069	0.461
MOD_Plk_1	244	250	PF00069	0.461
MOD_Plk_1	30	36	PF00069	0.741
MOD_Plk_4	126	132	PF00069	0.472
MOD_Plk_4	195	201	PF00069	0.482
MOD_Plk_4	206	212	PF00069	0.489
MOD_Plk_4	228	234	PF00069	0.471
MOD_Plk_4	271	277	PF00069	0.461
MOD_Plk_4	4	10	PF00069	0.525
MOD_ProDKin_1	51	57	PF00069	0.730
MOD_SUMO_rev_2	209	218	PF00179	0.472
TRG_ENDOCYTIC_2	235	238	PF00928	0.461
TRG_ENDOCYTIC_2	26	29	PF00928	0.732
TRG_ENDOCYTIC_2	298	301	PF00928	0.335
TRG_ER_diArg_1	43	45	PF00400	0.717
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F8	Leptomonas seymouri	87%	100%
A0A0S4IX63	Bodo saltans	67%	100%
A0A1X0P7U3	Trypanosomatidae	74%	97%
A0A3Q8IB07	Leishmania donovani	26%	100%
A0A3Q8IC41	Leishmania donovani	22%	100%
A0A3Q8IIY4	Leishmania donovani	94%	100%
A0A3Q8IVH0	Leishmania donovani	27%	100%
A0A3R7MZI3	Trypanosoma rangeli	72%	97%
A0JWY6	Arthrobacter sp. (strain FB24)	28%	100%
A0LU50	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	28%	100%
A0QZ47	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	27%	100%
A1R6Q7	Paenarthrobacter aurescens (strain TC1)	29%	100%
A1SK13	Nocardioides sp. (strain ATCC BAA-499 / JS614)	29%	100%
A1UHS7	Mycobacterium sp. (strain KMS)	28%	99%
A3Q193	Mycobacterium sp. (strain JLS)	28%	99%
A4FBY1	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	27%	100%
A4HC34	Leishmania braziliensis	26%	100%
A4HLC5	Leishmania braziliensis	21%	100%
A4HN55	Leishmania braziliensis	27%	100%
A4HZI9	Leishmania infantum	22%	100%
A4IBS2	Leishmania infantum	27%	100%
A4IDD6	Leishmania infantum	94%	100%
A4TB64	Mycolicibacterium gilvum (strain PYR-GCK)	27%	100%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	22%	100%
A6USJ3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	30%	100%
A7KE01	Salmo salar	33%	100%
A7KII6	Salmo salar	33%	100%
A8LH54	Frankia sp. (strain EAN1pec)	30%	100%
B1MAI2	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	25%	100%
B1W306	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	27%	100%
B6YSH9	Thermococcus onnurineus (strain NA1)	21%	100%
B8H8L6	Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6)	30%	100%
B8ZRF3	Mycobacterium leprae (strain Br4923)	27%	100%
C5A2C2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	21%	100%
C5BVA2	Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)	27%	100%
C6A2V9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	29%	100%
C6A459	Thermococcus sibiricus (strain DSM 12597 / MM 739)	20%	100%
C6WID8	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)	29%	100%
C7MWV7	Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)	27%	100%
C7P6N4	Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)	35%	100%
C9REN7	Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)	37%	100%
C9Z4D0	Streptomyces scabiei (strain 87.22)	27%	100%
D0A312	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	97%
D1A2S9	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9)	28%	100%
D1BHT9	Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)	29%	100%
D1BS26	Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07)	26%	100%
D2ATV1	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)	29%	100%
D2Q4H4	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)	27%	100%
D2S6E2	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20)	27%	100%
D3Q557	Stackebrandtia nassauensis (strain DSM 44728 / CIP 108903 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)	26%	100%
D3S8M7	Methanocaldococcus sp. (strain FS406-22)	33%	100%
E9AFK8	Leishmania major	26%	100%
E9ANS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AST7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AVG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AVH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B6R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O23717	Arabidopsis thaliana	64%	100%
O24361	Spinacia oleracea	62%	100%
O24733	Thermococcus sp. (strain JCM 11816 / KS-1)	22%	100%
O35521	Mus terricolor	32%	100%
O35522	Mus musculus bactrianus	32%	100%
O35523	Mus platythrix	32%	100%
O35524	Mus spicilegus	32%	100%
O55234	Mus musculus	63%	100%
O59219	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	22%	100%
P28062	Homo sapiens	59%	100%
P28063	Mus musculus	60%	100%
P28064	Rattus norvegicus	61%	100%
P28065	Homo sapiens	32%	100%
P28074	Homo sapiens	63%	100%
P28075	Rattus norvegicus	63%	100%
P28076	Mus musculus	32%	100%
P28077	Rattus norvegicus	33%	100%
P30656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
P34065	Gallus gallus	54%	100%
Q0RLT7	Frankia alni (strain ACN14a)	32%	100%
Q18GX3	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	36%	100%
Q1B797	Mycobacterium sp. (strain MCS)	28%	99%
Q2FQL8	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	36%	100%
Q2J9Q3	Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3)	31%	100%
Q32KL2	Bos taurus	63%	100%
Q3SZC2	Bos taurus	33%	100%
Q3T112	Bos taurus	60%	100%
Q49780	Mycobacterium leprae (strain TN)	27%	100%
Q4Q1Q9	Leishmania major	94%	100%
Q4QC00	Leishmania major	22%	100%
Q4QC13	Leishmania major	26%	100%
Q4QGU1	Leishmania major	32%	100%
Q54BC8	Dictyostelium discoideum	59%	100%
Q58634	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	34%	100%
Q5JIU9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	22%	100%
Q5R8S2	Pongo abelii	63%	100%
Q5W416	Canis lupus familiaris	58%	100%
Q7AKQ5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	27%	100%
Q828I8	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	27%	100%
Q86A21	Dictyostelium discoideum	26%	100%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	35%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	24%	100%
Q8U0L6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	23%	100%
Q8UW64	Oryzias latipes	29%	100%
Q9GNZ8	Leishmania infantum	26%	100%
Q9LIP2	Arabidopsis thaliana	63%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	31%	100%
Q9V122	Pyrococcus abyssi (strain GE5 / Orsay)	22%	100%
Q9XUV0	Caenorhabditis elegans	48%	100%
V5B1X4	Trypanosoma cruzi	25%	100%
V5BU39	Trypanosoma cruzi	71%	97%