LeishMANIAdb
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Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proteasome subunit beta
Gene product:
proteasome subunit beta type-5, putative
Species:
Leishmania braziliensis
UniProt:
A4HP29_LEIBR
TriTrypDb:
LbrM.35.1840 , LBRM2903_350024700
Length:
302

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0005839 proteasome core complex 3 12
GO:0019774 proteasome core complex, beta-subunit complex 2 1
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

A4HP29
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP29

PDB structure(s): 6qm7_L , 6qm7_Z , 6qm8_L , 6qm8_Z , 6tcz_l , 6td5_l

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 12
GO:0030163 protein catabolic process 4 1
GO:0043170 macromolecule metabolic process 3 12
GO:0044238 primary metabolic process 2 12
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 12
GO:0004175 endopeptidase activity 4 12
GO:0004298 threonine-type endopeptidase activity 5 12
GO:0008233 peptidase activity 3 12
GO:0016787 hydrolase activity 2 12
GO:0070003 threonine-type peptidase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 263 267 PF00656 0.461
CLV_NRD_NRD_1 242 244 PF00675 0.278
CLV_NRD_NRD_1 256 258 PF00675 0.227
CLV_NRD_NRD_1 44 46 PF00675 0.712
CLV_PCSK_KEX2_1 256 258 PF00082 0.261
CLV_PCSK_KEX2_1 44 46 PF00082 0.744
CLV_PCSK_SKI1_1 257 261 PF00082 0.287
DEG_Nend_Nbox_1 1 3 PF02207 0.565
DOC_CYCLIN_yCln2_LP_2 34 40 PF00134 0.625
DOC_MAPK_gen_1 97 105 PF00069 0.461
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P7F8 Leptomonas seymouri 87% 100%
A0A0S4IX63 Bodo saltans 67% 100%
A0A1X0P7U3 Trypanosomatidae 74% 97%
A0A3Q8IB07 Leishmania donovani 26% 100%
A0A3Q8IC41 Leishmania donovani 22% 100%
A0A3Q8IIY4 Leishmania donovani 94% 100%
A0A3Q8IVH0 Leishmania donovani 27% 100%
A0A3R7MZI3 Trypanosoma rangeli 72% 97%
A0JWY6 Arthrobacter sp. (strain FB24) 28% 100%
A0LU50 Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B) 28% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS