Putative universal minicircle sequence binding protein (UMSBP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

universal minicircle sequence binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HP28_LEIBR

TriTrypDb:

LbrM.35.1830 , LBRM2903_350024600

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP28

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0045727	positive regulation of translation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000765	regulation of cytoplasmic translation	7	1
GO:2000767	positive regulation of cytoplasmic translation	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0045182	translation regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	126	128	PF00082	0.653
CLV_PCSK_KEX2_1	8	10	PF00082	0.649
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.653
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.649
DEG_SCF_TRCP1_1	265	270	PF00400	0.158
DOC_USP7_MATH_1	214	218	PF00917	0.480
DOC_USP7_MATH_1	245	249	PF00917	0.627
DOC_USP7_MATH_2	59	65	PF00917	0.582
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BIR_III_4	35	39	PF00653	0.393
LIG_FHA_1	2	8	PF00498	0.667
LIG_SH3_3	4	10	PF00018	0.684
MOD_GlcNHglycan	13	16	PF01048	0.389
MOD_GlcNHglycan	162	165	PF01048	0.627
MOD_GlcNHglycan	175	178	PF01048	0.270
MOD_GlcNHglycan	190	193	PF01048	0.547
MOD_GlcNHglycan	265	268	PF01048	0.173
MOD_GlcNHglycan	63	66	PF01048	0.590
MOD_GlcNHglycan	87	90	PF01048	0.580
MOD_GSK3_1	173	180	PF00069	0.243
MOD_GSK3_1	214	221	PF00069	0.551
MOD_GSK3_1	245	252	PF00069	0.631
MOD_GSK3_1	263	270	PF00069	0.173
MOD_GSK3_1	9	16	PF00069	0.613
MOD_NEK2_2	138	143	PF00069	0.366
MOD_NEK2_2	166	171	PF00069	0.340
MOD_NEK2_2	194	199	PF00069	0.243
MOD_NEK2_2	225	230	PF00069	0.285
MOD_NEK2_2	256	261	PF00069	0.370
MOD_PIKK_1	112	118	PF00454	0.577
MOD_PIKK_1	155	161	PF00454	0.430
MOD_PIKK_1	183	189	PF00454	0.358
MOD_PKA_2	40	46	PF00069	0.575
MOD_PKB_1	9	17	PF00069	0.603
MOD_Plk_1	138	144	PF00069	0.366
MOD_Plk_1	166	172	PF00069	0.340
MOD_Plk_1	194	200	PF00069	0.243
MOD_Plk_1	225	231	PF00069	0.285
MOD_Plk_1	256	262	PF00069	0.380
MOD_SUMO_rev_2	2	10	PF00179	0.661
MOD_SUMO_rev_2	55	64	PF00179	0.243
TRG_NLS_MonoCore_2	7	12	PF00514	0.640
TRG_NLS_MonoExtC_3	7	13	PF00514	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P715	Leptomonas seymouri	70%	98%
A0A0S4JI86	Bodo saltans	29%	100%
A0A1X0P815	Trypanosomatidae	52%	100%
A0A1X0P8V4	Trypanosomatidae	34%	100%
A0A3Q8IQS7	Leishmania donovani	89%	100%
A0A3R7K9Q9	Trypanosoma rangeli	33%	100%
A4IDD5	Leishmania infantum	89%	100%
D0A309	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AST6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	93%
O65639	Arabidopsis thaliana	41%	92%
Q04832	Leishmania major	90%	100%
Q12476	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	80%
Q4Q1R0	Leishmania major	89%	98%
Q94C69	Arabidopsis thaliana	36%	92%
V5BJZ6	Trypanosoma cruzi	33%	100%
V5BU64	Trypanosoma cruzi	47%	100%