Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP27_LEIBR

TriTrypDb:

LbrM.35.1820 , LBRM2903_350022400

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.471
CLV_C14_Caspase3-7	63	67	PF00656	0.602
CLV_NRD_NRD_1	311	313	PF00675	0.633
CLV_PCSK_SKI1_1	275	279	PF00082	0.393
CLV_PCSK_SKI1_1	404	408	PF00082	0.485
CLV_PCSK_SKI1_1	98	102	PF00082	0.434
DEG_APCC_DBOX_1	156	164	PF00400	0.588
DEG_SPOP_SBC_1	334	338	PF00917	0.645
DEG_SPOP_SBC_1	481	485	PF00917	0.591
DOC_CKS1_1	362	367	PF01111	0.482
DOC_CKS1_1	460	465	PF01111	0.340
DOC_CYCLIN_RxL_1	201	211	PF00134	0.567
DOC_CYCLIN_RxL_1	279	290	PF00134	0.529
DOC_CYCLIN_RxL_1	387	397	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	359	365	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.423
DOC_MAPK_DCC_7	5	15	PF00069	0.498
DOC_MAPK_gen_1	379	388	PF00069	0.386
DOC_MAPK_gen_1	95	104	PF00069	0.452
DOC_MAPK_MEF2A_6	210	219	PF00069	0.404
DOC_MAPK_MEF2A_6	409	416	PF00069	0.407
DOC_MAPK_MEF2A_6	95	104	PF00069	0.445
DOC_PP1_RVXF_1	202	209	PF00149	0.454
DOC_USP7_MATH_1	132	136	PF00917	0.754
DOC_USP7_MATH_1	141	145	PF00917	0.596
DOC_USP7_MATH_1	29	33	PF00917	0.647
DOC_USP7_MATH_1	301	305	PF00917	0.494
DOC_USP7_MATH_1	307	311	PF00917	0.431
DOC_USP7_MATH_1	334	338	PF00917	0.630
DOC_USP7_MATH_1	48	52	PF00917	0.560
DOC_USP7_MATH_1	482	486	PF00917	0.623
DOC_USP7_MATH_1	6	10	PF00917	0.671
DOC_USP7_MATH_2	79	85	PF00917	0.390
DOC_WW_Pin1_4	235	240	PF00397	0.653
DOC_WW_Pin1_4	284	289	PF00397	0.425
DOC_WW_Pin1_4	330	335	PF00397	0.614
DOC_WW_Pin1_4	36	41	PF00397	0.577
DOC_WW_Pin1_4	361	366	PF00397	0.484
DOC_WW_Pin1_4	408	413	PF00397	0.470
DOC_WW_Pin1_4	459	464	PF00397	0.445
LIG_14-3-3_CanoR_1	16	22	PF00244	0.672
LIG_14-3-3_CanoR_1	204	209	PF00244	0.658
LIG_14-3-3_CanoR_1	28	36	PF00244	0.666
LIG_14-3-3_CanoR_1	355	360	PF00244	0.495
LIG_14-3-3_CanoR_1	404	412	PF00244	0.573
LIG_14-3-3_CanoR_1	5	11	PF00244	0.664
LIG_Actin_WH2_2	269	287	PF00022	0.404
LIG_APCC_ABBA_1	386	391	PF00400	0.396
LIG_APCC_ABBA_1	94	99	PF00400	0.444
LIG_BRCT_BRCA1_1	473	477	PF00533	0.428
LIG_BRCT_BRCA1_1	83	87	PF00533	0.408
LIG_FHA_1	182	188	PF00498	0.592
LIG_FHA_1	224	230	PF00498	0.652
LIG_FHA_1	340	346	PF00498	0.523
LIG_FHA_1	409	415	PF00498	0.568
LIG_FHA_1	460	466	PF00498	0.397
LIG_FHA_1	99	105	PF00498	0.449
LIG_FHA_2	198	204	PF00498	0.585
LIG_FHA_2	216	222	PF00498	0.394
LIG_FHA_2	285	291	PF00498	0.427
LIG_FHA_2	338	344	PF00498	0.551
LIG_FHA_2	362	368	PF00498	0.505
LIG_FHA_2	408	414	PF00498	0.495
LIG_FHA_2	416	422	PF00498	0.468
LIG_FHA_2	448	454	PF00498	0.390
LIG_LIR_Apic_2	207	212	PF02991	0.354
LIG_LIR_Gen_1	18	29	PF02991	0.759
LIG_LIR_Nem_3	18	24	PF02991	0.644
LIG_MYND_1	2	6	PF01753	0.502
LIG_NRBOX	401	407	PF00104	0.340
LIG_Pex14_2	294	298	PF04695	0.436
LIG_SH2_STAP1	373	377	PF00017	0.454
LIG_SH2_STAP1	438	442	PF00017	0.481
LIG_SH2_STAT3	373	376	PF00017	0.459
LIG_SH2_STAT5	258	261	PF00017	0.388
LIG_SH2_STAT5	384	387	PF00017	0.373
LIG_SH3_3	134	140	PF00018	0.637
LIG_SH3_3	193	199	PF00018	0.726
LIG_SH3_3	359	365	PF00018	0.488
LIG_SH3_3	457	463	PF00018	0.378
LIG_SUMO_SIM_par_1	99	106	PF11976	0.579
LIG_SxIP_EBH_1	148	157	PF03271	0.512
LIG_TRAF2_1	128	131	PF00917	0.629
LIG_TRAF2_1	351	354	PF00917	0.467
LIG_WRC_WIRS_1	291	296	PF05994	0.390
MOD_CK1_1	185	191	PF00069	0.683
MOD_CK1_1	20	26	PF00069	0.676
MOD_CK1_1	233	239	PF00069	0.663
MOD_CK1_1	330	336	PF00069	0.672
MOD_CK1_1	337	343	PF00069	0.522
MOD_CK1_1	39	45	PF00069	0.517
MOD_CK1_1	417	423	PF00069	0.434
MOD_CK1_1	60	66	PF00069	0.672
MOD_CK2_1	197	203	PF00069	0.567
MOD_CK2_1	215	221	PF00069	0.391
MOD_CK2_1	29	35	PF00069	0.510
MOD_CK2_1	297	303	PF00069	0.641
MOD_CK2_1	333	339	PF00069	0.703
MOD_CK2_1	361	367	PF00069	0.474
MOD_CK2_1	407	413	PF00069	0.556
MOD_CK2_1	415	421	PF00069	0.519
MOD_GlcNHglycan	108	111	PF01048	0.601
MOD_GlcNHglycan	200	203	PF01048	0.609
MOD_GlcNHglycan	29	32	PF01048	0.649
MOD_GlcNHglycan	299	302	PF01048	0.661
MOD_GlcNHglycan	303	306	PF01048	0.515
MOD_GlcNHglycan	330	333	PF01048	0.644
MOD_GlcNHglycan	397	401	PF01048	0.488
MOD_GlcNHglycan	438	441	PF01048	0.490
MOD_GlcNHglycan	91	94	PF01048	0.377
MOD_GSK3_1	114	121	PF00069	0.559
MOD_GSK3_1	181	188	PF00069	0.651
MOD_GSK3_1	20	27	PF00069	0.611
MOD_GSK3_1	215	222	PF00069	0.450
MOD_GSK3_1	290	297	PF00069	0.532
MOD_GSK3_1	328	335	PF00069	0.607
MOD_GSK3_1	404	411	PF00069	0.586
MOD_GSK3_1	436	443	PF00069	0.565
MOD_GSK3_1	471	478	PF00069	0.509
MOD_GSK3_1	57	64	PF00069	0.679
MOD_NEK2_1	119	124	PF00069	0.523
MOD_NEK2_1	15	20	PF00069	0.582
MOD_NEK2_1	181	186	PF00069	0.470
MOD_NEK2_1	215	220	PF00069	0.384
MOD_NEK2_1	294	299	PF00069	0.609
MOD_NEK2_1	317	322	PF00069	0.568
MOD_NEK2_1	377	382	PF00069	0.391
MOD_NEK2_1	396	401	PF00069	0.476
MOD_NEK2_1	471	476	PF00069	0.530
MOD_NEK2_1	55	60	PF00069	0.543
MOD_NEK2_1	82	87	PF00069	0.417
MOD_NEK2_2	29	34	PF00069	0.507
MOD_PIKK_1	230	236	PF00454	0.633
MOD_PIKK_1	404	410	PF00454	0.404
MOD_PIKK_1	444	450	PF00454	0.603
MOD_PK_1	182	188	PF00069	0.613
MOD_PKA_2	15	21	PF00069	0.605
MOD_PKA_2	170	176	PF00069	0.524
MOD_PKA_2	27	33	PF00069	0.751
MOD_PKA_2	317	323	PF00069	0.545
MOD_PKA_2	354	360	PF00069	0.510
MOD_Plk_1	220	226	PF00069	0.416
MOD_Plk_1	412	418	PF00069	0.595
MOD_Plk_1	98	104	PF00069	0.446
MOD_Plk_2-3	290	296	PF00069	0.501
MOD_Plk_4	114	120	PF00069	0.471
MOD_Plk_4	170	176	PF00069	0.496
MOD_Plk_4	182	188	PF00069	0.648
MOD_Plk_4	204	210	PF00069	0.520
MOD_Plk_4	215	221	PF00069	0.382
MOD_Plk_4	471	477	PF00069	0.500
MOD_Plk_4	82	88	PF00069	0.481
MOD_ProDKin_1	235	241	PF00069	0.643
MOD_ProDKin_1	284	290	PF00069	0.427
MOD_ProDKin_1	330	336	PF00069	0.616
MOD_ProDKin_1	36	42	PF00069	0.579
MOD_ProDKin_1	361	367	PF00069	0.483
MOD_ProDKin_1	408	414	PF00069	0.468
MOD_ProDKin_1	459	465	PF00069	0.443
MOD_SUMO_rev_2	308	314	PF00179	0.485
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.372
TRG_ER_diArg_1	2	5	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK24	Leptomonas seymouri	52%	100%
A0A0S4JIK9	Bodo saltans	31%	100%
A0A1X0P835	Trypanosomatidae	37%	98%
A0A3R7KEY6	Trypanosoma rangeli	39%	100%
A0A3S7XAM2	Leishmania donovani	78%	100%
A4HP08	Leishmania braziliensis	100%	100%
A4IDB7	Leishmania infantum	78%	100%
D0A2Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q1S8	Leishmania major	76%	100%
V5B4F6	Trypanosoma cruzi	38%	100%