Putative poly-zinc finger protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly-zinc finger protein 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HP24_LEIBR

TriTrypDb:

LbrM.35.1790 , LBRM2903_350024500

Length:

135

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP24

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0045727	positive regulation of translation	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000765	regulation of cytoplasmic translation	7	1
GO:2000767	positive regulation of cytoplasmic translation	8	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0045182	translation regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.454
CLV_NRD_NRD_1	119	121	PF00675	0.350
CLV_NRD_NRD_1	128	130	PF00675	0.316
CLV_PCSK_KEX2_1	111	113	PF00082	0.579
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.590
DOC_USP7_MATH_1	110	114	PF00917	0.529
DOC_USP7_MATH_1	19	23	PF00917	0.499
DOC_USP7_UBL2_3	117	121	PF12436	0.413
LIG_REV1ctd_RIR_1	48	58	PF16727	0.194
LIG_SH2_STAT5	94	97	PF00017	0.413
LIG_SH3_1	104	110	PF00018	0.413
LIG_SH3_1	60	66	PF00018	0.413
LIG_SH3_2	107	112	PF14604	0.579
LIG_SH3_2	63	68	PF14604	0.567
LIG_SH3_3	104	110	PF00018	0.413
LIG_SH3_3	60	66	PF00018	0.298
LIG_TRAF2_1	43	46	PF00917	0.554
MOD_CK1_1	40	46	PF00069	0.552
MOD_CK1_1	85	91	PF00069	0.403
MOD_CK2_1	40	46	PF00069	0.548
MOD_Cter_Amidation	122	125	PF01082	0.413
MOD_GlcNHglycan	112	115	PF01048	0.450
MOD_GlcNHglycan	17	20	PF01048	0.536
MOD_GlcNHglycan	21	24	PF01048	0.504
MOD_GlcNHglycan	42	45	PF01048	0.414
MOD_GSK3_1	10	17	PF00069	0.358
MOD_N-GLC_1	75	80	PF02516	0.307
MOD_NEK2_2	115	120	PF00069	0.413
MOD_PIKK_1	75	81	PF00454	0.307
MOD_Plk_4	68	74	PF00069	0.545
MOD_SUMO_for_1	67	70	PF00179	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B4	Leptomonas seymouri	43%	100%
A0A0N1I8Z8	Leptomonas seymouri	43%	100%
A0A0N1PD50	Leptomonas seymouri	87%	100%
A0A1X0P8V4	Trypanosomatidae	46%	70%
A0A3Q8IK17	Leishmania donovani	39%	77%
A0A3Q8IKG2	Leishmania donovani	39%	100%
A0A3R7K9Q9	Trypanosoma rangeli	47%	70%
A0A3S5H821	Leishmania donovani	91%	100%
A0A422MWM4	Trypanosoma rangeli	34%	100%
A4HP21	Leishmania braziliensis	39%	100%
A4HP22	Leishmania braziliensis	39%	100%
A4IDD1	Leishmania infantum	39%	100%
A4IDD2	Leishmania infantum	39%	100%
A4IDD4	Leishmania infantum	91%	100%
D0A311	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	96%
E9AST2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AST3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	74%
E9AST5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O42395	Gallus gallus	39%	78%
P36627	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	75%
P53849	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	88%
P53996	Mus musculus	39%	76%
P62633	Homo sapiens	38%	76%
P62634	Rattus norvegicus	38%	76%
Q3T0Q6	Bos taurus	38%	79%
Q4Q1R1	Leishmania major	89%	100%
Q4Q1R3	Leishmania major	38%	77%
Q4Q1R4	Leishmania major	39%	100%
Q5R5R5	Pongo abelii	38%	76%
Q8T8R1	Drosophila melanogaster	36%	82%
Q8WW36	Homo sapiens	34%	81%
V5BJZ6	Trypanosoma cruzi	47%	70%
V5BU64	Trypanosoma cruzi	38%	70%
V5BU71	Trypanosoma cruzi	38%	100%