LeishMANIAdb
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Universal minicircle sequence binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Universal minicircle sequence binding protein
Gene product:
universal minicircle sequence binding protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HP21_LEIBR
TriTrypDb:
LbrM.35.1760 , LBRM2903_350025400
Length:
115

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HP21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP21

Function

Biological processes
Term Name Level Count
GO:0006417 regulation of translation 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009891 positive regulation of biosynthetic process 5 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010557 positive regulation of macromolecule biosynthetic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031328 positive regulation of cellular biosynthetic process 6 1
GO:0034248 regulation of amide metabolic process 5 1
GO:0034250 positive regulation of amide metabolic process 6 1
GO:0045727 positive regulation of translation 7 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 1
GO:2000765 regulation of cytoplasmic translation 7 1
GO:2000767 positive regulation of cytoplasmic translation 8 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 13
GO:0005488 binding 1 13
GO:0008270 zinc ion binding 6 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0046914 transition metal ion binding 5 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901363 heterocyclic compound binding 2 13
GO:0003723 RNA binding 4 1
GO:0003727 single-stranded RNA binding 5 1
GO:0003729 mRNA binding 5 1
GO:0045182 translation regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 44 46 PF00675 0.613
CLV_NRD_NRD_1 92 94 PF00675 0.570
DOC_USP7_MATH_1 24 28 PF00917 0.621
LIG_BIR_II_1 1 5 PF00653 0.537
LIG_FHA_1 102 108 PF00498 0.436
LIG_FHA_1 54 60 PF00498 0.439
LIG_FHA_1 80 86 PF00498 0.484
MOD_CK1_1 2 8 PF00069 0.513
MOD_GlcNHglycan 1 4 PF01048 0.603
MOD_GSK3_1 101 108 PF00069 0.409
MOD_GSK3_1 31 38 PF00069 0.439
MOD_GSK3_1 53 60 PF00069 0.439
MOD_GSK3_1 79 86 PF00069 0.439
MOD_NEK2_1 15 20 PF00069 0.503
MOD_NEK2_2 24 29 PF00069 0.514
MOD_SUMO_rev_2 38 47 PF00179 0.439
MOD_SUMO_rev_2 60 69 PF00179 0.439
MOD_SUMO_rev_2 86 95 PF00179 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7B4 Leptomonas seymouri 85% 99%
A0A0N1I8Z8 Leptomonas seymouri 87% 99%
A0A0N1PD50 Leptomonas seymouri 40% 85%
A0A3Q8IKG2 Leishmania donovani 96% 100%
A0A3S5H821 Leishmania donovani 39% 85%
A0A422MWM4 Trypanosoma rangeli 46% 94%
A4HP22 Leishmania braziliensis 99% 100%
A4HP24 Leishmania braziliensis 39% 85%
A4IDD1 Leishmania infantum 96% 100%
A4IDD2 Leishmania infantum 94% 100%
A4IDD4 Leishmania infantum 39% 85%
D0A311 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 82%
E9AST2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9AST5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 85%
O42395 Gallus gallus 34% 67%
P53849 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 43% 75%
Q3T0Q6 Bos taurus 34% 68%
Q4Q1R1 Leishmania major 41% 100%
Q4Q1R4 Leishmania major 96% 100%
Q8T8R1 Drosophila melanogaster 42% 70%
Q8WW36 Homo sapiens 36% 69%
V5BU71 Trypanosoma cruzi 48% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS