Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP16_LEIBR

TriTrypDb:

LbrM.35.1710 , LBRM2903_350023700

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP16

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.469
CLV_NRD_NRD_1	206	208	PF00675	0.630
CLV_NRD_NRD_1	248	250	PF00675	0.691
CLV_NRD_NRD_1	339	341	PF00675	0.688
CLV_NRD_NRD_1	364	366	PF00675	0.324
CLV_NRD_NRD_1	455	457	PF00675	0.522
CLV_NRD_NRD_1	80	82	PF00675	0.559
CLV_NRD_NRD_1	91	93	PF00675	0.474
CLV_PCSK_KEX2_1	116	118	PF00082	0.579
CLV_PCSK_KEX2_1	206	208	PF00082	0.658
CLV_PCSK_KEX2_1	248	250	PF00082	0.588
CLV_PCSK_KEX2_1	339	341	PF00082	0.688
CLV_PCSK_KEX2_1	455	457	PF00082	0.499
CLV_PCSK_KEX2_1	82	84	PF00082	0.552
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.552
CLV_PCSK_SKI1_1	155	159	PF00082	0.454
CLV_PCSK_SKI1_1	249	253	PF00082	0.638
CLV_PCSK_SKI1_1	257	261	PF00082	0.553
CLV_PCSK_SKI1_1	318	322	PF00082	0.574
CLV_PCSK_SKI1_1	389	393	PF00082	0.597
CLV_PCSK_SKI1_1	411	415	PF00082	0.541
CLV_PCSK_SKI1_1	430	434	PF00082	0.749
CLV_PCSK_SKI1_1	456	460	PF00082	0.453
CLV_PCSK_SKI1_1	464	468	PF00082	0.391
CLV_Separin_Metazoa	386	390	PF03568	0.464
CLV_Separin_Metazoa	89	93	PF03568	0.532
DEG_APCC_DBOX_1	115	123	PF00400	0.414
DEG_APCC_DBOX_1	256	264	PF00400	0.492
DEG_APCC_DBOX_1	364	372	PF00400	0.478
DOC_CYCLIN_RxL_1	452	462	PF00134	0.554
DOC_MAPK_gen_1	133	141	PF00069	0.493
DOC_MAPK_gen_1	406	412	PF00069	0.403
DOC_MAPK_gen_1	452	460	PF00069	0.567
DOC_MAPK_gen_1	81	90	PF00069	0.547
DOC_MAPK_MEF2A_6	155	162	PF00069	0.546
DOC_USP7_MATH_1	230	234	PF00917	0.637
DOC_USP7_MATH_1	290	294	PF00917	0.723
DOC_USP7_MATH_1	3	7	PF00917	0.676
DOC_USP7_MATH_1	327	331	PF00917	0.813
DOC_USP7_MATH_1	341	345	PF00917	0.656
DOC_USP7_MATH_1	347	351	PF00917	0.652
DOC_USP7_MATH_1	36	40	PF00917	0.486
DOC_USP7_UBL2_3	407	411	PF12436	0.531
DOC_WW_Pin1_4	196	201	PF00397	0.517
DOC_WW_Pin1_4	235	240	PF00397	0.594
DOC_WW_Pin1_4	325	330	PF00397	0.634
DOC_WW_Pin1_4	440	445	PF00397	0.688
LIG_14-3-3_CanoR_1	206	212	PF00244	0.634
LIG_14-3-3_CanoR_1	229	239	PF00244	0.720
LIG_14-3-3_CanoR_1	249	259	PF00244	0.590
LIG_14-3-3_CanoR_1	381	388	PF00244	0.588
LIG_14-3-3_CanoR_1	455	459	PF00244	0.483
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_CaM_IQ_9	34	50	PF13499	0.398
LIG_Clathr_ClatBox_1	159	163	PF01394	0.541
LIG_FHA_1	25	31	PF00498	0.419
LIG_FHA_1	431	437	PF00498	0.630
LIG_FHA_1	455	461	PF00498	0.539
LIG_FHA_2	123	129	PF00498	0.386
LIG_FHA_2	186	192	PF00498	0.629
LIG_FHA_2	21	27	PF00498	0.599
LIG_FHA_2	97	103	PF00498	0.360
LIG_GBD_Chelix_1	459	467	PF00786	0.466
LIG_LIR_Apic_2	224	230	PF02991	0.594
LIG_LIR_Gen_1	188	198	PF02991	0.575
LIG_LIR_Nem_3	188	193	PF02991	0.532
LIG_LYPXL_SIV_4	290	298	PF13949	0.519
LIG_LYPXL_yS_3	291	294	PF13949	0.516
LIG_MAD2	280	288	PF02301	0.636
LIG_NRBOX	462	468	PF00104	0.470
LIG_NRBOX	86	92	PF00104	0.488
LIG_RPA_C_Fungi	201	213	PF08784	0.515
LIG_SH2_NCK_1	267	271	PF00017	0.624
LIG_SH2_SRC	267	270	PF00017	0.694
LIG_SH2_STAP1	375	379	PF00017	0.544
LIG_SH2_STAP1	55	59	PF00017	0.427
LIG_SH3_3	284	290	PF00018	0.605
LIG_SH3_3	343	349	PF00018	0.711
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.540
LIG_SUMO_SIM_par_1	158	163	PF11976	0.541
LIG_SUMO_SIM_par_1	456	462	PF11976	0.341
LIG_TRAF2_1	383	386	PF00917	0.511
LIG_TRAF2_1	94	97	PF00917	0.447
LIG_UBA3_1	87	93	PF00899	0.504
MOD_CDK_SPK_2	235	240	PF00069	0.510
MOD_CDK_SPxK_1	325	331	PF00069	0.640
MOD_CK1_1	10	16	PF00069	0.565
MOD_CK1_1	18	24	PF00069	0.557
MOD_CK1_1	233	239	PF00069	0.680
MOD_CK1_1	293	299	PF00069	0.739
MOD_CK1_1	311	317	PF00069	0.738
MOD_CK1_1	443	449	PF00069	0.655
MOD_CK2_1	122	128	PF00069	0.459
MOD_CK2_1	185	191	PF00069	0.621
MOD_CK2_1	3	9	PF00069	0.615
MOD_CK2_1	96	102	PF00069	0.351
MOD_GlcNHglycan	1	4	PF01048	0.791
MOD_GlcNHglycan	17	20	PF01048	0.501
MOD_GlcNHglycan	170	173	PF01048	0.365
MOD_GlcNHglycan	209	212	PF01048	0.695
MOD_GlcNHglycan	252	255	PF01048	0.630
MOD_GlcNHglycan	310	313	PF01048	0.710
MOD_GlcNHglycan	331	334	PF01048	0.792
MOD_GlcNHglycan	343	346	PF01048	0.686
MOD_GlcNHglycan	399	402	PF01048	0.524
MOD_GlcNHglycan	469	472	PF01048	0.424
MOD_GlcNHglycan	5	8	PF01048	0.522
MOD_GlcNHglycan	9	12	PF01048	0.592
MOD_GSK3_1	101	108	PF00069	0.353
MOD_GSK3_1	11	18	PF00069	0.486
MOD_GSK3_1	128	135	PF00069	0.508
MOD_GSK3_1	168	175	PF00069	0.553
MOD_GSK3_1	20	27	PF00069	0.519
MOD_GSK3_1	201	208	PF00069	0.634
MOD_GSK3_1	231	238	PF00069	0.616
MOD_GSK3_1	290	297	PF00069	0.684
MOD_GSK3_1	3	10	PF00069	0.634
MOD_GSK3_1	323	330	PF00069	0.785
MOD_GSK3_1	36	43	PF00069	0.410
MOD_GSK3_1	442	449	PF00069	0.636
MOD_GSK3_1	467	474	PF00069	0.516
MOD_LATS_1	205	211	PF00433	0.614
MOD_N-GLC_1	105	110	PF02516	0.332
MOD_N-GLC_1	294	299	PF02516	0.728
MOD_NEK2_1	1	6	PF00069	0.734
MOD_NEK2_1	101	106	PF00069	0.421
MOD_NEK2_1	15	20	PF00069	0.498
MOD_NEK2_1	231	236	PF00069	0.621
MOD_NEK2_1	250	255	PF00069	0.779
MOD_NEK2_1	322	327	PF00069	0.524
MOD_NEK2_1	467	472	PF00069	0.470
MOD_NEK2_2	422	427	PF00069	0.401
MOD_PIKK_1	1	7	PF00454	0.570
MOD_PIKK_1	128	134	PF00454	0.560
MOD_PIKK_1	320	326	PF00454	0.638
MOD_PIKK_1	446	452	PF00454	0.476
MOD_PIKK_1	96	102	PF00454	0.346
MOD_PKA_1	206	212	PF00069	0.573
MOD_PKA_1	339	345	PF00069	0.522
MOD_PKA_2	132	138	PF00069	0.562
MOD_PKA_2	168	174	PF00069	0.546
MOD_PKA_2	205	211	PF00069	0.628
MOD_PKA_2	333	339	PF00069	0.607
MOD_PKA_2	397	403	PF00069	0.440
MOD_PKA_2	454	460	PF00069	0.460
MOD_PKA_2	76	82	PF00069	0.514
MOD_Plk_1	294	300	PF00069	0.700
MOD_Plk_1	375	381	PF00069	0.552
MOD_Plk_1	96	102	PF00069	0.470
MOD_Plk_4	26	32	PF00069	0.408
MOD_Plk_4	271	277	PF00069	0.676
MOD_Plk_4	375	381	PF00069	0.339
MOD_Plk_4	422	428	PF00069	0.447
MOD_ProDKin_1	196	202	PF00069	0.521
MOD_ProDKin_1	235	241	PF00069	0.597
MOD_ProDKin_1	325	331	PF00069	0.636
MOD_ProDKin_1	440	446	PF00069	0.683
MOD_SUMO_for_1	148	151	PF00179	0.542
MOD_SUMO_for_1	165	168	PF00179	0.378
MOD_SUMO_rev_2	128	137	PF00179	0.543
MOD_SUMO_rev_2	21	30	PF00179	0.507
TRG_DiLeu_BaEn_1	408	413	PF01217	0.401
TRG_DiLeu_BaEn_1	462	467	PF01217	0.470
TRG_DiLeu_BaEn_4	96	102	PF01217	0.549
TRG_ENDOCYTIC_2	190	193	PF00928	0.542
TRG_ENDOCYTIC_2	291	294	PF00928	0.610
TRG_ER_diArg_1	115	117	PF00400	0.616
TRG_ER_diArg_1	195	198	PF00400	0.704
TRG_ER_diArg_1	247	249	PF00400	0.563
TRG_ER_diArg_1	339	341	PF00400	0.712
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	464	469	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F5	Leptomonas seymouri	57%	98%
A0A0S4ISW4	Bodo saltans	33%	100%
A0A1X0P856	Trypanosomatidae	38%	100%
A0A3Q8INJ9	Leishmania donovani	79%	100%
A0A3R7RIJ2	Trypanosoma rangeli	37%	100%
A4IDC6	Leishmania infantum	78%	100%
E9ASS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q1R9	Leishmania major	78%	100%
V5BU44	Trypanosoma cruzi	39%	100%