Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP16_LEIBR

TriTrypDb:

LbrM.35.1710 , LBRM2903_350023700

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HP16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP16

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.469
CLV_NRD_NRD_1	206	208	PF00675	0.630
CLV_NRD_NRD_1	248	250	PF00675	0.691
CLV_NRD_NRD_1	339	341	PF00675	0.688
CLV_NRD_NRD_1	364	366	PF00675	0.324
CLV_NRD_NRD_1	455	457	PF00675	0.522
CLV_NRD_NRD_1	80	82	PF00675	0.559
CLV_NRD_NRD_1	91	93	PF00675	0.474
CLV_PCSK_KEX2_1	116	118	PF00082	0.579
CLV_PCSK_KEX2_1	206	208	PF00082	0.658

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F5	Leptomonas seymouri	57%	98%
A0A0S4ISW4	Bodo saltans	33%	100%
A0A1X0P856	Trypanosomatidae	38%	100%
A0A3Q8INJ9	Leishmania donovani	79%	100%
A0A3R7RIJ2	Trypanosoma rangeli	37%	100%
A4IDC6	Leishmania infantum	78%	100%
E9ASS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q1R9	Leishmania major	78%	100%
V5BU44	Trypanosoma cruzi	39%	100%

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