B box-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP15_LEIBR

TriTrypDb:

LbrM.35.1690 , LBRM2903_350023500

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP15

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.516
CLV_C14_Caspase3-7	360	364	PF00656	0.387
CLV_MEL_PAP_1	741	747	PF00089	0.621
CLV_NRD_NRD_1	276	278	PF00675	0.604
CLV_NRD_NRD_1	400	402	PF00675	0.578
CLV_NRD_NRD_1	501	503	PF00675	0.428
CLV_NRD_NRD_1	547	549	PF00675	0.593
CLV_NRD_NRD_1	750	752	PF00675	0.596
CLV_NRD_NRD_1	813	815	PF00675	0.738
CLV_NRD_NRD_1	840	842	PF00675	0.817
CLV_PCSK_KEX2_1	275	277	PF00082	0.608
CLV_PCSK_KEX2_1	3	5	PF00082	0.778
CLV_PCSK_KEX2_1	400	402	PF00082	0.578
CLV_PCSK_KEX2_1	501	503	PF00082	0.610
CLV_PCSK_KEX2_1	522	524	PF00082	0.606
CLV_PCSK_KEX2_1	547	549	PF00082	0.583
CLV_PCSK_KEX2_1	750	752	PF00082	0.604
CLV_PCSK_KEX2_1	832	834	PF00082	0.599
CLV_PCSK_KEX2_1	840	842	PF00082	0.762
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.728
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.553
CLV_PCSK_PC1ET2_1	832	834	PF00082	0.599
CLV_PCSK_SKI1_1	119	123	PF00082	0.444
CLV_PCSK_SKI1_1	131	135	PF00082	0.524
CLV_PCSK_SKI1_1	377	381	PF00082	0.546
CLV_PCSK_SKI1_1	501	505	PF00082	0.608
CLV_PCSK_SKI1_1	59	63	PF00082	0.535
CLV_PCSK_SKI1_1	775	779	PF00082	0.743
DEG_APCC_DBOX_1	500	508	PF00400	0.428
DEG_SPOP_SBC_1	145	149	PF00917	0.533
DEG_SPOP_SBC_1	152	156	PF00917	0.477
DEG_SPOP_SBC_1	679	683	PF00917	0.551
DOC_ANK_TNKS_1	7	14	PF00023	0.561
DOC_CYCLIN_RxL_1	641	649	PF00134	0.569
DOC_CYCLIN_RxL_1	772	783	PF00134	0.738
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.695
DOC_MAPK_gen_1	735	743	PF00069	0.805
DOC_MAPK_gen_1	840	847	PF00069	0.773
DOC_MAPK_MEF2A_6	840	849	PF00069	0.756
DOC_PP1_RVXF_1	478	485	PF00149	0.469
DOC_PP2B_LxvP_1	62	65	PF13499	0.660
DOC_PP4_FxxP_1	70	73	PF00568	0.666
DOC_USP7_MATH_1	145	149	PF00917	0.558
DOC_USP7_MATH_1	222	226	PF00917	0.665
DOC_USP7_MATH_1	228	232	PF00917	0.464
DOC_USP7_MATH_1	256	260	PF00917	0.353
DOC_USP7_MATH_1	411	415	PF00917	0.382
DOC_USP7_MATH_1	558	562	PF00917	0.531
DOC_USP7_MATH_1	593	597	PF00917	0.662
DOC_USP7_MATH_1	654	658	PF00917	0.539
DOC_USP7_MATH_1	679	683	PF00917	0.551
DOC_USP7_MATH_1	710	714	PF00917	0.548
DOC_USP7_MATH_1	73	77	PF00917	0.675
DOC_USP7_MATH_1	733	737	PF00917	0.544
DOC_USP7_MATH_1	792	796	PF00917	0.688
DOC_USP7_MATH_2	823	829	PF00917	0.571
DOC_WW_Pin1_4	148	153	PF00397	0.764
DOC_WW_Pin1_4	203	208	PF00397	0.530
DOC_WW_Pin1_4	224	229	PF00397	0.638
DOC_WW_Pin1_4	488	493	PF00397	0.650
DOC_WW_Pin1_4	646	651	PF00397	0.631
DOC_WW_Pin1_4	668	673	PF00397	0.530
DOC_WW_Pin1_4	827	832	PF00397	0.590
LIG_14-3-3_CanoR_1	197	207	PF00244	0.611
LIG_14-3-3_CanoR_1	237	243	PF00244	0.366
LIG_14-3-3_CanoR_1	255	263	PF00244	0.502
LIG_14-3-3_CanoR_1	281	289	PF00244	0.494
LIG_14-3-3_CanoR_1	480	485	PF00244	0.648
LIG_14-3-3_CanoR_1	501	510	PF00244	0.429
LIG_14-3-3_CanoR_1	523	529	PF00244	0.562
LIG_14-3-3_CanoR_1	594	602	PF00244	0.534
LIG_14-3-3_CanoR_1	630	635	PF00244	0.722
LIG_14-3-3_CanoR_1	744	748	PF00244	0.652
LIG_14-3-3_CanoR_1	781	786	PF00244	0.600
LIG_14-3-3_CanoR_1	790	798	PF00244	0.685
LIG_14-3-3_CanoR_1	840	847	PF00244	0.756
LIG_Actin_WH2_2	362	379	PF00022	0.533
LIG_Actin_WH2_2	391	408	PF00022	0.563
LIG_APCC_ABBA_1	290	295	PF00400	0.437
LIG_BIR_II_1	1	5	PF00653	0.800
LIG_BIR_III_4	345	349	PF00653	0.458
LIG_BRCT_BRCA1_1	66	70	PF00533	0.679
LIG_DLG_GKlike_1	480	487	PF00625	0.643
LIG_DLG_GKlike_1	630	638	PF00625	0.615
LIG_EH1_1	409	417	PF00400	0.463
LIG_FHA_1	452	458	PF00498	0.539
LIG_FHA_1	524	530	PF00498	0.611
LIG_FHA_1	597	603	PF00498	0.626
LIG_FHA_1	662	668	PF00498	0.700
LIG_FHA_1	686	692	PF00498	0.794
LIG_FHA_1	800	806	PF00498	0.719
LIG_FHA_1	840	846	PF00498	0.758
LIG_FHA_1	91	97	PF00498	0.519
LIG_FHA_2	358	364	PF00498	0.403
LIG_FHA_2	460	466	PF00498	0.424
LIG_FHA_2	489	495	PF00498	0.633
LIG_FHA_2	582	588	PF00498	0.553
LIG_FHA_2	756	762	PF00498	0.569
LIG_FHA_2	807	813	PF00498	0.641
LIG_LIR_Apic_2	552	558	PF02991	0.595
LIG_LIR_Apic_2	67	73	PF02991	0.671
LIG_LIR_Gen_1	483	492	PF02991	0.643
LIG_LIR_Nem_3	483	487	PF02991	0.631
LIG_LIR_Nem_3	494	500	PF02991	0.524
LIG_LIR_Nem_3	657	662	PF02991	0.531
LIG_LIR_Nem_3	67	71	PF02991	0.687
LIG_LIR_Nem_3	696	701	PF02991	0.792
LIG_MYND_1	69	73	PF01753	0.637
LIG_PDZ_Class_2	844	849	PF00595	0.754
LIG_PTAP_UEV_1	218	223	PF05743	0.686
LIG_SH2_CRK	500	504	PF00017	0.613
LIG_SH2_CRK	555	559	PF00017	0.542
LIG_SH2_CRK	659	663	PF00017	0.536
LIG_SH2_NCK_1	555	559	PF00017	0.571
LIG_SH2_STAP1	358	362	PF00017	0.536
LIG_SH2_STAP1	665	669	PF00017	0.724
LIG_SH2_STAT5	555	558	PF00017	0.574
LIG_SH2_STAT5	807	810	PF00017	0.798
LIG_SH3_3	213	219	PF00018	0.729
LIG_SH3_3	40	46	PF00018	0.534
LIG_SH3_3	513	519	PF00018	0.668
LIG_SH3_3	561	567	PF00018	0.523
LIG_SH3_3	598	604	PF00018	0.745
LIG_SH3_3	666	672	PF00018	0.568
LIG_SH3_3	742	748	PF00018	0.731
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.404
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.590
LIG_SUMO_SIM_par_1	603	609	PF11976	0.530
LIG_SUMO_SIM_par_1	82	88	PF11976	0.708
LIG_SxIP_EBH_1	594	608	PF03271	0.532
LIG_TRAF2_1	103	106	PF00917	0.490
LIG_TRAF2_1	379	382	PF00917	0.361
LIG_WRC_WIRS_1	481	486	PF05994	0.645
LIG_WW_3	544	548	PF00397	0.564
LIG_WW_3	747	751	PF00397	0.666
MOD_CDC14_SPxK_1	671	674	PF00782	0.530
MOD_CDK_SPK_2	827	832	PF00069	0.590
MOD_CDK_SPxK_1	668	674	PF00069	0.532
MOD_CDK_SPxK_1	827	833	PF00069	0.590
MOD_CK1_1	138	144	PF00069	0.633
MOD_CK1_1	148	154	PF00069	0.697
MOD_CK1_1	16	22	PF00069	0.671
MOD_CK1_1	203	209	PF00069	0.679
MOD_CK1_1	431	437	PF00069	0.642
MOD_CK1_1	450	456	PF00069	0.344
MOD_CK1_1	48	54	PF00069	0.553
MOD_CK1_1	525	531	PF00069	0.751
MOD_CK1_1	596	602	PF00069	0.531
MOD_CK1_1	611	617	PF00069	0.485
MOD_CK1_1	635	641	PF00069	0.757
MOD_CK1_1	655	661	PF00069	0.744
MOD_CK1_1	696	702	PF00069	0.554
MOD_CK1_1	791	797	PF00069	0.748
MOD_CK1_1	826	832	PF00069	0.683
MOD_CK1_1	91	97	PF00069	0.678
MOD_CK1_1	98	104	PF00069	0.650
MOD_CK2_1	228	234	PF00069	0.584
MOD_CK2_1	27	33	PF00069	0.605
MOD_CK2_1	459	465	PF00069	0.416
MOD_CK2_1	488	494	PF00069	0.481
MOD_CK2_1	6	12	PF00069	0.630
MOD_CK2_1	73	79	PF00069	0.636
MOD_Cter_Amidation	398	401	PF01082	0.500
MOD_GlcNHglycan	14	18	PF01048	0.626
MOD_GlcNHglycan	141	144	PF01048	0.663
MOD_GlcNHglycan	155	158	PF01048	0.570
MOD_GlcNHglycan	179	182	PF01048	0.626
MOD_GlcNHglycan	219	222	PF01048	0.681
MOD_GlcNHglycan	224	227	PF01048	0.575
MOD_GlcNHglycan	393	397	PF01048	0.600
MOD_GlcNHglycan	402	405	PF01048	0.501
MOD_GlcNHglycan	430	433	PF01048	0.413
MOD_GlcNHglycan	474	477	PF01048	0.547
MOD_GlcNHglycan	512	515	PF01048	0.665
MOD_GlcNHglycan	577	580	PF01048	0.593
MOD_GlcNHglycan	613	616	PF01048	0.551
MOD_GlcNHglycan	634	637	PF01048	0.710
MOD_GlcNHglycan	682	685	PF01048	0.692
MOD_GlcNHglycan	698	701	PF01048	0.574
MOD_GlcNHglycan	75	78	PF01048	0.611
MOD_GlcNHglycan	790	793	PF01048	0.649
MOD_GlcNHglycan	8	11	PF01048	0.631
MOD_GlcNHglycan	825	828	PF01048	0.667
MOD_GSK3_1	127	134	PF00069	0.709
MOD_GSK3_1	135	142	PF00069	0.623
MOD_GSK3_1	144	151	PF00069	0.581
MOD_GSK3_1	155	162	PF00069	0.469
MOD_GSK3_1	196	203	PF00069	0.681
MOD_GSK3_1	2	9	PF00069	0.599
MOD_GSK3_1	224	231	PF00069	0.485
MOD_GSK3_1	328	335	PF00069	0.550
MOD_GSK3_1	418	425	PF00069	0.371
MOD_GSK3_1	447	454	PF00069	0.534
MOD_GSK3_1	525	532	PF00069	0.569
MOD_GSK3_1	549	556	PF00069	0.642
MOD_GSK3_1	571	578	PF00069	0.626
MOD_GSK3_1	592	599	PF00069	0.558
MOD_GSK3_1	626	633	PF00069	0.648
MOD_GSK3_1	634	641	PF00069	0.731
MOD_GSK3_1	733	740	PF00069	0.547
MOD_GSK3_1	751	758	PF00069	0.512
MOD_GSK3_1	788	795	PF00069	0.747
MOD_GSK3_1	823	830	PF00069	0.694
MOD_GSK3_1	835	842	PF00069	0.805
MOD_GSK3_1	88	95	PF00069	0.696
MOD_N-GLC_1	781	786	PF02516	0.704
MOD_N-GLC_1	91	96	PF02516	0.533
MOD_N-GLC_2	198	200	PF02516	0.512
MOD_N-GLC_2	477	479	PF02516	0.660
MOD_NEK2_1	135	140	PF00069	0.746
MOD_NEK2_1	153	158	PF00069	0.504
MOD_NEK2_1	280	285	PF00069	0.336
MOD_NEK2_1	293	298	PF00069	0.422
MOD_NEK2_1	416	421	PF00069	0.515
MOD_NEK2_1	529	534	PF00069	0.607
MOD_NEK2_1	6	11	PF00069	0.561
MOD_NEK2_1	606	611	PF00069	0.554
MOD_NEK2_1	618	623	PF00069	0.604
MOD_NEK2_1	626	631	PF00069	0.650
MOD_NEK2_1	634	639	PF00069	0.685
MOD_NEK2_1	743	748	PF00069	0.718
MOD_NEK2_1	798	803	PF00069	0.541
MOD_NEK2_2	212	217	PF00069	0.567
MOD_NEK2_2	372	377	PF00069	0.536
MOD_NEK2_2	685	690	PF00069	0.549
MOD_NEK2_2	733	738	PF00069	0.544
MOD_OFUCOSY	233	240	PF10250	0.340
MOD_OFUCOSY	294	300	PF10250	0.437
MOD_OFUCOSY	417	422	PF10250	0.343
MOD_PIKK_1	200	206	PF00454	0.697
MOD_PIKK_1	207	213	PF00454	0.631
MOD_PIKK_1	27	33	PF00454	0.642
MOD_PIKK_1	280	286	PF00454	0.410
MOD_PIKK_1	328	334	PF00454	0.518
MOD_PIKK_1	346	352	PF00454	0.352
MOD_PIKK_1	638	644	PF00454	0.716
MOD_PIKK_1	652	658	PF00454	0.540
MOD_PIKK_1	835	841	PF00454	0.764
MOD_PK_1	781	787	PF00069	0.551
MOD_PKA_1	400	406	PF00069	0.564
MOD_PKA_1	522	528	PF00069	0.558
MOD_PKA_1	814	820	PF00069	0.743
MOD_PKA_1	840	846	PF00069	0.758
MOD_PKA_2	196	202	PF00069	0.690
MOD_PKA_2	236	242	PF00069	0.348
MOD_PKA_2	254	260	PF00069	0.529
MOD_PKA_2	280	286	PF00069	0.494
MOD_PKA_2	399	405	PF00069	0.534
MOD_PKA_2	522	528	PF00069	0.583
MOD_PKA_2	593	599	PF00069	0.718
MOD_PKA_2	621	627	PF00069	0.549
MOD_PKA_2	710	716	PF00069	0.547
MOD_PKA_2	737	743	PF00069	0.799
MOD_PKA_2	780	786	PF00069	0.622
MOD_PKA_2	839	845	PF00069	0.796
MOD_PKB_1	630	638	PF00069	0.652
MOD_PKB_1	833	841	PF00069	0.586
MOD_Plk_1	191	197	PF00069	0.688
MOD_Plk_1	33	39	PF00069	0.603
MOD_Plk_1	458	464	PF00069	0.522
MOD_Plk_1	48	54	PF00069	0.627
MOD_Plk_1	553	559	PF00069	0.545
MOD_Plk_1	781	787	PF00069	0.551
MOD_Plk_1	91	97	PF00069	0.548
MOD_Plk_2-3	459	465	PF00069	0.416
MOD_Plk_4	159	165	PF00069	0.560
MOD_Plk_4	191	197	PF00069	0.660
MOD_Plk_4	411	417	PF00069	0.522
MOD_Plk_4	431	437	PF00069	0.586
MOD_Plk_4	480	486	PF00069	0.650
MOD_Plk_4	558	564	PF00069	0.524
MOD_Plk_4	597	603	PF00069	0.617
MOD_ProDKin_1	148	154	PF00069	0.760
MOD_ProDKin_1	203	209	PF00069	0.533
MOD_ProDKin_1	224	230	PF00069	0.618
MOD_ProDKin_1	488	494	PF00069	0.649
MOD_ProDKin_1	646	652	PF00069	0.632
MOD_ProDKin_1	668	674	PF00069	0.532
MOD_ProDKin_1	827	833	PF00069	0.590
MOD_SUMO_rev_2	128	133	PF00179	0.510
TRG_ENDOCYTIC_2	500	503	PF00928	0.644
TRG_ENDOCYTIC_2	659	662	PF00928	0.535
TRG_ER_diArg_1	275	277	PF00400	0.608
TRG_ER_diArg_1	500	502	PF00400	0.450
TRG_ER_diArg_1	546	548	PF00400	0.567
TRG_ER_diArg_1	749	751	PF00400	0.605
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	763	768	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAN9	Leishmania donovani	65%	100%
A4IDC4	Leishmania infantum	64%	100%
E9ASS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4Q1S1	Leishmania major	64%	99%