ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

engulfment and cell motility domain 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HP14_LEIBR

TriTrypDb:

LbrM.35.1680 , LBRM2903_350023200

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HP14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP14

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	6
GO:0008047	enzyme activator activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.620
CLV_NRD_NRD_1	14	16	PF00675	0.535
CLV_NRD_NRD_1	195	197	PF00675	0.681
CLV_NRD_NRD_1	298	300	PF00675	0.511
CLV_NRD_NRD_1	449	451	PF00675	0.777
CLV_NRD_NRD_1	672	674	PF00675	0.359
CLV_NRD_NRD_1	87	89	PF00675	0.541
CLV_PCSK_FUR_1	12	16	PF00082	0.406
CLV_PCSK_KEX2_1	11	13	PF00082	0.519
CLV_PCSK_KEX2_1	14	16	PF00082	0.531

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAP8	Leishmania donovani	58%	100%
A4IDC3	Leishmania infantum	59%	99%
E9ASS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4Q1S2	Leishmania major	58%	99%

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