ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

engulfment and cell motility domain 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HP14_LEIBR

TriTrypDb:

LbrM.35.1680 , LBRM2903_350023200

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP14

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	6
GO:0008047	enzyme activator activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.620
CLV_NRD_NRD_1	14	16	PF00675	0.535
CLV_NRD_NRD_1	195	197	PF00675	0.681
CLV_NRD_NRD_1	298	300	PF00675	0.511
CLV_NRD_NRD_1	449	451	PF00675	0.777
CLV_NRD_NRD_1	672	674	PF00675	0.359
CLV_NRD_NRD_1	87	89	PF00675	0.541
CLV_PCSK_FUR_1	12	16	PF00082	0.406
CLV_PCSK_KEX2_1	11	13	PF00082	0.519
CLV_PCSK_KEX2_1	14	16	PF00082	0.531
CLV_PCSK_KEX2_1	195	197	PF00082	0.680
CLV_PCSK_KEX2_1	298	300	PF00082	0.511
CLV_PCSK_KEX2_1	449	451	PF00082	0.649
CLV_PCSK_KEX2_1	574	576	PF00082	0.528
CLV_PCSK_KEX2_1	594	596	PF00082	0.469
CLV_PCSK_KEX2_1	672	674	PF00082	0.359
CLV_PCSK_KEX2_1	783	785	PF00082	0.339
CLV_PCSK_KEX2_1	87	89	PF00082	0.541
CLV_PCSK_KEX2_1	890	892	PF00082	0.358
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.409
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.516
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.469
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.289
CLV_PCSK_PC1ET2_1	890	892	PF00082	0.358
CLV_PCSK_SKI1_1	298	302	PF00082	0.513
CLV_PCSK_SKI1_1	626	630	PF00082	0.546
CLV_PCSK_SKI1_1	657	661	PF00082	0.519
CLV_PCSK_SKI1_1	672	676	PF00082	0.279
CLV_Separin_Metazoa	316	320	PF03568	0.520
DEG_APCC_DBOX_1	172	180	PF00400	0.525
DEG_APCC_DBOX_1	671	679	PF00400	0.359
DEG_SCF_FBW7_1	108	115	PF00400	0.533
DEG_SPOP_SBC_1	119	123	PF00917	0.522
DEG_SPOP_SBC_1	576	580	PF00917	0.650
DOC_ANK_TNKS_1	355	362	PF00023	0.557
DOC_CKS1_1	109	114	PF01111	0.533
DOC_CKS1_1	643	648	PF01111	0.432
DOC_CYCLIN_RxL_1	670	677	PF00134	0.359
DOC_MAPK_DCC_7	536	546	PF00069	0.380
DOC_MAPK_gen_1	425	434	PF00069	0.543
DOC_MAPK_gen_1	591	600	PF00069	0.475
DOC_MAPK_gen_1	657	666	PF00069	0.519
DOC_MAPK_gen_1	672	678	PF00069	0.279
DOC_MAPK_gen_1	910	916	PF00069	0.365
DOC_MAPK_MEF2A_6	660	668	PF00069	0.359
DOC_PP2B_LxvP_1	179	182	PF13499	0.636
DOC_PP2B_LxvP_1	409	412	PF13499	0.680
DOC_PP2B_LxvP_1	539	542	PF13499	0.378
DOC_PP2B_LxvP_1	65	68	PF13499	0.524
DOC_PP2B_LxvP_1	666	669	PF13499	0.229
DOC_PP4_FxxP_1	169	172	PF00568	0.645
DOC_PP4_FxxP_1	229	232	PF00568	0.557
DOC_PP4_FxxP_1	437	440	PF00568	0.545
DOC_PP4_FxxP_1	530	533	PF00568	0.451
DOC_PP4_FxxP_1	620	623	PF00568	0.522
DOC_USP7_MATH_1	118	122	PF00917	0.565
DOC_USP7_MATH_1	143	147	PF00917	0.617
DOC_USP7_MATH_1	22	26	PF00917	0.573
DOC_USP7_MATH_1	245	249	PF00917	0.656
DOC_USP7_MATH_1	274	278	PF00917	0.578
DOC_USP7_MATH_1	280	284	PF00917	0.598
DOC_USP7_MATH_1	386	390	PF00917	0.578
DOC_USP7_MATH_1	442	446	PF00917	0.631
DOC_USP7_MATH_1	560	564	PF00917	0.511
DOC_USP7_MATH_1	576	580	PF00917	0.576
DOC_USP7_MATH_1	641	645	PF00917	0.522
DOC_USP7_MATH_1	658	662	PF00917	0.319
DOC_USP7_MATH_1	695	699	PF00917	0.315
DOC_USP7_MATH_1	83	87	PF00917	0.549
DOC_USP7_MATH_1	842	846	PF00917	0.339
DOC_USP7_UBL2_3	911	915	PF12436	0.446
DOC_WW_Pin1_4	108	113	PF00397	0.551
DOC_WW_Pin1_4	139	144	PF00397	0.594
DOC_WW_Pin1_4	177	182	PF00397	0.539
DOC_WW_Pin1_4	184	189	PF00397	0.531
DOC_WW_Pin1_4	205	210	PF00397	0.564
DOC_WW_Pin1_4	327	332	PF00397	0.529
DOC_WW_Pin1_4	339	344	PF00397	0.639
DOC_WW_Pin1_4	464	469	PF00397	0.641
DOC_WW_Pin1_4	510	515	PF00397	0.506
DOC_WW_Pin1_4	580	585	PF00397	0.537
DOC_WW_Pin1_4	618	623	PF00397	0.522
DOC_WW_Pin1_4	63	68	PF00397	0.631
DOC_WW_Pin1_4	642	647	PF00397	0.480
DOC_WW_Pin1_4	699	704	PF00397	0.492
DOC_WW_Pin1_4	705	710	PF00397	0.412
DOC_WW_Pin1_4	763	768	PF00397	0.394
LIG_14-3-3_CanoR_1	306	312	PF00244	0.524
LIG_14-3-3_CanoR_1	380	384	PF00244	0.526
LIG_14-3-3_CanoR_1	536	540	PF00244	0.421
LIG_14-3-3_CanoR_1	609	615	PF00244	0.639
LIG_14-3-3_CanoR_1	657	666	PF00244	0.354
LIG_14-3-3_CanoR_1	673	679	PF00244	0.268
LIG_14-3-3_CanoR_1	784	794	PF00244	0.229
LIG_14-3-3_CanoR_1	824	834	PF00244	0.249
LIG_14-3-3_CanoR_1	87	95	PF00244	0.553
LIG_Actin_WH2_2	897	912	PF00022	0.449
LIG_APCC_ABBA_1	861	866	PF00400	0.359
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_4	806	810	PF00653	0.359
LIG_BRCT_BRCA1_1	120	124	PF00533	0.523
LIG_BRCT_BRCA1_1	562	566	PF00533	0.468
LIG_BRCT_BRCA1_1	715	719	PF00533	0.359
LIG_EVH1_2	542	546	PF00568	0.411
LIG_FHA_1	121	127	PF00498	0.534
LIG_FHA_1	199	205	PF00498	0.544
LIG_FHA_1	380	386	PF00498	0.504
LIG_FHA_1	4	10	PF00498	0.421
LIG_FHA_1	411	417	PF00498	0.668
LIG_FHA_1	552	558	PF00498	0.466
LIG_FHA_1	681	687	PF00498	0.463
LIG_FHA_1	729	735	PF00498	0.511
LIG_FHA_1	799	805	PF00498	0.359
LIG_FHA_1	836	842	PF00498	0.269
LIG_FHA_1	884	890	PF00498	0.609
LIG_FHA_2	101	107	PF00498	0.534
LIG_FHA_2	239	245	PF00498	0.523
LIG_FHA_2	346	352	PF00498	0.668
LIG_FHA_2	543	549	PF00498	0.419
LIG_FHA_2	627	633	PF00498	0.556
LIG_G3BP_FGDF_1	432	437	PF02136	0.514
LIG_LIR_Apic_2	167	172	PF02991	0.649
LIG_LIR_Apic_2	205	209	PF02991	0.556
LIG_LIR_Apic_2	325	331	PF02991	0.532
LIG_LIR_Apic_2	436	440	PF02991	0.512
LIG_LIR_Apic_2	527	533	PF02991	0.452
LIG_LIR_Gen_1	240	250	PF02991	0.630
LIG_LIR_Gen_1	375	386	PF02991	0.497
LIG_LIR_Gen_1	48	57	PF02991	0.590
LIG_LIR_Gen_1	548	557	PF02991	0.445
LIG_LIR_Gen_1	677	687	PF02991	0.359
LIG_LIR_Gen_1	711	722	PF02991	0.229
LIG_LIR_Gen_1	790	800	PF02991	0.359
LIG_LIR_Nem_3	160	166	PF02991	0.667
LIG_LIR_Nem_3	240	246	PF02991	0.628
LIG_LIR_Nem_3	41	47	PF02991	0.631
LIG_LIR_Nem_3	433	437	PF02991	0.523
LIG_LIR_Nem_3	463	469	PF02991	0.643
LIG_LIR_Nem_3	48	53	PF02991	0.583
LIG_LIR_Nem_3	545	550	PF02991	0.414
LIG_LIR_Nem_3	677	682	PF02991	0.359
LIG_LIR_Nem_3	711	717	PF02991	0.239
LIG_LIR_Nem_3	744	749	PF02991	0.443
LIG_LIR_Nem_3	790	796	PF02991	0.359
LIG_LIR_Nem_3	799	803	PF02991	0.287
LIG_LIR_Nem_3	896	900	PF02991	0.562
LIG_LYPXL_yS_3	44	47	PF13949	0.632
LIG_LYPXL_yS_3	847	850	PF13949	0.229
LIG_MYND_1	63	67	PF01753	0.520
LIG_Pex14_2	864	868	PF04695	0.359
LIG_SH2_CRK	328	332	PF00017	0.529
LIG_SH2_CRK	443	447	PF00017	0.494
LIG_SH2_STAP1	480	484	PF00017	0.508
LIG_SH2_STAP1	547	551	PF00017	0.421
LIG_SH2_STAT5	453	456	PF00017	0.513
LIG_SH2_STAT5	550	553	PF00017	0.533
LIG_SH2_STAT5	741	744	PF00017	0.359
LIG_SH2_STAT5	851	854	PF00017	0.406
LIG_SH2_STAT5	857	860	PF00017	0.376
LIG_SH3_3	169	175	PF00018	0.647
LIG_SH3_3	340	346	PF00018	0.544
LIG_SH3_3	380	386	PF00018	0.504
LIG_SH3_3	462	468	PF00018	0.511
LIG_SH3_3	495	501	PF00018	0.518
LIG_SH3_3	619	625	PF00018	0.524
LIG_SH3_3	640	646	PF00018	0.543
LIG_SH3_3	838	844	PF00018	0.229
LIG_Sin3_3	800	807	PF02671	0.339
LIG_SUMO_SIM_anti_2	467	476	PF11976	0.509
LIG_SUMO_SIM_par_1	174	180	PF11976	0.527
LIG_SUMO_SIM_par_1	381	387	PF11976	0.506
LIG_SUMO_SIM_par_1	467	476	PF11976	0.509
LIG_TRAF2_1	158	161	PF00917	0.551
LIG_TRAF2_1	213	216	PF00917	0.679
LIG_TRAF2_1	629	632	PF00917	0.536
LIG_TYR_ITIM	441	446	PF00017	0.491
LIG_WRC_WIRS_1	434	439	PF05994	0.508
LIG_WRC_WIRS_1	503	508	PF05994	0.642
MOD_CDK_SPK_2	510	515	PF00069	0.506
MOD_CDK_SPK_2	621	626	PF00069	0.527
MOD_CDK_SPxK_1	139	145	PF00069	0.565
MOD_CK1_1	104	110	PF00069	0.558
MOD_CK1_1	146	152	PF00069	0.565
MOD_CK1_1	180	186	PF00069	0.537
MOD_CK1_1	205	211	PF00069	0.652
MOD_CK1_1	285	291	PF00069	0.499
MOD_CK1_1	338	344	PF00069	0.670
MOD_CK1_1	345	351	PF00069	0.622
MOD_CK1_1	394	400	PF00069	0.634
MOD_CK1_1	414	420	PF00069	0.567
MOD_CK1_1	430	436	PF00069	0.661
MOD_CK1_1	445	451	PF00069	0.615
MOD_CK1_1	467	473	PF00069	0.627
MOD_CK1_1	531	537	PF00069	0.452
MOD_CK1_1	580	586	PF00069	0.535
MOD_CK1_1	596	602	PF00069	0.480
MOD_CK1_1	621	627	PF00069	0.580
MOD_CK1_1	66	72	PF00069	0.592
MOD_CK1_1	699	705	PF00069	0.336
MOD_CK1_1	708	714	PF00069	0.264
MOD_CK1_1	86	92	PF00069	0.601
MOD_CK2_1	100	106	PF00069	0.513
MOD_CK2_1	210	216	PF00069	0.679
MOD_CK2_1	238	244	PF00069	0.523
MOD_CK2_1	345	351	PF00069	0.609
MOD_CK2_1	542	548	PF00069	0.430
MOD_CK2_1	626	632	PF00069	0.562
MOD_CK2_1	88	94	PF00069	0.538
MOD_Cter_Amidation	193	196	PF01082	0.668
MOD_GlcNHglycan	183	186	PF01048	0.598
MOD_GlcNHglycan	211	215	PF01048	0.681
MOD_GlcNHglycan	24	28	PF01048	0.468
MOD_GlcNHglycan	267	270	PF01048	0.673
MOD_GlcNHglycan	282	285	PF01048	0.515
MOD_GlcNHglycan	309	312	PF01048	0.523
MOD_GlcNHglycan	396	399	PF01048	0.724
MOD_GlcNHglycan	428	432	PF01048	0.687
MOD_GlcNHglycan	506	509	PF01048	0.644
MOD_GlcNHglycan	561	565	PF01048	0.521
MOD_GlcNHglycan	775	778	PF01048	0.229
MOD_GlcNHglycan	90	93	PF01048	0.663
MOD_GlcNHglycan	94	98	PF01048	0.620
MOD_GSK3_1	100	107	PF00069	0.586
MOD_GSK3_1	108	115	PF00069	0.523
MOD_GSK3_1	118	125	PF00069	0.549
MOD_GSK3_1	139	146	PF00069	0.657
MOD_GSK3_1	177	184	PF00069	0.530
MOD_GSK3_1	198	205	PF00069	0.544
MOD_GSK3_1	230	237	PF00069	0.576
MOD_GSK3_1	282	289	PF00069	0.553
MOD_GSK3_1	307	314	PF00069	0.589
MOD_GSK3_1	334	341	PF00069	0.659
MOD_GSK3_1	410	417	PF00069	0.771
MOD_GSK3_1	423	430	PF00069	0.683
MOD_GSK3_1	502	509	PF00069	0.644
MOD_GSK3_1	524	531	PF00069	0.607
MOD_GSK3_1	576	583	PF00069	0.541
MOD_GSK3_1	674	681	PF00069	0.295
MOD_GSK3_1	695	702	PF00069	0.439
MOD_GSK3_1	73	80	PF00069	0.591
MOD_GSK3_1	763	770	PF00069	0.359
MOD_GSK3_1	826	833	PF00069	0.229
MOD_N-GLC_1	138	143	PF02516	0.579
MOD_NEK2_1	190	195	PF00069	0.562
MOD_NEK2_1	287	292	PF00069	0.595
MOD_NEK2_1	3	8	PF00069	0.430
MOD_NEK2_1	404	409	PF00069	0.514
MOD_NEK2_1	504	509	PF00069	0.659
MOD_NEK2_1	535	540	PF00069	0.442
MOD_NEK2_1	551	556	PF00069	0.426
MOD_NEK2_1	674	679	PF00069	0.307
MOD_NEK2_1	798	803	PF00069	0.359
MOD_NEK2_1	830	835	PF00069	0.229
MOD_NEK2_1	98	103	PF00069	0.660
MOD_NEK2_2	293	298	PF00069	0.517
MOD_NEK2_2	386	391	PF00069	0.523
MOD_PIKK_1	658	664	PF00454	0.339
MOD_PIKK_1	74	80	PF00454	0.654
MOD_PK_1	713	719	PF00069	0.359
MOD_PK_1	890	896	PF00069	0.343
MOD_PKA_1	298	304	PF00069	0.520
MOD_PKA_1	593	599	PF00069	0.471
MOD_PKA_1	890	896	PF00069	0.343
MOD_PKA_2	144	150	PF00069	0.652
MOD_PKA_2	262	268	PF00069	0.680
MOD_PKA_2	298	304	PF00069	0.520
MOD_PKA_2	379	385	PF00069	0.522
MOD_PKA_2	535	541	PF00069	0.411
MOD_PKA_2	728	734	PF00069	0.359
MOD_PKA_2	86	92	PF00069	0.559
MOD_PKA_2	890	896	PF00069	0.473
MOD_PKB_1	425	433	PF00069	0.526
MOD_Plk_1	159	165	PF00069	0.571
MOD_Plk_1	427	433	PF00069	0.731
MOD_Plk_1	639	645	PF00069	0.503
MOD_Plk_4	126	132	PF00069	0.546
MOD_Plk_4	287	293	PF00069	0.501
MOD_Plk_4	404	410	PF00069	0.654
MOD_Plk_4	411	417	PF00069	0.630
MOD_Plk_4	66	72	PF00069	0.532
MOD_Plk_4	660	666	PF00069	0.268
MOD_Plk_4	674	680	PF00069	0.338
MOD_ProDKin_1	108	114	PF00069	0.551
MOD_ProDKin_1	139	145	PF00069	0.597
MOD_ProDKin_1	177	183	PF00069	0.539
MOD_ProDKin_1	184	190	PF00069	0.535
MOD_ProDKin_1	205	211	PF00069	0.564
MOD_ProDKin_1	327	333	PF00069	0.528
MOD_ProDKin_1	339	345	PF00069	0.640
MOD_ProDKin_1	464	470	PF00069	0.639
MOD_ProDKin_1	510	516	PF00069	0.506
MOD_ProDKin_1	580	586	PF00069	0.535
MOD_ProDKin_1	618	624	PF00069	0.524
MOD_ProDKin_1	63	69	PF00069	0.632
MOD_ProDKin_1	642	648	PF00069	0.461
MOD_ProDKin_1	699	705	PF00069	0.492
MOD_ProDKin_1	763	769	PF00069	0.394
MOD_SUMO_for_1	27	30	PF00179	0.498
MOD_SUMO_for_1	712	715	PF00179	0.359
MOD_SUMO_rev_2	893	902	PF00179	0.528
TRG_DiLeu_BaEn_3	650	656	PF01217	0.333
TRG_DiLeu_BaEn_4	215	221	PF01217	0.543
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.523
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.518
TRG_ENDOCYTIC_2	378	381	PF00928	0.497
TRG_ENDOCYTIC_2	44	47	PF00928	0.632
TRG_ENDOCYTIC_2	443	446	PF00928	0.495
TRG_ENDOCYTIC_2	550	553	PF00928	0.429
TRG_ENDOCYTIC_2	746	749	PF00928	0.463
TRG_ENDOCYTIC_2	847	850	PF00928	0.359
TRG_ER_diArg_1	13	15	PF00400	0.542
TRG_ER_diArg_1	297	299	PF00400	0.518
TRG_ER_diArg_1	449	451	PF00400	0.801
TRG_ER_diArg_1	672	674	PF00400	0.359
TRG_ER_diArg_1	868	871	PF00400	0.359
TRG_NES_CRM1_1	373	384	PF08389	0.492
TRG_NLS_MonoExtC_3	10	15	PF00514	0.541
TRG_NLS_MonoExtN_4	590	597	PF00514	0.478
TRG_Pf-PMV_PEXEL_1	626	631	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAP8	Leishmania donovani	58%	100%
A4IDC3	Leishmania infantum	59%	99%
E9ASS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4Q1S2	Leishmania major	58%	99%