LeishMANIAdb
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Putative serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine protein kinase
Gene product:
serine/threonine protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HP13_LEIBR
TriTrypDb:
LbrM.35.1670 , LBRM2903_350022900
Length:
501

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 73
NetGPI no yes: 0, no: 73
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP13

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 74
GO:0006793 phosphorus metabolic process 3 74
GO:0006796 phosphate-containing compound metabolic process 4 74
GO:0006807 nitrogen compound metabolic process 2 74
GO:0008152 metabolic process 1 74
GO:0009987 cellular process 1 74
GO:0016310 phosphorylation 5 74
GO:0019538 protein metabolic process 3 74
GO:0036211 protein modification process 4 74
GO:0043170 macromolecule metabolic process 3 74
GO:0043412 macromolecule modification 4 74
GO:0044237 cellular metabolic process 2 74
GO:0044238 primary metabolic process 2 74
GO:0071704 organic substance metabolic process 2 74
GO:1901564 organonitrogen compound metabolic process 3 74
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 74
GO:0003824 catalytic activity 1 74
GO:0004672 protein kinase activity 3 74
GO:0004674 protein serine/threonine kinase activity 4 47
GO:0005488 binding 1 74
GO:0005524 ATP binding 5 74
GO:0016301 kinase activity 4 74
GO:0016740 transferase activity 2 74
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 74
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 74
GO:0017076 purine nucleotide binding 4 74
GO:0030554 adenyl nucleotide binding 5 74
GO:0032553 ribonucleotide binding 3 74
GO:0032555 purine ribonucleotide binding 4 74
GO:0032559 adenyl ribonucleotide binding 5 74
GO:0035639 purine ribonucleoside triphosphate binding 4 74
GO:0036094 small molecule binding 2 74
GO:0043167 ion binding 2 74
GO:0043168 anion binding 3 74
GO:0097159 organic cyclic compound binding 2 74
GO:0097367 carbohydrate derivative binding 2 74
GO:0140096 catalytic activity, acting on a protein 2 74
GO:1901265 nucleoside phosphate binding 3 74
GO:1901363 heterocyclic compound binding 2 74

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 367 371 PF00656 0.535
CLV_C14_Caspase3-7 455 459 PF00656 0.371
CLV_NRD_NRD_1 225 227 PF00675 0.261
CLV_NRD_NRD_1 294 296 PF00675 0.336
CLV_NRD_NRD_1 350 352 PF00675 0.545
CLV_NRD_NRD_1 395 397 PF00675 0.293
CLV_NRD_NRD_1 471 473 PF00675 0.321
CLV_NRD_NRD_1 59 61 PF00675 0.379
CLV_PCSK_KEX2_1 225 227 PF00082 0.279
CLV_PCSK_KEX2_1 249 251 PF00082 0.272
CLV_PCSK_KEX2_1 293 295 PF00082 0.345
CLV_PCSK_KEX2_1 349 351 PF00082 0.501
CLV_PCSK_KEX2_1 394 396 PF00082 0.307
CLV_PCSK_KEX2_1 471 473 PF00082 0.303
CLV_PCSK_KEX2_1 59 61 PF00082 0.339
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.239
CLV_PCSK_PC1ET2_1 293 295 PF00082 0.353
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.313
CLV_PCSK_SKI1_1 174 178 PF00082 0.301
CLV_PCSK_SKI1_1 299 303 PF00082 0.297
CLV_PCSK_SKI1_1 408 412 PF00082 0.225
CLV_PCSK_SKI1_1 471 475 PF00082 0.232
CLV_Separin_Metazoa 81 85 PF03568 0.165
DEG_APCC_DBOX_1 39 47 PF00400 0.484
DOC_CKS1_1 302 307 PF01111 0.263
DOC_CKS1_1 437 442 PF01111 0.304
DOC_MAPK_gen_1 174 183 PF00069 0.308
DOC_MAPK_gen_1 249 257 PF00069 0.139
DOC_MAPK_gen_1 37 47 PF00069 0.442
DOC_MAPK_gen_1 394 400 PF00069 0.280
DOC_MAPK_MEF2A_6 40 47 PF00069 0.342
DOC_MAPK_RevD_3 236 250 PF00069 0.288
DOC_PP1_RVXF_1 469 476 PF00149 0.268
DOC_USP7_MATH_1 30 34 PF00917 0.528
DOC_USP7_MATH_1 489 493 PF00917 0.312
DOC_WW_Pin1_4 212 217 PF00397 0.310
DOC_WW_Pin1_4 26 31 PF00397 0.691
DOC_WW_Pin1_4 274 279 PF00397 0.229
DOC_WW_Pin1_4 301 306 PF00397 0.270
DOC_WW_Pin1_4 368 373 PF00397 0.529
DOC_WW_Pin1_4 436 441 PF00397 0.313
DOC_WW_Pin1_4 75 80 PF00397 0.277
LIG_14-3-3_CanoR_1 351 357 PF00244 0.592
LIG_14-3-3_CanoR_1 488 494 PF00244 0.362
LIG_APCC_ABBA_1 398 403 PF00400 0.167
LIG_APCC_ABBAyCdc20_2 169 175 PF00400 0.314
LIG_BIR_II_1 1 5 PF00653 0.558
LIG_BRCT_BRCA1_1 35 39 PF00533 0.519
LIG_BRCT_BRCA1_1 437 441 PF00533 0.418
LIG_CaM_IQ_9 421 437 PF13499 0.395
LIG_Clathr_ClatBox_1 418 422 PF01394 0.167
LIG_deltaCOP1_diTrp_1 484 493 PF00928 0.363
LIG_FHA_1 17 23 PF00498 0.457
LIG_FHA_1 304 310 PF00498 0.441
LIG_FHA_1 333 339 PF00498 0.534
LIG_FHA_1 361 367 PF00498 0.498
LIG_FHA_1 373 379 PF00498 0.446
LIG_FHA_1 409 415 PF00498 0.340
LIG_FHA_1 418 424 PF00498 0.347
LIG_FHA_2 201 207 PF00498 0.325
LIG_FHA_2 22 28 PF00498 0.502
LIG_FHA_2 339 345 PF00498 0.471
LIG_FHA_2 453 459 PF00498 0.317
LIG_FHA_2 76 82 PF00498 0.173
LIG_Integrin_isoDGR_2 469 471 PF01839 0.167
LIG_IRF3_LxIS_1 305 312 PF10401 0.217
LIG_LIR_Apic_2 215 221 PF02991 0.302
LIG_LIR_Gen_1 193 204 PF02991 0.248
LIG_LIR_Gen_1 438 448 PF02991 0.295
LIG_LIR_Gen_1 96 105 PF02991 0.305
LIG_LIR_Nem_3 36 42 PF02991 0.466
LIG_LIR_Nem_3 438 444 PF02991 0.295
LIG_LIR_Nem_3 445 451 PF02991 0.279
LIG_LIR_Nem_3 492 496 PF02991 0.256
LIG_LIR_Nem_3 94 100 PF02991 0.287
LIG_NRBOX 237 243 PF00104 0.248
LIG_PCNA_PIPBox_1 487 496 PF02747 0.167
LIG_PCNA_yPIPBox_3 113 124 PF02747 0.257
LIG_PCNA_yPIPBox_3 281 295 PF02747 0.459
LIG_Pex14_1 393 397 PF04695 0.278
LIG_Pex14_2 16 20 PF04695 0.373
LIG_Pex14_2 463 467 PF04695 0.284
LIG_SH2_GRB2like 127 130 PF00017 0.314
LIG_SH2_GRB2like 200 203 PF00017 0.430
LIG_SH2_NCK_1 127 131 PF00017 0.339
LIG_SH2_PTP2 218 221 PF00017 0.288
LIG_SH2_PTP2 310 313 PF00017 0.213
LIG_SH2_PTP2 397 400 PF00017 0.167
LIG_SH2_SRC 127 130 PF00017 0.313
LIG_SH2_SRC 42 45 PF00017 0.199
LIG_SH2_STAP1 200 204 PF00017 0.284
LIG_SH2_STAP1 229 233 PF00017 0.329
LIG_SH2_STAP1 57 61 PF00017 0.182
LIG_SH2_STAT3 77 80 PF00017 0.165
LIG_SH2_STAT5 218 221 PF00017 0.301
LIG_SH2_STAT5 310 313 PF00017 0.343
LIG_SH2_STAT5 397 400 PF00017 0.276
LIG_SH2_STAT5 42 45 PF00017 0.343
LIG_SH2_STAT5 454 457 PF00017 0.261
LIG_SH2_STAT5 77 80 PF00017 0.400
LIG_SH2_STAT5 97 100 PF00017 0.286
LIG_SUMO_SIM_anti_2 420 425 PF11976 0.330
LIG_SUMO_SIM_par_1 416 422 PF11976 0.335
LIG_TRAF2_1 24 27 PF00917 0.584
LIG_TRAF2_1 328 331 PF00917 0.510
LIG_TRAF2_1 341 344 PF00917 0.569
LIG_TRAF2_1 78 81 PF00917 0.165
LIG_TYR_ITIM 241 246 PF00017 0.310
LIG_UBA3_1 241 249 PF00899 0.295
LIG_WRC_WIRS_1 490 495 PF05994 0.167
MOD_CDC14_SPxK_1 371 374 PF00782 0.311
MOD_CDK_SPxK_1 368 374 PF00069 0.604
MOD_CDK_SPxxK_3 301 308 PF00069 0.170
MOD_CK1_1 2 8 PF00069 0.445
MOD_CK1_1 297 303 PF00069 0.171
MOD_CK1_1 33 39 PF00069 0.476
MOD_CK1_1 389 395 PF00069 0.351
MOD_CK1_1 428 434 PF00069 0.295
MOD_CK1_1 452 458 PF00069 0.268
MOD_CK1_1 49 55 PF00069 0.283
MOD_CK2_1 21 27 PF00069 0.511
MOD_CK2_1 338 344 PF00069 0.467
MOD_CK2_1 439 445 PF00069 0.302
MOD_CK2_1 75 81 PF00069 0.193
MOD_Cter_Amidation 469 472 PF01082 0.302
MOD_GlcNHglycan 1 4 PF01048 0.593
MOD_GlcNHglycan 13 16 PF01048 0.375
MOD_GlcNHglycan 177 180 PF01048 0.328
MOD_GlcNHglycan 326 329 PF01048 0.465
MOD_GlcNHglycan 48 51 PF01048 0.287
MOD_GlcNHglycan 85 88 PF01048 0.418
MOD_GSK3_1 208 215 PF00069 0.293
MOD_GSK3_1 26 33 PF00069 0.616
MOD_GSK3_1 279 286 PF00069 0.312
MOD_GSK3_1 297 304 PF00069 0.401
MOD_GSK3_1 360 367 PF00069 0.432
MOD_GSK3_1 368 375 PF00069 0.393
MOD_GSK3_1 385 392 PF00069 0.335
MOD_GSK3_1 413 420 PF00069 0.335
MOD_GSK3_1 435 442 PF00069 0.357
MOD_N-GLC_1 138 143 PF02516 0.175
MOD_NEK2_1 182 187 PF00069 0.290
MOD_NEK2_1 194 199 PF00069 0.285
MOD_NEK2_1 261 266 PF00069 0.302
MOD_NEK2_1 309 314 PF00069 0.321
MOD_NEK2_1 332 337 PF00069 0.366
MOD_NEK2_1 360 365 PF00069 0.468
MOD_OFUCOSY 90 95 PF10250 0.165
MOD_PKA_1 294 300 PF00069 0.300
MOD_PKA_2 294 300 PF00069 0.290
MOD_PKA_2 33 39 PF00069 0.489
MOD_PKA_2 428 434 PF00069 0.167
MOD_PKA_2 83 89 PF00069 0.401
MOD_Plk_1 330 336 PF00069 0.552
MOD_Plk_1 389 395 PF00069 0.332
MOD_Plk_4 279 285 PF00069 0.262
MOD_Plk_4 297 303 PF00069 0.271
MOD_Plk_4 380 386 PF00069 0.205
MOD_Plk_4 489 495 PF00069 0.416
MOD_Plk_4 51 57 PF00069 0.305
MOD_ProDKin_1 212 218 PF00069 0.310
MOD_ProDKin_1 26 32 PF00069 0.694
MOD_ProDKin_1 274 280 PF00069 0.229
MOD_ProDKin_1 301 307 PF00069 0.270
MOD_ProDKin_1 368 374 PF00069 0.516
MOD_ProDKin_1 436 442 PF00069 0.313
MOD_ProDKin_1 75 81 PF00069 0.277
MOD_SUMO_rev_2 23 30 PF00179 0.531
TRG_DiLeu_BaEn_1 88 93 PF01217 0.310
TRG_ENDOCYTIC_2 243 246 PF00928 0.312
TRG_ENDOCYTIC_2 310 313 PF00928 0.339
TRG_ENDOCYTIC_2 397 400 PF00928 0.306
TRG_ENDOCYTIC_2 401 404 PF00928 0.277
TRG_ENDOCYTIC_2 42 45 PF00928 0.384
TRG_ENDOCYTIC_2 97 100 PF00928 0.303
TRG_ER_diArg_1 137 140 PF00400 0.313
TRG_ER_diArg_1 224 226 PF00400 0.272
TRG_ER_diArg_1 294 296 PF00400 0.306
TRG_ER_diArg_1 349 351 PF00400 0.557
TRG_ER_diArg_1 395 397 PF00400 0.294
TRG_ER_diArg_1 471 473 PF00400 0.327
TRG_ER_diArg_1 59 62 PF00400 0.413
TRG_NES_CRM1_1 485 500 PF08389 0.203
TRG_NLS_MonoExtN_4 292 297 PF00514 0.433
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.437
TRG_Pf-PMV_PEXEL_1 336 340 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 408 413 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 472 476 PF00026 0.267

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 33% 100%
A0A0N0P953 Leptomonas seymouri 34% 100%
A0A0N1I9A0 Leptomonas seymouri 30% 77%
A0A0N1PD05 Leptomonas seymouri 32% 100%
A0A0S4IHW4 Bodo saltans 28% 100%
A0A0S4IRZ7 Bodo saltans 34% 100%
A0A0S4IVW1 Bodo saltans 25% 80%
A0A0S4IX86 Bodo saltans 33% 100%
A0A0S4J7K4 Bodo saltans 26% 100%
A0A0S4J804 Bodo saltans 37% 96%
A0A0S4JIJ6 Bodo saltans 29% 89%
A0A1X0NIA0 Trypanosomatidae 33% 100%
A0A1X0NIX2 Trypanosomatidae 30% 100%
A0A1X0NJV4 Trypanosomatidae 28% 98%
A0A1X0NUB2 Trypanosomatidae 29% 86%
A0A1X0P1A2 Trypanosomatidae 28% 100%
A0A1X0P527 Trypanosomatidae 34% 100%
A0A1X0P549 Trypanosomatidae 36% 100%
A0A1X0P863 Trypanosomatidae 56% 100%
A0A1X0P8W3 Trypanosomatidae 35% 68%
A0A1X0P994 Trypanosomatidae 56% 100%
A0A3Q8IAQ1 Leishmania donovani 37% 100%
A0A3Q8IFW0 Leishmania donovani 34% 100%
A0A3Q8IIG1 Leishmania donovani 29% 100%
A0A3Q8IJM9 Leishmania donovani 35% 100%
A0A3R7KCZ4 Trypanosoma rangeli 35% 100%
A0A3R7MKG5 Trypanosoma rangeli 31% 100%
A0A3S7X5M4 Leishmania donovani 30% 76%
A0A3S7X6T8 Leishmania donovani 31% 100%
A0A3S7X7D5 Leishmania donovani 28% 100%
A0A3S7XAL3 Leishmania donovani 79% 100%
A0A3S7XAT9 Leishmania donovani 90% 100%
A0A422NCP0 Trypanosoma rangeli 56% 100%
A0A422NH41 Trypanosoma rangeli 30% 87%
A4HCE6 Leishmania braziliensis 36% 100%
A4HJT5 Leishmania braziliensis 38% 100%
A4HJW2 Leishmania braziliensis 33% 92%
A4HKG9 Leishmania braziliensis 29% 100%
A4HLR0 Leishmania braziliensis 32% 97%
A4HN71 Leishmania braziliensis 31% 100%
A4HNI1 Leishmania braziliensis 35% 97%
A4HP12 Leishmania braziliensis 59% 100%
A4HZW8 Leishmania infantum 37% 100%
A4I435 Leishmania infantum 29% 100%
A4I7C4 Leishmania infantum 33% 100%
A4I7Z6 Leishmania infantum 30% 76%
A4I960 Leishmania infantum 31% 100%
A4I9H1 Leishmania infantum 28% 100%
A4IC37 Leishmania infantum 36% 100%
A4IDC1 Leishmania infantum 59% 98%
A4IDC2 Leishmania infantum 90% 100%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 87%
E9AFZ2 Leishmania major 35% 96%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 98%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 76%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
Q03428 Trypanosoma brucei brucei 33% 100%
Q08942 Trypanosoma brucei brucei 34% 100%
Q4Q1S3 Leishmania major 90% 100%
Q4Q1S4 Leishmania major 59% 100%
Q4Q3Y9 Leishmania major 31% 97%
Q4Q598 Leishmania major 30% 100%
Q4Q5T9 Leishmania major 33% 93%
Q4Q7W2 Leishmania major 29% 100%
Q4QBQ2 Leishmania major 36% 100%
Q5KQF5 Oryza sativa subsp. japonica 27% 100%
Q6DGS3 Danio rerio 28% 90%
Q84VQ3 Arabidopsis thaliana 26% 100%
Q8IBS5 Plasmodium falciparum (isolate 3D7) 26% 95%
Q8RXT4 Arabidopsis thaliana 28% 90%
V5BC28 Trypanosoma cruzi 30% 100%
V5BHW8 Trypanosoma cruzi 25% 79%
V5BPJ0 Trypanosoma cruzi 57% 100%
V5D579 Trypanosoma cruzi 33% 100%
V5DFW9 Trypanosoma cruzi 29% 86%
V5DKY9 Trypanosoma cruzi 34% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS