LeishMANIAdb
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Putative nima-related protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nima-related protein kinase
Gene product:
nima-related protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HP12_LEIBR
TriTrypDb:
LbrM.35.1660 , LBRM2903_350022900 *
Length:
509

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 66
NetGPI no yes: 0, no: 66
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HP12
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP12

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 67
GO:0006793 phosphorus metabolic process 3 67
GO:0006796 phosphate-containing compound metabolic process 4 67
GO:0006807 nitrogen compound metabolic process 2 67
GO:0008152 metabolic process 1 67
GO:0009987 cellular process 1 67
GO:0016310 phosphorylation 5 67
GO:0019538 protein metabolic process 3 67
GO:0036211 protein modification process 4 67
GO:0043170 macromolecule metabolic process 3 67
GO:0043412 macromolecule modification 4 67
GO:0044237 cellular metabolic process 2 67
GO:0044238 primary metabolic process 2 67
GO:0071704 organic substance metabolic process 2 67
GO:1901564 organonitrogen compound metabolic process 3 67
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 67
GO:0003824 catalytic activity 1 67
GO:0004672 protein kinase activity 3 67
GO:0004674 protein serine/threonine kinase activity 4 49
GO:0005488 binding 1 67
GO:0005524 ATP binding 5 67
GO:0016301 kinase activity 4 67
GO:0016740 transferase activity 2 67
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 67
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 67
GO:0017076 purine nucleotide binding 4 67
GO:0030554 adenyl nucleotide binding 5 67
GO:0032553 ribonucleotide binding 3 67
GO:0032555 purine ribonucleotide binding 4 67
GO:0032559 adenyl ribonucleotide binding 5 67
GO:0035639 purine ribonucleoside triphosphate binding 4 67
GO:0036094 small molecule binding 2 67
GO:0043167 ion binding 2 67
GO:0043168 anion binding 3 67
GO:0097159 organic cyclic compound binding 2 67
GO:0097367 carbohydrate derivative binding 2 67
GO:0140096 catalytic activity, acting on a protein 2 67
GO:1901265 nucleoside phosphate binding 3 67
GO:1901363 heterocyclic compound binding 2 67

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.376
CLV_C14_Caspase3-7 5 9 PF00656 0.353
CLV_NRD_NRD_1 220 222 PF00675 0.247
CLV_NRD_NRD_1 289 291 PF00675 0.365
CLV_PCSK_KEX2_1 220 222 PF00082 0.243
CLV_PCSK_KEX2_1 244 246 PF00082 0.268
CLV_PCSK_KEX2_1 289 291 PF00082 0.358
CLV_PCSK_KEX2_1 335 337 PF00082 0.457
CLV_PCSK_KEX2_1 342 344 PF00082 0.427
CLV_PCSK_KEX2_1 395 397 PF00082 0.384
CLV_PCSK_KEX2_1 470 472 PF00082 0.397
CLV_PCSK_KEX2_1 54 56 PF00082 0.339
CLV_PCSK_PC1ET2_1 244 246 PF00082 0.240
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.487
CLV_PCSK_PC1ET2_1 342 344 PF00082 0.313
CLV_PCSK_PC1ET2_1 395 397 PF00082 0.390
CLV_PCSK_PC1ET2_1 470 472 PF00082 0.366
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.259
CLV_PCSK_SKI1_1 169 173 PF00082 0.299
CLV_PCSK_SKI1_1 303 307 PF00082 0.409
CLV_PCSK_SKI1_1 335 339 PF00082 0.413
DEG_SCF_FBW7_2 436 442 PF00400 0.431
DEG_SPOP_SBC_1 358 362 PF00917 0.540
DEG_SPOP_SBC_1 369 373 PF00917 0.617
DOC_CKS1_1 436 441 PF01111 0.450
DOC_CYCLIN_RxL_1 467 478 PF00134 0.418
DOC_MAPK_gen_1 169 178 PF00069 0.301
DOC_MAPK_gen_1 394 400 PF00069 0.336
DOC_MAPK_gen_1 416 424 PF00069 0.378
DOC_MAPK_MEF2A_6 418 426 PF00069 0.358
DOC_MAPK_RevD_3 231 245 PF00069 0.303
DOC_PP1_RVXF_1 468 475 PF00149 0.359
DOC_PP2B_LxvP_1 297 300 PF13499 0.289
DOC_PP4_FxxP_1 447 450 PF00568 0.339
DOC_USP7_MATH_1 266 270 PF00917 0.350
DOC_USP7_MATH_1 291 295 PF00917 0.233
DOC_WW_Pin1_4 207 212 PF00397 0.303
DOC_WW_Pin1_4 269 274 PF00397 0.274
DOC_WW_Pin1_4 365 370 PF00397 0.595
DOC_WW_Pin1_4 435 440 PF00397 0.431
LIG_14-3-3_CanoR_1 13 19 PF00244 0.237
LIG_14-3-3_CanoR_1 137 143 PF00244 0.305
LIG_14-3-3_CanoR_1 289 299 PF00244 0.293
LIG_14-3-3_CanoR_1 336 345 PF00244 0.517
LIG_14-3-3_CanoR_1 471 475 PF00244 0.459
LIG_14-3-3_CanoR_1 55 62 PF00244 0.324
LIG_APCC_ABBAyCdc20_2 164 170 PF00400 0.303
LIG_BIR_II_1 1 5 PF00653 0.610
LIG_BIR_III_2 445 449 PF00653 0.233
LIG_BRCT_BRCA1_1 436 440 PF00533 0.559
LIG_BRCT_BRCA1_1 458 462 PF00533 0.386
LIG_FHA_1 278 284 PF00498 0.292
LIG_FHA_1 332 338 PF00498 0.553
LIG_FHA_1 359 365 PF00498 0.534
LIG_FHA_1 369 375 PF00498 0.579
LIG_FHA_1 45 51 PF00498 0.326
LIG_FHA_2 139 145 PF00498 0.342
LIG_FHA_2 196 202 PF00498 0.333
LIG_FHA_2 26 32 PF00498 0.439
LIG_FHA_2 3 9 PF00498 0.401
LIG_FHA_2 360 366 PF00498 0.490
LIG_FHA_2 376 382 PF00498 0.384
LIG_FHA_2 407 413 PF00498 0.458
LIG_FHA_2 439 445 PF00498 0.426
LIG_FHA_2 474 480 PF00498 0.424
LIG_IRF3_LxIS_1 420 427 PF10401 0.424
LIG_LIR_Apic_2 210 216 PF02991 0.294
LIG_LIR_Apic_2 444 450 PF02991 0.352
LIG_LIR_Gen_1 188 199 PF02991 0.241
LIG_LIR_Gen_1 437 448 PF02991 0.385
LIG_LIR_Nem_3 437 443 PF02991 0.407
LIG_NRBOX 151 157 PF00104 0.166
LIG_NRBOX 232 238 PF00104 0.259
LIG_NRBOX 305 311 PF00104 0.198
LIG_PCNA_yPIPBox_3 104 116 PF02747 0.257
LIG_PCNA_yPIPBox_3 295 305 PF02747 0.273
LIG_PCNA_yPIPBox_3 77 88 PF02747 0.245
LIG_Pex14_1 393 397 PF04695 0.351
LIG_Pex14_2 18 22 PF04695 0.399
LIG_Pex14_2 462 466 PF04695 0.322
LIG_PTB_Apo_2 411 418 PF02174 0.562
LIG_PTB_Apo_2 86 93 PF02174 0.278
LIG_SH2_GRB2like 122 125 PF00017 0.338
LIG_SH2_GRB2like 195 198 PF00017 0.429
LIG_SH2_NCK_1 122 126 PF00017 0.315
LIG_SH2_PTP2 213 216 PF00017 0.319
LIG_SH2_SRC 122 125 PF00017 0.297
LIG_SH2_STAP1 195 199 PF00017 0.271
LIG_SH2_STAP1 224 228 PF00017 0.320
LIG_SH2_STAT5 213 216 PF00017 0.293
LIG_SH2_STAT5 397 400 PF00017 0.305
LIG_SH2_STAT5 453 456 PF00017 0.360
LIG_SUMO_SIM_par_1 421 427 PF11976 0.385
LIG_TYR_ITIM 236 241 PF00017 0.307
LIG_UBA3_1 236 244 PF00899 0.292
LIG_UBA3_1 296 303 PF00899 0.235
MOD_CDK_SPxxK_3 269 276 PF00069 0.415
MOD_CK1_1 2 8 PF00069 0.440
MOD_CK1_1 269 275 PF00069 0.344
MOD_CK1_1 352 358 PF00069 0.577
MOD_CK1_1 427 433 PF00069 0.438
MOD_CK1_1 44 50 PF00069 0.279
MOD_CK1_1 473 479 PF00069 0.482
MOD_CK2_1 138 144 PF00069 0.372
MOD_CK2_1 14 20 PF00069 0.354
MOD_CK2_1 25 31 PF00069 0.409
MOD_CK2_1 359 365 PF00069 0.519
MOD_CK2_1 375 381 PF00069 0.384
MOD_CK2_1 438 444 PF00069 0.410
MOD_CK2_1 473 479 PF00069 0.330
MOD_CK2_1 54 60 PF00069 0.240
MOD_Cter_Amidation 468 471 PF01082 0.406
MOD_GlcNHglycan 1 4 PF01048 0.626
MOD_GlcNHglycan 172 175 PF01048 0.321
MOD_GlcNHglycan 283 286 PF01048 0.285
MOD_GlcNHglycan 306 309 PF01048 0.299
MOD_GlcNHglycan 350 355 PF01048 0.555
MOD_GlcNHglycan 43 46 PF01048 0.287
MOD_GlcNHglycan 499 505 PF01048 0.713
MOD_GSK3_1 131 138 PF00069 0.381
MOD_GSK3_1 14 21 PF00069 0.371
MOD_GSK3_1 203 210 PF00069 0.306
MOD_GSK3_1 277 284 PF00069 0.314
MOD_GSK3_1 285 292 PF00069 0.334
MOD_GSK3_1 349 356 PF00069 0.509
MOD_GSK3_1 365 372 PF00069 0.493
MOD_GSK3_1 434 441 PF00069 0.462
MOD_N-GLC_1 269 274 PF02516 0.322
MOD_N-GLC_1 456 461 PF02516 0.336
MOD_NEK2_1 1 6 PF00069 0.367
MOD_NEK2_1 177 182 PF00069 0.282
MOD_NEK2_1 189 194 PF00069 0.282
MOD_NEK2_1 256 261 PF00069 0.313
MOD_NEK2_1 304 309 PF00069 0.302
MOD_NEK2_1 349 354 PF00069 0.465
MOD_NEK2_1 370 375 PF00069 0.518
MOD_NEK2_2 375 380 PF00069 0.381
MOD_PIKK_1 312 318 PF00454 0.395
MOD_PKA_1 289 295 PF00069 0.297
MOD_PKA_1 385 391 PF00069 0.394
MOD_PKA_1 470 476 PF00069 0.233
MOD_PKA_1 54 60 PF00069 0.309
MOD_PKA_2 289 295 PF00069 0.288
MOD_PKA_2 470 476 PF00069 0.501
MOD_PKA_2 54 60 PF00069 0.300
MOD_Plk_1 456 462 PF00069 0.539
MOD_Plk_1 500 506 PF00069 0.441
MOD_Plk_2-3 406 412 PF00069 0.527
MOD_Plk_2-3 70 76 PF00069 0.314
MOD_Plk_4 359 365 PF00069 0.555
MOD_Plk_4 406 412 PF00069 0.522
MOD_Plk_4 456 462 PF00069 0.402
MOD_Plk_4 46 52 PF00069 0.304
MOD_ProDKin_1 207 213 PF00069 0.303
MOD_ProDKin_1 269 275 PF00069 0.274
MOD_ProDKin_1 365 371 PF00069 0.574
MOD_ProDKin_1 435 441 PF00069 0.437
MOD_SUMO_for_1 23 26 PF00179 0.365
MOD_SUMO_rev_2 127 134 PF00179 0.334
MOD_SUMO_rev_2 328 337 PF00179 0.435
TRG_DiLeu_BaEn_1 333 338 PF01217 0.523
TRG_DiLeu_BaEn_1 83 88 PF01217 0.303
TRG_DiLeu_BaLyEn_6 292 297 PF01217 0.417
TRG_DiLeu_LyEn_5 333 338 PF01217 0.265
TRG_ENDOCYTIC_2 238 241 PF00928 0.295
TRG_ENDOCYTIC_2 397 400 PF00928 0.343
TRG_ER_diArg_1 219 221 PF00400 0.271
TRG_ER_diArg_1 289 291 PF00400 0.356
TRG_NES_CRM1_1 111 121 PF08389 0.166
TRG_Pf-PMV_PEXEL_1 336 341 PF00026 0.474
TRG_Pf-PMV_PEXEL_1 482 487 PF00026 0.406

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 34% 100%
A0A0N0P953 Leptomonas seymouri 35% 100%
A0A0N1I9A0 Leptomonas seymouri 30% 78%
A0A0N1PD05 Leptomonas seymouri 34% 100%
A0A0N1PDW7 Leptomonas seymouri 26% 100%
A0A0S4IMB7 Bodo saltans 38% 100%
A0A0S4IRZ7 Bodo saltans 34% 100%
A0A0S4IVW1 Bodo saltans 27% 81%
A0A0S4IX86 Bodo saltans 37% 100%
A0A0S4J804 Bodo saltans 38% 97%
A0A0S4JIJ6 Bodo saltans 27% 90%
A0A0S4JPZ1 Bodo saltans 32% 100%
A0A0S4JWD5 Bodo saltans 24% 100%
A0A1X0NIA0 Trypanosomatidae 39% 100%
A0A1X0NIX2 Trypanosomatidae 34% 100%
A0A1X0NTL6 Trypanosomatidae 33% 100%
A0A1X0NTR6 Trypanosomatidae 25% 100%
A0A1X0NUB2 Trypanosomatidae 30% 88%
A0A1X0P022 Trypanosomatidae 24% 79%
A0A1X0P527 Trypanosomatidae 37% 100%
A0A1X0P549 Trypanosomatidae 37% 100%
A0A1X0P863 Trypanosomatidae 75% 100%
A0A1X0P994 Trypanosomatidae 70% 100%
A0A3Q8IAQ1 Leishmania donovani 42% 100%
A0A3Q8IC87 Leishmania donovani 26% 100%
A0A3Q8IDK8 Leishmania donovani 27% 91%
A0A3Q8IFK8 Leishmania donovani 33% 100%
A0A3Q8IFW0 Leishmania donovani 34% 100%
A0A3Q8IHA5 Leishmania donovani 26% 100%
A0A3Q8IIG1 Leishmania donovani 32% 100%
A0A3Q8IJM9 Leishmania donovani 35% 100%
A0A3R7KCZ4 Trypanosoma rangeli 36% 100%
A0A3R7MKG5 Trypanosoma rangeli 34% 100%
A0A3S5H528 Leishmania donovani 27% 100%
A0A3S7X2W3 Leishmania donovani 26% 100%
A0A3S7X5M4 Leishmania donovani 30% 78%
A0A3S7X6T8 Leishmania donovani 36% 100%
A0A3S7X9R4 Leishmania donovani 30% 100%
A0A3S7X9S2 Leishmania donovani 30% 100%
A0A3S7XAL3 Leishmania donovani 71% 100%
A0A3S7XAT9 Leishmania donovani 58% 100%
A0A422NCP0 Trypanosoma rangeli 74% 100%
A0A422NH41 Trypanosoma rangeli 31% 88%
A4HCD7 Leishmania braziliensis 26% 100%
A4HCE6 Leishmania braziliensis 40% 100%
A4HH03 Leishmania braziliensis 28% 100%
A4HHN1 Leishmania braziliensis 27% 100%
A4HJT5 Leishmania braziliensis 33% 95%
A4HJW2 Leishmania braziliensis 34% 91%
A4HKG9 Leishmania braziliensis 30% 100%
A4HLR0 Leishmania braziliensis 35% 97%
A4HN71 Leishmania braziliensis 29% 100%
A4HNI1 Leishmania braziliensis 34% 97%
A4HP13 Leishmania braziliensis 59% 100%
A4HRT2 Leishmania infantum 27% 100%
A4HZV1 Leishmania infantum 26% 100%
A4HZW8 Leishmania infantum 42% 100%
A4I2I8 Leishmania infantum 27% 100%
A4I349 Leishmania infantum 27% 90%
A4I435 Leishmania infantum 32% 100%
A4I4U6 Leishmania infantum 26% 100%
A4I7A1 Leishmania infantum 33% 100%
A4I7C4 Leishmania infantum 34% 100%
A4I7Z6 Leishmania infantum 30% 78%
A4I960 Leishmania infantum 35% 100%
A4IBT4 Leishmania infantum 29% 100%
A4IBT9 Leishmania infantum 29% 100%
A4IC37 Leishmania infantum 35% 100%
A4IDC1 Leishmania infantum 97% 100%
A4IDC2 Leishmania infantum 58% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZUU2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 77%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 89%
E9ACG8 Leishmania major 27% 100%
E9AFM1 Leishmania major 29% 100%
E9AFZ2 Leishmania major 35% 97%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AYN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AZF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 93%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 78%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
P45894 Caenorhabditis elegans 27% 86%
P51955 Homo sapiens 28% 100%
Q03428 Trypanosoma brucei brucei 35% 100%
Q08942 Trypanosoma brucei brucei 36% 100%
Q4Q1S3 Leishmania major 58% 100%
Q4Q1S4 Leishmania major 97% 100%
Q4Q3Y9 Leishmania major 35% 97%
Q4Q598 Leishmania major 29% 100%
Q4Q5T9 Leishmania major 34% 92%
Q4Q5W2 Leishmania major 34% 95%
Q4Q7W2 Leishmania major 32% 100%
Q4Q9K2 Leishmania major 32% 100%
Q4QBQ2 Leishmania major 42% 100%
Q4QBR6 Leishmania major 26% 100%
Q8RXT4 Arabidopsis thaliana 26% 92%
Q9CAU7 Arabidopsis thaliana 25% 84%
Q9GNR4 Leishmania major 29% 100%
Q9R0A5 Mus musculus 32% 100%
Q9Y077 Leishmania major 26% 100%
V5BC28 Trypanosoma cruzi 34% 100%
V5BPJ0 Trypanosoma cruzi 74% 100%
V5D579 Trypanosoma cruzi 36% 100%
V5DFW9 Trypanosoma cruzi 32% 87%
V5DKY9 Trypanosoma cruzi 34% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS