HSCB_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP11_LEIBR

TriTrypDb:

LbrM.35.1650 , LBRM2903_350022800

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.469
CLV_NRD_NRD_1	38	40	PF00675	0.609
CLV_NRD_NRD_1	75	77	PF00675	0.494
CLV_NRD_NRD_1	8	10	PF00675	0.621
CLV_PCSK_KEX2_1	127	129	PF00082	0.467
CLV_PCSK_KEX2_1	38	40	PF00082	0.586
CLV_PCSK_KEX2_1	64	66	PF00082	0.695
CLV_PCSK_KEX2_1	8	10	PF00082	0.626
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.467
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.763
CLV_PCSK_SKI1_1	157	161	PF00082	0.589
CLV_PCSK_SKI1_1	77	81	PF00082	0.656
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DOC_MAPK_gen_1	147	156	PF00069	0.532
DOC_MAPK_gen_1	15	24	PF00069	0.692
DOC_USP7_MATH_1	102	106	PF00917	0.438
DOC_USP7_MATH_1	40	44	PF00917	0.645
DOC_USP7_MATH_1	51	55	PF00917	0.519
DOC_WW_Pin1_4	70	75	PF00397	0.753
LIG_14-3-3_CanoR_1	147	152	PF00244	0.483
LIG_14-3-3_CanoR_1	27	31	PF00244	0.548
LIG_14-3-3_CanoR_1	39	48	PF00244	0.549
LIG_14-3-3_CanoR_1	76	85	PF00244	0.479
LIG_14-3-3_CanoR_1	8	14	PF00244	0.435
LIG_DCNL_PONY_1	1	4	PF03556	0.449
LIG_DLG_GKlike_1	147	154	PF00625	0.339
LIG_FHA_1	120	126	PF00498	0.466
LIG_FHA_2	163	169	PF00498	0.525
LIG_FHA_2	56	62	PF00498	0.658
LIG_FHA_2	67	73	PF00498	0.551
LIG_FHA_2	78	84	PF00498	0.610
LIG_IRF3_LxIS_1	2	7	PF10401	0.443
LIG_LIR_Gen_1	162	169	PF02991	0.347
LIG_LIR_Nem_3	162	166	PF02991	0.330
LIG_SH2_STAP1	152	156	PF00017	0.576
LIG_SH2_STAT5	110	113	PF00017	0.560
LIG_SH2_STAT5	36	39	PF00017	0.677
LIG_SUMO_SIM_par_1	58	63	PF11976	0.520
LIG_WRC_WIRS_1	89	94	PF05994	0.464
MOD_CDK_SPxK_1	70	76	PF00069	0.606
MOD_CDK_SPxxK_3	70	77	PF00069	0.751
MOD_CK1_1	105	111	PF00069	0.450
MOD_CK1_1	7	13	PF00069	0.434
MOD_CK2_1	147	153	PF00069	0.514
MOD_CK2_1	162	168	PF00069	0.498
MOD_CK2_1	66	72	PF00069	0.614
MOD_CK2_1	77	83	PF00069	0.613
MOD_CK2_1	88	94	PF00069	0.378
MOD_GlcNHglycan	53	56	PF01048	0.641
MOD_GlcNHglycan	9	12	PF01048	0.586
MOD_GSK3_1	102	109	PF00069	0.497
MOD_GSK3_1	51	58	PF00069	0.590
MOD_GSK3_1	66	73	PF00069	0.592
MOD_N-GLC_1	119	124	PF02516	0.335
MOD_NEK2_1	2	7	PF00069	0.614
MOD_NEK2_1	41	46	PF00069	0.556
MOD_NEK2_1	60	65	PF00069	0.450
MOD_NEK2_1	88	93	PF00069	0.454
MOD_PIKK_1	119	125	PF00454	0.446
MOD_PKA_2	26	32	PF00069	0.646
MOD_PKA_2	7	13	PF00069	0.651
MOD_Plk_1	55	61	PF00069	0.455
MOD_Plk_2-3	162	168	PF00069	0.520
MOD_Plk_4	106	112	PF00069	0.480
MOD_Plk_4	55	61	PF00069	0.455
MOD_ProDKin_1	70	76	PF00069	0.754
MOD_SUMO_for_1	159	162	PF00179	0.546
MOD_SUMO_rev_2	150	156	PF00179	0.421
MOD_SUMO_rev_2	97	105	PF00179	0.454
TRG_DiLeu_BaEn_1	94	99	PF01217	0.429
TRG_ER_diArg_1	14	17	PF00400	0.706
TRG_ER_diArg_1	37	39	PF00400	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJJ7	Leptomonas seymouri	53%	100%
A0A1X0P7Y0	Trypanosomatidae	38%	100%
A0A3Q8IQR8	Leishmania donovani	69%	99%
A4IDC0	Leishmania infantum	68%	99%
E9ASS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4Q1S5	Leishmania major	69%	100%
V5BPL2	Trypanosoma cruzi	41%	100%