VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP10_LEIBR

TriTrypDb:

LbrM.35.1640 , LBRM2903_350022700

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.541
CLV_C14_Caspase3-7	289	293	PF00656	0.610
CLV_C14_Caspase3-7	383	387	PF00656	0.558
CLV_C14_Caspase3-7	437	441	PF00656	0.438
CLV_C14_Caspase3-7	489	493	PF00656	0.541
CLV_NRD_NRD_1	274	276	PF00675	0.619
CLV_NRD_NRD_1	673	675	PF00675	0.444
CLV_NRD_NRD_1	730	732	PF00675	0.552
CLV_NRD_NRD_1	872	874	PF00675	0.520
CLV_PCSK_KEX2_1	117	119	PF00082	0.438
CLV_PCSK_KEX2_1	273	275	PF00082	0.626
CLV_PCSK_KEX2_1	673	675	PF00082	0.472
CLV_PCSK_KEX2_1	730	732	PF00082	0.526
CLV_PCSK_KEX2_1	868	870	PF00082	0.544
CLV_PCSK_KEX2_1	872	874	PF00082	0.489
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.438
CLV_PCSK_PC1ET2_1	868	870	PF00082	0.593
CLV_PCSK_SKI1_1	246	250	PF00082	0.516
CLV_PCSK_SKI1_1	318	322	PF00082	0.494
CLV_PCSK_SKI1_1	380	384	PF00082	0.504
CLV_PCSK_SKI1_1	411	415	PF00082	0.407
CLV_PCSK_SKI1_1	53	57	PF00082	0.449
CLV_PCSK_SKI1_1	531	535	PF00082	0.562
CLV_PCSK_SKI1_1	674	678	PF00082	0.601
CLV_PCSK_SKI1_1	680	684	PF00082	0.540
CLV_PCSK_SKI1_1	705	709	PF00082	0.497
CLV_PCSK_SKI1_1	802	806	PF00082	0.488
CLV_PCSK_SKI1_1	818	822	PF00082	0.669
CLV_PCSK_SKI1_1	85	89	PF00082	0.633
CLV_PCSK_SKI1_1	877	881	PF00082	0.435
CLV_PCSK_SKI1_1	908	912	PF00082	0.634
DEG_APCC_DBOX_1	84	92	PF00400	0.622
DEG_APCC_DBOX_1	872	880	PF00400	0.409
DEG_SPOP_SBC_1	849	853	PF00917	0.524
DOC_ANK_TNKS_1	273	280	PF00023	0.569
DOC_CYCLIN_RxL_1	408	417	PF00134	0.438
DOC_CYCLIN_RxL_1	526	538	PF00134	0.556
DOC_MAPK_FxFP_2	521	524	PF00069	0.449
DOC_MAPK_gen_1	82	91	PF00069	0.626
DOC_MAPK_RevD_3	658	674	PF00069	0.430
DOC_PP1_RVXF_1	206	213	PF00149	0.467
DOC_PP2B_LxvP_1	578	581	PF13499	0.698
DOC_PP4_FxxP_1	521	524	PF00568	0.449
DOC_PP4_FxxP_1	55	58	PF00568	0.472
DOC_USP7_MATH_1	155	159	PF00917	0.550
DOC_USP7_MATH_1	258	262	PF00917	0.682
DOC_USP7_MATH_1	291	295	PF00917	0.720
DOC_USP7_MATH_1	535	539	PF00917	0.543
DOC_USP7_MATH_1	548	552	PF00917	0.507
DOC_USP7_MATH_1	565	569	PF00917	0.755
DOC_USP7_MATH_1	581	585	PF00917	0.724
DOC_USP7_MATH_1	592	596	PF00917	0.626
DOC_USP7_MATH_1	652	656	PF00917	0.500
DOC_USP7_MATH_1	681	685	PF00917	0.691
DOC_USP7_MATH_1	70	74	PF00917	0.463
DOC_USP7_MATH_1	751	755	PF00917	0.805
DOC_USP7_MATH_1	849	853	PF00917	0.664
DOC_USP7_MATH_1	888	892	PF00917	0.455
DOC_USP7_UBL2_3	233	237	PF12436	0.489
DOC_USP7_UBL2_3	304	308	PF12436	0.508
DOC_USP7_UBL2_3	545	549	PF12436	0.397
DOC_USP7_UBL2_3	641	645	PF12436	0.481
DOC_USP7_UBL2_3	817	821	PF12436	0.656
DOC_USP7_UBL2_3	880	884	PF12436	0.552
DOC_WW_Pin1_4	11	16	PF00397	0.458
DOC_WW_Pin1_4	123	128	PF00397	0.355
DOC_WW_Pin1_4	480	485	PF00397	0.575
DOC_WW_Pin1_4	644	649	PF00397	0.592
DOC_WW_Pin1_4	742	747	PF00397	0.718
DOC_WW_Pin1_4	787	792	PF00397	0.691
DOC_WW_Pin1_4	850	855	PF00397	0.618
LIG_14-3-3_CanoR_1	118	128	PF00244	0.539
LIG_14-3-3_CanoR_1	494	503	PF00244	0.548
LIG_14-3-3_CanoR_1	519	524	PF00244	0.412
LIG_14-3-3_CanoR_1	673	679	PF00244	0.591
LIG_Actin_WH2_2	307	324	PF00022	0.492
LIG_Actin_WH2_2	457	475	PF00022	0.384
LIG_BRCT_BRCA1_1	550	554	PF00533	0.522
LIG_BRCT_BRCA1_1	654	658	PF00533	0.295
LIG_CaM_IQ_9	810	825	PF13499	0.606
LIG_FHA_1	151	157	PF00498	0.449
LIG_FHA_1	354	360	PF00498	0.456
LIG_FHA_1	413	419	PF00498	0.570
LIG_FHA_1	44	50	PF00498	0.396
LIG_FHA_1	481	487	PF00498	0.640
LIG_FHA_1	634	640	PF00498	0.487
LIG_FHA_1	663	669	PF00498	0.438
LIG_FHA_1	736	742	PF00498	0.492
LIG_FHA_1	792	798	PF00498	0.793
LIG_FHA_2	213	219	PF00498	0.504
LIG_FHA_2	332	338	PF00498	0.719
LIG_FHA_2	342	348	PF00498	0.609
LIG_FHA_2	381	387	PF00498	0.452
LIG_FHA_2	487	493	PF00498	0.489
LIG_GBD_Chelix_1	190	198	PF00786	0.396
LIG_IRF3_LxIS_1	163	170	PF10401	0.393
LIG_LIR_Apic_2	520	524	PF02991	0.450
LIG_LIR_Gen_1	165	172	PF02991	0.321
LIG_LIR_Gen_1	34	43	PF02991	0.316
LIG_LIR_Gen_1	360	369	PF02991	0.328
LIG_LIR_Gen_1	5	11	PF02991	0.400
LIG_LIR_Nem_3	139	145	PF02991	0.350
LIG_LIR_Nem_3	165	169	PF02991	0.308
LIG_LIR_Nem_3	34	38	PF02991	0.314
LIG_LIR_Nem_3	389	394	PF02991	0.350
LIG_LIR_Nem_3	5	9	PF02991	0.386
LIG_LIR_Nem_3	551	557	PF02991	0.439
LIG_PAM2_1	502	514	PF00658	0.392
LIG_PCNA_yPIPBox_3	593	603	PF02747	0.420
LIG_PTB_Apo_2	428	435	PF02174	0.455
LIG_PTB_Apo_2	463	470	PF02174	0.459
LIG_PTB_Phospho_1	463	469	PF10480	0.458
LIG_RPA_C_Fungi	107	119	PF08784	0.382
LIG_SH2_CRK	394	398	PF00017	0.486
LIG_SH2_CRK	399	403	PF00017	0.546
LIG_SH2_CRK	469	473	PF00017	0.351
LIG_SH2_SRC	723	726	PF00017	0.636
LIG_SH2_STAP1	725	729	PF00017	0.518
LIG_SH2_STAT5	128	131	PF00017	0.424
LIG_SH2_STAT5	394	397	PF00017	0.354
LIG_SH2_STAT5	463	466	PF00017	0.385
LIG_SH2_STAT5	474	477	PF00017	0.367
LIG_SH2_STAT5	659	662	PF00017	0.475
LIG_SH2_STAT5	723	726	PF00017	0.636
LIG_SH3_1	274	280	PF00018	0.482
LIG_SH3_3	274	280	PF00018	0.663
LIG_SH3_3	446	452	PF00018	0.567
LIG_SH3_3	627	633	PF00018	0.463
LIG_SH3_3	695	701	PF00018	0.695
LIG_SH3_3	738	744	PF00018	0.696
LIG_SH3_3	829	835	PF00018	0.483
LIG_SH3_3	900	906	PF00018	0.568
LIG_TRAF2_1	452	455	PF00917	0.446
LIG_TYR_ITIM	397	402	PF00017	0.306
LIG_WRC_WIRS_1	163	168	PF05994	0.333
LIG_WRC_WIRS_1	518	523	PF05994	0.283
LIG_WRC_WIRS_1	675	680	PF05994	0.511
LIG_WRC_WIRS_1	724	729	PF05994	0.645
MOD_CK1_1	150	156	PF00069	0.350
MOD_CK1_1	170	176	PF00069	0.322
MOD_CK1_1	189	195	PF00069	0.412
MOD_CK1_1	417	423	PF00069	0.593
MOD_CK1_1	459	465	PF00069	0.415
MOD_CK1_1	595	601	PF00069	0.642
MOD_CK1_1	62	68	PF00069	0.265
MOD_CK1_1	647	653	PF00069	0.622
MOD_CK1_1	745	751	PF00069	0.708
MOD_CK1_1	756	762	PF00069	0.609
MOD_CK1_1	768	774	PF00069	0.691
MOD_CK1_1	848	854	PF00069	0.747
MOD_CK2_1	23	29	PF00069	0.555
MOD_CK2_1	258	264	PF00069	0.607
MOD_CK2_1	291	297	PF00069	0.516
MOD_CK2_1	331	337	PF00069	0.696
MOD_CK2_1	341	347	PF00069	0.570
MOD_CK2_1	558	564	PF00069	0.516
MOD_CK2_1	605	611	PF00069	0.472
MOD_CK2_1	631	637	PF00069	0.537
MOD_CK2_1	681	687	PF00069	0.697
MOD_Cter_Amidation	870	873	PF01082	0.552
MOD_GlcNHglycan	119	122	PF01048	0.603
MOD_GlcNHglycan	131	134	PF01048	0.400
MOD_GlcNHglycan	157	160	PF01048	0.569
MOD_GlcNHglycan	251	254	PF01048	0.570
MOD_GlcNHglycan	339	342	PF01048	0.665
MOD_GlcNHglycan	458	461	PF01048	0.474
MOD_GlcNHglycan	498	501	PF01048	0.633
MOD_GlcNHglycan	506	509	PF01048	0.493
MOD_GlcNHglycan	537	540	PF01048	0.441
MOD_GlcNHglycan	550	553	PF01048	0.500
MOD_GlcNHglycan	560	563	PF01048	0.475
MOD_GlcNHglycan	567	570	PF01048	0.567
MOD_GlcNHglycan	589	592	PF01048	0.627
MOD_GlcNHglycan	61	64	PF01048	0.472
MOD_GlcNHglycan	614	617	PF01048	0.732
MOD_GlcNHglycan	618	621	PF01048	0.738
MOD_GlcNHglycan	713	716	PF01048	0.622
MOD_GlcNHglycan	752	756	PF01048	0.772
MOD_GlcNHglycan	76	80	PF01048	0.628
MOD_GlcNHglycan	765	768	PF01048	0.585
MOD_GlcNHglycan	770	773	PF01048	0.547
MOD_GlcNHglycan	802	805	PF01048	0.590
MOD_GlcNHglycan	847	850	PF01048	0.752
MOD_GlcNHglycan	855	858	PF01048	0.624
MOD_GlcNHglycan	890	893	PF01048	0.606
MOD_GSK3_1	119	126	PF00069	0.515
MOD_GSK3_1	310	317	PF00069	0.720
MOD_GSK3_1	337	344	PF00069	0.573
MOD_GSK3_1	349	356	PF00069	0.398
MOD_GSK3_1	413	420	PF00069	0.612
MOD_GSK3_1	486	493	PF00069	0.493
MOD_GSK3_1	494	501	PF00069	0.585
MOD_GSK3_1	581	588	PF00069	0.617
MOD_GSK3_1	607	614	PF00069	0.617
MOD_GSK3_1	616	623	PF00069	0.706
MOD_GSK3_1	676	683	PF00069	0.562
MOD_GSK3_1	688	695	PF00069	0.610
MOD_GSK3_1	699	706	PF00069	0.592
MOD_GSK3_1	756	763	PF00069	0.791
MOD_GSK3_1	781	788	PF00069	0.610
MOD_GSK3_1	845	852	PF00069	0.658
MOD_N-GLC_1	595	600	PF02516	0.585
MOD_N-GLC_1	604	609	PF02516	0.477
MOD_NEK2_1	119	124	PF00069	0.432
MOD_NEK2_1	147	152	PF00069	0.396
MOD_NEK2_1	212	217	PF00069	0.478
MOD_NEK2_1	249	254	PF00069	0.464
MOD_NEK2_1	281	286	PF00069	0.572
MOD_NEK2_1	310	315	PF00069	0.653
MOD_NEK2_1	325	330	PF00069	0.457
MOD_NEK2_1	348	353	PF00069	0.440
MOD_NEK2_1	354	359	PF00069	0.324
MOD_NEK2_1	413	418	PF00069	0.375
MOD_NEK2_1	434	439	PF00069	0.404
MOD_NEK2_1	486	491	PF00069	0.520
MOD_NEK2_1	496	501	PF00069	0.598
MOD_NEK2_1	693	698	PF00069	0.598
MOD_NEK2_1	703	708	PF00069	0.594
MOD_NEK2_1	765	770	PF00069	0.601
MOD_NEK2_1	785	790	PF00069	0.413
MOD_NEK2_2	48	53	PF00069	0.386
MOD_PIKK_1	302	308	PF00454	0.507
MOD_PIKK_1	70	76	PF00454	0.506
MOD_PK_1	326	332	PF00069	0.509
MOD_PKA_1	117	123	PF00069	0.439
MOD_PKA_1	837	843	PF00069	0.742
MOD_PKA_2	117	123	PF00069	0.604
MOD_PKA_2	337	343	PF00069	0.443
MOD_PKA_2	592	598	PF00069	0.660
MOD_PKB_1	110	118	PF00069	0.392
MOD_PKB_1	75	83	PF00069	0.497
MOD_Plk_1	326	332	PF00069	0.732
MOD_Plk_1	595	601	PF00069	0.582
MOD_Plk_1	826	832	PF00069	0.544
MOD_Plk_2-3	264	270	PF00069	0.512
MOD_Plk_4	162	168	PF00069	0.478
MOD_Plk_4	349	355	PF00069	0.521
MOD_Plk_4	424	430	PF00069	0.419
MOD_Plk_4	434	440	PF00069	0.373
MOD_Plk_4	486	492	PF00069	0.490
MOD_Plk_4	498	504	PF00069	0.579
MOD_Plk_4	598	604	PF00069	0.503
MOD_Plk_4	652	658	PF00069	0.477
MOD_Plk_4	659	665	PF00069	0.411
MOD_Plk_4	688	694	PF00069	0.629
MOD_ProDKin_1	11	17	PF00069	0.451
MOD_ProDKin_1	123	129	PF00069	0.346
MOD_ProDKin_1	480	486	PF00069	0.580
MOD_ProDKin_1	644	650	PF00069	0.590
MOD_ProDKin_1	742	748	PF00069	0.721
MOD_ProDKin_1	787	793	PF00069	0.692
MOD_ProDKin_1	850	856	PF00069	0.619
MOD_SUMO_for_1	529	532	PF00179	0.574
MOD_SUMO_rev_2	139	145	PF00179	0.350
MOD_SUMO_rev_2	454	459	PF00179	0.478
TRG_DiLeu_BaEn_1	345	350	PF01217	0.510
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.551
TRG_ENDOCYTIC_2	142	145	PF00928	0.330
TRG_ENDOCYTIC_2	394	397	PF00928	0.341
TRG_ENDOCYTIC_2	399	402	PF00928	0.424
TRG_ENDOCYTIC_2	469	472	PF00928	0.329
TRG_ER_diArg_1	109	112	PF00400	0.335
TRG_ER_diArg_1	272	275	PF00400	0.664
TRG_ER_diArg_1	672	674	PF00400	0.470
TRG_ER_diArg_1	729	731	PF00400	0.540
TRG_NLS_MonoExtN_4	818	825	PF00514	0.540
TRG_NLS_MonoExtN_4	865	871	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W5	Leptomonas seymouri	56%	94%
A0A1X0P867	Trypanosomatidae	38%	100%
A0A3S5H820	Leishmania donovani	69%	96%
A0A422NID2	Trypanosoma rangeli	37%	100%
A4IDB9	Leishmania infantum	69%	96%
D0A2Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ASS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q1S6	Leishmania major	71%	100%
V5BU47	Trypanosoma cruzi	39%	100%