Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP06_LEIBR

TriTrypDb:

LbrM.35.1600 , LBRM2903_350022200

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.635
CLV_C14_Caspase3-7	58	62	PF00656	0.601
CLV_NRD_NRD_1	179	181	PF00675	0.599
CLV_NRD_NRD_1	28	30	PF00675	0.801
CLV_NRD_NRD_1	301	303	PF00675	0.808
CLV_NRD_NRD_1	35	37	PF00675	0.699
CLV_NRD_NRD_1	467	469	PF00675	0.692
CLV_NRD_NRD_1	474	476	PF00675	0.616
CLV_NRD_NRD_1	50	52	PF00675	0.551
CLV_NRD_NRD_1	600	602	PF00675	0.583
CLV_NRD_NRD_1	618	620	PF00675	0.498
CLV_NRD_NRD_1	77	79	PF00675	0.701
CLV_PCSK_FUR_1	75	79	PF00082	0.708
CLV_PCSK_KEX2_1	179	181	PF00082	0.599
CLV_PCSK_KEX2_1	28	30	PF00082	0.799
CLV_PCSK_KEX2_1	301	303	PF00082	0.808
CLV_PCSK_KEX2_1	399	401	PF00082	0.824
CLV_PCSK_KEX2_1	467	469	PF00082	0.692
CLV_PCSK_KEX2_1	474	476	PF00082	0.616
CLV_PCSK_KEX2_1	50	52	PF00082	0.603
CLV_PCSK_KEX2_1	600	602	PF00082	0.587
CLV_PCSK_KEX2_1	617	619	PF00082	0.508
CLV_PCSK_KEX2_1	77	79	PF00082	0.701
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.596
CLV_PCSK_PC7_1	395	401	PF00082	0.732
CLV_PCSK_PC7_1	613	619	PF00082	0.659
CLV_PCSK_SKI1_1	301	305	PF00082	0.811
CLV_PCSK_SKI1_1	335	339	PF00082	0.689
CLV_PCSK_SKI1_1	517	521	PF00082	0.586
DEG_COP1_1	415	423	PF00400	0.581
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DEG_SCF_FBW7_1	314	319	PF00400	0.602
DEG_SCF_TRCP1_1	354	360	PF00400	0.616
DEG_SPOP_SBC_1	188	192	PF00917	0.676
DEG_SPOP_SBC_1	227	231	PF00917	0.801
DEG_SPOP_SBC_1	390	394	PF00917	0.766
DEG_SPOP_SBC_1	97	101	PF00917	0.542
DOC_ANK_TNKS_1	212	219	PF00023	0.565
DOC_CKS1_1	313	318	PF01111	0.600
DOC_CYCLIN_RxL_1	298	308	PF00134	0.814
DOC_MAPK_gen_1	600	609	PF00069	0.449
DOC_MAPK_MEF2A_6	600	609	PF00069	0.430
DOC_MAPK_RevD_3	605	618	PF00069	0.444
DOC_MAPK_RevD_3	63	78	PF00069	0.686
DOC_PP1_RVXF_1	34	41	PF00149	0.799
DOC_PP1_RVXF_1	611	617	PF00149	0.400
DOC_PP4_FxxP_1	40	43	PF00568	0.793
DOC_PP4_FxxP_1	5	8	PF00568	0.793
DOC_USP7_MATH_1	132	136	PF00917	0.606
DOC_USP7_MATH_1	149	153	PF00917	0.757
DOC_USP7_MATH_1	158	162	PF00917	0.653
DOC_USP7_MATH_1	188	192	PF00917	0.768
DOC_USP7_MATH_1	369	373	PF00917	0.681
DOC_USP7_MATH_1	390	394	PF00917	0.766
DOC_USP7_MATH_1	419	423	PF00917	0.539
DOC_USP7_MATH_1	542	546	PF00917	0.779
DOC_USP7_MATH_1	583	587	PF00917	0.544
DOC_USP7_UBL2_3	165	169	PF12436	0.590
DOC_WW_Pin1_4	112	117	PF00397	0.606
DOC_WW_Pin1_4	138	143	PF00397	0.794
DOC_WW_Pin1_4	254	259	PF00397	0.642
DOC_WW_Pin1_4	285	290	PF00397	0.604
DOC_WW_Pin1_4	312	317	PF00397	0.830
DOC_WW_Pin1_4	361	366	PF00397	0.835
DOC_WW_Pin1_4	367	372	PF00397	0.736
DOC_WW_Pin1_4	377	382	PF00397	0.577
DOC_WW_Pin1_4	440	445	PF00397	0.663
DOC_WW_Pin1_4	467	472	PF00397	0.759
LIG_14-3-3_CanoR_1	151	155	PF00244	0.646
LIG_14-3-3_CanoR_1	183	188	PF00244	0.832
LIG_14-3-3_CanoR_1	197	201	PF00244	0.637
LIG_14-3-3_CanoR_1	225	234	PF00244	0.718
LIG_14-3-3_CanoR_1	348	352	PF00244	0.724
LIG_14-3-3_CanoR_1	357	365	PF00244	0.625
LIG_14-3-3_CanoR_1	39	43	PF00244	0.581
LIG_14-3-3_CanoR_1	475	481	PF00244	0.623
LIG_14-3-3_CanoR_1	488	497	PF00244	0.519
LIG_14-3-3_CanoR_1	50	56	PF00244	0.559
LIG_14-3-3_CanoR_1	517	527	PF00244	0.582
LIG_14-3-3_CanoR_1	550	554	PF00244	0.671
LIG_BIR_III_2	61	65	PF00653	0.541
LIG_BRCT_BRCA1_1	230	234	PF00533	0.602
LIG_BRCT_BRCA1_1	30	34	PF00533	0.570
LIG_FHA_1	143	149	PF00498	0.636
LIG_FHA_1	30	36	PF00498	0.571
LIG_FHA_1	321	327	PF00498	0.617
LIG_FHA_1	338	344	PF00498	0.509
LIG_FHA_1	409	415	PF00498	0.675
LIG_FHA_1	549	555	PF00498	0.632
LIG_FHA_1	591	597	PF00498	0.453
LIG_FHA_1	97	103	PF00498	0.549
LIG_FHA_2	105	111	PF00498	0.605
LIG_FHA_2	304	310	PF00498	0.674
LIG_FHA_2	317	323	PF00498	0.765
LIG_FHA_2	325	331	PF00498	0.699
LIG_FHA_2	348	354	PF00498	0.610
LIG_FHA_2	399	405	PF00498	0.659
LIG_FHA_2	477	483	PF00498	0.789
LIG_Integrin_isoDGR_2	502	504	PF01839	0.604
LIG_LIR_Apic_2	310	316	PF02991	0.821
LIG_LIR_Gen_1	247	253	PF02991	0.588
LIG_LIR_Gen_1	526	535	PF02991	0.591
LIG_LIR_Gen_1	570	580	PF02991	0.622
LIG_LIR_Nem_3	247	251	PF02991	0.587
LIG_LIR_Nem_3	288	294	PF02991	0.761
LIG_LIR_Nem_3	425	429	PF02991	0.590
LIG_LIR_Nem_3	526	530	PF02991	0.583
LIG_LIR_Nem_3	557	563	PF02991	0.720
LIG_LIR_Nem_3	570	575	PF02991	0.639
LIG_LYPXL_S_1	559	563	PF13949	0.551
LIG_PDZ_Class_1	621	626	PF00595	0.772
LIG_Pex14_2	234	238	PF04695	0.590
LIG_Pex14_2	337	341	PF04695	0.601
LIG_Pex14_2	516	520	PF04695	0.588
LIG_SH2_GRB2like	201	204	PF00017	0.578
LIG_SH2_PTP2	313	316	PF00017	0.792
LIG_SH2_STAT5	313	316	PF00017	0.825
LIG_SH3_2	287	292	PF14604	0.606
LIG_SH3_3	111	117	PF00018	0.715
LIG_SH3_3	121	127	PF00018	0.649
LIG_SH3_3	255	261	PF00018	0.599
LIG_SH3_3	284	290	PF00018	0.603
LIG_SUMO_SIM_par_1	144	153	PF11976	0.601
LIG_SUMO_SIM_par_1	249	257	PF11976	0.593
LIG_SUMO_SIM_par_1	410	417	PF11976	0.584
LIG_SUMO_SIM_par_1	63	68	PF11976	0.747
LIG_SUMO_SIM_par_1	89	94	PF11976	0.587
LIG_TRAF2_1	350	353	PF00917	0.607
LIG_TRAF2_2	21	26	PF00917	0.769
LIG_WRC_WIRS_1	338	343	PF05994	0.599
LIG_WRC_WIRS_1	423	428	PF05994	0.587
LIG_WRC_WIRS_1	524	529	PF05994	0.682
LIG_WW_3	180	184	PF00397	0.603
MOD_CDC14_SPxK_1	380	383	PF00782	0.619
MOD_CDK_SPK_2	312	317	PF00069	0.602
MOD_CDK_SPK_2	377	382	PF00069	0.615
MOD_CDK_SPxK_1	377	383	PF00069	0.662
MOD_CDK_SPxxK_3	285	292	PF00069	0.608
MOD_CDK_SPxxK_3	467	474	PF00069	0.569
MOD_CK1_1	135	141	PF00069	0.564
MOD_CK1_1	191	197	PF00069	0.730
MOD_CK1_1	202	208	PF00069	0.744
MOD_CK1_1	228	234	PF00069	0.806
MOD_CK1_1	241	247	PF00069	0.589
MOD_CK1_1	256	262	PF00069	0.657
MOD_CK1_1	271	277	PF00069	0.582
MOD_CK1_1	305	311	PF00069	0.594
MOD_CK1_1	360	366	PF00069	0.825
MOD_CK1_1	391	397	PF00069	0.755
MOD_CK1_1	422	428	PF00069	0.719
MOD_CK1_1	430	436	PF00069	0.631
MOD_CK1_1	437	443	PF00069	0.663
MOD_CK1_1	456	462	PF00069	0.583
MOD_CK1_1	470	476	PF00069	0.584
MOD_CK1_1	491	497	PF00069	0.813
MOD_CK1_1	518	524	PF00069	0.772
MOD_CK1_1	526	532	PF00069	0.647
MOD_CK1_1	53	59	PF00069	0.585
MOD_CK1_1	546	552	PF00069	0.667
MOD_CK1_1	96	102	PF00069	0.713
MOD_CK2_1	104	110	PF00069	0.631
MOD_CK2_1	138	144	PF00069	0.592
MOD_CK2_1	187	193	PF00069	0.823
MOD_CK2_1	303	309	PF00069	0.590
MOD_CK2_1	324	330	PF00069	0.837
MOD_CK2_1	347	353	PF00069	0.760
MOD_CK2_1	360	366	PF00069	0.683
MOD_CK2_1	445	451	PF00069	0.603
MOD_CK2_1	476	482	PF00069	0.790
MOD_CK2_1	579	585	PF00069	0.741
MOD_GlcNHglycan	162	165	PF01048	0.646
MOD_GlcNHglycan	206	209	PF01048	0.780
MOD_GlcNHglycan	231	234	PF01048	0.685
MOD_GlcNHglycan	352	357	PF01048	0.699
MOD_GlcNHglycan	485	488	PF01048	0.763
MOD_GlcNHglycan	490	493	PF01048	0.788
MOD_GlcNHglycan	506	509	PF01048	0.566
MOD_GlcNHglycan	517	520	PF01048	0.572
MOD_GlcNHglycan	556	559	PF01048	0.688
MOD_GlcNHglycan	58	61	PF01048	0.775
MOD_GlcNHglycan	581	584	PF01048	0.544
MOD_GlcNHglycan	585	588	PF01048	0.698
MOD_GlcNHglycan	93	96	PF01048	0.725
MOD_GSK3_1	138	145	PF00069	0.744
MOD_GSK3_1	15	22	PF00069	0.820
MOD_GSK3_1	183	190	PF00069	0.849
MOD_GSK3_1	191	198	PF00069	0.692
MOD_GSK3_1	199	206	PF00069	0.575
MOD_GSK3_1	225	232	PF00069	0.793
MOD_GSK3_1	236	243	PF00069	0.646
MOD_GSK3_1	24	31	PF00069	0.675
MOD_GSK3_1	249	256	PF00069	0.668
MOD_GSK3_1	303	310	PF00069	0.762
MOD_GSK3_1	312	319	PF00069	0.736
MOD_GSK3_1	320	327	PF00069	0.616
MOD_GSK3_1	352	359	PF00069	0.797
MOD_GSK3_1	360	367	PF00069	0.748
MOD_GSK3_1	377	384	PF00069	0.674
MOD_GSK3_1	385	392	PF00069	0.631
MOD_GSK3_1	403	410	PF00069	0.547
MOD_GSK3_1	427	434	PF00069	0.626
MOD_GSK3_1	445	452	PF00069	0.697
MOD_GSK3_1	46	53	PF00069	0.591
MOD_GSK3_1	511	518	PF00069	0.637
MOD_GSK3_1	542	549	PF00069	0.749
MOD_GSK3_1	563	570	PF00069	0.571
MOD_GSK3_1	575	582	PF00069	0.579
MOD_GSK3_1	93	100	PF00069	0.540
MOD_N-GLC_1	112	117	PF02516	0.595
MOD_N-GLC_1	202	207	PF02516	0.578
MOD_NEK2_1	137	142	PF00069	0.639
MOD_NEK2_1	159	164	PF00069	0.586
MOD_NEK2_1	238	243	PF00069	0.588
MOD_NEK2_1	429	434	PF00069	0.602
MOD_NEK2_1	46	51	PF00069	0.588
MOD_NEK2_1	55	60	PF00069	0.545
MOD_NEK2_1	553	558	PF00069	0.768
MOD_NEK2_1	563	568	PF00069	0.674
MOD_NEK2_1	575	580	PF00069	0.578
MOD_NEK2_2	132	137	PF00069	0.557
MOD_PIKK_1	19	25	PF00454	0.789
MOD_PIKK_1	271	277	PF00454	0.645
MOD_PIKK_1	434	440	PF00454	0.617
MOD_PK_1	357	363	PF00069	0.617
MOD_PKA_1	28	34	PF00069	0.798
MOD_PKA_1	50	56	PF00069	0.598
MOD_PKA_1	600	606	PF00069	0.574
MOD_PKA_2	104	110	PF00069	0.604
MOD_PKA_2	150	156	PF00069	0.648
MOD_PKA_2	196	202	PF00069	0.658
MOD_PKA_2	24	30	PF00069	0.697
MOD_PKA_2	316	322	PF00069	0.741
MOD_PKA_2	324	330	PF00069	0.794
MOD_PKA_2	347	353	PF00069	0.723
MOD_PKA_2	356	362	PF00069	0.630
MOD_PKA_2	38	44	PF00069	0.629
MOD_PKA_2	430	436	PF00069	0.695
MOD_PKA_2	456	462	PF00069	0.591
MOD_PKA_2	50	56	PF00069	0.556
MOD_PKA_2	511	517	PF00069	0.777
MOD_PKA_2	549	555	PF00069	0.689
MOD_PKA_2	600	606	PF00069	0.525
MOD_PKB_1	504	512	PF00069	0.705
MOD_Plk_1	195	201	PF00069	0.609
MOD_Plk_1	308	314	PF00069	0.631
MOD_Plk_1	403	409	PF00069	0.586
MOD_Plk_1	449	455	PF00069	0.786
MOD_Plk_1	512	518	PF00069	0.820
MOD_Plk_2-3	398	404	PF00069	0.595
MOD_Plk_2-3	590	596	PF00069	0.670
MOD_Plk_4	132	138	PF00069	0.558
MOD_Plk_4	196	202	PF00069	0.616
MOD_Plk_4	309	315	PF00069	0.812
MOD_Plk_4	316	322	PF00069	0.704
MOD_Plk_4	369	375	PF00069	0.806
MOD_Plk_4	549	555	PF00069	0.773
MOD_ProDKin_1	112	118	PF00069	0.606
MOD_ProDKin_1	138	144	PF00069	0.796
MOD_ProDKin_1	254	260	PF00069	0.644
MOD_ProDKin_1	285	291	PF00069	0.607
MOD_ProDKin_1	312	318	PF00069	0.828
MOD_ProDKin_1	361	367	PF00069	0.834
MOD_ProDKin_1	377	383	PF00069	0.578
MOD_ProDKin_1	440	446	PF00069	0.658
MOD_ProDKin_1	467	473	PF00069	0.759
MOD_SUMO_for_1	605	608	PF00179	0.656
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.607
TRG_ENDOCYTIC_2	291	294	PF00928	0.803
TRG_ENDOCYTIC_2	560	563	PF00928	0.724
TRG_ENDOCYTIC_2	572	575	PF00928	0.656
TRG_ER_diArg_1	179	181	PF00400	0.599
TRG_ER_diArg_1	301	303	PF00400	0.808
TRG_ER_diArg_1	466	468	PF00400	0.608
TRG_ER_diArg_1	50	52	PF00400	0.603
TRG_ER_diArg_1	569	572	PF00400	0.567
TRG_ER_diArg_1	600	602	PF00400	0.614
TRG_ER_diArg_1	616	619	PF00400	0.493
TRG_ER_diArg_1	74	77	PF00400	0.710
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IK06	Leishmania donovani	49%	96%
A4HP26	Leishmania braziliensis	97%	100%
A4IDB5	Leishmania infantum	48%	96%
E9ASR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	96%
Q4Q1T0	Leishmania major	50%	100%