Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HP05_LEIBR

TriTrypDb:

LbrM.35.1590 , LBRM2903_350022100

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP05

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	56	58	PF00675	0.546
CLV_PCSK_SKI1_1	141	145	PF00082	0.369
CLV_PCSK_SKI1_1	49	53	PF00082	0.404
CLV_PCSK_SKI1_1	87	91	PF00082	0.410
DEG_SPOP_SBC_1	104	108	PF00917	0.472
DOC_USP7_MATH_1	102	106	PF00917	0.614
DOC_USP7_MATH_1	3	7	PF00917	0.686
DOC_WW_Pin1_4	63	68	PF00397	0.417
LIG_14-3-3_CanoR_1	87	92	PF00244	0.413
LIG_14-3-3_CanoR_1	95	101	PF00244	0.402
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BIR_III_4	130	134	PF00653	0.509
LIG_BRCT_BRCA1_1	65	69	PF00533	0.558
LIG_FHA_1	105	111	PF00498	0.707
LIG_FHA_1	148	154	PF00498	0.460
LIG_FHA_1	63	69	PF00498	0.572
LIG_FHA_2	68	74	PF00498	0.480
LIG_LIR_Gen_1	75	85	PF02991	0.402
LIG_LIR_Nem_3	138	143	PF02991	0.382
LIG_LIR_Nem_3	31	36	PF02991	0.417
LIG_LIR_Nem_3	75	81	PF02991	0.381
LIG_NRBOX	143	149	PF00104	0.521
LIG_SH2_STAT5	23	26	PF00017	0.438
LIG_SH3_1	42	48	PF00018	0.413
LIG_SH3_3	42	48	PF00018	0.413
LIG_SUMO_SIM_par_1	79	84	PF11976	0.374
LIG_TRAF2_1	119	122	PF00917	0.515
MOD_CK1_1	105	111	PF00069	0.654
MOD_CK2_1	73	79	PF00069	0.495
MOD_GlcNHglycan	1	4	PF01048	0.678
MOD_GlcNHglycan	112	115	PF01048	0.605
MOD_GSK3_1	100	107	PF00069	0.546
MOD_GSK3_1	143	150	PF00069	0.497
MOD_GSK3_1	63	70	PF00069	0.516
MOD_N-GLC_2	96	98	PF02516	0.390
MOD_NEK2_1	147	152	PF00069	0.543
MOD_NEK2_1	94	99	PF00069	0.399
MOD_PIKK_1	17	23	PF00454	0.549
MOD_PIKK_1	89	95	PF00454	0.310
MOD_PKA_2	94	100	PF00069	0.417
MOD_Plk_2-3	73	79	PF00069	0.409
MOD_Plk_4	143	149	PF00069	0.476
MOD_Plk_4	73	79	PF00069	0.386
MOD_ProDKin_1	63	69	PF00069	0.407
MOD_SUMO_rev_2	55	65	PF00179	0.537
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX85	Leptomonas seymouri	69%	93%
A0A0S4JG18	Bodo saltans	50%	100%
A0A1X0P8S8	Trypanosomatidae	53%	97%
A0A3Q8IKE9	Leishmania donovani	83%	100%
A0A422NI72	Trypanosoma rangeli	56%	100%
A4IDB4	Leishmania infantum	83%	100%
D0A2Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ASR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q1T1	Leishmania major	82%	100%
Q9D581	Mus musculus	26%	100%
V5BJX8	Trypanosoma cruzi	54%	100%