Putative translation elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation elongation factor 1-beta, putative

Species:

Leishmania braziliensis

UniProt:

A4HP03_LEIBR

TriTrypDb:

LbrM.35.1570 , LBRM2903_350021800

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 22

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005853	eukaryotic translation elongation factor 1 complex	2	21
GO:0032991	protein-containing complex	1	21
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HP03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP03

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0003746	translation elongation factor activity	4	21
GO:0005488	binding	1	21
GO:0008135	translation factor activity, RNA binding	3	21
GO:0045182	translation regulator activity	1	21
GO:0090079	translation regulator activity, nucleic acid binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21
GO:0005085	guanyl-nucleotide exchange factor activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	106	110	PF00082	0.667
DOC_MAPK_gen_1	169	177	PF00069	0.328
DOC_USP7_MATH_1	122	126	PF00917	0.543
DOC_USP7_MATH_1	15	19	PF00917	0.573
DOC_USP7_UBL2_3	109	113	PF12436	0.627
DOC_USP7_UBL2_3	114	118	PF12436	0.574
DOC_WW_Pin1_4	18	23	PF00397	0.617
LIG_14-3-3_CanoR_1	10	15	PF00244	0.493
LIG_14-3-3_CanoR_1	46	51	PF00244	0.617
LIG_APCC_ABBA_1	89	94	PF00400	0.603
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	12	16	PF00533	0.502
LIG_BRCT_BRCA1_1	124	128	PF00533	0.340
LIG_Clathr_ClatBox_1	174	178	PF01394	0.328
LIG_FHA_2	1	7	PF00498	0.579
LIG_FHA_2	114	120	PF00498	0.462
LIG_FHA_2	93	99	PF00498	0.617
LIG_Integrin_isoDGR_2	8	10	PF01839	0.490
LIG_PCNA_yPIPBox_3	37	46	PF02747	0.552
LIG_Pex14_2	16	20	PF04695	0.651
LIG_Pex14_2	30	34	PF04695	0.490
LIG_SH3_3	70	76	PF00018	0.690
LIG_SUMO_SIM_par_1	173	180	PF11976	0.328
LIG_TRAF2_1	95	98	PF00917	0.594
LIG_UBA3_1	126	131	PF00899	0.434
LIG_UBA3_1	174	181	PF00899	0.324
LIG_WRC_WIRS_1	191	196	PF05994	0.214
MOD_CK1_1	18	24	PF00069	0.628
MOD_CK1_1	60	66	PF00069	0.615
MOD_CK2_1	58	64	PF00069	0.623
MOD_CK2_1	92	98	PF00069	0.643
MOD_GlcNHglycan	17	20	PF01048	0.632
MOD_GlcNHglycan	182	185	PF01048	0.358
MOD_GlcNHglycan	60	63	PF01048	0.669
MOD_NEK2_1	33	38	PF00069	0.531
MOD_NEK2_1	58	63	PF00069	0.495
MOD_PIKK_1	10	16	PF00454	0.508
MOD_PKA_1	113	119	PF00069	0.524
MOD_Plk_2-3	197	203	PF00069	0.346
MOD_Plk_4	122	128	PF00069	0.338
MOD_Plk_4	46	52	PF00069	0.635
MOD_ProDKin_1	18	24	PF00069	0.616
MOD_SUMO_rev_2	110	116	PF00179	0.533
MOD_SUMO_rev_2	124	132	PF00179	0.307
MOD_SUMO_rev_2	152	162	PF00179	0.328
MOD_SUMO_rev_2	178	183	PF00179	0.330
MOD_SUMO_rev_2	98	108	PF00179	0.670
TRG_DiLeu_BaEn_4	98	104	PF01217	0.636
TRG_NLS_MonoExtC_3	113	118	PF00514	0.619
TRG_NLS_MonoExtN_4	113	118	PF00514	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W7	Leptomonas seymouri	87%	100%
A0A0N1HZF7	Leptomonas seymouri	60%	88%
A0A0S4JC29	Bodo saltans	69%	100%
A0A0S4JK70	Bodo saltans	54%	85%
A0A1X0P9D3	Trypanosomatidae	75%	100%
A0A1X0PA37	Trypanosomatidae	59%	91%
A0A3Q8IVV7	Leishmania donovani	86%	99%
A0A3R7MFZ8	Trypanosoma rangeli	69%	100%
A0A3S5H7W1	Leishmania donovani	61%	87%
A0A422N8N9	Trypanosoma rangeli	61%	92%
A4HAJ1	Leishmania braziliensis	66%	100%
A4HAJ3	Leishmania braziliensis	63%	100%
A4HAJ7	Leishmania braziliensis	63%	100%
A4I9P1	Leishmania infantum	61%	87%
A4IDB2	Leishmania infantum	86%	99%
D0A2X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9ASR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B4Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	86%
O70251	Mus musculus	41%	93%
O74173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	98%
O81918	Beta vulgaris	37%	90%
O96827	Drosophila melanogaster	44%	94%
P12262	Artemia salina	38%	100%
P24534	Homo sapiens	40%	93%
P29522	Bombyx mori	43%	94%
P29692	Homo sapiens	49%	74%
P30151	Xenopus laevis	41%	92%
P32192	Artemia salina	54%	88%
P34460	Caenorhabditis elegans	40%	98%
P34826	Oryctolagus cuniculus	39%	93%
P34827	Trypanosoma cruzi	61%	94%
P48006	Arabidopsis thaliana	39%	90%
P57776	Mus musculus	43%	74%
P78590	Candida albicans (strain WO-1)	31%	98%
P93447	Spuriopimpinella brachycarpa	39%	92%
Q40680	Oryza sativa subsp. japonica	35%	91%
Q40682	Oryza sativa subsp. japonica	36%	92%
Q4Q3C1	Leishmania major	64%	100%
Q4R3D4	Macaca fascicularis	49%	74%
Q5E983	Bos taurus	38%	93%
Q66NE2	Leishmania major	89%	100%
Q68FR9	Rattus norvegicus	43%	74%
Q69BZ7	Penicillium citrinum	33%	92%
Q6DET9	Xenopus tropicalis	39%	92%
Q84WM9	Arabidopsis thaliana	36%	92%
Q9GRF8	Dictyostelium discoideum	41%	97%
Q9SI20	Arabidopsis thaliana	39%	90%
Q9YGQ1	Gallus gallus	40%	93%