Calpain-15

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calpain-15

Gene product:

Zn-finger in Ran binding protein and others, putative

Species:

Leishmania braziliensis

UniProt:

A4HP02_LEIBR

TriTrypDb:

LbrM.35.1560 , LBRM2903_350021700

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HP02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP02

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.458
CLV_C14_Caspase3-7	266	270	PF00656	0.460
CLV_NRD_NRD_1	119	121	PF00675	0.512
CLV_NRD_NRD_1	122	124	PF00675	0.487
CLV_NRD_NRD_1	175	177	PF00675	0.605
CLV_NRD_NRD_1	257	259	PF00675	0.580
CLV_NRD_NRD_1	407	409	PF00675	0.459
CLV_NRD_NRD_1	468	470	PF00675	0.305
CLV_NRD_NRD_1	542	544	PF00675	0.418
CLV_NRD_NRD_1	555	557	PF00675	0.459
CLV_NRD_NRD_1	89	91	PF00675	0.350
CLV_PCSK_FUR_1	466	470	PF00082	0.307
CLV_PCSK_KEX2_1	175	177	PF00082	0.614
CLV_PCSK_KEX2_1	257	259	PF00082	0.639
CLV_PCSK_KEX2_1	407	409	PF00082	0.444
CLV_PCSK_KEX2_1	468	470	PF00082	0.305
CLV_PCSK_KEX2_1	9	11	PF00082	0.524
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.497
CLV_PCSK_SKI1_1	10	14	PF00082	0.596
CLV_PCSK_SKI1_1	2	6	PF00082	0.648
CLV_PCSK_SKI1_1	231	235	PF00082	0.579
CLV_PCSK_SKI1_1	557	561	PF00082	0.483
CLV_Separin_Metazoa	172	176	PF03568	0.606
DEG_APCC_DBOX_1	1	9	PF00400	0.587
DEG_Nend_UBRbox_1	1	4	PF02207	0.491
DEG_SCF_FBW7_1	13	20	PF00400	0.441
DOC_CKS1_1	14	19	PF01111	0.535
DOC_CYCLIN_RxL_1	7	16	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.506
DOC_PP2B_LxvP_1	233	236	PF13499	0.636
DOC_PP4_FxxP_1	203	206	PF00568	0.656
DOC_USP7_MATH_1	219	223	PF00917	0.627
DOC_USP7_MATH_1	417	421	PF00917	0.232
DOC_USP7_MATH_1	78	82	PF00917	0.398
DOC_USP7_UBL2_3	525	529	PF12436	0.308
DOC_WW_Pin1_4	13	18	PF00397	0.693
DOC_WW_Pin1_4	20	25	PF00397	0.678
DOC_WW_Pin1_4	249	254	PF00397	0.722
DOC_WW_Pin1_4	305	310	PF00397	0.490
DOC_WW_Pin1_4	413	418	PF00397	0.350
LIG_14-3-3_CanoR_1	2	12	PF00244	0.516
LIG_14-3-3_CanoR_1	285	294	PF00244	0.515
LIG_14-3-3_CanoR_1	476	484	PF00244	0.603
LIG_14-3-3_CanoR_1	54	60	PF00244	0.613
LIG_14-3-3_CanoR_1	64	68	PF00244	0.564
LIG_BRCT_BRCA1_1	131	135	PF00533	0.381
LIG_BRCT_BRCA1_1	325	329	PF00533	0.406
LIG_BRCT_BRCA1_1	35	39	PF00533	0.561
LIG_BRCT_BRCA1_1	527	531	PF00533	0.293
LIG_FHA_1	202	208	PF00498	0.534
LIG_FHA_1	345	351	PF00498	0.541
LIG_FHA_1	441	447	PF00498	0.696
LIG_FHA_1	58	64	PF00498	0.575
LIG_FHA_2	264	270	PF00498	0.588
LIG_FHA_2	306	312	PF00498	0.454
LIG_FHA_2	367	373	PF00498	0.648
LIG_FHA_2	465	471	PF00498	0.514
LIG_FHA_2	515	521	PF00498	0.323
LIG_FHA_2	87	93	PF00498	0.210
LIG_HOMEOBOX	280	283	PF00046	0.405
LIG_LIR_Apic_2	200	206	PF02991	0.651
LIG_LIR_Apic_2	311	315	PF02991	0.425
LIG_LIR_Gen_1	189	199	PF02991	0.484
LIG_LIR_Gen_1	53	63	PF02991	0.429
LIG_LIR_Nem_3	113	119	PF02991	0.418
LIG_LIR_Nem_3	189	194	PF02991	0.462
LIG_LIR_Nem_3	348	354	PF02991	0.318
LIG_LIR_Nem_3	53	59	PF02991	0.520
LIG_MLH1_MIPbox_1	36	40	PF16413	0.427
LIG_NRBOX	58	64	PF00104	0.427
LIG_PCNA_yPIPBox_3	257	268	PF02747	0.460
LIG_PDZ_Class_2	556	561	PF00595	0.535
LIG_Pex14_1	455	459	PF04695	0.523
LIG_SH2_CRK	116	120	PF00017	0.402
LIG_SH2_CRK	191	195	PF00017	0.488
LIG_SH2_CRK	351	355	PF00017	0.388
LIG_SH2_CRK	56	60	PF00017	0.587
LIG_SH2_NCK_1	161	165	PF00017	0.351
LIG_SH2_NCK_1	191	195	PF00017	0.589
LIG_SH2_STAP1	527	531	PF00017	0.417
LIG_SH2_STAT3	384	387	PF00017	0.637
LIG_SH2_STAT5	384	387	PF00017	0.763
LIG_SH2_STAT5	396	399	PF00017	0.289
LIG_SH2_STAT5	459	462	PF00017	0.525
LIG_SH2_STAT5	56	59	PF00017	0.629
LIG_SH3_2	21	26	PF14604	0.476
LIG_SH3_3	18	24	PF00018	0.661
LIG_SH3_3	237	243	PF00018	0.488
LIG_SH3_3	271	277	PF00018	0.577
LIG_SH3_3	416	422	PF00018	0.423
LIG_SH3_CIN85_PxpxPR_1	363	368	PF14604	0.470
LIG_SxIP_EBH_1	327	341	PF03271	0.278
LIG_TYR_ITIM	114	119	PF00017	0.376
MOD_CDC14_SPxK_1	23	26	PF00782	0.458
MOD_CDK_SPK_2	413	418	PF00069	0.350
MOD_CDK_SPxK_1	20	26	PF00069	0.475
MOD_CK1_1	129	135	PF00069	0.472
MOD_CK1_1	20	26	PF00069	0.567
MOD_CK1_1	3	9	PF00069	0.646
MOD_CK1_1	33	39	PF00069	0.621
MOD_CK1_1	398	404	PF00069	0.328
MOD_CK1_1	406	412	PF00069	0.308
MOD_CK1_1	514	520	PF00069	0.557
MOD_CK1_1	66	72	PF00069	0.561
MOD_CK2_1	164	170	PF00069	0.450
MOD_CK2_1	219	225	PF00069	0.467
MOD_CK2_1	305	311	PF00069	0.473
MOD_CK2_1	366	372	PF00069	0.654
MOD_CK2_1	530	536	PF00069	0.377
MOD_CK2_1	86	92	PF00069	0.209
MOD_DYRK1A_RPxSP_1	418	422	PF00069	0.193
MOD_GlcNHglycan	221	224	PF01048	0.680
MOD_GlcNHglycan	430	433	PF01048	0.699
MOD_GlcNHglycan	500	504	PF01048	0.690
MOD_GlcNHglycan	505	508	PF01048	0.616
MOD_GlcNHglycan	517	520	PF01048	0.203
MOD_GlcNHglycan	547	550	PF01048	0.670
MOD_GSK3_1	13	20	PF00069	0.624
MOD_GSK3_1	213	220	PF00069	0.615
MOD_GSK3_1	30	37	PF00069	0.678
MOD_GSK3_1	395	402	PF00069	0.484
MOD_GSK3_1	413	420	PF00069	0.223
MOD_GSK3_1	424	431	PF00069	0.502
MOD_GSK3_1	460	467	PF00069	0.404
MOD_GSK3_1	499	506	PF00069	0.677
MOD_GSK3_1	50	57	PF00069	0.588
MOD_GSK3_1	511	518	PF00069	0.443
MOD_N-GLC_1	285	290	PF02516	0.585
MOD_N-GLC_1	403	408	PF02516	0.389
MOD_N-GLC_1	50	55	PF02516	0.712
MOD_NEK2_1	217	222	PF00069	0.559
MOD_NEK2_1	30	35	PF00069	0.683
MOD_NEK2_1	323	328	PF00069	0.380
MOD_NEK2_1	403	408	PF00069	0.435
MOD_NEK2_1	412	417	PF00069	0.446
MOD_NEK2_1	430	435	PF00069	0.624
MOD_NEK2_1	438	443	PF00069	0.552
MOD_NEK2_1	49	54	PF00069	0.593
MOD_NEK2_1	545	550	PF00069	0.464
MOD_NEK2_1	63	68	PF00069	0.478
MOD_NEK2_2	346	351	PF00069	0.361
MOD_NEK2_2	78	83	PF00069	0.350
MOD_OFUCOSY	284	289	PF10250	0.434
MOD_OFUCOSY	77	82	PF10250	0.350
MOD_PKA_2	217	223	PF00069	0.578
MOD_PKA_2	284	290	PF00069	0.550
MOD_PKA_2	406	412	PF00069	0.337
MOD_PKA_2	417	423	PF00069	0.327
MOD_PKA_2	475	481	PF00069	0.483
MOD_PKA_2	515	521	PF00069	0.205
MOD_PKA_2	63	69	PF00069	0.655
MOD_Plk_1	296	302	PF00069	0.500
MOD_Plk_2-3	192	198	PF00069	0.623
MOD_Plk_2-3	366	372	PF00069	0.596
MOD_Plk_4	263	269	PF00069	0.696
MOD_Plk_4	346	352	PF00069	0.426
MOD_ProDKin_1	13	19	PF00069	0.693
MOD_ProDKin_1	20	26	PF00069	0.683
MOD_ProDKin_1	249	255	PF00069	0.721
MOD_ProDKin_1	305	311	PF00069	0.488
MOD_ProDKin_1	413	419	PF00069	0.350
TRG_DiLeu_BaEn_1	99	104	PF01217	0.350
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.453
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.481
TRG_ENDOCYTIC_2	116	119	PF00928	0.398
TRG_ENDOCYTIC_2	191	194	PF00928	0.482
TRG_ENDOCYTIC_2	351	354	PF00928	0.342
TRG_ENDOCYTIC_2	56	59	PF00928	0.653
TRG_ER_diArg_1	174	176	PF00400	0.609
TRG_ER_diArg_1	332	335	PF00400	0.292
TRG_ER_diArg_1	465	468	PF00400	0.364
TRG_ER_diArg_1	531	534	PF00400	0.471
TRG_NLS_MonoExtC_3	119	124	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U7	Leptomonas seymouri	54%	98%
A0A0S4JG42	Bodo saltans	39%	100%
A0A1X0P892	Trypanosomatidae	44%	100%
A0A3R7KC50	Trypanosoma rangeli	45%	100%
A0A3S7XAK2	Leishmania donovani	75%	100%
A4ICJ4	Leishmania infantum	75%	100%
D0A2X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ASR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q1T4	Leishmania major	76%	100%
V5BJY2	Trypanosoma cruzi	44%	100%