RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted RanGDP binding protein

Species:

Leishmania braziliensis

UniProt:

A4HP01_LEIBR

TriTrypDb:

LbrM.35.1550 , LBRM2903_350021600

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HP01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP01

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.665
CLV_C14_Caspase3-7	665	669	PF00656	0.547
CLV_NRD_NRD_1	194	196	PF00675	0.588
CLV_NRD_NRD_1	31	33	PF00675	0.611
CLV_NRD_NRD_1	504	506	PF00675	0.452
CLV_NRD_NRD_1	576	578	PF00675	0.534
CLV_NRD_NRD_1	591	593	PF00675	0.358
CLV_NRD_NRD_1	795	797	PF00675	0.421
CLV_PCSK_FUR_1	29	33	PF00082	0.443
CLV_PCSK_KEX2_1	194	196	PF00082	0.588
CLV_PCSK_KEX2_1	29	31	PF00082	0.608
CLV_PCSK_KEX2_1	504	506	PF00082	0.452
CLV_PCSK_KEX2_1	591	593	PF00082	0.463
CLV_PCSK_KEX2_1	794	796	PF00082	0.386
CLV_PCSK_SKI1_1	238	242	PF00082	0.622
CLV_PCSK_SKI1_1	313	317	PF00082	0.594
CLV_PCSK_SKI1_1	484	488	PF00082	0.524
CLV_PCSK_SKI1_1	505	509	PF00082	0.593
CLV_PCSK_SKI1_1	577	581	PF00082	0.530
CLV_PCSK_SKI1_1	762	766	PF00082	0.377
DEG_APCC_DBOX_1	692	700	PF00400	0.466
DEG_APCC_DBOX_1	793	801	PF00400	0.512
DEG_Nend_UBRbox_3	1	3	PF02207	0.551
DEG_SCF_FBW7_1	404	410	PF00400	0.659
DEG_SCF_FBW7_1	738	745	PF00400	0.422
DEG_SPOP_SBC_1	542	546	PF00917	0.449
DEG_SPOP_SBC_1	662	666	PF00917	0.541
DOC_CKS1_1	1	6	PF01111	0.456
DOC_CKS1_1	404	409	PF01111	0.661
DOC_CYCLIN_RxL_1	574	583	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	842	848	PF00134	0.469
DOC_MAPK_gen_1	29	38	PF00069	0.685
DOC_MAPK_gen_1	808	817	PF00069	0.491
DOC_PP1_RVXF_1	202	209	PF00149	0.489
DOC_PP1_RVXF_1	323	330	PF00149	0.544
DOC_PP1_RVXF_1	503	510	PF00149	0.521
DOC_PP1_RVXF_1	695	702	PF00149	0.460
DOC_PP2B_LxvP_1	166	169	PF13499	0.459
DOC_USP7_MATH_1	21	25	PF00917	0.468
DOC_USP7_MATH_1	266	270	PF00917	0.618
DOC_USP7_MATH_1	454	458	PF00917	0.722
DOC_USP7_MATH_1	469	473	PF00917	0.602
DOC_USP7_MATH_1	564	568	PF00917	0.472
DOC_USP7_MATH_1	662	666	PF00917	0.644
DOC_USP7_UBL2_3	433	437	PF12436	0.526
DOC_WW_Pin1_4	393	398	PF00397	0.635
DOC_WW_Pin1_4	403	408	PF00397	0.625
DOC_WW_Pin1_4	465	470	PF00397	0.722
DOC_WW_Pin1_4	471	476	PF00397	0.683
DOC_WW_Pin1_4	55	60	PF00397	0.702
DOC_WW_Pin1_4	658	663	PF00397	0.647
DOC_WW_Pin1_4	738	743	PF00397	0.542
DOC_WW_Pin1_4	810	815	PF00397	0.439
DOC_WW_Pin1_4	837	842	PF00397	0.535
LIG_14-3-3_CanoR_1	15	19	PF00244	0.655
LIG_14-3-3_CanoR_1	214	220	PF00244	0.423
LIG_14-3-3_CanoR_1	29	38	PF00244	0.603
LIG_14-3-3_CanoR_1	313	322	PF00244	0.573
LIG_14-3-3_CanoR_1	325	330	PF00244	0.589
LIG_14-3-3_CanoR_1	504	510	PF00244	0.536
LIG_14-3-3_CanoR_1	523	531	PF00244	0.627
LIG_14-3-3_CanoR_1	532	538	PF00244	0.539
LIG_14-3-3_CanoR_1	651	657	PF00244	0.596
LIG_14-3-3_CanoR_1	762	770	PF00244	0.350
LIG_14-3-3_CanoR_1	772	780	PF00244	0.277
LIG_BIR_III_2	852	856	PF00653	0.534
LIG_BIR_III_4	704	708	PF00653	0.389
LIG_BRCT_BRCA1_1	106	110	PF00533	0.468
LIG_BRCT_BRCA1_1	47	51	PF00533	0.545
LIG_BRCT_BRCA1_1	533	537	PF00533	0.411
LIG_deltaCOP1_diTrp_1	370	376	PF00928	0.357
LIG_eIF4E_1	823	829	PF01652	0.251
LIG_FHA_1	250	256	PF00498	0.549
LIG_FHA_1	31	37	PF00498	0.499
LIG_FHA_1	496	502	PF00498	0.528
LIG_FHA_1	537	543	PF00498	0.440
LIG_FHA_1	638	644	PF00498	0.310
LIG_FHA_1	77	83	PF00498	0.640
LIG_FHA_1	774	780	PF00498	0.274
LIG_FHA_2	365	371	PF00498	0.350
LIG_FHA_2	506	512	PF00498	0.579
LIG_FHA_2	627	633	PF00498	0.523
LIG_FHA_2	653	659	PF00498	0.573
LIG_FHA_2	811	817	PF00498	0.386
LIG_LIR_Apic_2	568	574	PF02991	0.424
LIG_LIR_Gen_1	188	197	PF02991	0.540
LIG_LIR_Gen_1	215	224	PF02991	0.501
LIG_LIR_Gen_1	370	378	PF02991	0.397
LIG_LIR_Gen_1	508	516	PF02991	0.543
LIG_LIR_Nem_3	188	193	PF02991	0.580
LIG_LIR_Nem_3	215	219	PF02991	0.416
LIG_LIR_Nem_3	239	244	PF02991	0.605
LIG_LIR_Nem_3	370	374	PF02991	0.425
LIG_LIR_Nem_3	491	497	PF02991	0.602
LIG_LIR_Nem_3	508	512	PF02991	0.391
LIG_NRBOX	64	70	PF00104	0.435
LIG_PDZ_Class_2	860	865	PF00595	0.633
LIG_Pex14_1	571	575	PF04695	0.415
LIG_PTB_Apo_2	337	344	PF02174	0.552
LIG_Rb_LxCxE_1	611	634	PF01857	0.480
LIG_SH2_CRK	216	220	PF00017	0.442
LIG_SH2_NCK_1	86	90	PF00017	0.482
LIG_SH2_SRC	8	11	PF00017	0.600
LIG_SH2_STAP1	497	501	PF00017	0.311
LIG_SH2_STAP1	8	12	PF00017	0.461
LIG_SH2_STAP1	86	90	PF00017	0.482
LIG_SH2_STAT5	497	500	PF00017	0.310
LIG_SH2_STAT5	575	578	PF00017	0.446
LIG_SH2_STAT5	823	826	PF00017	0.555
LIG_SH3_3	145	151	PF00018	0.673
LIG_SH3_3	360	366	PF00018	0.413
LIG_SH3_3	442	448	PF00018	0.565
LIG_SUMO_SIM_anti_2	559	564	PF11976	0.622
LIG_SUMO_SIM_par_1	812	820	PF11976	0.425
LIG_TRAF2_1	583	586	PF00917	0.399
LIG_TRAF2_1	59	62	PF00917	0.618
LIG_TRAF2_1	629	632	PF00917	0.452
LIG_UBA3_1	342	346	PF00899	0.380
LIG_WW_3	406	410	PF00397	0.491
MOD_CDK_SPK_2	471	476	PF00069	0.520
MOD_CDK_SPxK_1	403	409	PF00069	0.500
MOD_CDK_SPxxK_3	837	844	PF00069	0.412
MOD_CK1_1	161	167	PF00069	0.649
MOD_CK1_1	173	179	PF00069	0.649
MOD_CK1_1	218	224	PF00069	0.572
MOD_CK1_1	236	242	PF00069	0.417
MOD_CK1_1	341	347	PF00069	0.400
MOD_CK1_1	396	402	PF00069	0.536
MOD_CK1_1	470	476	PF00069	0.705
MOD_CK1_1	664	670	PF00069	0.578
MOD_CK1_1	78	84	PF00069	0.670
MOD_CK1_1	783	789	PF00069	0.458
MOD_CK1_1	799	805	PF00069	0.350
MOD_CK1_1	837	843	PF00069	0.572
MOD_CK2_1	108	114	PF00069	0.532
MOD_CK2_1	521	527	PF00069	0.492
MOD_CK2_1	55	61	PF00069	0.491
MOD_CK2_1	580	586	PF00069	0.326
MOD_CK2_1	626	632	PF00069	0.531
MOD_CK2_1	713	719	PF00069	0.338
MOD_CK2_1	742	748	PF00069	0.412
MOD_CK2_1	830	836	PF00069	0.521
MOD_CK2_1	88	94	PF00069	0.677
MOD_GlcNHglycan	119	124	PF01048	0.612
MOD_GlcNHglycan	160	163	PF01048	0.657
MOD_GlcNHglycan	222	225	PF01048	0.524
MOD_GlcNHglycan	231	234	PF01048	0.544
MOD_GlcNHglycan	238	241	PF01048	0.703
MOD_GlcNHglycan	266	269	PF01048	0.611
MOD_GlcNHglycan	411	414	PF01048	0.728
MOD_GlcNHglycan	425	428	PF01048	0.748
MOD_GlcNHglycan	685	689	PF01048	0.316
MOD_GlcNHglycan	744	747	PF01048	0.353
MOD_GlcNHglycan	824	827	PF01048	0.517
MOD_GSK3_1	100	107	PF00069	0.696
MOD_GSK3_1	108	115	PF00069	0.609
MOD_GSK3_1	119	126	PF00069	0.597
MOD_GSK3_1	173	180	PF00069	0.644
MOD_GSK3_1	215	222	PF00069	0.445
MOD_GSK3_1	229	236	PF00069	0.431
MOD_GSK3_1	30	37	PF00069	0.500
MOD_GSK3_1	313	320	PF00069	0.544
MOD_GSK3_1	393	400	PF00069	0.625
MOD_GSK3_1	403	410	PF00069	0.696
MOD_GSK3_1	465	472	PF00069	0.668
MOD_GSK3_1	532	539	PF00069	0.610
MOD_GSK3_1	541	548	PF00069	0.704
MOD_GSK3_1	658	665	PF00069	0.581
MOD_GSK3_1	709	716	PF00069	0.330
MOD_GSK3_1	738	745	PF00069	0.416
MOD_GSK3_1	76	83	PF00069	0.610
MOD_GSK3_1	764	771	PF00069	0.477
MOD_GSK3_1	796	803	PF00069	0.466
MOD_GSK3_1	830	837	PF00069	0.418
MOD_GSK3_1	84	91	PF00069	0.647
MOD_LATS_1	503	509	PF00433	0.458
MOD_N-GLC_1	505	510	PF02516	0.526
MOD_N-GLC_1	713	718	PF02516	0.274
MOD_N-GLC_1	780	785	PF02516	0.403
MOD_N-GLC_1	837	842	PF02516	0.664
MOD_NEK2_1	14	19	PF00069	0.659
MOD_NEK2_1	158	163	PF00069	0.652
MOD_NEK2_1	219	224	PF00069	0.594
MOD_NEK2_1	327	332	PF00069	0.564
MOD_NEK2_1	358	363	PF00069	0.615
MOD_NEK2_1	378	383	PF00069	0.455
MOD_NEK2_1	429	434	PF00069	0.687
MOD_NEK2_1	531	536	PF00069	0.620
MOD_NEK2_1	580	585	PF00069	0.502
MOD_NEK2_1	684	689	PF00069	0.450
MOD_NEK2_1	764	769	PF00069	0.286
MOD_NEK2_1	780	785	PF00069	0.369
MOD_NEK2_1	800	805	PF00069	0.250
MOD_NEK2_1	822	827	PF00069	0.301
MOD_NEK2_2	189	194	PF00069	0.634
MOD_NEK2_2	454	459	PF00069	0.507
MOD_PIKK_1	108	114	PF00454	0.637
MOD_PIKK_1	313	319	PF00454	0.540
MOD_PIKK_1	580	586	PF00454	0.397
MOD_PK_1	532	538	PF00069	0.412
MOD_PKA_1	30	36	PF00069	0.527
MOD_PKA_2	108	114	PF00069	0.724
MOD_PKA_2	14	20	PF00069	0.655
MOD_PKA_2	30	36	PF00069	0.508
MOD_PKA_2	531	537	PF00069	0.516
MOD_PKA_2	580	586	PF00069	0.372
MOD_PKA_2	783	789	PF00069	0.431
MOD_PKA_2	817	823	PF00069	0.343
MOD_PKB_1	521	529	PF00069	0.355
MOD_PKB_1	711	719	PF00069	0.290
MOD_PKB_1	794	802	PF00069	0.517
MOD_Plk_1	170	176	PF00069	0.543
MOD_Plk_1	400	406	PF00069	0.747
MOD_Plk_1	505	511	PF00069	0.537
MOD_Plk_1	526	532	PF00069	0.370
MOD_Plk_1	558	564	PF00069	0.460
MOD_Plk_1	610	616	PF00069	0.470
MOD_Plk_1	780	786	PF00069	0.544
MOD_Plk_1	859	865	PF00069	0.548
MOD_Plk_2-3	416	422	PF00069	0.497
MOD_Plk_4	123	129	PF00069	0.565
MOD_Plk_4	23	29	PF00069	0.502
MOD_Plk_4	250	256	PF00069	0.370
MOD_Plk_4	338	344	PF00069	0.530
MOD_Plk_4	358	364	PF00069	0.348
MOD_Plk_4	431	437	PF00069	0.741
MOD_Plk_4	462	468	PF00069	0.503
MOD_Plk_4	532	538	PF00069	0.648
MOD_Plk_4	558	564	PF00069	0.430
MOD_Plk_4	824	830	PF00069	0.323
MOD_ProDKin_1	393	399	PF00069	0.638
MOD_ProDKin_1	403	409	PF00069	0.625
MOD_ProDKin_1	465	471	PF00069	0.719
MOD_ProDKin_1	55	61	PF00069	0.700
MOD_ProDKin_1	658	664	PF00069	0.644
MOD_ProDKin_1	738	744	PF00069	0.539
MOD_ProDKin_1	810	816	PF00069	0.439
MOD_ProDKin_1	837	843	PF00069	0.544
MOD_SUMO_for_1	475	478	PF00179	0.526
MOD_SUMO_rev_2	102	107	PF00179	0.480
TRG_DiLeu_BaEn_1	61	66	PF01217	0.565
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.434
TRG_ENDOCYTIC_2	216	219	PF00928	0.406
TRG_ER_diArg_1	193	195	PF00400	0.610
TRG_ER_diArg_1	28	31	PF00400	0.611
TRG_ER_diArg_1	281	284	PF00400	0.356
TRG_ER_diArg_1	38	41	PF00400	0.470
TRG_ER_diArg_1	520	523	PF00400	0.431
TRG_ER_diArg_1	690	693	PF00400	0.430
TRG_ER_diArg_1	782	785	PF00400	0.452
TRG_ER_diArg_1	794	796	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS2	Leptomonas seymouri	43%	100%
A0A0S4JGK3	Bodo saltans	28%	100%
A0A1X0P808	Trypanosomatidae	32%	82%
A0A3Q8IJ60	Leishmania donovani	70%	99%
A4ICJ5	Leishmania infantum	70%	99%
D0A2X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	86%
E9ASR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4Q1T5	Leishmania major	68%	100%
V5B4G3	Trypanosoma cruzi	33%	86%