Cilia- and flagella-associated protein 36

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

The ARF-like 2 binding protein BART, putative

Species:

Leishmania braziliensis

UniProt:

A4HP00_LEIBR

TriTrypDb:

LbrM.35.1540 , LBRM2903_350021500

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0097546	ciliary base	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HP00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HP00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.525
CLV_C14_Caspase3-7	54	58	PF00656	0.590
CLV_C14_Caspase3-7	87	91	PF00656	0.405
CLV_NRD_NRD_1	178	180	PF00675	0.558
CLV_NRD_NRD_1	435	437	PF00675	0.507
CLV_NRD_NRD_1	445	447	PF00675	0.616
CLV_PCSK_KEX2_1	120	122	PF00082	0.288
CLV_PCSK_KEX2_1	178	180	PF00082	0.594
CLV_PCSK_KEX2_1	377	379	PF00082	0.645
CLV_PCSK_KEX2_1	435	437	PF00082	0.507
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.334
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.678
CLV_PCSK_SKI1_1	100	104	PF00082	0.332
CLV_PCSK_SKI1_1	338	342	PF00082	0.670
CLV_PCSK_SKI1_1	5	9	PF00082	0.386
DEG_COP1_1	358	368	PF00400	0.529
DEG_SCF_FBW7_1	364	371	PF00400	0.606
DEG_SPOP_SBC_1	339	343	PF00917	0.773
DOC_CKS1_1	20	25	PF01111	0.496
DOC_CKS1_1	365	370	PF01111	0.497
DOC_CYCLIN_RxL_1	118	126	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.405
DOC_MAPK_gen_1	120	127	PF00069	0.488
DOC_MAPK_gen_1	178	185	PF00069	0.612
DOC_MAPK_MEF2A_6	120	127	PF00069	0.496
DOC_MAPK_MEF2A_6	178	185	PF00069	0.584
DOC_MAPK_NFAT4_5	120	128	PF00069	0.496
DOC_PP2B_LxvP_1	67	70	PF13499	0.412
DOC_PP4_FxxP_1	284	287	PF00568	0.700
DOC_USP7_MATH_1	132	136	PF00917	0.560
DOC_USP7_MATH_1	321	325	PF00917	0.716
DOC_USP7_MATH_1	339	343	PF00917	0.535
DOC_USP7_MATH_1	425	429	PF00917	0.730
DOC_USP7_MATH_1	77	81	PF00917	0.572
DOC_WW_Pin1_4	14	19	PF00397	0.482
DOC_WW_Pin1_4	283	288	PF00397	0.728
DOC_WW_Pin1_4	315	320	PF00397	0.529
DOC_WW_Pin1_4	360	365	PF00397	0.736
LIG_14-3-3_CanoR_1	215	224	PF00244	0.524
LIG_14-3-3_CanoR_1	5	14	PF00244	0.586
LIG_14-3-3_CterR_2	446	450	PF00244	0.783
LIG_BIR_III_2	330	334	PF00653	0.520
LIG_BIR_III_4	166	170	PF00653	0.463
LIG_FHA_1	114	120	PF00498	0.553
LIG_FHA_1	297	303	PF00498	0.757
LIG_FHA_1	428	434	PF00498	0.564
LIG_FHA_1	59	65	PF00498	0.476
LIG_FHA_1	6	12	PF00498	0.526
LIG_FHA_2	20	26	PF00498	0.513
LIG_FHA_2	369	375	PF00498	0.599
LIG_GBD_Chelix_1	433	441	PF00786	0.570
LIG_Integrin_RGD_1	438	440	PF01839	0.608
LIG_LIR_Apic_2	17	23	PF02991	0.482
LIG_LIR_Apic_2	283	287	PF02991	0.681
LIG_LIR_Gen_1	109	119	PF02991	0.502
LIG_LIR_Gen_1	44	52	PF02991	0.512
LIG_LIR_Nem_3	109	114	PF02991	0.496
LIG_LIR_Nem_3	258	264	PF02991	0.430
LIG_LIR_Nem_3	44	48	PF02991	0.512
LIG_PCNA_PIPBox_1	398	407	PF02747	0.635
LIG_PCNA_yPIPBox_3	392	405	PF02747	0.617
LIG_SH2_CRK	45	49	PF00017	0.505
LIG_SH2_NCK_1	264	268	PF00017	0.455
LIG_SH2_STAP1	115	119	PF00017	0.492
LIG_SH2_STAT5	113	116	PF00017	0.451
LIG_SH2_STAT5	45	48	PF00017	0.534
LIG_SH3_3	284	290	PF00018	0.674
LIG_SH3_3	291	297	PF00018	0.653
LIG_SH3_3	317	323	PF00018	0.688
LIG_SH3_3	362	368	PF00018	0.654
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.594
LIG_TRAF2_1	171	174	PF00917	0.514
LIG_TRAF2_1	189	192	PF00917	0.486
LIG_TRAF2_1	371	374	PF00917	0.589
LIG_TRAF2_1	396	399	PF00917	0.572
LIG_TYR_ITIM	43	48	PF00017	0.550
LIG_WRC_WIRS_1	401	406	PF05994	0.634
LIG_WRC_WIRS_1	60	65	PF05994	0.438
MOD_CK1_1	153	159	PF00069	0.497
MOD_CK1_1	409	415	PF00069	0.636
MOD_CK1_1	58	64	PF00069	0.583
MOD_CK1_1	81	87	PF00069	0.545
MOD_CK2_1	234	240	PF00069	0.479
MOD_CK2_1	282	288	PF00069	0.614
MOD_CK2_1	368	374	PF00069	0.607
MOD_CK2_1	393	399	PF00069	0.581
MOD_CK2_1	81	87	PF00069	0.405
MOD_CK2_1	88	94	PF00069	0.386
MOD_Cter_Amidation	444	447	PF01082	0.625
MOD_GlcNHglycan	129	132	PF01048	0.407
MOD_GlcNHglycan	14	17	PF01048	0.386
MOD_GlcNHglycan	155	158	PF01048	0.568
MOD_GlcNHglycan	187	190	PF01048	0.369
MOD_GlcNHglycan	348	351	PF01048	0.754
MOD_GlcNHglycan	360	363	PF01048	0.661
MOD_GlcNHglycan	416	419	PF01048	0.683
MOD_GSK3_1	1	8	PF00069	0.479
MOD_GSK3_1	109	116	PF00069	0.575
MOD_GSK3_1	181	188	PF00069	0.380
MOD_GSK3_1	296	303	PF00069	0.585
MOD_GSK3_1	311	318	PF00069	0.631
MOD_GSK3_1	334	341	PF00069	0.688
MOD_GSK3_1	360	367	PF00069	0.696
MOD_GSK3_1	406	413	PF00069	0.636
MOD_GSK3_1	55	62	PF00069	0.492
MOD_GSK3_1	77	84	PF00069	0.558
MOD_GSK3_1	86	93	PF00069	0.546
MOD_N-GLC_1	109	114	PF02516	0.350
MOD_N-GLC_1	262	267	PF02516	0.645
MOD_N-GLC_1	36	41	PF02516	0.372
MOD_N-GLC_1	406	411	PF02516	0.656
MOD_N-GLC_2	31	33	PF02516	0.362
MOD_NEK2_1	1	6	PF00069	0.474
MOD_NEK2_1	150	155	PF00069	0.520
MOD_NEK2_1	185	190	PF00069	0.383
MOD_NEK2_1	304	309	PF00069	0.510
MOD_NEK2_1	43	48	PF00069	0.525
MOD_NEK2_1	55	60	PF00069	0.461
MOD_NEK2_1	78	83	PF00069	0.586
MOD_PIKK_1	132	138	PF00454	0.485
MOD_PIKK_1	341	347	PF00454	0.780
MOD_PKA_2	393	399	PF00069	0.556
MOD_Plk_1	109	115	PF00069	0.550
MOD_Plk_1	181	187	PF00069	0.528
MOD_Plk_1	262	268	PF00069	0.668
MOD_Plk_1	425	431	PF00069	0.519
MOD_Plk_1	43	49	PF00069	0.513
MOD_Plk_4	113	119	PF00069	0.558
MOD_Plk_4	223	229	PF00069	0.392
MOD_Plk_4	300	306	PF00069	0.649
MOD_Plk_4	400	406	PF00069	0.637
MOD_Plk_4	43	49	PF00069	0.540
MOD_Plk_4	55	61	PF00069	0.498
MOD_ProDKin_1	14	20	PF00069	0.482
MOD_ProDKin_1	283	289	PF00069	0.731
MOD_ProDKin_1	315	321	PF00069	0.533
MOD_ProDKin_1	360	366	PF00069	0.733
MOD_SUMO_rev_2	149	156	PF00179	0.519
TRG_ENDOCYTIC_2	115	118	PF00928	0.451
TRG_ENDOCYTIC_2	45	48	PF00928	0.505
TRG_ER_diArg_1	177	179	PF00400	0.584
TRG_ER_diArg_1	435	438	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F6	Leptomonas seymouri	46%	100%
A0A0S4JFM0	Bodo saltans	31%	100%
A0A1X0P8V3	Trypanosomatidae	29%	100%
A0A3R7MMF8	Trypanosoma rangeli	30%	100%
A0A3S7XAM0	Leishmania donovani	68%	100%
A4ICJ6	Leishmania infantum	68%	100%
E9ASR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q1T6	Leishmania major	68%	99%
V5DL00	Trypanosoma cruzi	33%	100%