Amino acid transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid transporter

Species:

Leishmania braziliensis

UniProt:

A4HNZ6_LEIBR

TriTrypDb:

LbrM.35.1500 , LBRM2903_350021100

Length:

469

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

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Cellular components
Term	Name	Level	Count
GO:0005774	vacuolar membrane	5	2
GO:0016020	membrane	2	19
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	19

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Expansion

Sequence features

A4HNZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNZ6

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.574
CLV_C14_Caspase3-7	9	13	PF00656	0.589
CLV_PCSK_KEX2_1	15	17	PF00082	0.481
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.517
CLV_PCSK_SKI1_1	360	364	PF00082	0.147
CLV_PCSK_SKI1_1	366	370	PF00082	0.149
DEG_APCC_DBOX_1	281	289	PF00400	0.147
DEG_APCC_DBOX_1	425	433	PF00400	0.498
DEG_MDM2_SWIB_1	171	179	PF02201	0.141
DEG_Nend_UBRbox_2	1	3	PF02207	0.541

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H0	Leptomonas seymouri	31%	100%
A0A0N0P8T9	Leptomonas seymouri	21%	94%
A0A0N1PCP5	Leptomonas seymouri	29%	99%
A0A0S4ISI1	Bodo saltans	22%	78%
A0A1X0NHS6	Trypanosomatidae	31%	98%
A0A1X0NNX9	Trypanosomatidae	22%	100%
A0A1X0NZK6	Trypanosomatidae	34%	97%
A0A1X0P7Z8	Trypanosomatidae	50%	75%
A0A381MBS1	Leishmania infantum	30%	96%
A0A3Q8IB21	Leishmania donovani	30%	96%

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