Amino acid transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid transporter

Species:

Leishmania braziliensis

UniProt:

A4HNZ6_LEIBR

TriTrypDb:

LbrM.35.1500 , LBRM2903_350021100

Length:

469

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19
GO:0005774	vacuolar membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

A4HNZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNZ6

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.574
CLV_C14_Caspase3-7	9	13	PF00656	0.589
CLV_PCSK_KEX2_1	15	17	PF00082	0.481
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.517
CLV_PCSK_SKI1_1	360	364	PF00082	0.147
CLV_PCSK_SKI1_1	366	370	PF00082	0.149
DEG_APCC_DBOX_1	281	289	PF00400	0.147
DEG_APCC_DBOX_1	425	433	PF00400	0.498
DEG_MDM2_SWIB_1	171	179	PF02201	0.141
DEG_Nend_UBRbox_2	1	3	PF02207	0.541
DOC_CDC14_PxL_1	401	409	PF14671	0.174
DOC_CKS1_1	187	192	PF01111	0.210
DOC_CKS1_1	240	245	PF01111	0.141
DOC_MAPK_FxFP_2	334	337	PF00069	0.307
DOC_MAPK_gen_1	117	125	PF00069	0.391
DOC_MAPK_gen_1	279	288	PF00069	0.402
DOC_MAPK_gen_1	359	367	PF00069	0.434
DOC_MAPK_MEF2A_6	306	315	PF00069	0.208
DOC_MAPK_MEF2A_6	321	330	PF00069	0.240
DOC_MAPK_MEF2A_6	360	369	PF00069	0.425
DOC_MAPK_MEF2A_6	426	433	PF00069	0.484
DOC_MAPK_MEF2A_6	441	450	PF00069	0.456
DOC_MAPK_NFAT4_5	426	434	PF00069	0.549
DOC_PP1_RVXF_1	140	147	PF00149	0.397
DOC_PP1_RVXF_1	242	249	PF00149	0.186
DOC_PP2B_LxvP_1	313	316	PF13499	0.160
DOC_PP2B_PxIxI_1	341	347	PF00149	0.147
DOC_PP4_FxxP_1	334	337	PF00568	0.307
DOC_PP4_FxxP_1	433	436	PF00568	0.446
DOC_PP4_FxxP_1	81	84	PF00568	0.266
DOC_USP7_MATH_1	20	24	PF00917	0.540
DOC_WW_Pin1_4	186	191	PF00397	0.343
DOC_WW_Pin1_4	239	244	PF00397	0.208
LIG_14-3-3_CanoR_1	282	286	PF00244	0.210
LIG_14-3-3_CanoR_1	59	65	PF00244	0.515
LIG_BRCT_BRCA1_1	146	150	PF00533	0.226
LIG_BRCT_BRCA1_1	163	167	PF00533	0.289
LIG_BRCT_BRCA1_1	22	26	PF00533	0.545
LIG_BRCT_BRCA1_1	330	334	PF00533	0.174
LIG_Clathr_ClatBox_1	430	434	PF01394	0.393
LIG_deltaCOP1_diTrp_1	173	180	PF00928	0.282
LIG_EH1_1	91	99	PF00400	0.296
LIG_eIF4E_1	444	450	PF01652	0.220
LIG_eIF4E_1	92	98	PF01652	0.262
LIG_FHA_1	108	114	PF00498	0.373
LIG_FHA_1	183	189	PF00498	0.226
LIG_FHA_1	240	246	PF00498	0.213
LIG_FHA_1	288	294	PF00498	0.286
LIG_FHA_1	307	313	PF00498	0.248
LIG_FHA_1	321	327	PF00498	0.194
LIG_FHA_1	382	388	PF00498	0.240
LIG_FHA_2	218	224	PF00498	0.196
LIG_FHA_2	4	10	PF00498	0.712
LIG_GBD_Chelix_1	408	416	PF00786	0.141
LIG_GBD_Chelix_1	93	101	PF00786	0.359
LIG_LIR_Apic_2	331	337	PF02991	0.174
LIG_LIR_Gen_1	147	158	PF02991	0.179
LIG_LIR_Gen_1	164	171	PF02991	0.326
LIG_LIR_Gen_1	290	300	PF02991	0.278
LIG_LIR_Gen_1	34	42	PF02991	0.655
LIG_LIR_Gen_1	427	436	PF02991	0.408
LIG_LIR_Gen_1	442	453	PF02991	0.333
LIG_LIR_Gen_1	58	69	PF02991	0.463
LIG_LIR_Nem_3	127	131	PF02991	0.435
LIG_LIR_Nem_3	138	143	PF02991	0.427
LIG_LIR_Nem_3	147	153	PF02991	0.125
LIG_LIR_Nem_3	164	170	PF02991	0.293
LIG_LIR_Nem_3	174	180	PF02991	0.234
LIG_LIR_Nem_3	290	295	PF02991	0.305
LIG_LIR_Nem_3	34	40	PF02991	0.601
LIG_LIR_Nem_3	372	376	PF02991	0.337
LIG_LIR_Nem_3	394	398	PF02991	0.364
LIG_LIR_Nem_3	427	431	PF02991	0.466
LIG_LIR_Nem_3	442	448	PF02991	0.427
LIG_LIR_Nem_3	58	64	PF02991	0.554
LIG_LYPXL_yS_3	128	131	PF13949	0.360
LIG_NRBOX	323	329	PF00104	0.187
LIG_NRBOX	97	103	PF00104	0.262
LIG_PALB2_WD40_1	451	459	PF16756	0.147
LIG_Pex14_2	146	150	PF04695	0.174
LIG_Pex14_2	155	159	PF04695	0.174
LIG_Pex14_2	167	171	PF04695	0.145
LIG_Pex14_2	291	295	PF04695	0.147
LIG_Pex14_2	391	395	PF04695	0.174
LIG_SH2_CRK	203	207	PF00017	0.429
LIG_SH2_CRK	283	287	PF00017	0.341
LIG_SH2_CRK	461	465	PF00017	0.273
LIG_SH2_CRK	61	65	PF00017	0.423
LIG_SH2_NCK_1	37	41	PF00017	0.483
LIG_SH2_NCK_1	461	465	PF00017	0.431
LIG_SH2_PTP2	445	448	PF00017	0.420
LIG_SH2_SRC	340	343	PF00017	0.262
LIG_SH2_SRC	87	90	PF00017	0.156
LIG_SH2_STAP1	162	166	PF00017	0.299
LIG_SH2_STAP1	203	207	PF00017	0.187
LIG_SH2_STAP1	283	287	PF00017	0.262
LIG_SH2_STAP1	61	65	PF00017	0.341
LIG_SH2_STAT5	139	142	PF00017	0.460
LIG_SH2_STAT5	283	286	PF00017	0.240
LIG_SH2_STAT5	292	295	PF00017	0.282
LIG_SH2_STAT5	340	343	PF00017	0.326
LIG_SH2_STAT5	37	40	PF00017	0.661
LIG_SH2_STAT5	428	431	PF00017	0.448
LIG_SH2_STAT5	437	440	PF00017	0.505
LIG_SH2_STAT5	445	448	PF00017	0.274
LIG_SH2_STAT5	461	464	PF00017	0.305
LIG_SH2_STAT5	92	95	PF00017	0.303
LIG_SH3_3	184	190	PF00018	0.326
LIG_SH3_3	258	264	PF00018	0.165
LIG_SH3_3	399	405	PF00018	0.210
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.392
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.392
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.279
LIG_SUMO_SIM_anti_2	427	434	PF11976	0.390
LIG_SUMO_SIM_par_1	184	189	PF11976	0.252
LIG_SUMO_SIM_par_1	211	217	PF11976	0.353
LIG_SUMO_SIM_par_1	220	225	PF11976	0.302
LIG_SUMO_SIM_par_1	284	290	PF11976	0.377
LIG_SUMO_SIM_par_1	427	434	PF11976	0.390
LIG_SUMO_SIM_par_1	462	468	PF11976	0.238
LIG_SUMO_SIM_par_1	6	12	PF11976	0.540
LIG_TYR_ITIM	201	206	PF00017	0.521
LIG_TYR_ITIM	281	286	PF00017	0.207
LIG_TYR_ITIM	35	40	PF00017	0.484
LIG_TYR_ITIM	459	464	PF00017	0.392
LIG_WRC_WIRS_1	288	293	PF05994	0.147
LIG_WRC_WIRS_1	388	393	PF05994	0.187
MOD_CDK_SPK_2	239	244	PF00069	0.141
MOD_CK1_1	217	223	PF00069	0.244
MOD_CK1_1	354	360	PF00069	0.423
MOD_CK1_1	41	47	PF00069	0.531
MOD_CK2_1	26	32	PF00069	0.556
MOD_CK2_1	421	427	PF00069	0.520
MOD_CK2_1	462	468	PF00069	0.348
MOD_Cter_Amidation	13	16	PF01082	0.340
MOD_GlcNHglycan	21	25	PF01048	0.379
MOD_GlcNHglycan	216	219	PF01048	0.293
MOD_GlcNHglycan	249	252	PF01048	0.171
MOD_GlcNHglycan	317	320	PF01048	0.426
MOD_GSK3_1	144	151	PF00069	0.174
MOD_GSK3_1	15	22	PF00069	0.635
MOD_GSK3_1	182	189	PF00069	0.327
MOD_GSK3_1	31	38	PF00069	0.606
MOD_GSK3_1	387	394	PF00069	0.359
MOD_GSK3_1	435	442	PF00069	0.505
MOD_N-GLC_1	171	176	PF02516	0.341
MOD_N-GLC_1	369	374	PF02516	0.147
MOD_N-GLC_1	42	47	PF02516	0.462
MOD_NEK2_1	148	153	PF00069	0.254
MOD_NEK2_1	171	176	PF00069	0.240
MOD_NEK2_1	26	31	PF00069	0.616
MOD_NEK2_1	281	286	PF00069	0.373
MOD_NEK2_1	307	312	PF00069	0.237
MOD_NEK2_1	328	333	PF00069	0.289
MOD_NEK2_1	351	356	PF00069	0.413
MOD_NEK2_1	369	374	PF00069	0.406
MOD_NEK2_1	391	396	PF00069	0.262
MOD_NEK2_1	400	405	PF00069	0.166
MOD_NEK2_1	42	47	PF00069	0.530
MOD_NEK2_1	459	464	PF00069	0.177
MOD_NEK2_2	162	167	PF00069	0.174
MOD_NEK2_2	287	292	PF00069	0.147
MOD_PIKK_1	148	154	PF00454	0.265
MOD_PIKK_1	439	445	PF00454	0.393
MOD_PKA_1	15	21	PF00069	0.542
MOD_PKA_2	15	21	PF00069	0.688
MOD_PKA_2	225	231	PF00069	0.141
MOD_PKA_2	281	287	PF00069	0.293
MOD_Plk_1	107	113	PF00069	0.314
MOD_Plk_1	171	177	PF00069	0.158
MOD_Plk_1	265	271	PF00069	0.360
MOD_Plk_1	31	37	PF00069	0.590
MOD_Plk_1	369	375	PF00069	0.341
MOD_Plk_1	38	44	PF00069	0.570
MOD_Plk_4	109	115	PF00069	0.347
MOD_Plk_4	162	168	PF00069	0.236
MOD_Plk_4	182	188	PF00069	0.276
MOD_Plk_4	189	195	PF00069	0.254
MOD_Plk_4	202	208	PF00069	0.296
MOD_Plk_4	281	287	PF00069	0.304
MOD_Plk_4	3	9	PF00069	0.742
MOD_Plk_4	307	313	PF00069	0.227
MOD_Plk_4	328	334	PF00069	0.179
MOD_Plk_4	387	393	PF00069	0.285
MOD_Plk_4	459	465	PF00069	0.175
MOD_Plk_4	60	66	PF00069	0.411
MOD_Plk_4	82	88	PF00069	0.282
MOD_ProDKin_1	186	192	PF00069	0.343
MOD_ProDKin_1	239	245	PF00069	0.208
MOD_SUMO_rev_2	354	362	PF00179	0.423
TRG_DiLeu_BaEn_1	427	432	PF01217	0.383
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.141
TRG_ENDOCYTIC_2	128	131	PF00928	0.423
TRG_ENDOCYTIC_2	177	180	PF00928	0.270
TRG_ENDOCYTIC_2	203	206	PF00928	0.265
TRG_ENDOCYTIC_2	283	286	PF00928	0.271
TRG_ENDOCYTIC_2	292	295	PF00928	0.285
TRG_ENDOCYTIC_2	37	40	PF00928	0.661
TRG_ENDOCYTIC_2	428	431	PF00928	0.429
TRG_ENDOCYTIC_2	445	448	PF00928	0.329
TRG_ENDOCYTIC_2	460	463	PF00928	0.282
TRG_ENDOCYTIC_2	61	64	PF00928	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H0	Leptomonas seymouri	31%	100%
A0A0N0P8T9	Leptomonas seymouri	21%	94%
A0A0N1PCP5	Leptomonas seymouri	29%	99%
A0A0S4ISI1	Bodo saltans	22%	78%
A0A1X0NHS6	Trypanosomatidae	31%	98%
A0A1X0NNX9	Trypanosomatidae	22%	100%
A0A1X0NZK6	Trypanosomatidae	34%	97%
A0A1X0P7Z8	Trypanosomatidae	50%	75%
A0A381MBS1	Leishmania infantum	30%	96%
A0A3Q8IB21	Leishmania donovani	30%	96%
A0A3R7RFB5	Trypanosoma rangeli	21%	93%
A0A3S5H6G5	Leishmania donovani	30%	96%
A0A422MZQ8	Trypanosoma rangeli	52%	79%
A4H662	Leishmania braziliensis	34%	100%
A4HNQ0	Leishmania braziliensis	23%	97%
A4HUI4	Leishmania infantum	29%	96%
A4I887	Leishmania infantum	21%	97%
C9ZW15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
D0A2X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	81%
E9AN82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	96%
F4ILY9	Arabidopsis thaliana	24%	100%
F4KBM7	Arabidopsis thaliana	22%	100%
P36062	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	68%
Q10074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	71%
Q495M3	Homo sapiens	23%	97%
Q495N2	Homo sapiens	26%	100%
Q4KL91	Xenopus laevis	22%	90%
Q4QHE2	Leishmania major	31%	100%
Q4QHE4	Leishmania major	31%	100%
Q4V5R4	Drosophila melanogaster	23%	100%
Q4V8B1	Rattus norvegicus	24%	98%
Q6YBV0	Homo sapiens	26%	93%
Q7Z2H8	Homo sapiens	24%	99%
Q811P0	Mus musculus	24%	98%
Q8BHK3	Mus musculus	25%	98%
Q8CH36	Mus musculus	25%	94%
Q8K415	Rattus norvegicus	26%	98%
Q8K4D3	Mus musculus	24%	99%
Q924A5	Rattus norvegicus	24%	99%
Q9FKY3	Arabidopsis thaliana	26%	100%
Q9M8L9	Arabidopsis thaliana	23%	96%
Q9SVG0	Arabidopsis thaliana	26%	100%
Q9W056	Drosophila melanogaster	24%	100%
V5BHF0	Trypanosoma cruzi	30%	99%
V5BJY7	Trypanosoma cruzi	53%	79%