LeishMANIAdb
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Putative transitional endoplasmic reticulum ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative transitional endoplasmic reticulum ATPase
Gene product:
Valosin-containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HNZ5_LEIBR
TriTrypDb:
LbrM.35.1490 , LBRM2903_350021000
Length:
785

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 3
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0016020 membrane 2 1
GO:0032991 protein-containing complex 1 1
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098552 side of membrane 2 1
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane 4 1
GO:0098562 cytoplasmic side of membrane 3 1
GO:0098796 membrane protein complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:0140534 endoplasmic reticulum protein-containing complex 2 1

Expansion

Sequence features

A4HNZ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNZ5

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins 6 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006950 response to stress 2 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007017 microtubule-based process 2 1
GO:0007051 spindle organization 3 1
GO:0007052 mitotic spindle organization 4 1
GO:0008104 protein localization 4 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 3
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0022402 cell cycle process 2 1
GO:0022411 cellular component disassembly 4 1
GO:0030163 protein catabolic process 4 1
GO:0030433 ubiquitin-dependent ERAD pathway 6 1
GO:0030970 retrograde protein transport, ER to cytosol 5 1
GO:0032527 protein exit from endoplasmic reticulum 5 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0033036 macromolecule localization 2 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0050896 response to stimulus 1 1
GO:0051179 localization 1 1
GO:0051228 mitotic spindle disassembly 5 1
GO:0051230 spindle disassembly 4 1
GO:0051234 establishment of localization 2 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051716 cellular response to stimulus 2 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0071705 nitrogen compound transport 4 1
GO:0071712 ER-associated misfolded protein catabolic process 6 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097352 autophagosome maturation 6 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901698 response to nitrogen compound 3 1
GO:1902850 microtubule cytoskeleton organization involved in mitosis 4 1
GO:1903008 organelle disassembly 5 1
GO:1903047 mitotic cell cycle process 3 1
GO:1903513 endoplasmic reticulum to cytosol transport 4 1
GO:0051301 cell division 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0005515 protein binding 2 1
GO:0031593 polyubiquitin modification-dependent protein binding 4 1
GO:0042802 identical protein binding 3 1
GO:0140030 modification-dependent protein binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 186 190 PF00656 0.646
CLV_C14_Caspase3-7 294 298 PF00656 0.371
CLV_C14_Caspase3-7 320 324 PF00656 0.357
CLV_C14_Caspase3-7 425 429 PF00656 0.302
CLV_C14_Caspase3-7 567 571 PF00656 0.357
CLV_C14_Caspase3-7 594 598 PF00656 0.357
CLV_NRD_NRD_1 199 201 PF00675 0.580
CLV_NRD_NRD_1 276 278 PF00675 0.395
CLV_NRD_NRD_1 348 350 PF00675 0.357
CLV_NRD_NRD_1 649 651 PF00675 0.461
CLV_NRD_NRD_1 731 733 PF00675 0.495
CLV_NRD_NRD_1 740 742 PF00675 0.474
CLV_NRD_NRD_1 80 82 PF00675 0.358
CLV_PCSK_KEX2_1 302 304 PF00082 0.371
CLV_PCSK_KEX2_1 312 314 PF00082 0.371
CLV_PCSK_KEX2_1 348 350 PF00082 0.357
CLV_PCSK_KEX2_1 35 37 PF00082 0.376
CLV_PCSK_KEX2_1 476 478 PF00082 0.439
CLV_PCSK_KEX2_1 731 733 PF00082 0.492
CLV_PCSK_KEX2_1 740 742 PF00082 0.468
CLV_PCSK_KEX2_1 80 82 PF00082 0.376
CLV_PCSK_PC1ET2_1 302 304 PF00082 0.371
CLV_PCSK_PC1ET2_1 312 314 PF00082 0.371
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.376
CLV_PCSK_PC1ET2_1 476 478 PF00082 0.439
CLV_PCSK_SKI1_1 135 139 PF00082 0.400
CLV_PCSK_SKI1_1 229 233 PF00082 0.352
CLV_PCSK_SKI1_1 277 281 PF00082 0.371
CLV_PCSK_SKI1_1 376 380 PF00082 0.457
CLV_PCSK_SKI1_1 388 392 PF00082 0.357
CLV_PCSK_SKI1_1 502 506 PF00082 0.357
CLV_PCSK_SKI1_1 514 518 PF00082 0.357
CLV_PCSK_SKI1_1 550 554 PF00082 0.357
CLV_PCSK_SKI1_1 603 607 PF00082 0.357
DEG_APCC_DBOX_1 199 207 PF00400 0.460
DEG_APCC_DBOX_1 413 421 PF00400 0.469
DOC_CKS1_1 459 464 PF01111 0.508
DOC_MAPK_gen_1 11 19 PF00069 0.619
DOC_MAPK_gen_1 326 333 PF00069 0.376
DOC_MAPK_gen_1 348 359 PF00069 0.357
DOC_MAPK_gen_1 35 42 PF00069 0.372
DOC_MAPK_gen_1 376 386 PF00069 0.465
DOC_MAPK_gen_1 51 61 PF00069 0.306
DOC_MAPK_gen_1 623 633 PF00069 0.357
DOC_MAPK_gen_1 77 87 PF00069 0.376
DOC_MAPK_MEF2A_6 207 214 PF00069 0.447
DOC_MAPK_MEF2A_6 285 292 PF00069 0.371
DOC_MAPK_MEF2A_6 352 361 PF00069 0.357
DOC_MAPK_MEF2A_6 54 63 PF00069 0.357
DOC_MAPK_MEF2A_6 557 565 PF00069 0.346
DOC_MAPK_MEF2A_6 626 635 PF00069 0.357
DOC_MAPK_MEF2A_6 80 87 PF00069 0.376
DOC_MAPK_RevD_3 288 303 PF00069 0.371
DOC_PP1_RVXF_1 148 155 PF00149 0.357
DOC_PP1_RVXF_1 500 507 PF00149 0.424
DOC_PP4_FxxP_1 125 128 PF00568 0.357
DOC_PP4_FxxP_1 506 509 PF00568 0.342
DOC_PP4_MxPP_1 498 501 PF00568 0.547
DOC_USP7_MATH_1 148 152 PF00917 0.376
DOC_USP7_MATH_1 269 273 PF00917 0.371
DOC_USP7_MATH_1 390 394 PF00917 0.376
DOC_USP7_MATH_1 653 657 PF00917 0.539
DOC_USP7_MATH_1 730 734 PF00917 0.505
DOC_USP7_MATH_1 769 773 PF00917 0.820
DOC_WW_Pin1_4 165 170 PF00397 0.400
DOC_WW_Pin1_4 458 463 PF00397 0.518
DOC_WW_Pin1_4 496 501 PF00397 0.496
DOC_WW_Pin1_4 649 654 PF00397 0.458
LIG_14-3-3_CanoR_1 313 322 PF00244 0.354
LIG_14-3-3_CanoR_1 56 60 PF00244 0.430
LIG_14-3-3_CanoR_1 731 739 PF00244 0.484
LIG_14-3-3_CanoR_1 92 101 PF00244 0.249
LIG_Actin_WH2_2 261 279 PF00022 0.371
LIG_Actin_WH2_2 439 457 PF00022 0.515
LIG_BIR_II_1 1 5 PF00653 0.676
LIG_BRCT_BRCA1_1 150 154 PF00533 0.376
LIG_BRCT_BRCA1_1 392 396 PF00533 0.502
LIG_BRCT_BRCA1_1 751 755 PF00533 0.586
LIG_CaM_IQ_9 435 450 PF13499 0.572
LIG_CtBP_PxDLS_1 4 8 PF00389 0.530
LIG_deltaCOP1_diTrp_1 488 493 PF00928 0.465
LIG_FHA_1 45 51 PF00498 0.357
LIG_FHA_1 459 465 PF00498 0.486
LIG_FHA_1 56 62 PF00498 0.357
LIG_FHA_1 88 94 PF00498 0.376
LIG_FHA_2 318 324 PF00498 0.357
LIG_FHA_2 455 461 PF00498 0.561
LIG_FHA_2 592 598 PF00498 0.357
LIG_GBD_Chelix_1 314 322 PF00786 0.371
LIG_Integrin_RGD_1 44 46 PF01839 0.357
LIG_LIR_Apic_2 123 128 PF02991 0.357
LIG_LIR_Gen_1 120 130 PF02991 0.357
LIG_LIR_Gen_1 163 172 PF02991 0.376
LIG_LIR_Nem_3 120 125 PF02991 0.357
LIG_LIR_Nem_3 132 137 PF02991 0.357
LIG_LIR_Nem_3 151 157 PF02991 0.357
LIG_LIR_Nem_3 163 167 PF02991 0.353
LIG_LIR_Nem_3 218 223 PF02991 0.487
LIG_LIR_Nem_3 252 258 PF02991 0.353
LIG_SH2_CRK 134 138 PF00017 0.357
LIG_SH2_CRK 164 168 PF00017 0.400
LIG_SH2_CRK 234 238 PF00017 0.371
LIG_SH2_CRK 507 511 PF00017 0.357
LIG_SH2_NCK_1 193 197 PF00017 0.437
LIG_SH2_PTP2 632 635 PF00017 0.357
LIG_SH2_SRC 193 196 PF00017 0.445
LIG_SH2_STAT5 129 132 PF00017 0.357
LIG_SH2_STAT5 164 167 PF00017 0.400
LIG_SH2_STAT5 632 635 PF00017 0.357
LIG_SH3_3 16 22 PF00018 0.444
LIG_SH3_3 207 213 PF00018 0.449
LIG_SH3_3 456 462 PF00018 0.545
LIG_SH3_3 480 486 PF00018 0.437
LIG_SH3_3 613 619 PF00018 0.382
LIG_SUMO_SIM_anti_2 329 335 PF11976 0.390
LIG_SUMO_SIM_anti_2 415 421 PF11976 0.469
LIG_SUMO_SIM_anti_2 640 646 PF11976 0.421
LIG_SUMO_SIM_par_1 155 160 PF11976 0.357
LIG_SUMO_SIM_par_1 316 323 PF11976 0.376
LIG_TRAF2_1 279 282 PF00917 0.395
LIG_TYR_ITIM 191 196 PF00017 0.447
LIG_TYR_ITIM 630 635 PF00017 0.357
LIG_UBA3_1 219 226 PF00899 0.489
LIG_UBA3_1 318 326 PF00899 0.380
LIG_UBA3_1 370 376 PF00899 0.434
LIG_UBA3_1 630 638 PF00899 0.370
LIG_WW_3 226 230 PF00397 0.450
MOD_CDC14_SPxK_1 499 502 PF00782 0.488
MOD_CDK_SPxK_1 496 502 PF00069 0.494
MOD_CK1_1 168 174 PF00069 0.400
MOD_CK1_1 239 245 PF00069 0.352
MOD_CK1_1 28 34 PF00069 0.469
MOD_CK2_1 454 460 PF00069 0.555
MOD_CK2_1 730 736 PF00069 0.595
MOD_Cter_Amidation 51 54 PF01082 0.357
MOD_GlcNHglycan 117 120 PF01048 0.311
MOD_GlcNHglycan 238 241 PF01048 0.352
MOD_GlcNHglycan 451 454 PF01048 0.516
MOD_GlcNHglycan 670 673 PF01048 0.357
MOD_GlcNHglycan 674 678 PF01048 0.357
MOD_GlcNHglycan 702 705 PF01048 0.612
MOD_GlcNHglycan 771 774 PF01048 0.722
MOD_GSK3_1 168 175 PF00069 0.469
MOD_GSK3_1 313 320 PF00069 0.371
MOD_GSK3_1 454 461 PF00069 0.556
MOD_GSK3_1 568 575 PF00069 0.411
MOD_GSK3_1 645 652 PF00069 0.501
MOD_GSK3_1 664 671 PF00069 0.206
MOD_GSK3_1 745 752 PF00069 0.531
MOD_N-GLC_1 115 120 PF02516 0.357
MOD_N-GLC_1 249 254 PF02516 0.352
MOD_NEK2_1 130 135 PF00069 0.410
MOD_NEK2_1 334 339 PF00069 0.376
MOD_NEK2_1 446 451 PF00069 0.511
MOD_NEK2_1 454 459 PF00069 0.541
MOD_NEK2_1 7 12 PF00069 0.516
MOD_NEK2_1 700 705 PF00069 0.634
MOD_NEK2_1 744 749 PF00069 0.480
MOD_NEK2_1 755 760 PF00069 0.620
MOD_NEK2_1 87 92 PF00069 0.376
MOD_PIKK_1 313 319 PF00454 0.373
MOD_PIKK_1 326 332 PF00454 0.385
MOD_PIKK_1 435 441 PF00454 0.545
MOD_PIKK_1 454 460 PF00454 0.412
MOD_PKA_2 454 460 PF00069 0.542
MOD_PKA_2 55 61 PF00069 0.357
MOD_PKA_2 687 693 PF00069 0.357
MOD_PKA_2 7 13 PF00069 0.504
MOD_PKA_2 730 736 PF00069 0.486
MOD_Plk_1 110 116 PF00069 0.484
MOD_Plk_1 25 31 PF00069 0.362
MOD_Plk_1 423 429 PF00069 0.357
MOD_Plk_1 716 722 PF00069 0.423
MOD_Plk_2-3 415 421 PF00069 0.364
MOD_Plk_2-3 423 429 PF00069 0.346
MOD_Plk_4 139 145 PF00069 0.498
MOD_Plk_4 168 174 PF00069 0.357
MOD_Plk_4 239 245 PF00069 0.352
MOD_Plk_4 25 31 PF00069 0.375
MOD_Plk_4 317 323 PF00069 0.357
MOD_Plk_4 415 421 PF00069 0.376
MOD_Plk_4 44 50 PF00069 0.238
MOD_Plk_4 512 518 PF00069 0.357
MOD_Plk_4 536 542 PF00069 0.357
MOD_ProDKin_1 165 171 PF00069 0.400
MOD_ProDKin_1 458 464 PF00069 0.504
MOD_ProDKin_1 496 502 PF00069 0.494
MOD_ProDKin_1 649 655 PF00069 0.452
MOD_SUMO_for_1 301 304 PF00179 0.371
MOD_SUMO_for_1 475 478 PF00179 0.431
MOD_SUMO_rev_2 151 157 PF00179 0.376
MOD_SUMO_rev_2 694 703 PF00179 0.430
TRG_DiLeu_BaEn_1 478 483 PF01217 0.430
TRG_ENDOCYTIC_2 134 137 PF00928 0.357
TRG_ENDOCYTIC_2 164 167 PF00928 0.400
TRG_ENDOCYTIC_2 193 196 PF00928 0.445
TRG_ENDOCYTIC_2 632 635 PF00928 0.357
TRG_ENDOCYTIC_2 742 745 PF00928 0.472
TRG_ER_diArg_1 347 349 PF00400 0.357
TRG_ER_diArg_1 739 741 PF00400 0.604
TRG_NES_CRM1_1 205 218 PF08389 0.454
TRG_NES_CRM1_1 425 440 PF08389 0.510
TRG_NLS_Bipartite_1 35 57 PF00514 0.376
TRG_NLS_MonoExtN_4 51 57 PF00514 0.357
TRG_Pf-PMV_PEXEL_1 477 481 PF00026 0.440
TRG_Pf-PMV_PEXEL_1 587 591 PF00026 0.342

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3G0 Leptomonas seymouri 92% 99%
A0A0N0P6J4 Leptomonas seymouri 44% 100%
A0A0S4IMC7 Bodo saltans 54% 100%
A0A0S4JAU3 Bodo saltans 44% 100%
A0A0S4JI00 Bodo saltans 73% 100%
A0A1X0P433 Trypanosomatidae 45% 100%
A0A1X0P870 Trypanosomatidae 84% 100%
A0A1X0PA10 Trypanosomatidae 29% 86%
A0A3Q8IQP5 Leishmania donovani 96% 100%
A0A3R7M308 Trypanosoma rangeli 33% 100%
A0A3R7M9L0 Trypanosoma rangeli 84% 100%
A0A3R7MK02 Trypanosoma rangeli 30% 100%
A0A3S7X0L3 Leishmania donovani 45% 100%
A0A422MWE3 Trypanosoma rangeli 43% 100%
A4HFM9 Leishmania braziliensis 45% 100%
A4I2Q7 Leishmania infantum 45% 100%
A4ICJ9 Leishmania infantum 93% 100%
A7YSY2 Bos taurus 39% 100%
C9ZR48 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 99%
D0A2X0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 100%
D0A5V8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D4A2B7 Rattus norvegicus 34% 100%
E9AD83 Leishmania major 46% 100%
E9ASQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9AZ07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
G1X4S3 Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) 36% 66%
O05209 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 50% 100%
O13764 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 83%
O14325 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 100%
O15381 Homo sapiens 42% 92%
O28972 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 48% 100%
O60058 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 97%
P03974 Sus scrofa 73% 97%
P23787 Xenopus laevis 72% 98%
P25694 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 64% 94%
P32794 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 100%
P46462 Rattus norvegicus 73% 97%
P46463 Komagataella pastoris 31% 68%
P54609 Arabidopsis thaliana 70% 97%
P54774 Glycine max 70% 97%
P54811 Caenorhabditis elegans 69% 97%
P54812 Caenorhabditis elegans 70% 97%
P55072 Homo sapiens 73% 97%
Q01853 Mus musculus 73% 97%
Q07590 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 44% 100%
Q07844 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 94%
Q13608 Homo sapiens 36% 80%
Q3UMC0 Mus musculus 48% 88%
Q3ZBT1 Bos taurus 73% 97%
Q4Q1T9 Leishmania major 96% 100%
Q54SY2 Dictyostelium discoideum 39% 91%
Q58556 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 49% 87%
Q5AWS6 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 66% 95%
Q6CPV1 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 34% 78%
Q6GL04 Xenopus tropicalis 73% 98%
Q75JI3 Dictyostelium discoideum 28% 100%
Q7KN62 Drosophila melanogaster 69% 98%
Q7ZU99 Danio rerio 72% 97%
Q8NB90 Homo sapiens 49% 88%
Q8RY16 Arabidopsis thaliana 33% 83%
Q8SSJ5 Encephalitozoon cuniculi (strain GB-M1) 59% 100%
Q96372 Capsicum annuum 70% 98%
Q99LC9 Mus musculus 36% 80%
Q9DBY8 Mus musculus 41% 92%
Q9HPF0 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 42% 100%
Q9LZF6 Arabidopsis thaliana 71% 97%
Q9NAG4 Caenorhabditis elegans 36% 97%
Q9P3A7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 65% 96%
Q9SCN8 Arabidopsis thaliana 70% 96%
Q9SS94 Arabidopsis thaliana 42% 96%
V5BD45 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS