Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNZ3_LEIBR

TriTrypDb:

LbrM.35.1470 , LBRM2903_350021200

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.648
CLV_PCSK_KEX2_1	170	172	PF00082	0.445
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.445
CLV_PCSK_SKI1_1	231	235	PF00082	0.388
CLV_PCSK_SKI1_1	349	353	PF00082	0.460
CLV_PCSK_SKI1_1	362	366	PF00082	0.216
CLV_PCSK_SKI1_1	391	395	PF00082	0.470
CLV_PCSK_SKI1_1	411	415	PF00082	0.171
CLV_PCSK_SKI1_1	481	485	PF00082	0.541
DEG_APCC_DBOX_1	348	356	PF00400	0.282
DEG_SPOP_SBC_1	148	152	PF00917	0.537
DOC_ANK_TNKS_1	212	219	PF00023	0.574
DOC_CKS1_1	46	51	PF01111	0.462
DOC_CYCLIN_RxL_1	359	366	PF00134	0.226
DOC_MAPK_gen_1	64	72	PF00069	0.455
DOC_MAPK_MEF2A_6	532	541	PF00069	0.437
DOC_MAPK_MEF2A_6	64	72	PF00069	0.455
DOC_PP2B_LxvP_1	33	36	PF13499	0.450
DOC_USP7_MATH_1	47	51	PF00917	0.513
DOC_WW_Pin1_4	100	105	PF00397	0.467
DOC_WW_Pin1_4	144	149	PF00397	0.746
DOC_WW_Pin1_4	378	383	PF00397	0.481
DOC_WW_Pin1_4	45	50	PF00397	0.411
LIG_14-3-3_CanoR_1	222	227	PF00244	0.532
LIG_14-3-3_CanoR_1	391	400	PF00244	0.427
LIG_14-3-3_CanoR_1	481	487	PF00244	0.374
LIG_Actin_WH2_2	467	483	PF00022	0.351
LIG_Clathr_ClatBox_1	123	127	PF01394	0.452
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.395
LIG_EH1_1	487	495	PF00400	0.494
LIG_FHA_1	134	140	PF00498	0.608
LIG_FHA_1	144	150	PF00498	0.773
LIG_FHA_1	253	259	PF00498	0.399
LIG_FHA_1	261	267	PF00498	0.379
LIG_FHA_1	280	286	PF00498	0.281
LIG_FHA_1	355	361	PF00498	0.400
LIG_FHA_1	39	45	PF00498	0.438
LIG_FHA_1	468	474	PF00498	0.511
LIG_FHA_1	485	491	PF00498	0.200
LIG_FHA_1	51	57	PF00498	0.460
LIG_FHA_1	532	538	PF00498	0.322
LIG_FHA_2	150	156	PF00498	0.580
LIG_FHA_2	246	252	PF00498	0.496
LIG_FHA_2	361	367	PF00498	0.433
LIG_FHA_2	56	62	PF00498	0.532
LIG_Integrin_RGD_1	179	181	PF01839	0.431
LIG_LIR_Gen_1	246	257	PF02991	0.421
LIG_LIR_Gen_1	366	375	PF02991	0.313
LIG_LIR_Gen_1	415	423	PF02991	0.394
LIG_LIR_Gen_1	425	432	PF02991	0.408
LIG_LIR_Gen_1	86	97	PF02991	0.393
LIG_LIR_Nem_3	246	252	PF02991	0.428
LIG_LIR_Nem_3	366	370	PF02991	0.406
LIG_LIR_Nem_3	394	400	PF02991	0.296
LIG_LIR_Nem_3	415	420	PF02991	0.381
LIG_LIR_Nem_3	425	430	PF02991	0.415
LIG_LIR_Nem_3	86	92	PF02991	0.379
LIG_LYPXL_S_1	396	400	PF13949	0.483
LIG_LYPXL_yS_3	397	400	PF13949	0.287
LIG_NRBOX	488	494	PF00104	0.424
LIG_PCNA_PIPBox_1	226	235	PF02747	0.293
LIG_Pex14_1	253	257	PF04695	0.389
LIG_Pex14_2	249	253	PF04695	0.386
LIG_Pex14_2	412	416	PF04695	0.347
LIG_Rb_LxCxE_1	88	103	PF01857	0.554
LIG_SH2_CRK	89	93	PF00017	0.353
LIG_SH2_STAT3	166	169	PF00017	0.599
LIG_SH2_STAT5	166	169	PF00017	0.580
LIG_SH2_STAT5	257	260	PF00017	0.408
LIG_SH2_STAT5	78	81	PF00017	0.403
LIG_SH2_STAT5	89	92	PF00017	0.309
LIG_SH3_3	102	108	PF00018	0.353
LIG_SH3_3	123	129	PF00018	0.401
LIG_SH3_3	142	148	PF00018	0.740
LIG_SH3_3	159	165	PF00018	0.648
LIG_SH3_3	234	240	PF00018	0.503
LIG_SH3_3	41	47	PF00018	0.391
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.412
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.490
LIG_SUMO_SIM_anti_2	470	475	PF11976	0.524
LIG_SUMO_SIM_par_1	121	127	PF11976	0.532
LIG_SUMO_SIM_par_1	350	357	PF11976	0.477
LIG_SUMO_SIM_par_1	83	88	PF11976	0.348
LIG_TRAF2_1	116	119	PF00917	0.614
LIG_TRAF2_1	243	246	PF00917	0.524
LIG_TRAF2_1	93	96	PF00917	0.479
LIG_TYR_ITIM	87	92	PF00017	0.410
LIG_UBA3_1	226	231	PF00899	0.469
LIG_UBA3_1	440	447	PF00899	0.453
LIG_UBA3_1	492	501	PF00899	0.432
LIG_WRC_WIRS_1	56	61	PF05994	0.517
MOD_CDK_SPxK_1	100	106	PF00069	0.434
MOD_CK1_1	147	153	PF00069	0.740
MOD_CK1_1	187	193	PF00069	0.529
MOD_CK1_1	225	231	PF00069	0.427
MOD_CK1_1	297	303	PF00069	0.507
MOD_CK1_1	340	346	PF00069	0.313
MOD_CK1_1	50	56	PF00069	0.547
MOD_CK2_1	329	335	PF00069	0.402
MOD_CK2_1	340	346	PF00069	0.391
MOD_CK2_1	360	366	PF00069	0.443
MOD_CK2_1	55	61	PF00069	0.481
MOD_CK2_1	90	96	PF00069	0.518
MOD_CMANNOS	253	256	PF00535	0.393
MOD_GlcNHglycan	155	159	PF01048	0.714
MOD_GlcNHglycan	29	32	PF01048	0.500
MOD_GSK3_1	143	150	PF00069	0.733
MOD_GSK3_1	20	27	PF00069	0.486
MOD_GSK3_1	252	259	PF00069	0.482
MOD_GSK3_1	309	316	PF00069	0.524
MOD_GSK3_1	378	385	PF00069	0.540
MOD_GSK3_1	412	419	PF00069	0.375
MOD_N-GLC_1	100	105	PF02516	0.467
MOD_N-GLC_1	24	29	PF02516	0.544
MOD_N-GLC_1	309	314	PF02516	0.508
MOD_N-GLC_1	318	323	PF02516	0.394
MOD_N-GLC_1	329	334	PF02516	0.213
MOD_N-GLC_1	360	365	PF02516	0.445
MOD_NEK2_1	149	154	PF00069	0.720
MOD_NEK2_1	184	189	PF00069	0.563
MOD_NEK2_1	294	299	PF00069	0.442
MOD_NEK2_1	38	43	PF00069	0.369
MOD_NEK2_1	384	389	PF00069	0.411
MOD_NEK2_1	403	408	PF00069	0.407
MOD_NEK2_1	412	417	PF00069	0.360
MOD_NEK2_1	537	542	PF00069	0.416
MOD_NEK2_1	544	549	PF00069	0.440
MOD_NEK2_1	60	65	PF00069	0.510
MOD_PIKK_1	207	213	PF00454	0.447
MOD_PIKK_1	313	319	PF00454	0.329
MOD_PIKK_1	382	388	PF00454	0.337
MOD_PKA_2	403	409	PF00069	0.497
MOD_PKA_2	531	537	PF00069	0.470
MOD_PKB_1	18	26	PF00069	0.512
MOD_Plk_1	154	160	PF00069	0.706
MOD_Plk_1	24	30	PF00069	0.541
MOD_Plk_1	245	251	PF00069	0.472
MOD_Plk_1	260	266	PF00069	0.305
MOD_Plk_1	309	315	PF00069	0.509
MOD_Plk_1	329	335	PF00069	0.214
MOD_Plk_1	360	366	PF00069	0.431
MOD_Plk_2-3	245	251	PF00069	0.546
MOD_Plk_4	187	193	PF00069	0.554
MOD_Plk_4	222	228	PF00069	0.407
MOD_Plk_4	252	258	PF00069	0.403
MOD_Plk_4	309	315	PF00069	0.482
MOD_Plk_4	337	343	PF00069	0.479
MOD_Plk_4	360	366	PF00069	0.402
MOD_Plk_4	403	409	PF00069	0.403
MOD_Plk_4	412	418	PF00069	0.338
MOD_Plk_4	502	508	PF00069	0.441
MOD_Plk_4	55	61	PF00069	0.513
MOD_ProDKin_1	100	106	PF00069	0.471
MOD_ProDKin_1	144	150	PF00069	0.748
MOD_ProDKin_1	378	384	PF00069	0.473
MOD_ProDKin_1	45	51	PF00069	0.411
MOD_SUMO_for_1	290	293	PF00179	0.352
TRG_DiLeu_BaEn_1	119	124	PF01217	0.489
TRG_DiLeu_BaEn_1	201	206	PF01217	0.530
TRG_DiLeu_BaEn_3	425	431	PF01217	0.297
TRG_DiLeu_BaEn_4	95	101	PF01217	0.538
TRG_DiLeu_LyEn_5	95	100	PF01217	0.447
TRG_ENDOCYTIC_2	397	400	PF00928	0.487
TRG_ENDOCYTIC_2	89	92	PF00928	0.349
TRG_ER_diArg_1	421	424	PF00400	0.312
TRG_NES_CRM1_1	344	356	PF08389	0.293
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.216
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E7	Leptomonas seymouri	67%	98%
A0A0S4JC36	Bodo saltans	39%	100%
A0A1X0P7Z1	Trypanosomatidae	44%	100%
A0A3Q8IIW2	Leishmania donovani	79%	100%
A0A422MZU5	Trypanosoma rangeli	47%	100%
A4HNZ7	Leishmania braziliensis	99%	100%
A4ICJ8	Leishmania infantum	79%	91%
D0A2X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ASQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	88%
Q4Q1T8	Leishmania major	79%	100%
V5BU60	Trypanosoma cruzi	46%	100%