PARP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNZ2_LEIBR

TriTrypDb:

LbrM.35.1460 , LBRM2903_350020600

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HNZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNZ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.688
CLV_C14_Caspase3-7	243	247	PF00656	0.758
CLV_NRD_NRD_1	182	184	PF00675	0.748
CLV_NRD_NRD_1	24	26	PF00675	0.487
CLV_NRD_NRD_1	263	265	PF00675	0.683
CLV_NRD_NRD_1	4	6	PF00675	0.445
CLV_PCSK_KEX2_1	176	178	PF00082	0.697
CLV_PCSK_KEX2_1	263	265	PF00082	0.644
CLV_PCSK_KEX2_1	4	6	PF00082	0.451
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.697
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.644
CLV_PCSK_SKI1_1	112	116	PF00082	0.290
CLV_PCSK_SKI1_1	151	155	PF00082	0.670
DEG_Nend_Nbox_1	1	3	PF02207	0.471
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.233
DOC_MAPK_gen_1	176	182	PF00069	0.640
DOC_MAPK_gen_1	51	60	PF00069	0.561
DOC_MAPK_MEF2A_6	25	34	PF00069	0.483
DOC_USP7_MATH_1	157	161	PF00917	0.793
DOC_USP7_MATH_1	248	252	PF00917	0.771
DOC_USP7_MATH_1	42	46	PF00917	0.508
DOC_USP7_UBL2_3	154	158	PF12436	0.754
DOC_USP7_UBL2_3	259	263	PF12436	0.704
DOC_USP7_UBL2_3	51	55	PF12436	0.512
DOC_WW_Pin1_4	136	141	PF00397	0.424
DOC_WW_Pin1_4	165	170	PF00397	0.606
LIG_14-3-3_CanoR_1	4	10	PF00244	0.499
LIG_14-3-3_CterR_2	264	267	PF00244	0.559
LIG_deltaCOP1_diTrp_1	74	78	PF00928	0.561
LIG_FHA_1	125	131	PF00498	0.576
LIG_FHA_1	211	217	PF00498	0.554
LIG_FHA_1	60	66	PF00498	0.513
LIG_FHA_1	93	99	PF00498	0.473
LIG_FHA_2	170	176	PF00498	0.673
LIG_FHA_2	189	195	PF00498	0.583
LIG_FHA_2	225	231	PF00498	0.531
LIG_FHA_2	234	240	PF00498	0.531
LIG_FHA_2	241	247	PF00498	0.695
LIG_LIR_Nem_3	230	235	PF02991	0.529
LIG_LIR_Nem_3	75	81	PF02991	0.486
LIG_SH2_STAP1	205	209	PF00017	0.593
LIG_SH2_STAT5	235	238	PF00017	0.561
LIG_SH3_2	178	183	PF14604	0.781
LIG_SH3_3	175	181	PF00018	0.756
LIG_SH3_4	259	266	PF00018	0.707
LIG_TRAF2_1	227	230	PF00917	0.591
MOD_CK1_1	199	205	PF00069	0.608
MOD_CK1_1	251	257	PF00069	0.699
MOD_CK1_1	45	51	PF00069	0.531
MOD_CK2_1	169	175	PF00069	0.723
MOD_CK2_1	224	230	PF00069	0.531
MOD_Cter_Amidation	49	52	PF01082	0.361
MOD_GlcNHglycan	161	164	PF01048	0.802
MOD_GlcNHglycan	169	172	PF01048	0.560
MOD_GlcNHglycan	252	256	PF01048	0.691
MOD_GlcNHglycan	38	41	PF01048	0.276
MOD_GSK3_1	165	172	PF00069	0.632
MOD_LATS_1	231	237	PF00433	0.591
MOD_N-GLC_1	188	193	PF02516	0.540
MOD_N-GLC_1	240	245	PF02516	0.770
MOD_N-GLC_1	45	50	PF02516	0.391
MOD_OFUCOSY	44	49	PF10250	0.331
MOD_PKA_1	25	31	PF00069	0.515
MOD_Plk_1	125	131	PF00069	0.555
MOD_Plk_4	125	131	PF00069	0.555
MOD_ProDKin_1	136	142	PF00069	0.421
MOD_ProDKin_1	165	171	PF00069	0.607
TRG_ER_diArg_1	177	180	PF00400	0.535
TRG_ER_diArg_1	3	5	PF00400	0.456
TRG_ER_diLys_1	263	267	PF00400	0.553
TRG_NLS_MonoCore_2	262	267	PF00514	0.715
TRG_NLS_MonoExtN_4	260	267	PF00514	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA52	Leptomonas seymouri	61%	100%
A0A0S4J2P2	Bodo saltans	39%	97%
A0A1X0P7R0	Trypanosomatidae	42%	100%
A0A3S5H819	Leishmania donovani	74%	93%
A4ICK1	Leishmania infantum	74%	93%
D0A369	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1U1	Leishmania major	76%	100%