J domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNZ0_LEIBR

TriTrypDb:

LbrM.35.1440 , LBRM2903_350020400

Length:

341

Annotations

LeishMANIAdb annotations

Apparently a chaperone for some membrane-associated process unique to Kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HNZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.651
CLV_NRD_NRD_1	166	168	PF00675	0.394
CLV_NRD_NRD_1	30	32	PF00675	0.528
CLV_NRD_NRD_1	323	325	PF00675	0.427
CLV_PCSK_FUR_1	81	85	PF00082	0.432
CLV_PCSK_KEX2_1	136	138	PF00082	0.495
CLV_PCSK_KEX2_1	165	167	PF00082	0.399
CLV_PCSK_KEX2_1	30	32	PF00082	0.528
CLV_PCSK_KEX2_1	83	85	PF00082	0.396
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.373
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.414
CLV_PCSK_SKI1_1	298	302	PF00082	0.401
CLV_PCSK_SKI1_1	325	329	PF00082	0.426
CLV_PCSK_SKI1_1	4	8	PF00082	0.465
CLV_PCSK_SKI1_1	56	60	PF00082	0.500
DEG_Nend_UBRbox_4	1	3	PF02207	0.564
DEG_SPOP_SBC_1	289	293	PF00917	0.574
DEG_SPOP_SBC_1	309	313	PF00917	0.500
DOC_MAPK_gen_1	165	172	PF00069	0.595
DOC_MAPK_gen_1	252	261	PF00069	0.566
DOC_PP1_RVXF_1	66	72	PF00149	0.568
DOC_PP2B_LxvP_1	305	308	PF13499	0.638
DOC_PP4_FxxP_1	303	306	PF00568	0.630
DOC_USP7_MATH_1	228	232	PF00917	0.511
DOC_USP7_MATH_1	289	293	PF00917	0.521
DOC_USP7_MATH_1	308	312	PF00917	0.602
DOC_USP7_MATH_1	98	102	PF00917	0.743
DOC_WW_Pin1_4	146	151	PF00397	0.579
LIG_14-3-3_CanoR_1	237	241	PF00244	0.597
LIG_14-3-3_CanoR_1	255	260	PF00244	0.602
LIG_14-3-3_CanoR_1	331	340	PF00244	0.707
LIG_14-3-3_CanoR_1	68	77	PF00244	0.500
LIG_14-3-3_CanoR_1	8	14	PF00244	0.719
LIG_BRCT_BRCA1_1	61	65	PF00533	0.663
LIG_FHA_1	302	308	PF00498	0.565
LIG_FHA_2	237	243	PF00498	0.660
LIG_FHA_2	276	282	PF00498	0.659
LIG_FHA_2	47	53	PF00498	0.616
LIG_FHA_2	74	80	PF00498	0.688
LIG_LIR_Apic_2	301	306	PF02991	0.632
LIG_LIR_Gen_1	118	128	PF02991	0.574
LIG_LIR_Gen_1	184	191	PF02991	0.274
LIG_LIR_Gen_1	313	323	PF02991	0.439
LIG_LIR_Nem_3	118	124	PF02991	0.583
LIG_LIR_Nem_3	126	131	PF02991	0.523
LIG_LIR_Nem_3	184	190	PF02991	0.371
LIG_LIR_Nem_3	313	319	PF02991	0.436
LIG_Pex14_2	154	158	PF04695	0.701
LIG_RPA_C_Fungi	26	38	PF08784	0.620
LIG_SH2_CRK	128	132	PF00017	0.537
LIG_SH2_NCK_1	128	132	PF00017	0.474
LIG_SH2_PTP2	316	319	PF00017	0.272
LIG_SH2_STAT5	203	206	PF00017	0.489
LIG_SH2_STAT5	233	236	PF00017	0.341
LIG_SH2_STAT5	316	319	PF00017	0.291
LIG_SH2_STAT5	87	90	PF00017	0.456
LIG_SUMO_SIM_par_1	325	330	PF11976	0.545
LIG_TRAF2_1	239	242	PF00917	0.585
LIG_TYR_ITIM	314	319	PF00017	0.273
MOD_CK1_1	101	107	PF00069	0.755
MOD_CK1_1	111	117	PF00069	0.613
MOD_CK1_1	12	18	PF00069	0.691
MOD_CK1_1	146	152	PF00069	0.685
MOD_CK1_1	292	298	PF00069	0.463
MOD_CK1_1	41	47	PF00069	0.755
MOD_CK2_1	236	242	PF00069	0.502
MOD_CK2_1	275	281	PF00069	0.517
MOD_CK2_1	46	52	PF00069	0.655
MOD_CK2_1	60	66	PF00069	0.527
MOD_CK2_1	69	75	PF00069	0.580
MOD_GlcNHglycan	100	103	PF01048	0.637
MOD_GlcNHglycan	104	107	PF01048	0.664
MOD_GlcNHglycan	113	116	PF01048	0.599
MOD_GlcNHglycan	14	17	PF01048	0.677
MOD_GlcNHglycan	145	148	PF01048	0.707
MOD_GlcNHglycan	191	194	PF01048	0.491
MOD_GlcNHglycan	264	267	PF01048	0.503
MOD_GlcNHglycan	333	336	PF01048	0.574
MOD_GlcNHglycan	40	43	PF01048	0.718
MOD_GlcNHglycan	71	74	PF01048	0.396
MOD_GSK3_1	142	149	PF00069	0.644
MOD_GSK3_1	194	201	PF00069	0.566
MOD_GSK3_1	275	282	PF00069	0.356
MOD_GSK3_1	288	295	PF00069	0.521
MOD_GSK3_1	41	48	PF00069	0.724
MOD_GSK3_1	69	76	PF00069	0.634
MOD_GSK3_1	8	15	PF00069	0.626
MOD_GSK3_1	94	101	PF00069	0.628
MOD_N-GLC_1	131	136	PF02516	0.422
MOD_N-GLC_1	143	148	PF02516	0.730
MOD_N-GLC_1	194	199	PF02516	0.605
MOD_N-GLC_1	60	65	PF02516	0.461
MOD_NEK2_1	180	185	PF00069	0.227
MOD_NEK2_1	189	194	PF00069	0.355
MOD_NEK2_1	69	74	PF00069	0.370
MOD_PIKK_1	108	114	PF00454	0.509
MOD_PK_1	255	261	PF00069	0.358
MOD_PKA_2	236	242	PF00069	0.336
MOD_PKA_2	38	44	PF00069	0.524
MOD_PKA_2	9	15	PF00069	0.686
MOD_Plk_1	194	200	PF00069	0.605
MOD_Plk_1	309	315	PF00069	0.596
MOD_Plk_2-3	236	242	PF00069	0.589
MOD_Plk_2-3	75	81	PF00069	0.611
MOD_Plk_4	229	235	PF00069	0.481
MOD_Plk_4	310	316	PF00069	0.556
MOD_Plk_4	9	15	PF00069	0.629
MOD_ProDKin_1	146	152	PF00069	0.469
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.609
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.217
TRG_ENDOCYTIC_2	128	131	PF00928	0.421
TRG_ENDOCYTIC_2	316	319	PF00928	0.272
TRG_ENDOCYTIC_2	86	89	PF00928	0.549
TRG_ER_diArg_1	165	167	PF00400	0.586
TRG_ER_diArg_1	29	31	PF00400	0.712
TRG_ER_diArg_1	7	10	PF00400	0.715
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P358	Leptomonas seymouri	58%	92%
A0A0S4IZF1	Bodo saltans	30%	100%
A0A1X0P876	Trypanosomatidae	42%	100%
A0A3R7N2F8	Trypanosoma rangeli	39%	100%
A0A3S7XAJ1	Leishmania donovani	73%	75%
A4ICK3	Leishmania infantum	74%	100%
D0A2V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	73%
Q4Q1U3	Leishmania major	75%	100%
V5BUV1	Trypanosoma cruzi	40%	100%