Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNY9_LEIBR

TriTrypDb:

LbrM.35.1430 , LBRM2903_350020300

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	140	146	PF00089	0.620
CLV_NRD_NRD_1	153	155	PF00675	0.520
CLV_NRD_NRD_1	158	160	PF00675	0.527
CLV_NRD_NRD_1	24	26	PF00675	0.683
CLV_NRD_NRD_1	240	242	PF00675	0.565
CLV_NRD_NRD_1	38	40	PF00675	0.532
CLV_NRD_NRD_1	45	47	PF00675	0.699
CLV_PCSK_KEX2_1	152	154	PF00082	0.527
CLV_PCSK_KEX2_1	24	26	PF00082	0.683
CLV_PCSK_KEX2_1	240	242	PF00082	0.578
CLV_PCSK_KEX2_1	37	39	PF00082	0.538
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.481
DEG_Nend_UBRbox_3	1	3	PF02207	0.661
DOC_CKS1_1	93	98	PF01111	0.729
DOC_CKS1_1	99	104	PF01111	0.666
DOC_MAPK_gen_1	24	34	PF00069	0.726
DOC_MAPK_RevD_3	140	153	PF00069	0.558
DOC_PP4_FxxP_1	298	301	PF00568	0.515
DOC_USP7_MATH_1	3	7	PF00917	0.751
DOC_USP7_MATH_1	301	305	PF00917	0.713
DOC_USP7_MATH_1	311	315	PF00917	0.583
DOC_USP7_MATH_1	329	333	PF00917	0.460
DOC_USP7_MATH_1	352	356	PF00917	0.574
DOC_USP7_MATH_1	403	407	PF00917	0.733
DOC_USP7_MATH_1	9	13	PF00917	0.735
DOC_WW_Pin1_4	107	112	PF00397	0.607
DOC_WW_Pin1_4	240	245	PF00397	0.416
DOC_WW_Pin1_4	246	251	PF00397	0.466
DOC_WW_Pin1_4	255	260	PF00397	0.520
DOC_WW_Pin1_4	312	317	PF00397	0.617
DOC_WW_Pin1_4	354	359	PF00397	0.669
DOC_WW_Pin1_4	63	68	PF00397	0.777
DOC_WW_Pin1_4	92	97	PF00397	0.657
DOC_WW_Pin1_4	98	103	PF00397	0.604
LIG_14-3-3_CanoR_1	119	126	PF00244	0.510
LIG_14-3-3_CanoR_1	143	149	PF00244	0.537
LIG_14-3-3_CanoR_1	218	226	PF00244	0.562
LIG_14-3-3_CanoR_1	24	34	PF00244	0.597
LIG_14-3-3_CanoR_1	266	275	PF00244	0.602
LIG_14-3-3_CanoR_1	331	340	PF00244	0.645
LIG_14-3-3_CanoR_1	38	44	PF00244	0.594
LIG_14-3-3_CanoR_1	398	407	PF00244	0.707
LIG_14-3-3_CanoR_1	63	67	PF00244	0.619
LIG_14-3-3_CanoR_1	88	93	PF00244	0.621
LIG_Actin_WH2_2	261	278	PF00022	0.489
LIG_BRCT_BRCA1_1	247	251	PF00533	0.580
LIG_BRCT_BRCA1_1	294	298	PF00533	0.507
LIG_Clathr_ClatBox_1	380	384	PF01394	0.524
LIG_FHA_1	268	274	PF00498	0.519
LIG_FHA_1	87	93	PF00498	0.591
LIG_FHA_1	99	105	PF00498	0.543
LIG_FHA_2	371	377	PF00498	0.770
LIG_Integrin_isoDGR_2	106	108	PF01839	0.569
LIG_LIR_Apic_2	295	301	PF02991	0.511
LIG_LIR_Gen_1	252	262	PF02991	0.631
LIG_LIR_Nem_3	12	16	PF02991	0.756
LIG_LIR_Nem_3	238	242	PF02991	0.561
LIG_LIR_Nem_3	248	254	PF02991	0.593
LIG_LIR_Nem_3	28	33	PF02991	0.589
LIG_LIR_Nem_3	66	72	PF02991	0.750
LIG_PDZ_Class_2	423	428	PF00595	0.588
LIG_SH2_CRK	30	34	PF00017	0.591
LIG_SH2_GRB2like	197	200	PF00017	0.346
LIG_SH3_3	305	311	PF00018	0.731
LIG_SH3_3	75	81	PF00018	0.773
LIG_SH3_5	26	30	PF00018	0.661
LIG_WRC_WIRS_1	13	18	PF05994	0.547
LIG_WRC_WIRS_1	319	324	PF05994	0.609
MOD_CDK_SPK_2	107	112	PF00069	0.546
MOD_CDK_SPK_2	63	68	PF00069	0.729
MOD_CDK_SPK_2	92	97	PF00069	0.667
MOD_CDK_SPxxK_3	63	70	PF00069	0.648
MOD_CK1_1	12	18	PF00069	0.745
MOD_CK1_1	249	255	PF00069	0.543
MOD_CK1_1	267	273	PF00069	0.520
MOD_CK1_1	287	293	PF00069	0.577
MOD_CK1_1	314	320	PF00069	0.645
MOD_CK1_1	332	338	PF00069	0.574
MOD_CK1_1	366	372	PF00069	0.614
MOD_CK1_1	40	46	PF00069	0.609
MOD_CK1_1	401	407	PF00069	0.685
MOD_CK1_1	417	423	PF00069	0.556
MOD_CK1_1	48	54	PF00069	0.762
MOD_CK2_1	287	293	PF00069	0.556
MOD_CK2_1	370	376	PF00069	0.674
MOD_CK2_1	407	413	PF00069	0.719
MOD_GlcNHglycan	130	133	PF01048	0.553
MOD_GlcNHglycan	18	21	PF01048	0.793
MOD_GlcNHglycan	226	229	PF01048	0.527
MOD_GlcNHglycan	251	254	PF01048	0.617
MOD_GlcNHglycan	303	306	PF01048	0.716
MOD_GlcNHglycan	334	337	PF01048	0.761
MOD_GlcNHglycan	354	357	PF01048	0.736
MOD_GlcNHglycan	368	371	PF01048	0.521
MOD_GlcNHglycan	47	50	PF01048	0.734
MOD_GSK3_1	12	19	PF00069	0.567
MOD_GSK3_1	128	135	PF00069	0.510
MOD_GSK3_1	245	252	PF00069	0.588
MOD_GSK3_1	287	294	PF00069	0.606
MOD_GSK3_1	314	321	PF00069	0.653
MOD_GSK3_1	350	357	PF00069	0.681
MOD_GSK3_1	366	373	PF00069	0.612
MOD_GSK3_1	401	408	PF00069	0.767
MOD_GSK3_1	79	86	PF00069	0.710
MOD_GSK3_1	88	95	PF00069	0.683
MOD_N-GLC_1	329	334	PF02516	0.686
MOD_N-GLC_1	389	394	PF02516	0.609
MOD_NEK2_1	16	21	PF00069	0.804
MOD_NEK2_1	389	394	PF00069	0.531
MOD_NEK2_2	188	193	PF00069	0.329
MOD_PIKK_1	178	184	PF00454	0.489
MOD_PIKK_1	267	273	PF00454	0.520
MOD_PIKK_1	345	351	PF00454	0.556
MOD_PIKK_1	83	89	PF00454	0.749
MOD_PKA_1	37	43	PF00069	0.601
MOD_PKA_2	142	148	PF00069	0.535
MOD_PKA_2	219	225	PF00069	0.595
MOD_PKA_2	37	43	PF00069	0.551
MOD_PKA_2	45	51	PF00069	0.690
MOD_PKA_2	62	68	PF00069	0.638
MOD_PKA_2	87	93	PF00069	0.796
MOD_PKA_2	9	15	PF00069	0.672
MOD_PKB_1	216	224	PF00069	0.487
MOD_Plk_1	292	298	PF00069	0.504
MOD_Plk_1	332	338	PF00069	0.549
MOD_Plk_1	389	395	PF00069	0.544
MOD_Plk_1	401	407	PF00069	0.494
MOD_Plk_4	164	170	PF00069	0.410
MOD_Plk_4	314	320	PF00069	0.772
MOD_Plk_4	414	420	PF00069	0.568
MOD_Plk_4	88	94	PF00069	0.589
MOD_ProDKin_1	107	113	PF00069	0.633
MOD_ProDKin_1	240	246	PF00069	0.457
MOD_ProDKin_1	255	261	PF00069	0.539
MOD_ProDKin_1	312	318	PF00069	0.616
MOD_ProDKin_1	354	360	PF00069	0.668
MOD_ProDKin_1	63	69	PF00069	0.779
MOD_ProDKin_1	92	98	PF00069	0.657
MOD_SUMO_rev_2	122	126	PF00179	0.480
MOD_SUMO_rev_2	281	287	PF00179	0.436
MOD_SUMO_rev_2	371	381	PF00179	0.518
TRG_ENDOCYTIC_2	13	16	PF00928	0.731
TRG_ENDOCYTIC_2	30	33	PF00928	0.593
TRG_ER_diArg_1	152	154	PF00400	0.613
TRG_ER_diArg_1	201	204	PF00400	0.631
TRG_ER_diArg_1	239	241	PF00400	0.637
TRG_ER_diArg_1	24	26	PF00400	0.778
TRG_ER_diArg_1	422	425	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ64	Leptomonas seymouri	37%	100%
A0A3S7XAJ3	Leishmania donovani	58%	100%
A4ICK4	Leishmania infantum	58%	100%
E9ASQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4Q1U4	Leishmania major	61%	100%
V5BZP1	Trypanosoma cruzi	25%	90%