BILBO1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNY8_LEIBR

TriTrypDb:

LbrM.35.1420 , LBRM2903_350020200

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.489
CLV_NRD_NRD_1	210	212	PF00675	0.467
CLV_NRD_NRD_1	220	222	PF00675	0.469
CLV_PCSK_FUR_1	208	212	PF00082	0.606
CLV_PCSK_KEX2_1	176	178	PF00082	0.486
CLV_PCSK_KEX2_1	208	210	PF00082	0.472
CLV_PCSK_KEX2_1	220	222	PF00082	0.455
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.351
CLV_PCSK_SKI1_1	217	221	PF00082	0.546
CLV_PCSK_SKI1_1	230	234	PF00082	0.363
CLV_PCSK_SKI1_1	241	245	PF00082	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.407
DOC_CKS1_1	155	160	PF01111	0.623
DOC_CYCLIN_yClb5_NLxxxL_5	14	21	PF00134	0.447
DOC_MAPK_MEF2A_6	14	21	PF00069	0.337
DOC_PP2B_LxvP_1	106	109	PF13499	0.484
DOC_USP7_MATH_1	112	116	PF00917	0.600
DOC_USP7_MATH_1	134	138	PF00917	0.628
DOC_USP7_MATH_1	147	151	PF00917	0.616
DOC_WW_Pin1_4	154	159	PF00397	0.651
DOC_WW_Pin1_4	163	168	PF00397	0.538
DOC_WW_Pin1_4	251	256	PF00397	0.696
LIG_14-3-3_CanoR_1	116	121	PF00244	0.660
LIG_14-3-3_CanoR_1	185	190	PF00244	0.600
LIG_Actin_WH2_2	57	75	PF00022	0.341
LIG_APCC_ABBA_1	64	69	PF00400	0.355
LIG_BIR_III_2	22	26	PF00653	0.227
LIG_BRCT_BRCA1_1	123	127	PF00533	0.493
LIG_FHA_1	121	127	PF00498	0.653
LIG_FHA_1	213	219	PF00498	0.586
LIG_LIR_Gen_1	124	134	PF02991	0.501
LIG_LIR_Gen_1	56	67	PF02991	0.457
LIG_LIR_Gen_1	85	94	PF02991	0.333
LIG_LIR_Nem_3	124	130	PF02991	0.496
LIG_LIR_Nem_3	237	243	PF02991	0.471
LIG_LIR_Nem_3	85	89	PF02991	0.333
LIG_SH2_CRK	86	90	PF00017	0.335
LIG_SH2_SRC	67	70	PF00017	0.335
LIG_SH2_STAP1	67	71	PF00017	0.335
LIG_SH2_STAP1	86	90	PF00017	0.150
LIG_SH2_STAT3	90	93	PF00017	0.335
LIG_SH2_STAT5	90	93	PF00017	0.355
LIG_SH3_2	109	114	PF14604	0.600
LIG_SH3_3	105	111	PF00018	0.306
LIG_SH3_3	152	158	PF00018	0.634
LIG_SH3_3	52	58	PF00018	0.432
LIG_SH3_3	88	94	PF00018	0.341
LIG_WW_3	107	111	PF00397	0.527
MOD_CDC14_SPxK_1	166	169	PF00782	0.562
MOD_CDK_SPxK_1	163	169	PF00069	0.584
MOD_CK1_1	115	121	PF00069	0.715
MOD_CK1_1	135	141	PF00069	0.654
MOD_CK1_1	163	169	PF00069	0.542
MOD_CK1_1	228	234	PF00069	0.395
MOD_CK2_1	116	122	PF00069	0.494
MOD_CK2_1	188	194	PF00069	0.496
MOD_CK2_1	51	57	PF00069	0.266
MOD_GlcNHglycan	122	126	PF01048	0.645
MOD_GlcNHglycan	134	137	PF01048	0.543
MOD_GlcNHglycan	142	145	PF01048	0.756
MOD_GlcNHglycan	149	152	PF01048	0.720
MOD_GlcNHglycan	162	165	PF01048	0.663
MOD_GlcNHglycan	230	233	PF01048	0.525
MOD_GlcNHglycan	46	49	PF01048	0.408
MOD_GSK3_1	112	119	PF00069	0.697
MOD_GSK3_1	121	128	PF00069	0.644
MOD_GSK3_1	132	139	PF00069	0.549
MOD_GSK3_1	184	191	PF00069	0.517
MOD_GSK3_1	49	56	PF00069	0.356
MOD_GSK3_1	72	79	PF00069	0.419
MOD_N-GLC_1	50	55	PF02516	0.341
MOD_NEK2_1	120	125	PF00069	0.704
MOD_NEK2_1	49	54	PF00069	0.285
MOD_NEK2_1	72	77	PF00069	0.466
MOD_PIKK_1	225	231	PF00454	0.602
MOD_PIKK_1	93	99	PF00454	0.463
MOD_PK_1	76	82	PF00069	0.349
MOD_PKA_2	115	121	PF00069	0.746
MOD_PKA_2	184	190	PF00069	0.575
MOD_PKA_2	72	78	PF00069	0.480
MOD_PKB_1	114	122	PF00069	0.735
MOD_Plk_1	121	127	PF00069	0.618
MOD_Plk_1	17	23	PF00069	0.278
MOD_Plk_1	50	56	PF00069	0.258
MOD_Plk_4	116	122	PF00069	0.534
MOD_Plk_4	60	66	PF00069	0.449
MOD_ProDKin_1	154	160	PF00069	0.648
MOD_ProDKin_1	163	169	PF00069	0.534
MOD_ProDKin_1	251	257	PF00069	0.738
TRG_DiLeu_BaEn_1	214	219	PF01217	0.577
TRG_DiLeu_BaEn_1	246	251	PF01217	0.578
TRG_DiLeu_BaEn_2	238	244	PF01217	0.480
TRG_DiLeu_LyEn_5	214	219	PF01217	0.577
TRG_ENDOCYTIC_2	67	70	PF00928	0.386
TRG_ENDOCYTIC_2	86	89	PF00928	0.150
TRG_ER_diArg_1	113	116	PF00400	0.435
TRG_ER_diArg_1	208	211	PF00400	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R9	Leptomonas seymouri	54%	93%
A0A0S4J2G2	Bodo saltans	43%	100%
A0A1X0P9F2	Trypanosomatidae	44%	100%
A0A3Q8IH20	Leishmania donovani	76%	100%
A0A422N0I0	Trypanosoma rangeli	41%	100%
A4ICK5	Leishmania infantum	76%	100%
E9ASQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q1U5	Leishmania major	74%	100%
V5BQB2	Trypanosoma cruzi	43%	100%