Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HNY7_LEIBR

TriTrypDb:

LbrM.35.1410 , LBRM2903_350020100

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032797	SMN complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

A4HNY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNY7

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0022618	ribonucleoprotein complex assembly	6	9
GO:0043933	protein-containing complex organization	4	9
GO:0065003	protein-containing complex assembly	5	9
GO:0071826	ribonucleoprotein complex subunit organization	5	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.629
CLV_C14_Caspase3-7	354	358	PF00656	0.567
CLV_C14_Caspase3-7	369	373	PF00656	0.591
CLV_NRD_NRD_1	169	171	PF00675	0.492
CLV_NRD_NRD_1	290	292	PF00675	0.505
CLV_NRD_NRD_1	78	80	PF00675	0.494
CLV_PCSK_FUR_1	288	292	PF00082	0.512
CLV_PCSK_KEX2_1	288	290	PF00082	0.492
CLV_PCSK_KEX2_1	486	488	PF00082	0.533
CLV_PCSK_KEX2_1	78	80	PF00082	0.554
CLV_PCSK_KEX2_1	84	86	PF00082	0.569
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.461
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.548
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.557
CLV_PCSK_SKI1_1	126	130	PF00082	0.468
CLV_PCSK_SKI1_1	417	421	PF00082	0.394
CLV_PCSK_SKI1_1	81	85	PF00082	0.634
DEG_APCC_DBOX_1	416	424	PF00400	0.453
DEG_SIAH_1	141	149	PF03145	0.562
DEG_SPOP_SBC_1	328	332	PF00917	0.440
DEG_SPOP_SBC_1	51	55	PF00917	0.463
DOC_CKS1_1	292	297	PF01111	0.361
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.457
DOC_MAPK_gen_1	189	199	PF00069	0.487
DOC_PP1_RVXF_1	396	402	PF00149	0.463
DOC_PP2B_LxvP_1	453	456	PF13499	0.492
DOC_PP2B_LxvP_1	96	99	PF13499	0.457
DOC_PP4_FxxP_1	425	428	PF00568	0.449
DOC_USP7_MATH_1	329	333	PF00917	0.364
DOC_USP7_MATH_1	337	341	PF00917	0.317
DOC_USP7_MATH_1	51	55	PF00917	0.505
DOC_USP7_MATH_1	83	87	PF00917	0.690
DOC_USP7_UBL2_3	80	84	PF12436	0.683
DOC_USP7_UBL2_3	9	13	PF12436	0.496
DOC_WW_Pin1_4	138	143	PF00397	0.567
DOC_WW_Pin1_4	291	296	PF00397	0.312
DOC_WW_Pin1_4	410	415	PF00397	0.609
LIG_14-3-3_CanoR_1	259	267	PF00244	0.530
LIG_14-3-3_CanoR_1	275	283	PF00244	0.494
LIG_14-3-3_CanoR_1	319	326	PF00244	0.373
LIG_14-3-3_CanoR_1	344	352	PF00244	0.466
LIG_14-3-3_CanoR_1	363	367	PF00244	0.761
LIG_14-3-3_CanoR_1	374	382	PF00244	0.499
LIG_14-3-3_CanoR_1	417	423	PF00244	0.354
LIG_14-3-3_CanoR_1	436	445	PF00244	0.473
LIG_14-3-3_CanoR_1	474	480	PF00244	0.405
LIG_Actin_WH2_2	186	203	PF00022	0.464
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_3	1	5	PF00653	0.435
LIG_BRCT_BRCA1_1	178	182	PF00533	0.455
LIG_BRCT_BRCA1_1	331	335	PF00533	0.418
LIG_BRCT_BRCA1_1	404	408	PF00533	0.354
LIG_FHA_1	123	129	PF00498	0.536
LIG_FHA_1	141	147	PF00498	0.461
LIG_FHA_1	259	265	PF00498	0.335
LIG_FHA_1	27	33	PF00498	0.462
LIG_FHA_1	394	400	PF00498	0.673
LIG_FHA_1	44	50	PF00498	0.711
LIG_FHA_1	459	465	PF00498	0.449
LIG_FHA_1	55	61	PF00498	0.543
LIG_FHA_2	104	110	PF00498	0.432
LIG_FHA_2	127	133	PF00498	0.655
LIG_FHA_2	242	248	PF00498	0.292
LIG_FHA_2	292	298	PF00498	0.376
LIG_FHA_2	430	436	PF00498	0.386
LIG_FHA_2	476	482	PF00498	0.289
LIG_LIR_Gen_1	195	204	PF02991	0.426
LIG_LIR_Gen_1	266	272	PF02991	0.299
LIG_LIR_Gen_1	421	428	PF02991	0.354
LIG_LIR_LC3C_4	57	62	PF02991	0.569
LIG_LIR_Nem_3	195	199	PF02991	0.439
LIG_LIR_Nem_3	266	270	PF02991	0.307
LIG_LIR_Nem_3	421	425	PF02991	0.351
LIG_LIR_Nem_3	481	485	PF02991	0.479
LIG_MYND_1	410	414	PF01753	0.312
LIG_NRBOX	319	325	PF00104	0.273
LIG_PCNA_PIPBox_1	416	425	PF02747	0.354
LIG_PCNA_yPIPBox_3	416	424	PF02747	0.356
LIG_Pex14_1	162	166	PF04695	0.344
LIG_PTAP_UEV_1	141	146	PF05743	0.564
LIG_RPA_C_Fungi	270	282	PF08784	0.268
LIG_SH2_CRK	283	287	PF00017	0.373
LIG_SH2_GRB2like	306	309	PF00017	0.378
LIG_SH2_PTP2	196	199	PF00017	0.535
LIG_SH2_SRC	366	369	PF00017	0.492
LIG_SH2_STAP1	37	41	PF00017	0.518
LIG_SH2_STAT5	196	199	PF00017	0.406
LIG_SH2_STAT5	306	309	PF00017	0.398
LIG_SH2_STAT5	7	10	PF00017	0.426
LIG_SH3_3	136	142	PF00018	0.608
LIG_SH3_3	252	258	PF00018	0.379
LIG_SH3_3	289	295	PF00018	0.502
LIG_SH3_3	403	409	PF00018	0.609
LIG_SH3_3	453	459	PF00018	0.386
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.359
LIG_SUMO_SIM_anti_2	52	64	PF11976	0.550
LIG_TRAF2_1	388	391	PF00917	0.567
LIG_TRAF2_1	90	93	PF00917	0.553
LIG_WRC_WIRS_1	419	424	PF05994	0.351
MOD_CDK_SPxxK_3	410	417	PF00069	0.357
MOD_CK1_1	103	109	PF00069	0.697
MOD_CK1_1	274	280	PF00069	0.385
MOD_CK1_1	284	290	PF00069	0.453
MOD_CK1_1	327	333	PF00069	0.339
MOD_CK1_1	373	379	PF00069	0.727
MOD_CK1_1	430	436	PF00069	0.534
MOD_CK1_1	53	59	PF00069	0.641
MOD_CK2_1	206	212	PF00069	0.361
MOD_CK2_1	362	368	PF00069	0.733
MOD_CK2_1	429	435	PF00069	0.472
MOD_CK2_1	87	93	PF00069	0.489
MOD_Cter_Amidation	10	13	PF01082	0.566
MOD_DYRK1A_RPxSP_1	291	295	PF00069	0.293
MOD_GlcNHglycan	276	279	PF01048	0.417
MOD_GlcNHglycan	326	329	PF01048	0.363
MOD_GlcNHglycan	331	334	PF01048	0.273
MOD_GlcNHglycan	402	405	PF01048	0.543
MOD_GlcNHglycan	438	441	PF01048	0.323
MOD_GlcNHglycan	450	453	PF01048	0.355
MOD_GlcNHglycan	57	60	PF01048	0.629
MOD_GSK3_1	101	108	PF00069	0.446
MOD_GSK3_1	122	129	PF00069	0.448
MOD_GSK3_1	223	230	PF00069	0.599
MOD_GSK3_1	324	331	PF00069	0.342
MOD_GSK3_1	333	340	PF00069	0.298
MOD_GSK3_1	347	354	PF00069	0.444
MOD_GSK3_1	362	369	PF00069	0.803
MOD_GSK3_1	400	407	PF00069	0.415
MOD_GSK3_1	426	433	PF00069	0.518
MOD_GSK3_1	49	56	PF00069	0.610
MOD_GSK3_1	83	90	PF00069	0.620
MOD_N-GLC_1	370	375	PF02516	0.470
MOD_NEK2_1	100	105	PF00069	0.450
MOD_NEK2_1	211	216	PF00069	0.512
MOD_NEK2_1	251	256	PF00069	0.539
MOD_NEK2_1	324	329	PF00069	0.486
MOD_NEK2_1	335	340	PF00069	0.372
MOD_NEK2_1	402	407	PF00069	0.364
MOD_NEK2_1	434	439	PF00069	0.353
MOD_NEK2_1	468	473	PF00069	0.422
MOD_PIKK_1	258	264	PF00454	0.383
MOD_PK_1	351	357	PF00069	0.442
MOD_PKA_2	258	264	PF00069	0.547
MOD_PKA_2	274	280	PF00069	0.474
MOD_PKA_2	318	324	PF00069	0.382
MOD_PKA_2	362	368	PF00069	0.730
MOD_PKA_2	373	379	PF00069	0.488
MOD_PKA_2	435	441	PF00069	0.515
MOD_PKB_1	85	93	PF00069	0.678
MOD_Plk_1	126	132	PF00069	0.453
MOD_Plk_1	183	189	PF00069	0.425
MOD_Plk_1	27	33	PF00069	0.698
MOD_Plk_2-3	206	212	PF00069	0.266
MOD_Plk_2-3	362	368	PF00069	0.724
MOD_Plk_4	176	182	PF00069	0.554
MOD_Plk_4	206	212	PF00069	0.293
MOD_Plk_4	216	222	PF00069	0.391
MOD_Plk_4	27	33	PF00069	0.684
MOD_Plk_4	281	287	PF00069	0.369
MOD_Plk_4	418	424	PF00069	0.333
MOD_ProDKin_1	138	144	PF00069	0.564
MOD_ProDKin_1	291	297	PF00069	0.314
MOD_ProDKin_1	410	416	PF00069	0.601
MOD_SUMO_for_1	485	488	PF00179	0.380
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.451
TRG_ENDOCYTIC_2	196	199	PF00928	0.469
TRG_ENDOCYTIC_2	283	286	PF00928	0.369
TRG_ENDOCYTIC_2	7	10	PF00928	0.522
TRG_ER_diArg_1	288	291	PF00400	0.571
TRG_ER_diArg_1	378	381	PF00400	0.628
TRG_ER_diArg_1	79	82	PF00400	0.519
TRG_NLS_MonoCore_2	77	82	PF00514	0.582
TRG_NLS_MonoExtC_3	83	89	PF00514	0.488
TRG_NLS_MonoExtN_4	76	83	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC77	Leptomonas seymouri	44%	89%
A0A0S4IYS2	Bodo saltans	29%	100%
A0A1X0P8B5	Trypanosomatidae	29%	98%
A0A3Q8IJZ4	Leishmania donovani	77%	90%
A0A3R7RAQ0	Trypanosoma rangeli	30%	100%
A4ICK6	Leishmania infantum	77%	80%
D0A2V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9ASP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	79%
Q4Q1U6	Leishmania major	78%	100%