by homology
Contact email: dnandan@interchange.ubc.ca
Publication title: Identification of leishmania fructose-1 6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1
Publication 1st author(s): Nandan
Publication Identifier(s): 18028878
Host organism: -1
Interaction detection method(s): anti bait coimmunoprecipitation
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: western blot
ID(s) interactor A: Q9ES52
ID(s) interactor B: Q9U5N6
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania mexicana
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 6 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 20 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 6 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 12 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 13 |
| NetGPI | no | yes: 0, no: 13 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 13 |
| GO:0110165 | cellular anatomical entity | 1 | 14 |
| GO:0005777 | peroxisome | 6 | 1 |
| GO:0005829 | cytosol | 2 | 1 |
| GO:0020015 | glycosome | 7 | 1 |
| GO:0042579 | microbody | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
Related structures:
AlphaFold database: A4HNY6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | 3 | 14 |
| GO:0006082 | organic acid metabolic process | 3 | 14 |
| GO:0006090 | pyruvate metabolic process | 7 | 14 |
| GO:0006091 | generation of precursor metabolites and energy | 3 | 14 |
| GO:0006096 | glycolytic process | 5 | 14 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 14 |
| GO:0006163 | purine nucleotide metabolic process | 5 | 14 |
| GO:0006165 | obsolete nucleoside diphosphate phosphorylation | 6 | 14 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 14 |
| GO:0006753 | nucleoside phosphate metabolic process | 4 | 14 |
| GO:0006757 | obsolete ATP generation from ADP | 4 | 14 |
| GO:0006793 | phosphorus metabolic process | 3 | 14 |
| GO:0006796 | phosphate-containing compound metabolic process | 4 | 14 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 14 |
| GO:0008152 | metabolic process | 1 | 14 |
| GO:0009056 | catabolic process | 2 | 14 |
| GO:0009117 | nucleotide metabolic process | 5 | 14 |
| GO:0009132 | nucleoside diphosphate metabolic process | 5 | 14 |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 6 | 14 |
| GO:0009141 | nucleoside triphosphate metabolic process | 5 | 14 |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 6 | 14 |
| GO:0009150 | purine ribonucleotide metabolic process | 6 | 14 |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 7 | 14 |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 6 | 14 |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 6 | 14 |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 7 | 14 |
| GO:0009259 | ribonucleotide metabolic process | 5 | 14 |
| GO:0009987 | cellular process | 1 | 14 |
| GO:0016052 | carbohydrate catabolic process | 4 | 14 |
| GO:0016310 | phosphorylation | 5 | 14 |
| GO:0019637 | organophosphate metabolic process | 3 | 14 |
| GO:0019693 | ribose phosphate metabolic process | 4 | 14 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 14 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 14 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 14 |
| GO:0043436 | oxoacid metabolic process | 4 | 14 |
| GO:0044237 | cellular metabolic process | 2 | 14 |
| GO:0044238 | primary metabolic process | 2 | 14 |
| GO:0044281 | small molecule metabolic process | 2 | 14 |
| GO:0046031 | ADP metabolic process | 7 | 14 |
| GO:0046034 | ATP metabolic process | 7 | 14 |
| GO:0046483 | heterocycle metabolic process | 3 | 14 |
| GO:0046939 | obsolete nucleotide phosphorylation | 6 | 14 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 14 |
| GO:0071704 | organic substance metabolic process | 2 | 14 |
| GO:0072521 | purine-containing compound metabolic process | 4 | 14 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 14 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 14 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 14 |
| GO:1901575 | organic substance catabolic process | 3 | 14 |
| GO:0030388 | fructose 1,6-bisphosphate metabolic process | 4 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 14 |
| GO:0004332 | fructose-bisphosphate aldolase activity | 5 | 14 |
| GO:0016829 | lyase activity | 2 | 14 |
| GO:0016830 | carbon-carbon lyase activity | 3 | 14 |
| GO:0016832 | aldehyde-lyase activity | 4 | 14 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 136 | 140 | PF00656 | 0.483 |
| CLV_NRD_NRD_1 | 335 | 337 | PF00675 | 0.255 |
| CLV_NRD_NRD_1 | 66 | 68 | PF00675 | 0.260 |
| CLV_PCSK_KEX2_1 | 143 | 145 | PF00082 | 0.284 |
| CLV_PCSK_KEX2_1 | 335 | 337 | PF00082 | 0.265 |
| CLV_PCSK_KEX2_1 | 354 | 356 | PF00082 | 0.199 |
| CLV_PCSK_KEX2_1 | 52 | 54 | PF00082 | 0.282 |
| CLV_PCSK_KEX2_1 | 66 | 68 | PF00082 | 0.243 |
| CLV_PCSK_PC1ET2_1 | 143 | 145 | PF00082 | 0.284 |
| CLV_PCSK_PC1ET2_1 | 354 | 356 | PF00082 | 0.368 |
| CLV_PCSK_PC1ET2_1 | 52 | 54 | PF00082 | 0.288 |
| CLV_PCSK_SKI1_1 | 105 | 109 | PF00082 | 0.196 |
| CLV_PCSK_SKI1_1 | 304 | 308 | PF00082 | 0.196 |
| CLV_PCSK_SKI1_1 | 31 | 35 | PF00082 | 0.273 |
| CLV_PCSK_SKI1_1 | 335 | 339 | PF00082 | 0.263 |
| CLV_PCSK_SKI1_1 | 38 | 42 | PF00082 | 0.257 |
| DEG_SPOP_SBC_1 | 360 | 364 | PF00917 | 0.509 |
| DOC_AGCK_PIF_1 | 307 | 312 | PF00069 | 0.509 |
| DOC_ANK_TNKS_1 | 109 | 116 | PF00023 | 0.537 |
| DOC_ANK_TNKS_1 | 52 | 59 | PF00023 | 0.497 |
| DOC_CYCLIN_RxL_1 | 32 | 45 | PF00134 | 0.470 |
| DOC_CYCLIN_RxL_1 | 65 | 77 | PF00134 | 0.483 |
| DOC_CYCLIN_yCln2_LP_2 | 302 | 308 | PF00134 | 0.488 |
| DOC_MAPK_gen_1 | 52 | 59 | PF00069 | 0.473 |
| DOC_MAPK_gen_1 | 66 | 74 | PF00069 | 0.422 |
| DOC_MAPK_JIP1_4 | 304 | 310 | PF00069 | 0.462 |
| DOC_USP7_MATH_1 | 315 | 319 | PF00917 | 0.492 |
| DOC_USP7_MATH_1 | 360 | 364 | PF00917 | 0.561 |
| DOC_USP7_MATH_1 | 43 | 47 | PF00917 | 0.475 |
| DOC_WW_Pin1_4 | 252 | 257 | PF00397 | 0.424 |
| DOC_WW_Pin1_4 | 32 | 37 | PF00397 | 0.495 |
| LIG_14-3-3_CanoR_1 | 17 | 26 | PF00244 | 0.560 |
| LIG_14-3-3_CanoR_1 | 214 | 220 | PF00244 | 0.481 |
| LIG_14-3-3_CanoR_1 | 314 | 324 | PF00244 | 0.482 |
| LIG_14-3-3_CanoR_1 | 343 | 348 | PF00244 | 0.532 |
| LIG_APCC_ABBA_1 | 86 | 91 | PF00400 | 0.472 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.474 |
| LIG_BRCT_BRCA1_1 | 50 | 54 | PF00533 | 0.493 |
| LIG_DLG_GKlike_1 | 343 | 350 | PF00625 | 0.509 |
| LIG_FHA_1 | 133 | 139 | PF00498 | 0.464 |
| LIG_FHA_1 | 204 | 210 | PF00498 | 0.431 |
| LIG_FHA_2 | 166 | 172 | PF00498 | 0.472 |
| LIG_LIR_Nem_3 | 102 | 106 | PF02991 | 0.485 |
| LIG_LIR_Nem_3 | 217 | 223 | PF02991 | 0.514 |
| LIG_LIR_Nem_3 | 51 | 57 | PF02991 | 0.507 |
| LIG_OCRL_FandH_1 | 14 | 26 | PF00620 | 0.300 |
| LIG_Pex14_1 | 158 | 162 | PF04695 | 0.454 |
| LIG_Pex14_2 | 306 | 310 | PF04695 | 0.493 |
| LIG_SH2_CRK | 184 | 188 | PF00017 | 0.454 |
| LIG_SH2_CRK | 69 | 73 | PF00017 | 0.466 |
| LIG_SH2_GRB2like | 293 | 296 | PF00017 | 0.454 |
| LIG_SH2_SRC | 293 | 296 | PF00017 | 0.454 |
| LIG_SH2_STAP1 | 141 | 145 | PF00017 | 0.518 |
| LIG_SH2_STAP1 | 22 | 26 | PF00017 | 0.394 |
| LIG_SH2_STAP1 | 312 | 316 | PF00017 | 0.472 |
| LIG_SH2_STAT3 | 162 | 165 | PF00017 | 0.462 |
| LIG_SH2_STAT5 | 106 | 109 | PF00017 | 0.537 |
| LIG_SH2_STAT5 | 262 | 265 | PF00017 | 0.472 |
| LIG_SH2_STAT5 | 293 | 296 | PF00017 | 0.454 |
| LIG_SH2_STAT5 | 366 | 369 | PF00017 | 0.472 |
| LIG_SH2_STAT5 | 82 | 85 | PF00017 | 0.451 |
| LIG_WRC_WIRS_1 | 307 | 312 | PF05994 | 0.577 |
| MOD_CDC14_SPxK_1 | 35 | 38 | PF00782 | 0.396 |
| MOD_CDK_SPxK_1 | 32 | 38 | PF00069 | 0.568 |
| MOD_CK1_1 | 250 | 256 | PF00069 | 0.537 |
| MOD_CK1_1 | 361 | 367 | PF00069 | 0.559 |
| MOD_CK1_1 | 46 | 52 | PF00069 | 0.475 |
| MOD_CK2_1 | 165 | 171 | PF00069 | 0.472 |
| MOD_CK2_1 | 17 | 23 | PF00069 | 0.412 |
| MOD_CK2_1 | 57 | 63 | PF00069 | 0.497 |
| MOD_Cter_Amidation | 333 | 336 | PF01082 | 0.272 |
| MOD_GlcNHglycan | 145 | 148 | PF01048 | 0.354 |
| MOD_GlcNHglycan | 171 | 174 | PF01048 | 0.248 |
| MOD_GlcNHglycan | 19 | 22 | PF01048 | 0.599 |
| MOD_GlcNHglycan | 249 | 252 | PF01048 | 0.258 |
| MOD_GlcNHglycan | 281 | 284 | PF01048 | 0.254 |
| MOD_GlcNHglycan | 318 | 321 | PF01048 | 0.254 |
| MOD_GlcNHglycan | 328 | 331 | PF01048 | 0.254 |
| MOD_GlcNHglycan | 83 | 86 | PF01048 | 0.262 |
| MOD_GSK3_1 | 165 | 172 | PF00069 | 0.545 |
| MOD_GSK3_1 | 263 | 270 | PF00069 | 0.511 |
| MOD_GSK3_1 | 279 | 286 | PF00069 | 0.394 |
| MOD_GSK3_1 | 95 | 102 | PF00069 | 0.496 |
| MOD_N-GLC_1 | 165 | 170 | PF02516 | 0.256 |
| MOD_N-GLC_2 | 298 | 300 | PF02516 | 0.216 |
| MOD_NEK2_1 | 26 | 31 | PF00069 | 0.483 |
| MOD_NEK2_1 | 267 | 272 | PF00069 | 0.544 |
| MOD_NEK2_1 | 279 | 284 | PF00069 | 0.570 |
| MOD_NEK2_1 | 306 | 311 | PF00069 | 0.466 |
| MOD_NEK2_1 | 316 | 321 | PF00069 | 0.460 |
| MOD_PIKK_1 | 185 | 191 | PF00454 | 0.460 |
| MOD_PIKK_1 | 7 | 13 | PF00454 | 0.415 |
| MOD_PKA_1 | 143 | 149 | PF00069 | 0.568 |
| MOD_PKA_1 | 31 | 37 | PF00069 | 0.484 |
| MOD_PKA_2 | 143 | 149 | PF00069 | 0.568 |
| MOD_PKA_2 | 213 | 219 | PF00069 | 0.476 |
| MOD_PKB_1 | 341 | 349 | PF00069 | 0.568 |
| MOD_Plk_1 | 43 | 49 | PF00069 | 0.497 |
| MOD_Plk_1 | 89 | 95 | PF00069 | 0.472 |
| MOD_Plk_4 | 260 | 266 | PF00069 | 0.543 |
| MOD_Plk_4 | 361 | 367 | PF00069 | 0.483 |
| MOD_ProDKin_1 | 252 | 258 | PF00069 | 0.424 |
| MOD_ProDKin_1 | 32 | 38 | PF00069 | 0.495 |
| TRG_DiLeu_BaLyEn_6 | 121 | 126 | PF01217 | 0.537 |
| TRG_ENDOCYTIC_2 | 184 | 187 | PF00928 | 0.454 |
| TRG_ENDOCYTIC_2 | 262 | 265 | PF00928 | 0.568 |
| TRG_ENDOCYTIC_2 | 69 | 72 | PF00928 | 0.466 |
| TRG_ER_diArg_1 | 341 | 344 | PF00400 | 0.555 |
| TRG_NES_CRM1_1 | 77 | 91 | PF08389 | 0.470 |
| TRG_Pf-PMV_PEXEL_1 | 24 | 28 | PF00026 | 0.345 |
| TRG_Pf-PMV_PEXEL_1 | 70 | 75 | PF00026 | 0.283 |
| TRG_PTS2 | 1 | 12 | PF00400 | 0.365 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P299 | Leptomonas seymouri | 89% | 100% |
| A0A0N1I6D1 | Leptomonas seymouri | 62% | 100% |
| A0A0S4IZJ5 | Bodo saltans | 73% | 100% |
| A0A1X0NPL7 | Trypanosomatidae | 64% | 100% |
| A0A1X0P8X7 | Trypanosomatidae | 81% | 100% |
| A0A3Q8IFX2 | Leishmania donovani | 91% | 100% |
| A0A3R7JSV8 | Trypanosoma rangeli | 79% | 100% |
| A4ICK8 | Leishmania infantum | 91% | 100% |
| A5A6I5 | Pan troglodytes | 49% | 100% |
| A5IW31 | Staphylococcus aureus (strain JH9) | 26% | 100% |
| A6QK93 | Staphylococcus aureus (strain Newman) | 26% | 100% |
| A6U4Y6 | Staphylococcus aureus (strain JH1) | 26% | 100% |
| A7X6Y6 | Staphylococcus aureus (strain Mu3 / ATCC 700698) | 26% | 100% |
| A8Z3K5 | Staphylococcus aureus (strain USA300 / TCH1516) | 26% | 100% |
| B5DGM7 | Salmo salar | 48% | 100% |
| D0A2V3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 81% | 100% |
| E9ASP6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 92% | 100% |
| F4KGQ0 | Arabidopsis thaliana | 50% | 95% |
| O65581 | Arabidopsis thaliana | 50% | 100% |
| O65735 | Cicer arietinum | 48% | 100% |
| P00883 | Oryctolagus cuniculus | 50% | 100% |
| P00884 | Rattus norvegicus | 48% | 100% |
| P04075 | Homo sapiens | 50% | 100% |
| P05062 | Homo sapiens | 48% | 100% |
| P05063 | Mus musculus | 49% | 100% |
| P05064 | Mus musculus | 50% | 100% |
| P05065 | Rattus norvegicus | 50% | 100% |
| P07341 | Gallus gallus | 47% | 100% |
| P07752 | Trypanosoma brucei brucei | 80% | 100% |
| P07764 | Drosophila melanogaster | 48% | 100% |
| P08440 | Zea mays | 51% | 100% |
| P09117 | Rattus norvegicus | 50% | 100% |
| P09972 | Homo sapiens | 49% | 100% |
| P14223 | Plasmodium falciparum | 49% | 100% |
| P16096 | Spinacia oleracea | 48% | 94% |
| P17784 | Oryza sativa subsp. japonica | 50% | 100% |
| P22197 | Arabidopsis thaliana | 48% | 100% |
| P29356 | Spinacia oleracea | 51% | 100% |
| P46256 | Pisum sativum | 48% | 100% |
| P46257 | Pisum sativum | 49% | 100% |
| P46563 | Caenorhabditis elegans | 48% | 100% |
| P49577 | Plasmodium berghei (strain Anka) | 48% | 100% |
| P52210 | Ovis aries | 50% | 100% |
| P53442 | Schistosoma mansoni | 46% | 100% |
| P53445 | Lethenteron camtschaticum | 46% | 100% |
| P53446 | Lethenteron camtschaticum | 50% | 100% |
| P53447 | Sparus aurata | 48% | 100% |
| P53448 | Carassius auratus | 48% | 100% |
| P54216 | Caenorhabditis elegans | 47% | 100% |
| P67472 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 26% | 100% |
| P79226 | Oryctolagus cuniculus | 49% | 100% |
| P99117 | Staphylococcus aureus (strain N315) | 26% | 100% |
| Q01516 | Pisum sativum | 50% | 100% |
| Q01517 | Pisum sativum | 51% | 100% |
| Q07159 | Staphylococcus carnosus (strain TM300) | 28% | 100% |
| Q10A30 | Oryza sativa subsp. japonica | 49% | 100% |
| Q27744 | Plasmodium falciparum (isolate K1 / Thailand) | 49% | 100% |
| Q2FDQ4 | Staphylococcus aureus (strain USA300) | 26% | 100% |
| Q2FV17 | Staphylococcus aureus (strain NCTC 8325 / PS 47) | 26% | 100% |
| Q3T0S5 | Bos taurus | 49% | 100% |
| Q40677 | Oryza sativa subsp. japonica | 51% | 96% |
| Q42690 | Chlamydomonas reinhardtii | 49% | 99% |
| Q4KMC8 | Danio rerio | 46% | 100% |
| Q4L9B6 | Staphylococcus haemolyticus (strain JCSC1435) | 26% | 100% |
| Q4Q1V0 | Leishmania major | 91% | 100% |
| Q5HCU6 | Staphylococcus aureus (strain COL) | 26% | 100% |
| Q5N725 | Oryza sativa subsp. japonica | 49% | 100% |
| Q5NVR5 | Pongo abelii | 49% | 100% |
| Q5R1X4 | Pan troglodytes | 49% | 100% |
| Q5RFA6 | Pongo abelii | 48% | 100% |
| Q7KQL9 | Plasmodium falciparum (isolate 3D7) | 49% | 100% |
| Q86A67 | Dictyostelium discoideum | 49% | 100% |
| Q87AI0 | Xylella fastidiosa (strain Temecula1 / ATCC 700964) | 47% | 100% |
| Q8JH70 | Danio rerio | 47% | 100% |
| Q8JH71 | Danio rerio | 48% | 100% |
| Q8P5Z7 | Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) | 47% | 100% |
| Q8PHB5 | Xanthomonas axonopodis pv. citri (strain 306) | 47% | 100% |
| Q8SSM8 | Encephalitozoon cuniculi (strain GB-M1) | 38% | 100% |
| Q91Y97 | Mus musculus | 50% | 100% |
| Q944G9 | Arabidopsis thaliana | 50% | 93% |
| Q9GKW3 | Macaca fascicularis | 49% | 100% |
| Q9GP32 | Echinococcus multilocularis | 50% | 100% |
| Q9LF98 | Arabidopsis thaliana | 48% | 100% |
| Q9PF52 | Xylella fastidiosa (strain 9a5c) | 47% | 100% |
| Q9SJQ9 | Arabidopsis thaliana | 48% | 100% |
| Q9SJU4 | Arabidopsis thaliana | 51% | 93% |
| Q9ZU52 | Arabidopsis thaliana | 50% | 95% |
| V5DRF2 | Trypanosoma cruzi | 79% | 99% |