Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNY4_LEIBR

TriTrypDb:

LbrM.35.1370 , LBRM2903_350019700

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.238
CLV_NRD_NRD_1	199	201	PF00675	0.295
CLV_NRD_NRD_1	318	320	PF00675	0.294
CLV_NRD_NRD_1	401	403	PF00675	0.248
CLV_NRD_NRD_1	600	602	PF00675	0.282
CLV_PCSK_KEX2_1	199	201	PF00082	0.317
CLV_PCSK_KEX2_1	318	320	PF00082	0.294
CLV_PCSK_KEX2_1	599	601	PF00082	0.280
CLV_PCSK_SKI1_1	145	149	PF00082	0.369
CLV_PCSK_SKI1_1	166	170	PF00082	0.314
CLV_PCSK_SKI1_1	24	28	PF00082	0.516
CLV_PCSK_SKI1_1	268	272	PF00082	0.440
CLV_PCSK_SKI1_1	378	382	PF00082	0.304
CLV_PCSK_SKI1_1	403	407	PF00082	0.369
CLV_PCSK_SKI1_1	451	455	PF00082	0.304
CLV_PCSK_SKI1_1	600	604	PF00082	0.259
CLV_PCSK_SKI1_1	711	715	PF00082	0.423
CLV_PCSK_SKI1_1	742	746	PF00082	0.369
DEG_APCC_DBOX_1	23	31	PF00400	0.577
DEG_APCC_DBOX_1	317	325	PF00400	0.304
DEG_APCC_DBOX_1	598	606	PF00400	0.227
DEG_SPOP_SBC_1	123	127	PF00917	0.304
DOC_CDC14_PxL_1	257	265	PF14671	0.227
DOC_CKS1_1	215	220	PF01111	0.227
DOC_CKS1_1	726	731	PF01111	0.227
DOC_CYCLIN_RxL_1	163	173	PF00134	0.314
DOC_CYCLIN_RxL_1	375	383	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	263	269	PF00134	0.227
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.222
DOC_CYCLIN_yCln2_LP_2	617	623	PF00134	0.369
DOC_MAPK_gen_1	318	326	PF00069	0.342
DOC_MAPK_gen_1	392	401	PF00069	0.227
DOC_MAPK_gen_1	555	563	PF00069	0.248
DOC_MAPK_gen_1	698	706	PF00069	0.304
DOC_MAPK_MEF2A_6	318	325	PF00069	0.496
DOC_MAPK_RevD_3	303	319	PF00069	0.292
DOC_PP2B_LxvP_1	438	441	PF13499	0.478
DOC_PP2B_LxvP_1	99	102	PF13499	0.413
DOC_PP4_FxxP_1	688	691	PF00568	0.369
DOC_USP7_MATH_1	123	127	PF00917	0.304
DOC_USP7_MATH_1	15	19	PF00917	0.553
DOC_USP7_MATH_1	206	210	PF00917	0.390
DOC_USP7_MATH_1	287	291	PF00917	0.317
DOC_USP7_MATH_1	31	35	PF00917	0.513
DOC_USP7_MATH_1	487	491	PF00917	0.257
DOC_USP7_MATH_1	517	521	PF00917	0.227
DOC_USP7_MATH_1	576	580	PF00917	0.328
DOC_USP7_MATH_1	732	736	PF00917	0.227
DOC_WW_Pin1_4	131	136	PF00397	0.227
DOC_WW_Pin1_4	192	197	PF00397	0.288
DOC_WW_Pin1_4	199	204	PF00397	0.344
DOC_WW_Pin1_4	214	219	PF00397	0.360
DOC_WW_Pin1_4	262	267	PF00397	0.487
DOC_WW_Pin1_4	345	350	PF00397	0.248
DOC_WW_Pin1_4	415	420	PF00397	0.293
DOC_WW_Pin1_4	432	437	PF00397	0.432
DOC_WW_Pin1_4	565	570	PF00397	0.304
DOC_WW_Pin1_4	725	730	PF00397	0.290
DOC_WW_Pin1_4	75	80	PF00397	0.712
DOC_WW_Pin1_4	8	13	PF00397	0.629
LIG_14-3-3_CanoR_1	199	203	PF00244	0.227
LIG_14-3-3_CanoR_1	222	228	PF00244	0.347
LIG_14-3-3_CanoR_1	318	322	PF00244	0.313
LIG_14-3-3_CanoR_1	492	497	PF00244	0.369
LIG_14-3-3_CanoR_1	521	529	PF00244	0.227
LIG_14-3-3_CanoR_1	636	640	PF00244	0.400
LIG_14-3-3_CanoR_1	690	699	PF00244	0.369
LIG_Actin_WH2_2	321	336	PF00022	0.456
LIG_ActinCP_TwfCPI_2	688	698	PF01115	0.369
LIG_APCC_ABBA_1	152	157	PF00400	0.369
LIG_BIR_III_2	592	596	PF00653	0.369
LIG_BIR_III_4	470	474	PF00653	0.241
LIG_BRCT_BRCA1_1	102	106	PF00533	0.369
LIG_Clathr_ClatBox_1	305	309	PF01394	0.227
LIG_deltaCOP1_diTrp_1	443	447	PF00928	0.304
LIG_eIF4E_1	496	502	PF01652	0.227
LIG_FHA_1	108	114	PF00498	0.194
LIG_FHA_1	202	208	PF00498	0.347
LIG_FHA_1	218	224	PF00498	0.241
LIG_FHA_1	252	258	PF00498	0.227
LIG_FHA_1	291	297	PF00498	0.247
LIG_FHA_1	305	311	PF00498	0.323
LIG_FHA_1	437	443	PF00498	0.291
LIG_FHA_1	497	503	PF00498	0.222
LIG_FHA_1	5	11	PF00498	0.629
LIG_FHA_1	523	529	PF00498	0.227
LIG_FHA_1	549	555	PF00498	0.347
LIG_FHA_1	620	626	PF00498	0.312
LIG_FHA_1	656	662	PF00498	0.227
LIG_FHA_1	69	75	PF00498	0.558
LIG_FHA_1	95	101	PF00498	0.406
LIG_FHA_2	76	82	PF00498	0.783
LIG_LIR_Gen_1	146	156	PF02991	0.304
LIG_LIR_Gen_1	418	427	PF02991	0.282
LIG_LIR_Gen_1	434	442	PF02991	0.367
LIG_LIR_Nem_3	116	121	PF02991	0.304
LIG_LIR_Nem_3	146	151	PF02991	0.304
LIG_LIR_Nem_3	335	341	PF02991	0.352
LIG_LIR_Nem_3	418	423	PF02991	0.282
LIG_LIR_Nem_3	434	440	PF02991	0.367
LIG_LIR_Nem_3	495	500	PF02991	0.369
LIG_LIR_Nem_3	643	648	PF02991	0.223
LIG_MYND_1	415	419	PF01753	0.227
LIG_NRBOX	149	155	PF00104	0.304
LIG_NRBOX	310	316	PF00104	0.369
LIG_NRBOX	422	428	PF00104	0.227
LIG_NRBOX	461	467	PF00104	0.304
LIG_NRBOX	537	543	PF00104	0.369
LIG_NRBOX	95	101	PF00104	0.487
LIG_Pex14_2	155	159	PF04695	0.369
LIG_Pex14_2	688	692	PF04695	0.369
LIG_RPA_C_Fungi	314	326	PF08784	0.294
LIG_SH2_CRK	23	27	PF00017	0.516
LIG_SH2_GRB2like	479	482	PF00017	0.227
LIG_SH2_SRC	479	482	PF00017	0.227
LIG_SH2_STAT3	32	35	PF00017	0.579
LIG_SH2_STAT5	479	482	PF00017	0.369
LIG_SH2_STAT5	496	499	PF00017	0.210
LIG_SH2_STAT5	699	702	PF00017	0.304
LIG_SH3_1	200	206	PF00018	0.324
LIG_SH3_3	188	194	PF00018	0.426
LIG_SH3_3	200	206	PF00018	0.262
LIG_SH3_3	297	303	PF00018	0.227
LIG_SH3_3	408	414	PF00018	0.354
LIG_SH3_3	49	55	PF00018	0.496
LIG_SH3_3	523	529	PF00018	0.317
LIG_SH3_3	723	729	PF00018	0.227
LIG_SH3_3	734	740	PF00018	0.202
LIG_Sin3_3	745	752	PF02671	0.369
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.304
LIG_SUMO_SIM_anti_2	307	312	PF11976	0.369
LIG_SUMO_SIM_anti_2	320	325	PF11976	0.248
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.292
LIG_SUMO_SIM_par_1	302	307	PF11976	0.298
LIG_SUMO_SIM_par_1	322	327	PF11976	0.332
LIG_SUMO_SIM_par_1	77	83	PF11976	0.706
LIG_SUMO_SIM_par_1	97	104	PF11976	0.349
LIG_TRAF2_1	532	535	PF00917	0.227
LIG_TRAF2_1	90	93	PF00917	0.634
LIG_TYR_ITIM	336	341	PF00017	0.317
LIG_UBA3_1	744	750	PF00899	0.369
LIG_WW_3	163	167	PF00397	0.227
MOD_CDC14_SPxK_1	265	268	PF00782	0.227
MOD_CDK_SPxK_1	262	268	PF00069	0.369
MOD_CDK_SPxxK_3	192	199	PF00069	0.227
MOD_CDK_SPxxK_3	345	352	PF00069	0.227
MOD_CK1_1	131	137	PF00069	0.443
MOD_CK1_1	201	207	PF00069	0.340
MOD_CK1_1	290	296	PF00069	0.326
MOD_CK1_1	317	323	PF00069	0.317
MOD_CK1_1	348	354	PF00069	0.309
MOD_CK1_1	383	389	PF00069	0.369
MOD_CK1_1	418	424	PF00069	0.275
MOD_CK1_1	482	488	PF00069	0.318
MOD_CK1_1	490	496	PF00069	0.367
MOD_CK1_1	515	521	PF00069	0.347
MOD_CK1_1	580	586	PF00069	0.421
MOD_CK1_1	6	12	PF00069	0.593
MOD_CK1_1	649	655	PF00069	0.324
MOD_CK1_1	85	91	PF00069	0.647
MOD_CK1_1	95	101	PF00069	0.422
MOD_CK2_1	123	129	PF00069	0.227
MOD_CK2_1	274	280	PF00069	0.369
MOD_CK2_1	31	37	PF00069	0.511
MOD_CK2_1	542	548	PF00069	0.227
MOD_CK2_1	603	609	PF00069	0.304
MOD_CK2_1	87	93	PF00069	0.580
MOD_GlcNHglycan	175	179	PF01048	0.317
MOD_GlcNHglycan	369	372	PF01048	0.369
MOD_GlcNHglycan	385	388	PF01048	0.372
MOD_GlcNHglycan	481	484	PF01048	0.422
MOD_GlcNHglycan	489	492	PF01048	0.299
MOD_GlcNHglycan	579	582	PF01048	0.421
MOD_GlcNHglycan	589	592	PF01048	0.304
MOD_GlcNHglycan	650	654	PF01048	0.281
MOD_GlcNHglycan	692	695	PF01048	0.369
MOD_GlcNHglycan	84	87	PF01048	0.651
MOD_GSK3_1	124	131	PF00069	0.404
MOD_GSK3_1	176	183	PF00069	0.280
MOD_GSK3_1	198	205	PF00069	0.405
MOD_GSK3_1	2	9	PF00069	0.636
MOD_GSK3_1	236	243	PF00069	0.457
MOD_GSK3_1	283	290	PF00069	0.369
MOD_GSK3_1	341	348	PF00069	0.327
MOD_GSK3_1	428	435	PF00069	0.486
MOD_GSK3_1	479	486	PF00069	0.359
MOD_GSK3_1	492	499	PF00069	0.423
MOD_GSK3_1	563	570	PF00069	0.363
MOD_GSK3_1	576	583	PF00069	0.245
MOD_GSK3_1	600	607	PF00069	0.314
MOD_GSK3_1	615	622	PF00069	0.220
MOD_GSK3_1	655	662	PF00069	0.298
MOD_N-GLC_1	287	292	PF02516	0.227
MOD_N-GLC_1	548	553	PF02516	0.227
MOD_N-GLC_1	659	664	PF02516	0.237
MOD_NEK2_1	106	111	PF00069	0.482
MOD_NEK2_1	198	203	PF00069	0.227
MOD_NEK2_1	282	287	PF00069	0.315
MOD_NEK2_1	314	319	PF00069	0.372
MOD_NEK2_1	341	346	PF00069	0.437
MOD_NEK2_1	380	385	PF00069	0.340
MOD_NEK2_1	522	527	PF00069	0.347
MOD_NEK2_1	56	61	PF00069	0.639
MOD_NEK2_1	562	567	PF00069	0.360
MOD_NEK2_1	80	85	PF00069	0.529
MOD_PIKK_1	176	182	PF00454	0.311
MOD_PIKK_1	217	223	PF00454	0.290
MOD_PIKK_1	31	37	PF00454	0.511
MOD_PKA_1	600	606	PF00069	0.227
MOD_PKA_2	15	21	PF00069	0.530
MOD_PKA_2	198	204	PF00069	0.279
MOD_PKA_2	317	323	PF00069	0.313
MOD_PKA_2	393	399	PF00069	0.369
MOD_PKA_2	503	509	PF00069	0.296
MOD_PKA_2	520	526	PF00069	0.347
MOD_PKA_2	600	606	PF00069	0.314
MOD_PKA_2	635	641	PF00069	0.307
MOD_PKA_2	654	660	PF00069	0.496
MOD_Plk_1	245	251	PF00069	0.377
MOD_Plk_1	287	293	PF00069	0.227
MOD_Plk_1	512	518	PF00069	0.303
MOD_Plk_1	649	655	PF00069	0.390
MOD_Plk_1	733	739	PF00069	0.227
MOD_Plk_1	80	86	PF00069	0.595
MOD_Plk_1	92	98	PF00069	0.429
MOD_Plk_4	109	115	PF00069	0.340
MOD_Plk_4	206	212	PF00069	0.227
MOD_Plk_4	287	293	PF00069	0.236
MOD_Plk_4	324	330	PF00069	0.322
MOD_Plk_4	380	386	PF00069	0.369
MOD_Plk_4	492	498	PF00069	0.342
MOD_Plk_4	542	548	PF00069	0.227
MOD_Plk_4	635	641	PF00069	0.337
MOD_Plk_4	95	101	PF00069	0.553
MOD_ProDKin_1	131	137	PF00069	0.227
MOD_ProDKin_1	192	198	PF00069	0.288
MOD_ProDKin_1	199	205	PF00069	0.344
MOD_ProDKin_1	214	220	PF00069	0.381
MOD_ProDKin_1	262	268	PF00069	0.487
MOD_ProDKin_1	345	351	PF00069	0.248
MOD_ProDKin_1	415	421	PF00069	0.293
MOD_ProDKin_1	432	438	PF00069	0.432
MOD_ProDKin_1	565	571	PF00069	0.304
MOD_ProDKin_1	725	731	PF00069	0.290
MOD_ProDKin_1	75	81	PF00069	0.713
MOD_ProDKin_1	8	14	PF00069	0.626
MOD_SUMO_rev_2	545	551	PF00179	0.281
TRG_DiLeu_BaEn_1	537	542	PF01217	0.304
TRG_DiLeu_BaLyEn_6	412	417	PF01217	0.227
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.322
TRG_ENDOCYTIC_2	23	26	PF00928	0.518
TRG_ENDOCYTIC_2	338	341	PF00928	0.352
TRG_ER_diArg_1	198	200	PF00400	0.300
TRG_ER_diArg_1	391	394	PF00400	0.304
TRG_ER_diArg_1	554	557	PF00400	0.227
TRG_ER_diArg_1	598	601	PF00400	0.347
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	707	712	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYL2	Leptomonas seymouri	42%	100%
A0A3S7XAL8	Leishmania donovani	75%	100%
A4ICL0	Leishmania infantum	76%	100%
E9ASP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q1V2	Leishmania major	75%	100%