PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNY3_LEIBR

TriTrypDb:

LbrM.35.1360 , LBRM2903_350019600

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNY3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0004722	protein serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0017018	myosin phosphatase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.614
CLV_C14_Caspase3-7	336	340	PF00656	0.337
CLV_C14_Caspase3-7	558	562	PF00656	0.327
CLV_NRD_NRD_1	12	14	PF00675	0.255
CLV_NRD_NRD_1	123	125	PF00675	0.529
CLV_NRD_NRD_1	143	145	PF00675	0.311
CLV_NRD_NRD_1	235	237	PF00675	0.556
CLV_NRD_NRD_1	321	323	PF00675	0.337
CLV_NRD_NRD_1	360	362	PF00675	0.419
CLV_NRD_NRD_1	42	44	PF00675	0.433
CLV_NRD_NRD_1	491	493	PF00675	0.491
CLV_NRD_NRD_1	512	514	PF00675	0.414
CLV_NRD_NRD_1	60	62	PF00675	0.463
CLV_PCSK_KEX2_1	12	14	PF00082	0.381
CLV_PCSK_KEX2_1	142	144	PF00082	0.560
CLV_PCSK_KEX2_1	189	191	PF00082	0.731
CLV_PCSK_KEX2_1	321	323	PF00082	0.337
CLV_PCSK_KEX2_1	360	362	PF00082	0.343
CLV_PCSK_KEX2_1	493	495	PF00082	0.507
CLV_PCSK_KEX2_1	511	513	PF00082	0.371
CLV_PCSK_KEX2_1	576	578	PF00082	0.516
CLV_PCSK_KEX2_1	75	77	PF00082	0.452
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.577
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.566
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.516
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.452
CLV_PCSK_SKI1_1	12	16	PF00082	0.332
CLV_PCSK_SKI1_1	230	234	PF00082	0.613
CLV_PCSK_SKI1_1	246	250	PF00082	0.673
CLV_PCSK_SKI1_1	518	522	PF00082	0.479
CLV_Separin_Metazoa	554	558	PF03568	0.491
DEG_APCC_DBOX_1	12	20	PF00400	0.404
DEG_APCC_DBOX_1	523	531	PF00400	0.448
DEG_Nend_UBRbox_1	1	4	PF02207	0.565
DOC_CYCLIN_RxL_1	487	498	PF00134	0.287
DOC_MAPK_DCC_7	12	21	PF00069	0.483
DOC_MAPK_gen_1	12	21	PF00069	0.410
DOC_MAPK_gen_1	302	310	PF00069	0.371
DOC_MAPK_MEF2A_6	12	21	PF00069	0.444
DOC_MAPK_MEF2A_6	302	310	PF00069	0.371
DOC_MAPK_RevD_3	131	144	PF00069	0.470
DOC_PIKK_1	398	406	PF02985	0.420
DOC_PP1_RVXF_1	210	217	PF00149	0.370
DOC_PP2B_LxvP_1	14	17	PF13499	0.391
DOC_PP2B_PxIxI_1	16	22	PF00149	0.472
DOC_PP4_MxPP_1	240	243	PF00568	0.554
DOC_USP7_MATH_1	181	185	PF00917	0.486
DOC_USP7_MATH_1	206	210	PF00917	0.503
DOC_USP7_MATH_1	436	440	PF00917	0.339
DOC_WW_Pin1_4	218	223	PF00397	0.271
DOC_WW_Pin1_4	263	268	PF00397	0.482
DOC_WW_Pin1_4	359	364	PF00397	0.390
DOC_WW_Pin1_4	60	65	PF00397	0.650
LIG_14-3-3_CanoR_1	142	147	PF00244	0.519
LIG_14-3-3_CanoR_1	230	240	PF00244	0.576
LIG_14-3-3_CanoR_1	287	291	PF00244	0.309
LIG_14-3-3_CanoR_1	412	420	PF00244	0.423
LIG_14-3-3_CanoR_1	501	507	PF00244	0.358
LIG_14-3-3_CanoR_1	524	528	PF00244	0.542
LIG_APCC_ABBAyCdc20_2	143	149	PF00400	0.522
LIG_BRCT_BRCA1_1	279	283	PF00533	0.383
LIG_FHA_1	21	27	PF00498	0.440
LIG_FHA_1	303	309	PF00498	0.398
LIG_FHA_1	63	69	PF00498	0.661
LIG_FHA_2	146	152	PF00498	0.510
LIG_FHA_2	153	159	PF00498	0.572
LIG_FHA_2	190	196	PF00498	0.502
LIG_FHA_2	247	253	PF00498	0.423
LIG_FHA_2	393	399	PF00498	0.278
LIG_FHA_2	61	67	PF00498	0.635
LIG_FHA_2	92	98	PF00498	0.439
LIG_IBAR_NPY_1	341	343	PF08397	0.345
LIG_LIR_Apic_2	473	477	PF02991	0.406
LIG_LIR_Apic_2	69	74	PF02991	0.517
LIG_LIR_Gen_1	148	154	PF02991	0.443
LIG_LIR_Gen_1	266	277	PF02991	0.384
LIG_LIR_Gen_1	568	578	PF02991	0.452
LIG_LIR_Nem_3	148	153	PF02991	0.458
LIG_LIR_Nem_3	266	272	PF02991	0.330
LIG_LIR_Nem_3	317	323	PF02991	0.309
LIG_LIR_Nem_3	36	41	PF02991	0.461
LIG_LIR_Nem_3	376	380	PF02991	0.340
LIG_LIR_Nem_3	568	574	PF02991	0.470
LIG_NRBOX	258	264	PF00104	0.351
LIG_PDZ_Class_1	580	585	PF00595	0.418
LIG_Pex14_2	430	434	PF04695	0.419
LIG_PTB_Apo_2	338	345	PF02174	0.337
LIG_PTB_Phospho_1	338	344	PF10480	0.337
LIG_REV1ctd_RIR_1	168	176	PF16727	0.466
LIG_SH2_CRK	320	324	PF00017	0.419
LIG_SH2_GRB2like	343	346	PF00017	0.345
LIG_SH2_NCK_1	49	53	PF00017	0.416
LIG_SH2_PTP2	18	21	PF00017	0.403
LIG_SH2_SRC	162	165	PF00017	0.431
LIG_SH2_SRC	269	272	PF00017	0.243
LIG_SH2_STAP1	162	166	PF00017	0.326
LIG_SH2_STAT5	105	108	PF00017	0.335
LIG_SH2_STAT5	18	21	PF00017	0.403
LIG_SH2_STAT5	269	272	PF00017	0.359
LIG_SH2_STAT5	481	484	PF00017	0.395
LIG_SH2_STAT5	93	96	PF00017	0.460
LIG_SH3_1	125	131	PF00018	0.500
LIG_SH3_3	125	131	PF00018	0.561
LIG_SH3_3	199	205	PF00018	0.719
LIG_SH3_3	525	531	PF00018	0.368
LIG_SUMO_SIM_par_1	305	311	PF11976	0.373
LIG_TRAF2_1	205	208	PF00917	0.582
LIG_TYR_ITIM	16	21	PF00017	0.477
LIG_TYR_ITIM	318	323	PF00017	0.195
LIG_UBA3_1	10	15	PF00899	0.464
LIG_WRC_WIRS_1	35	40	PF05994	0.372
MOD_CK1_1	100	106	PF00069	0.379
MOD_CK1_1	111	117	PF00069	0.388
MOD_CK1_1	145	151	PF00069	0.417
MOD_CK1_1	152	158	PF00069	0.542
MOD_CK1_1	231	237	PF00069	0.454
MOD_CK1_1	69	75	PF00069	0.634
MOD_CK2_1	145	151	PF00069	0.506
MOD_CK2_1	246	252	PF00069	0.657
MOD_CK2_1	392	398	PF00069	0.318
MOD_CK2_1	399	405	PF00069	0.305
MOD_CK2_1	91	97	PF00069	0.517
MOD_Cter_Amidation	358	361	PF01082	0.357
MOD_GlcNHglycan	164	167	PF01048	0.485
MOD_GlcNHglycan	207	211	PF01048	0.427
MOD_GlcNHglycan	216	219	PF01048	0.373
MOD_GlcNHglycan	230	233	PF01048	0.495
MOD_GlcNHglycan	249	252	PF01048	0.501
MOD_GlcNHglycan	331	334	PF01048	0.261
MOD_GlcNHglycan	448	451	PF01048	0.532
MOD_GlcNHglycan	455	458	PF01048	0.607
MOD_GlcNHglycan	50	53	PF01048	0.462
MOD_GlcNHglycan	66	71	PF01048	0.477
MOD_GSK3_1	145	152	PF00069	0.543
MOD_GSK3_1	214	221	PF00069	0.486
MOD_GSK3_1	298	305	PF00069	0.467
MOD_GSK3_1	446	453	PF00069	0.508
MOD_GSK3_1	501	508	PF00069	0.530
MOD_GSK3_1	556	563	PF00069	0.321
MOD_GSK3_1	62	69	PF00069	0.728
MOD_GSK3_1	96	103	PF00069	0.399
MOD_N-GLC_1	580	585	PF02516	0.418
MOD_NEK2_1	216	221	PF00069	0.337
MOD_NEK2_1	277	282	PF00069	0.308
MOD_NEK2_1	29	34	PF00069	0.510
MOD_NEK2_1	48	53	PF00069	0.392
MOD_NEK2_1	89	94	PF00069	0.410
MOD_NEK2_2	351	356	PF00069	0.312
MOD_PIKK_1	261	267	PF00454	0.339
MOD_PKA_1	142	148	PF00069	0.495
MOD_PKA_1	189	195	PF00069	0.665
MOD_PKA_2	142	148	PF00069	0.402
MOD_PKA_2	189	195	PF00069	0.677
MOD_PKA_2	286	292	PF00069	0.354
MOD_PKA_2	453	459	PF00069	0.518
MOD_PKA_2	523	529	PF00069	0.521
MOD_PKA_2	556	562	PF00069	0.342
MOD_Plk_1	302	308	PF00069	0.432
MOD_Plk_1	398	404	PF00069	0.305
MOD_Plk_1	436	442	PF00069	0.487
MOD_Plk_1	66	72	PF00069	0.507
MOD_Plk_1	96	102	PF00069	0.500
MOD_Plk_2-3	399	405	PF00069	0.337
MOD_Plk_4	131	137	PF00069	0.403
MOD_Plk_4	149	155	PF00069	0.637
MOD_Plk_4	220	226	PF00069	0.495
MOD_Plk_4	505	511	PF00069	0.478
MOD_Plk_4	97	103	PF00069	0.457
MOD_ProDKin_1	218	224	PF00069	0.285
MOD_ProDKin_1	263	269	PF00069	0.471
MOD_ProDKin_1	359	365	PF00069	0.390
MOD_ProDKin_1	60	66	PF00069	0.653
TRG_DiLeu_BaEn_1	149	154	PF01217	0.488
TRG_DiLeu_BaEn_2	96	102	PF01217	0.494
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.513
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.307
TRG_ENDOCYTIC_2	18	21	PF00928	0.465
TRG_ENDOCYTIC_2	269	272	PF00928	0.243
TRG_ENDOCYTIC_2	320	323	PF00928	0.430
TRG_ENDOCYTIC_2	343	346	PF00928	0.425
TRG_ER_diArg_1	11	13	PF00400	0.251
TRG_ER_diArg_1	142	144	PF00400	0.568
TRG_ER_diArg_1	320	322	PF00400	0.331
TRG_ER_diArg_1	491	494	PF00400	0.441
TRG_ER_diArg_1	510	513	PF00400	0.268
TRG_NLS_MonoExtN_4	489	496	PF00514	0.285
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q6	Leptomonas seymouri	62%	100%
A0A0S4IM91	Bodo saltans	30%	100%
A0A0S4IRQ5	Bodo saltans	30%	100%
A0A1X0P810	Trypanosomatidae	46%	98%
A0A3S7XAR2	Leishmania donovani	81%	100%
A4ICL1	Leishmania infantum	81%	100%
D0A2U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
E9ASP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q1V3	Leishmania major	81%	100%
V5BZP6	Trypanosoma cruzi	45%	100%