Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNY2_LEIBR

TriTrypDb:

LbrM.35.1350 , LBRM2903_350019400 , LBRM2903_350019500

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	86	90	PF00656	0.674
CLV_NRD_NRD_1	202	204	PF00675	0.602
CLV_NRD_NRD_1	261	263	PF00675	0.513
CLV_NRD_NRD_1	295	297	PF00675	0.594
CLV_PCSK_KEX2_1	202	204	PF00082	0.455
CLV_PCSK_KEX2_1	261	263	PF00082	0.513
CLV_PCSK_KEX2_1	295	297	PF00082	0.594
CLV_PCSK_SKI1_1	149	153	PF00082	0.523
CLV_PCSK_SKI1_1	257	261	PF00082	0.501
CLV_PCSK_SKI1_1	6	10	PF00082	0.516
DEG_Nend_UBRbox_3	1	3	PF02207	0.519
DEG_SCF_FBW7_1	7	13	PF00400	0.520
DEG_SPOP_SBC_1	105	109	PF00917	0.526
DOC_CKS1_1	125	130	PF01111	0.835
DOC_CKS1_1	7	12	PF01111	0.572
DOC_CYCLIN_RxL_1	285	294	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.520
DOC_MAPK_gen_1	240	250	PF00069	0.528
DOC_MAPK_MEF2A_6	243	250	PF00069	0.522
DOC_MAPK_MEF2A_6	6	14	PF00069	0.520
DOC_MAPK_RevD_3	281	296	PF00069	0.560
DOC_USP7_MATH_1	104	108	PF00917	0.564
DOC_USP7_MATH_1	44	48	PF00917	0.810
DOC_WW_Pin1_4	124	129	PF00397	0.673
DOC_WW_Pin1_4	13	18	PF00397	0.749
DOC_WW_Pin1_4	238	243	PF00397	0.542
DOC_WW_Pin1_4	264	269	PF00397	0.527
DOC_WW_Pin1_4	6	11	PF00397	0.566
DOC_WW_Pin1_4	62	67	PF00397	0.590
LIG_14-3-3_CanoR_1	132	140	PF00244	0.794
LIG_14-3-3_CanoR_1	173	177	PF00244	0.564
LIG_14-3-3_CanoR_1	240	246	PF00244	0.538
LIG_14-3-3_CanoR_1	261	270	PF00244	0.522
LIG_14-3-3_CanoR_1	288	293	PF00244	0.567
LIG_14-3-3_CanoR_1	41	51	PF00244	0.645
LIG_Actin_WH2_2	157	175	PF00022	0.460
LIG_APCC_ABBA_1	81	86	PF00400	0.530
LIG_BRCT_BRCA1_1	14	18	PF00533	0.765
LIG_BRCT_BRCA1_1	23	27	PF00533	0.584
LIG_deltaCOP1_diTrp_1	330	337	PF00928	0.525
LIG_FHA_1	108	114	PF00498	0.554
LIG_FHA_1	133	139	PF00498	0.697
LIG_FHA_1	184	190	PF00498	0.526
LIG_FHA_1	24	30	PF00498	0.410
LIG_FHA_1	258	264	PF00498	0.505
LIG_FHA_1	265	271	PF00498	0.508
LIG_FHA_1	50	56	PF00498	0.539
LIG_FHA_1	7	13	PF00498	0.574
LIG_FHA_2	234	240	PF00498	0.548
LIG_IRF3_LxIS_1	168	175	PF10401	0.441
LIG_IRF3_LxIS_1	8	15	PF10401	0.519
LIG_LIR_Gen_1	158	168	PF02991	0.594
LIG_LIR_Gen_1	169	176	PF02991	0.466
LIG_LIR_Gen_1	9	18	PF02991	0.674
LIG_LIR_Nem_3	158	163	PF02991	0.607
LIG_LIR_Nem_3	169	174	PF02991	0.474
LIG_LIR_Nem_3	224	229	PF02991	0.646
LIG_LIR_Nem_3	274	280	PF02991	0.540
LIG_LIR_Nem_3	334	340	PF02991	0.519
LIG_LIR_Nem_3	9	14	PF02991	0.687
LIG_MYND_3	82	86	PF01753	0.529
LIG_Pex14_2	277	281	PF04695	0.549
LIG_SH2_STAT5	171	174	PF00017	0.715
LIG_SH2_STAT5	188	191	PF00017	0.518
LIG_SH3_3	116	122	PF00018	0.795
LIG_SH3_3	280	286	PF00018	0.543
LIG_SH3_3	4	10	PF00018	0.569
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.524
LIG_SUMO_SIM_par_1	246	251	PF11976	0.512
LIG_TRAF2_1	142	145	PF00917	0.497
LIG_TRAF2_1	90	93	PF00917	0.519
LIG_WW_3	285	289	PF00397	0.549
MOD_CDK_SPK_2	238	243	PF00069	0.542
MOD_CK1_1	107	113	PF00069	0.721
MOD_CK1_1	13	19	PF00069	0.727
MOD_CK1_1	21	27	PF00069	0.562
MOD_CK1_1	264	270	PF00069	0.526
MOD_CK1_1	272	278	PF00069	0.513
MOD_CK1_1	291	297	PF00069	0.523
MOD_CK2_1	147	153	PF00069	0.582
MOD_CK2_1	155	161	PF00069	0.636
MOD_CK2_1	233	239	PF00069	0.546
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.516
MOD_GlcNHglycan	148	152	PF01048	0.591
MOD_GlcNHglycan	18	21	PF01048	0.749
MOD_GlcNHglycan	23	26	PF01048	0.649
MOD_GSK3_1	120	127	PF00069	0.834
MOD_GSK3_1	155	162	PF00069	0.759
MOD_GSK3_1	234	241	PF00069	0.547
MOD_GSK3_1	257	264	PF00069	0.505
MOD_GSK3_1	269	276	PF00069	0.498
MOD_GSK3_1	6	13	PF00069	0.678
MOD_LATS_1	219	225	PF00433	0.442
MOD_N-GLC_1	105	110	PF02516	0.784
MOD_NEK2_1	12	17	PF00069	0.566
MOD_NEK2_1	172	177	PF00069	0.717
MOD_NEK2_1	18	23	PF00069	0.527
MOD_NEK2_1	204	209	PF00069	0.700
MOD_NEK2_1	270	275	PF00069	0.534
MOD_NEK2_1	28	33	PF00069	0.470
MOD_NEK2_1	35	40	PF00069	0.477
MOD_NEK2_2	44	49	PF00069	0.545
MOD_PIKK_1	241	247	PF00454	0.533
MOD_PIKK_1	36	42	PF00454	0.766
MOD_PK_1	221	227	PF00069	0.458
MOD_PK_1	77	83	PF00069	0.525
MOD_PKA_1	261	267	PF00069	0.521
MOD_PKA_2	131	137	PF00069	0.535
MOD_PKA_2	172	178	PF00069	0.452
MOD_PKA_2	261	267	PF00069	0.521
MOD_Plk_1	147	153	PF00069	0.597
MOD_Plk_1	77	83	PF00069	0.731
MOD_Plk_4	159	165	PF00069	0.742
MOD_Plk_4	221	227	PF00069	0.458
MOD_Plk_4	23	29	PF00069	0.518
MOD_Plk_4	77	83	PF00069	0.525
MOD_ProDKin_1	124	130	PF00069	0.672
MOD_ProDKin_1	13	19	PF00069	0.746
MOD_ProDKin_1	238	244	PF00069	0.542
MOD_ProDKin_1	264	270	PF00069	0.526
MOD_ProDKin_1	6	12	PF00069	0.567
MOD_ProDKin_1	62	68	PF00069	0.590
MOD_SUMO_rev_2	249	259	PF00179	0.501
TRG_DiLeu_BaEn_1	92	97	PF01217	0.529
TRG_DiLeu_BaEn_2	217	223	PF01217	0.703
TRG_ENDOCYTIC_2	171	174	PF00928	0.715
TRG_ENDOCYTIC_2	226	229	PF00928	0.760
TRG_ER_diArg_1	202	204	PF00400	0.636
TRG_ER_diArg_1	208	211	PF00400	0.684
TRG_ER_diArg_1	261	263	PF00400	0.513
TRG_ER_diArg_1	295	297	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAI1	Leishmania donovani	53%	69%
A4ICL2	Leishmania infantum	53%	69%
E9ASP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	68%
Q4Q1V4	Leishmania major	51%	69%