Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

GPI alpha-mannosyltransferase III

Species:

Leishmania braziliensis

UniProt:

A4HNY0_LEIBR

TriTrypDb:

LbrM.35.1330 , LBRM2903_350019100

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HNY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNY0

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	12
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	233	235	PF00675	0.249
CLV_NRD_NRD_1	428	430	PF00675	0.288
CLV_NRD_NRD_1	450	452	PF00675	0.425
CLV_NRD_NRD_1	457	459	PF00675	0.428
CLV_PCSK_KEX2_1	233	235	PF00082	0.157
CLV_PCSK_KEX2_1	321	323	PF00082	0.324
CLV_PCSK_KEX2_1	356	358	PF00082	0.345
CLV_PCSK_KEX2_1	428	430	PF00082	0.287
CLV_PCSK_KEX2_1	450	452	PF00082	0.425
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.324
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.404
CLV_PCSK_PC7_1	352	358	PF00082	0.249
CLV_PCSK_SKI1_1	18	22	PF00082	0.226
CLV_PCSK_SKI1_1	269	273	PF00082	0.493
CLV_PCSK_SKI1_1	27	31	PF00082	0.205
CLV_PCSK_SKI1_1	276	280	PF00082	0.509
CLV_PCSK_SKI1_1	357	361	PF00082	0.350
CLV_PCSK_SKI1_1	428	432	PF00082	0.294
CLV_PCSK_SKI1_1	508	512	PF00082	0.530
DEG_MDM2_SWIB_1	431	439	PF02201	0.170
DEG_Nend_UBRbox_2	1	3	PF02207	0.583
DEG_SPOP_SBC_1	145	149	PF00917	0.408
DOC_CDC14_PxL_1	381	389	PF14671	0.322
DOC_CKS1_1	271	276	PF01111	0.256
DOC_CKS1_1	477	482	PF01111	0.265
DOC_CKS1_1	600	605	PF01111	0.246
DOC_CYCLIN_RxL_1	425	432	PF00134	0.517
DOC_CYCLIN_RxL_1	521	533	PF00134	0.241
DOC_CYCLIN_yCln2_LP_2	560	566	PF00134	0.234
DOC_CYCLIN_yCln2_LP_2	587	593	PF00134	0.350
DOC_MAPK_DCC_7	239	249	PF00069	0.357
DOC_MAPK_DCC_7	378	388	PF00069	0.225
DOC_MAPK_gen_1	12	22	PF00069	0.442
DOC_MAPK_gen_1	276	286	PF00069	0.157
DOC_MAPK_gen_1	356	363	PF00069	0.219
DOC_MAPK_gen_1	527	537	PF00069	0.387
DOC_MAPK_MEF2A_6	15	24	PF00069	0.493
DOC_MAPK_MEF2A_6	27	34	PF00069	0.283
DOC_MAPK_MEF2A_6	356	363	PF00069	0.324
DOC_MAPK_MEF2A_6	500	507	PF00069	0.256
DOC_MAPK_NFAT4_5	27	35	PF00069	0.367
DOC_MAPK_RevD_3	221	235	PF00069	0.170
DOC_MAPK_RevD_3	308	322	PF00069	0.159
DOC_PP1_RVXF_1	267	273	PF00149	0.265
DOC_PP1_RVXF_1	274	281	PF00149	0.215
DOC_PP1_RVXF_1	376	383	PF00149	0.324
DOC_PP2B_LxvP_1	419	422	PF13499	0.517
DOC_PP2B_LxvP_1	529	532	PF13499	0.218
DOC_PP4_FxxP_1	382	385	PF00568	0.324
DOC_PP4_FxxP_1	600	603	PF00568	0.251
DOC_PP4_FxxP_1	77	80	PF00568	0.421
DOC_USP7_MATH_1	13	17	PF00917	0.561
DOC_USP7_MATH_1	146	150	PF00917	0.536
DOC_USP7_MATH_1	251	255	PF00917	0.233
DOC_USP7_MATH_1	405	409	PF00917	0.470
DOC_USP7_UBL2_3	546	550	PF12436	0.391
DOC_WW_Pin1_4	138	143	PF00397	0.457
DOC_WW_Pin1_4	270	275	PF00397	0.231
DOC_WW_Pin1_4	332	337	PF00397	0.467
DOC_WW_Pin1_4	36	41	PF00397	0.284
DOC_WW_Pin1_4	450	455	PF00397	0.359
DOC_WW_Pin1_4	476	481	PF00397	0.267
DOC_WW_Pin1_4	599	604	PF00397	0.222
LIG_14-3-3_CanoR_1	12	18	PF00244	0.577
LIG_14-3-3_CanoR_1	198	202	PF00244	0.247
LIG_14-3-3_CanoR_1	213	221	PF00244	0.235
LIG_14-3-3_CanoR_1	407	413	PF00244	0.520
LIG_14-3-3_CanoR_1	416	420	PF00244	0.539
LIG_14-3-3_CanoR_1	428	434	PF00244	0.485
LIG_14-3-3_CanoR_1	57	63	PF00244	0.317
LIG_Actin_RPEL_3	371	390	PF02755	0.279
LIG_Actin_WH2_2	110	127	PF00022	0.484
LIG_Actin_WH2_2	21	37	PF00022	0.194
LIG_BRCT_BRCA1_1	186	190	PF00533	0.300
LIG_BRCT_BRCA1_1	286	290	PF00533	0.159
LIG_BRCT_BRCA1_1	69	73	PF00533	0.265
LIG_deltaCOP1_diTrp_1	462	467	PF00928	0.195
LIG_deltaCOP1_diTrp_1	63	67	PF00928	0.157
LIG_eIF4E_1	337	343	PF01652	0.357
LIG_FHA_1	19	25	PF00498	0.404
LIG_FHA_1	213	219	PF00498	0.229
LIG_FHA_1	398	404	PF00498	0.447
LIG_FHA_1	440	446	PF00498	0.350
LIG_FHA_1	509	515	PF00498	0.217
LIG_FHA_2	579	585	PF00498	0.330
LIG_FHA_2	85	91	PF00498	0.465
LIG_GBD_Chelix_1	184	192	PF00786	0.435
LIG_LIR_Apic_2	474	480	PF02991	0.229
LIG_LIR_Apic_2	70	74	PF02991	0.344
LIG_LIR_Apic_2	8	13	PF02991	0.525
LIG_LIR_Gen_1	376	387	PF02991	0.281
LIG_LIR_Gen_1	414	425	PF02991	0.559
LIG_LIR_Gen_1	479	489	PF02991	0.253
LIG_LIR_Gen_1	48	55	PF02991	0.184
LIG_LIR_Gen_1	61	72	PF02991	0.235
LIG_LIR_Gen_1	610	621	PF02991	0.339
LIG_LIR_LC3C_4	418	421	PF02991	0.357
LIG_LIR_Nem_3	16	20	PF02991	0.561
LIG_LIR_Nem_3	186	192	PF02991	0.267
LIG_LIR_Nem_3	263	267	PF02991	0.263
LIG_LIR_Nem_3	273	278	PF02991	0.282
LIG_LIR_Nem_3	287	292	PF02991	0.239
LIG_LIR_Nem_3	376	382	PF02991	0.311
LIG_LIR_Nem_3	414	420	PF02991	0.559
LIG_LIR_Nem_3	455	460	PF02991	0.330
LIG_LIR_Nem_3	464	470	PF02991	0.324
LIG_LIR_Nem_3	479	485	PF02991	0.239
LIG_LIR_Nem_3	48	54	PF02991	0.217
LIG_LIR_Nem_3	61	67	PF02991	0.243
LIG_LIR_Nem_3	610	616	PF02991	0.411
LIG_LIR_Nem_3	70	76	PF02991	0.285
LIG_MLH1_MIPbox_1	186	190	PF16413	0.300
LIG_MLH1_MIPbox_1	286	290	PF16413	0.176
LIG_NRBOX	187	193	PF00104	0.243
LIG_NRBOX	19	25	PF00104	0.364
LIG_Pex14_2	311	315	PF04695	0.382
LIG_Pex14_2	431	435	PF04695	0.420
LIG_Pex14_2	73	77	PF04695	0.382
LIG_Pex14_2	82	86	PF04695	0.413
LIG_SH2_CRK	181	185	PF00017	0.268
LIG_SH2_CRK	267	271	PF00017	0.317
LIG_SH2_CRK	275	279	PF00017	0.317
LIG_SH2_CRK	477	481	PF00017	0.212
LIG_SH2_CRK	51	55	PF00017	0.239
LIG_SH2_CRK	593	597	PF00017	0.306
LIG_SH2_CRK	71	75	PF00017	0.170
LIG_SH2_GRB2like	181	184	PF00017	0.287
LIG_SH2_NCK_1	181	185	PF00017	0.317
LIG_SH2_NCK_1	369	373	PF00017	0.182
LIG_SH2_NCK_1	477	481	PF00017	0.158
LIG_SH2_SRC	337	340	PF00017	0.357
LIG_SH2_STAP1	181	185	PF00017	0.176
LIG_SH2_STAP1	199	203	PF00017	0.176
LIG_SH2_STAP1	267	271	PF00017	0.235
LIG_SH2_STAT5	264	267	PF00017	0.318
LIG_SH2_STAT5	289	292	PF00017	0.221
LIG_SH2_STAT5	298	301	PF00017	0.244
LIG_SH2_STAT5	381	384	PF00017	0.391
LIG_SH2_STAT5	528	531	PF00017	0.296
LIG_SH2_STAT5	613	616	PF00017	0.340
LIG_SH3_3	240	246	PF00018	0.170
LIG_SH3_3	268	274	PF00018	0.235
LIG_SH3_3	289	295	PF00018	0.288
LIG_SH3_3	492	498	PF00018	0.271
LIG_SH3_3	564	570	PF00018	0.401
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.170
LIG_SUMO_SIM_anti_2	391	397	PF11976	0.394
LIG_SUMO_SIM_anti_2	442	447	PF11976	0.428
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.200
LIG_SUMO_SIM_par_1	165	170	PF11976	0.282
LIG_SUMO_SIM_par_1	2	8	PF11976	0.388
LIG_SUMO_SIM_par_1	245	250	PF11976	0.219
LIG_SUMO_SIM_par_1	385	392	PF11976	0.346
LIG_SUMO_SIM_par_1	394	402	PF11976	0.351
LIG_TRFH_1	381	385	PF08558	0.377
LIG_TRFH_1	7	11	PF08558	0.225
LIG_TYR_ITIM	265	270	PF00017	0.315
LIG_TYR_ITIM	49	54	PF00017	0.250
LIG_UBA3_1	367	375	PF00899	0.170
LIG_UBA3_1	81	85	PF00899	0.437
MOD_CDK_SPxK_1	270	276	PF00069	0.170
MOD_CK1_1	141	147	PF00069	0.350
MOD_CK1_1	149	155	PF00069	0.277
MOD_CK1_1	332	338	PF00069	0.349
MOD_CK1_1	347	353	PF00069	0.376
MOD_CK1_1	401	407	PF00069	0.465
MOD_CK1_1	408	414	PF00069	0.374
MOD_CK1_1	423	429	PF00069	0.180
MOD_CK2_1	36	42	PF00069	0.268
MOD_CK2_1	578	584	PF00069	0.432
MOD_GlcNHglycan	132	135	PF01048	0.306
MOD_GlcNHglycan	143	146	PF01048	0.403
MOD_GlcNHglycan	148	151	PF01048	0.322
MOD_GlcNHglycan	249	252	PF01048	0.413
MOD_GlcNHglycan	255	258	PF01048	0.400
MOD_GlcNHglycan	331	334	PF01048	0.397
MOD_GlcNHglycan	403	406	PF01048	0.416
MOD_GlcNHglycan	422	425	PF01048	0.373
MOD_GSK3_1	136	143	PF00069	0.383
MOD_GSK3_1	145	152	PF00069	0.232
MOD_GSK3_1	155	162	PF00069	0.311
MOD_GSK3_1	247	254	PF00069	0.308
MOD_GSK3_1	341	348	PF00069	0.441
MOD_GSK3_1	397	404	PF00069	0.390
MOD_GSK3_1	407	414	PF00069	0.419
MOD_GSK3_1	615	622	PF00069	0.324
MOD_GSK3_1	84	91	PF00069	0.377
MOD_N-GLC_1	173	178	PF02516	0.170
MOD_N-GLC_2	99	101	PF02516	0.194
MOD_NEK2_1	128	133	PF00069	0.331
MOD_NEK2_1	173	178	PF00069	0.317
MOD_NEK2_1	190	195	PF00069	0.320
MOD_NEK2_1	247	252	PF00069	0.238
MOD_NEK2_1	284	289	PF00069	0.409
MOD_NEK2_1	30	35	PF00069	0.279
MOD_NEK2_1	343	348	PF00069	0.429
MOD_NEK2_1	367	372	PF00069	0.352
MOD_NEK2_1	388	393	PF00069	0.347
MOD_NEK2_1	398	403	PF00069	0.310
MOD_NEK2_1	576	581	PF00069	0.385
MOD_NEK2_1	67	72	PF00069	0.170
MOD_NEK2_1	84	89	PF00069	0.358
MOD_NEK2_2	197	202	PF00069	0.170
MOD_PKA_1	546	552	PF00069	0.367
MOD_PKA_2	197	203	PF00069	0.296
MOD_PKA_2	212	218	PF00069	0.235
MOD_PKA_2	406	412	PF00069	0.387
MOD_PKA_2	415	421	PF00069	0.210
MOD_Plk_1	110	116	PF00069	0.394
MOD_Plk_1	338	344	PF00069	0.221
MOD_Plk_4	110	116	PF00069	0.444
MOD_Plk_4	18	24	PF00069	0.237
MOD_Plk_4	184	190	PF00069	0.369
MOD_Plk_4	197	203	PF00069	0.328
MOD_Plk_4	2	8	PF00069	0.460
MOD_Plk_4	338	344	PF00069	0.393
MOD_Plk_4	362	368	PF00069	0.323
MOD_Plk_4	389	395	PF00069	0.355
MOD_Plk_4	452	458	PF00069	0.421
MOD_Plk_4	91	97	PF00069	0.385
MOD_ProDKin_1	138	144	PF00069	0.310
MOD_ProDKin_1	270	276	PF00069	0.274
MOD_ProDKin_1	332	338	PF00069	0.324
MOD_ProDKin_1	36	42	PF00069	0.284
MOD_ProDKin_1	450	456	PF00069	0.453
MOD_ProDKin_1	476	482	PF00069	0.324
MOD_ProDKin_1	599	605	PF00069	0.261
MOD_SUMO_rev_2	370	377	PF00179	0.371
MOD_SUMO_rev_2	539	549	PF00179	0.427
TRG_DiLeu_BaEn_2	185	191	PF01217	0.315
TRG_DiLeu_BaEn_2	219	225	PF01217	0.170
TRG_DiLeu_BaEn_2	62	68	PF01217	0.170
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.394
TRG_ENDOCYTIC_2	181	184	PF00928	0.318
TRG_ENDOCYTIC_2	199	202	PF00928	0.309
TRG_ENDOCYTIC_2	267	270	PF00928	0.310
TRG_ENDOCYTIC_2	275	278	PF00928	0.314
TRG_ENDOCYTIC_2	289	292	PF00928	0.311
TRG_ENDOCYTIC_2	296	299	PF00928	0.256
TRG_ENDOCYTIC_2	369	372	PF00928	0.260
TRG_ENDOCYTIC_2	381	384	PF00928	0.225
TRG_ENDOCYTIC_2	51	54	PF00928	0.254
TRG_ENDOCYTIC_2	528	531	PF00928	0.333
TRG_ENDOCYTIC_2	593	596	PF00928	0.363
TRG_ENDOCYTIC_2	613	616	PF00928	0.406
TRG_ER_diArg_1	428	430	PF00400	0.346
TRG_ER_diArg_1	449	451	PF00400	0.310
TRG_NES_CRM1_1	484	496	PF08389	0.314
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.229
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.170

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q8	Leptomonas seymouri	55%	100%
A0A0S4J7A7	Bodo saltans	31%	100%
A0A1X0P926	Trypanosomatidae	33%	100%
A0A3Q8IJ48	Leishmania donovani	70%	99%
A0A422NTW3	Trypanosoma rangeli	33%	100%
A4ICL4	Leishmania infantum	70%	99%
D0A2U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
P30777	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P86935	Trypanosoma brucei brucei	34%	100%
P86936	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	35%	100%
Q1LZA0	Bos taurus	23%	100%
Q4Q1V6	Leishmania major	67%	100%
Q4V7R2	Xenopus laevis	24%	100%
Q6CN76	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6FTY5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q94A15	Arabidopsis thaliana	25%	100%
Q9JJQ0	Mus musculus	23%	100%
Q9VZM5	Drosophila melanogaster	25%	100%
V5DRF7	Trypanosoma cruzi	34%	100%