Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNX8_LEIBR

TriTrypDb:

LbrM.35.1310 , LBRM2903_350018900

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	267	269	PF00675	0.525
CLV_PCSK_KEX2_1	267	269	PF00082	0.456
CLV_PCSK_SKI1_1	268	272	PF00082	0.539
CLV_PCSK_SKI1_1	6	10	PF00082	0.504
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DEG_SCF_FBW7_1	30	35	PF00400	0.317
DOC_CYCLIN_RxL_1	149	158	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.412
DOC_MAPK_gen_1	70	78	PF00069	0.495
DOC_MAPK_MEF2A_6	142	151	PF00069	0.566
DOC_MAPK_MEF2A_6	70	78	PF00069	0.390
DOC_MAPK_MEF2A_6	89	98	PF00069	0.392
DOC_PP2B_LxvP_1	189	192	PF13499	0.429
DOC_PP4_FxxP_1	79	82	PF00568	0.531
DOC_USP7_MATH_1	155	159	PF00917	0.610
DOC_USP7_MATH_1	216	220	PF00917	0.489
DOC_USP7_MATH_1	237	241	PF00917	0.520
DOC_USP7_MATH_1	82	86	PF00917	0.503
DOC_WW_Pin1_4	143	148	PF00397	0.544
DOC_WW_Pin1_4	28	33	PF00397	0.445
DOC_WW_Pin1_4	41	46	PF00397	0.416
LIG_14-3-3_CanoR_1	238	244	PF00244	0.323
LIG_14-3-3_CanoR_1	51	55	PF00244	0.488
LIG_Actin_WH2_2	35	53	PF00022	0.438
LIG_BRCT_BRCA1_1	230	234	PF00533	0.536
LIG_FHA_1	100	106	PF00498	0.521
LIG_FHA_1	123	129	PF00498	0.476
LIG_FHA_1	144	150	PF00498	0.547
LIG_FHA_1	177	183	PF00498	0.728
LIG_FHA_1	271	277	PF00498	0.481
LIG_FHA_1	89	95	PF00498	0.509
LIG_FHA_2	163	169	PF00498	0.623
LIG_FHA_2	317	323	PF00498	0.639
LIG_LIR_Gen_1	100	107	PF02991	0.418
LIG_LIR_Gen_1	219	227	PF02991	0.528
LIG_LIR_Gen_1	266	277	PF02991	0.408
LIG_LIR_Gen_1	35	43	PF02991	0.500
LIG_LIR_LC3C_4	125	129	PF02991	0.550
LIG_LIR_Nem_3	100	104	PF02991	0.411
LIG_LIR_Nem_3	201	206	PF02991	0.493
LIG_LIR_Nem_3	219	224	PF02991	0.384
LIG_LIR_Nem_3	266	272	PF02991	0.404
LIG_LIR_Nem_3	35	39	PF02991	0.491
LIG_PCNA_yPIPBox_3	61	75	PF02747	0.441
LIG_REV1ctd_RIR_1	14	24	PF16727	0.583
LIG_SH2_SRC	75	78	PF00017	0.500
LIG_SH2_STAP1	101	105	PF00017	0.553
LIG_SH2_STAT5	101	104	PF00017	0.434
LIG_SH2_STAT5	75	78	PF00017	0.500
LIG_SH3_2	147	152	PF14604	0.587
LIG_SH3_3	144	150	PF00018	0.526
LIG_SH3_3	255	261	PF00018	0.435
LIG_SH3_3	273	279	PF00018	0.258
LIG_SH3_3	39	45	PF00018	0.578
LIG_SH3_3	71	77	PF00018	0.396
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.510
LIG_SUMO_SIM_anti_2	60	67	PF11976	0.482
LIG_SUMO_SIM_par_1	125	131	PF11976	0.543
LIG_SUMO_SIM_par_1	60	67	PF11976	0.453
LIG_TRAF2_1	165	168	PF00917	0.477
LIG_TRAF2_1	239	242	PF00917	0.308
LIG_TRFH_1	28	32	PF08558	0.568
LIG_WRC_WIRS_1	138	143	PF05994	0.529
MOD_CDK_SPK_2	41	46	PF00069	0.491
MOD_CDK_SPxxK_3	41	48	PF00069	0.482
MOD_CK1_1	228	234	PF00069	0.484
MOD_CK1_1	57	63	PF00069	0.469
MOD_CK2_1	162	168	PF00069	0.473
MOD_CK2_1	236	242	PF00069	0.467
MOD_CK2_1	246	252	PF00069	0.336
MOD_GlcNHglycan	108	111	PF01048	0.596
MOD_GlcNHglycan	11	14	PF01048	0.456
MOD_GlcNHglycan	173	176	PF01048	0.719
MOD_GlcNHglycan	179	182	PF01048	0.698
MOD_GlcNHglycan	252	255	PF01048	0.640
MOD_GlcNHglycan	303	306	PF01048	0.552
MOD_GlcNHglycan	54	57	PF01048	0.595
MOD_GSK3_1	118	125	PF00069	0.660
MOD_GSK3_1	173	180	PF00069	0.724
MOD_GSK3_1	225	232	PF00069	0.434
MOD_GSK3_1	246	253	PF00069	0.484
MOD_GSK3_1	28	35	PF00069	0.428
MOD_GSK3_1	316	323	PF00069	0.519
MOD_GSK3_1	324	331	PF00069	0.680
MOD_GSK3_1	37	44	PF00069	0.436
MOD_GSK3_1	50	57	PF00069	0.486
MOD_N-GLC_1	28	33	PF02516	0.524
MOD_N-GLC_2	207	209	PF02516	0.573
MOD_NEK2_1	177	182	PF00069	0.680
MOD_NEK2_1	2	7	PF00069	0.640
MOD_NEK2_1	50	55	PF00069	0.460
MOD_NEK2_1	9	14	PF00069	0.514
MOD_NEK2_2	137	142	PF00069	0.524
MOD_NEK2_2	173	178	PF00069	0.498
MOD_PIKK_1	162	168	PF00454	0.716
MOD_PIKK_1	64	70	PF00454	0.471
MOD_PKA_2	225	231	PF00069	0.525
MOD_PKA_2	237	243	PF00069	0.271
MOD_PKA_2	307	313	PF00069	0.486
MOD_PKA_2	324	330	PF00069	0.593
MOD_PKA_2	50	56	PF00069	0.459
MOD_Plk_1	119	125	PF00069	0.615
MOD_Plk_1	99	105	PF00069	0.500
MOD_Plk_4	122	128	PF00069	0.501
MOD_Plk_4	155	161	PF00069	0.621
MOD_Plk_4	181	187	PF00069	0.706
MOD_Plk_4	217	223	PF00069	0.396
MOD_Plk_4	307	313	PF00069	0.400
MOD_Plk_4	38	44	PF00069	0.443
MOD_ProDKin_1	143	149	PF00069	0.539
MOD_ProDKin_1	28	34	PF00069	0.445
MOD_ProDKin_1	41	47	PF00069	0.410
MOD_SUMO_rev_2	158	165	PF00179	0.461
MOD_SUMO_rev_2	205	212	PF00179	0.319
TRG_DiLeu_BaEn_2	99	105	PF01217	0.305
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.729
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.428
TRG_ENDOCYTIC_2	101	104	PF00928	0.404
TRG_ENDOCYTIC_2	138	141	PF00928	0.515
TRG_ENDOCYTIC_2	203	206	PF00928	0.559
TRG_ENDOCYTIC_2	36	39	PF00928	0.506
TRG_ENDOCYTIC_2	75	78	PF00928	0.388
TRG_ER_diArg_1	267	269	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC55	Leptomonas seymouri	41%	100%
A0A1X0P8C4	Trypanosomatidae	29%	100%
A0A3S7XAI8	Leishmania donovani	75%	100%
A0A422NTW5	Trypanosoma rangeli	31%	100%
A4ICL6	Leishmania infantum	75%	100%
D0A2U4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ASN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q1V8	Leishmania major	75%	100%
V5BZS0	Trypanosoma cruzi	33%	100%