Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNX7_LEIBR

TriTrypDb:

LbrM.35.1300 , LBRM2903_350018800

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HNX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.633
CLV_C14_Caspase3-7	252	256	PF00656	0.582
CLV_C14_Caspase3-7	466	470	PF00656	0.603
CLV_C14_Caspase3-7	87	91	PF00656	0.728
CLV_NRD_NRD_1	101	103	PF00675	0.438
CLV_NRD_NRD_1	276	278	PF00675	0.434
CLV_NRD_NRD_1	318	320	PF00675	0.505
CLV_NRD_NRD_1	328	330	PF00675	0.508
CLV_NRD_NRD_1	4	6	PF00675	0.525
CLV_NRD_NRD_1	422	424	PF00675	0.366
CLV_NRD_NRD_1	479	481	PF00675	0.359
CLV_NRD_NRD_1	491	493	PF00675	0.304
CLV_NRD_NRD_1	557	559	PF00675	0.436
CLV_NRD_NRD_1	631	633	PF00675	0.460
CLV_PCSK_KEX2_1	101	103	PF00082	0.438
CLV_PCSK_KEX2_1	276	278	PF00082	0.434
CLV_PCSK_KEX2_1	317	319	PF00082	0.435
CLV_PCSK_KEX2_1	322	324	PF00082	0.546
CLV_PCSK_KEX2_1	328	330	PF00082	0.544
CLV_PCSK_KEX2_1	4	6	PF00082	0.523
CLV_PCSK_KEX2_1	421	423	PF00082	0.386
CLV_PCSK_KEX2_1	479	481	PF00082	0.382
CLV_PCSK_KEX2_1	491	493	PF00082	0.377
CLV_PCSK_KEX2_1	557	559	PF00082	0.436
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.435
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.546
CLV_PCSK_PC7_1	314	320	PF00082	0.409
CLV_PCSK_SKI1_1	151	155	PF00082	0.298
CLV_PCSK_SKI1_1	276	280	PF00082	0.433
CLV_PCSK_SKI1_1	299	303	PF00082	0.536
CLV_PCSK_SKI1_1	322	326	PF00082	0.502
CLV_PCSK_SKI1_1	422	426	PF00082	0.388
CLV_PCSK_SKI1_1	492	496	PF00082	0.344
CLV_PCSK_SKI1_1	564	568	PF00082	0.356
DEG_Nend_UBRbox_1	1	4	PF02207	0.749
DEG_ODPH_VHL_1	605	617	PF01847	0.425
DEG_SCF_FBW7_2	265	272	PF00400	0.660
DOC_ANK_TNKS_1	58	65	PF00023	0.808
DOC_CKS1_1	266	271	PF01111	0.566
DOC_CYCLIN_RxL_1	391	401	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	499	505	PF00134	0.604
DOC_MAPK_DCC_7	360	369	PF00069	0.612
DOC_MAPK_gen_1	151	160	PF00069	0.504
DOC_MAPK_gen_1	317	326	PF00069	0.624
DOC_MAPK_gen_1	557	567	PF00069	0.593
DOC_MAPK_HePTP_8	554	569	PF00069	0.687
DOC_MAPK_MEF2A_6	561	569	PF00069	0.556
DOC_PP1_RVXF_1	307	313	PF00149	0.591
DOC_PP1_RVXF_1	490	497	PF00149	0.641
DOC_PP2B_LxvP_1	158	161	PF13499	0.680
DOC_PP2B_LxvP_1	324	327	PF13499	0.637
DOC_PP4_FxxP_1	424	427	PF00568	0.573
DOC_SPAK_OSR1_1	507	511	PF12202	0.653
DOC_USP7_MATH_1	278	282	PF00917	0.640
DOC_USP7_MATH_1	359	363	PF00917	0.585
DOC_USP7_MATH_1	72	76	PF00917	0.767
DOC_WW_Pin1_4	265	270	PF00397	0.555
DOC_WW_Pin1_4	332	337	PF00397	0.622
DOC_WW_Pin1_4	398	403	PF00397	0.528
LIG_14-3-3_CanoR_1	107	112	PF00244	0.635
LIG_14-3-3_CanoR_1	216	224	PF00244	0.587
LIG_14-3-3_CanoR_1	318	326	PF00244	0.626
LIG_14-3-3_CanoR_1	360	364	PF00244	0.628
LIG_14-3-3_CanoR_1	415	424	PF00244	0.659
LIG_14-3-3_CanoR_1	51	56	PF00244	0.777
LIG_14-3-3_CanoR_1	632	636	PF00244	0.687
LIG_Actin_WH2_2	548	566	PF00022	0.631
LIG_AP2alpha_1	504	508	PF02296	0.664
LIG_APCC_ABBA_1	27	32	PF00400	0.626
LIG_APCC_ABBA_1	371	376	PF00400	0.538
LIG_BRCT_BRCA1_1	2	6	PF00533	0.659
LIG_Clathr_ClatBox_1	116	120	PF01394	0.682
LIG_deltaCOP1_diTrp_1	124	128	PF00928	0.611
LIG_EH1_1	427	435	PF00400	0.623
LIG_eIF4E_1	260	266	PF01652	0.512
LIG_FHA_1	144	150	PF00498	0.616
LIG_FHA_1	190	196	PF00498	0.759
LIG_FHA_1	216	222	PF00498	0.542
LIG_FHA_1	248	254	PF00498	0.738
LIG_FHA_1	266	272	PF00498	0.483
LIG_FHA_1	319	325	PF00498	0.626
LIG_FHA_1	32	38	PF00498	0.622
LIG_FHA_1	341	347	PF00498	0.643
LIG_FHA_1	405	411	PF00498	0.720
LIG_FHA_1	485	491	PF00498	0.462
LIG_FHA_1	537	543	PF00498	0.569
LIG_FHA_1	618	624	PF00498	0.439
LIG_FHA_1	635	641	PF00498	0.644
LIG_FHA_2	168	174	PF00498	0.633
LIG_FHA_2	283	289	PF00498	0.832
LIG_FHA_2	378	384	PF00498	0.543
LIG_IRF3_LxIS_1	220	227	PF10401	0.615
LIG_LIR_Apic_2	173	178	PF02991	0.647
LIG_LIR_Gen_1	136	143	PF02991	0.652
LIG_LIR_Gen_1	20	29	PF02991	0.647
LIG_LIR_Gen_1	258	266	PF02991	0.595
LIG_LIR_Gen_1	383	393	PF02991	0.564
LIG_LIR_Gen_1	493	504	PF02991	0.647
LIG_LIR_Gen_1	75	81	PF02991	0.672
LIG_LIR_Nem_3	124	129	PF02991	0.526
LIG_LIR_Nem_3	136	142	PF02991	0.601
LIG_LIR_Nem_3	20	24	PF02991	0.667
LIG_LIR_Nem_3	258	263	PF02991	0.601
LIG_LIR_Nem_3	493	499	PF02991	0.636
LIG_LIR_Nem_3	75	79	PF02991	0.671
LIG_PCNA_PIPBox_1	435	444	PF02747	0.597
LIG_PDZ_Class_2	636	641	PF00595	0.757
LIG_Pex14_2	308	312	PF04695	0.588
LIG_Pex14_2	424	428	PF04695	0.588
LIG_Pex14_2	504	508	PF04695	0.664
LIG_PTB_Apo_2	55	62	PF02174	0.745
LIG_SH2_CRK	139	143	PF00017	0.651
LIG_SH2_CRK	21	25	PF00017	0.687
LIG_SH2_PTP2	260	263	PF00017	0.584
LIG_SH2_SRC	28	31	PF00017	0.667
LIG_SH2_STAP1	139	143	PF00017	0.651
LIG_SH2_STAP1	412	416	PF00017	0.734
LIG_SH2_STAP1	586	590	PF00017	0.422
LIG_SH2_STAT3	152	155	PF00017	0.648
LIG_SH2_STAT5	152	155	PF00017	0.625
LIG_SH2_STAT5	21	24	PF00017	0.658
LIG_SH2_STAT5	236	239	PF00017	0.634
LIG_SH2_STAT5	260	263	PF00017	0.545
LIG_SH2_STAT5	28	31	PF00017	0.628
LIG_SH2_STAT5	412	415	PF00017	0.728
LIG_SH2_STAT5	618	621	PF00017	0.501
LIG_SH2_STAT5	76	79	PF00017	0.664
LIG_SH3_3	100	106	PF00018	0.635
LIG_SH3_3	174	180	PF00018	0.760
LIG_SH3_3	191	197	PF00018	0.660
LIG_SH3_3	360	366	PF00018	0.645
LIG_SH3_3	507	513	PF00018	0.608
LIG_SH3_3	587	593	PF00018	0.442
LIG_Sin3_3	368	375	PF02671	0.624
LIG_SUMO_SIM_par_1	209	215	PF11976	0.505
LIG_SUMO_SIM_par_1	34	40	PF11976	0.499
LIG_SUMO_SIM_par_1	376	383	PF11976	0.490
LIG_SUMO_SIM_par_1	538	543	PF11976	0.567
LIG_SUMO_SIM_par_1	578	584	PF11976	0.364
LIG_UBA3_1	149	157	PF00899	0.496
LIG_UBA3_1	378	384	PF00899	0.581
LIG_WRC_WIRS_1	618	623	PF05994	0.320
LIG_WW_3	104	108	PF00397	0.798
MOD_CK1_1	166	172	PF00069	0.794
MOD_CK1_1	184	190	PF00069	0.813
MOD_CK1_1	227	233	PF00069	0.578
MOD_CK1_1	247	253	PF00069	0.526
MOD_CK1_1	281	287	PF00069	0.708
MOD_CK1_1	31	37	PF00069	0.641
MOD_CK1_1	634	640	PF00069	0.732
MOD_CK1_1	88	94	PF00069	0.684
MOD_CK2_1	167	173	PF00069	0.637
MOD_CK2_1	282	288	PF00069	0.721
MOD_CK2_1	342	348	PF00069	0.632
MOD_CK2_1	377	383	PF00069	0.499
MOD_CK2_1	398	404	PF00069	0.499
MOD_Cter_Amidation	274	277	PF01082	0.499
MOD_GlcNHglycan	109	112	PF01048	0.571
MOD_GlcNHglycan	257	260	PF01048	0.388
MOD_GlcNHglycan	280	283	PF01048	0.488
MOD_GlcNHglycan	38	42	PF01048	0.499
MOD_GlcNHglycan	90	94	PF01048	0.487
MOD_GSK3_1	107	114	PF00069	0.744
MOD_GSK3_1	159	166	PF00069	0.639
MOD_GSK3_1	182	189	PF00069	0.816
MOD_GSK3_1	206	213	PF00069	0.594
MOD_GSK3_1	235	242	PF00069	0.623
MOD_GSK3_1	247	254	PF00069	0.711
MOD_GSK3_1	277	284	PF00069	0.769
MOD_GSK3_1	289	296	PF00069	0.787
MOD_GSK3_1	410	417	PF00069	0.570
MOD_GSK3_1	536	543	PF00069	0.554
MOD_GSK3_1	84	91	PF00069	0.793
MOD_LATS_1	49	55	PF00433	0.596
MOD_N-GLC_1	143	148	PF02516	0.329
MOD_N-GLC_1	57	62	PF02516	0.552
MOD_NEK2_1	19	24	PF00069	0.669
MOD_NEK2_1	235	240	PF00069	0.628
MOD_NEK2_1	410	415	PF00069	0.663
MOD_NEK2_1	428	433	PF00069	0.595
MOD_NEK2_1	495	500	PF00069	0.519
MOD_NEK2_1	540	545	PF00069	0.555
MOD_NEK2_2	377	382	PF00069	0.528
MOD_NEK2_2	486	491	PF00069	0.465
MOD_PIKK_1	215	221	PF00454	0.635
MOD_PIKK_1	224	230	PF00454	0.667
MOD_PIKK_1	244	250	PF00454	0.489
MOD_PKA_1	276	282	PF00069	0.637
MOD_PKA_1	317	323	PF00069	0.751
MOD_PKA_1	422	428	PF00069	0.583
MOD_PKA_2	215	221	PF00069	0.652
MOD_PKA_2	276	282	PF00069	0.637
MOD_PKA_2	317	323	PF00069	0.619
MOD_PKA_2	359	365	PF00069	0.634
MOD_PKA_2	414	420	PF00069	0.692
MOD_PKA_2	422	428	PF00069	0.578
MOD_PKA_2	536	542	PF00069	0.569
MOD_PKA_2	631	637	PF00069	0.662
MOD_Plk_1	133	139	PF00069	0.491
MOD_Plk_1	19	25	PF00069	0.702
MOD_Plk_1	57	63	PF00069	0.753
MOD_Plk_4	19	25	PF00069	0.650
MOD_Plk_4	428	434	PF00069	0.531
MOD_Plk_4	495	501	PF00069	0.521
MOD_Plk_4	51	57	PF00069	0.727
MOD_Plk_4	581	587	PF00069	0.523
MOD_Plk_4	72	78	PF00069	0.680
MOD_ProDKin_1	265	271	PF00069	0.562
MOD_ProDKin_1	332	338	PF00069	0.622
MOD_ProDKin_1	398	404	PF00069	0.535
MOD_SUMO_rev_2	227	233	PF00179	0.668
MOD_SUMO_rev_2	88	97	PF00179	0.629
TRG_DiLeu_BaEn_2	123	129	PF01217	0.620
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.690
TRG_ENDOCYTIC_2	139	142	PF00928	0.653
TRG_ENDOCYTIC_2	21	24	PF00928	0.658
TRG_ENDOCYTIC_2	260	263	PF00928	0.584
TRG_ENDOCYTIC_2	618	621	PF00928	0.430
TRG_ENDOCYTIC_2	76	79	PF00928	0.664
TRG_ER_diArg_1	101	103	PF00400	0.638
TRG_ER_diArg_1	327	329	PF00400	0.642
TRG_ER_diArg_1	4	6	PF00400	0.665
TRG_ER_diArg_1	420	423	PF00400	0.592
TRG_ER_diArg_1	478	480	PF00400	0.609
TRG_ER_diArg_1	490	492	PF00400	0.595
TRG_ER_diArg_1	556	558	PF00400	0.641
TRG_NLS_MonoExtN_4	319	326	PF00514	0.737
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWZ8	Leptomonas seymouri	55%	97%
A0A3S7XAL7	Leishmania donovani	72%	100%
A4ICL7	Leishmania infantum	72%	100%
D0A2U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ASN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q1V9	Leishmania major	72%	98%