Protein MEMO1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein MEMO1

Gene product:

AmmeMemoRadiSam system protein B, putative

Species:

Leishmania braziliensis

UniProt:

A4HNX6_LEIBR

TriTrypDb:

LbrM.35.1290 , LBRM2903_350018700

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.319
CLV_NRD_NRD_1	261	263	PF00675	0.365
CLV_PCSK_KEX2_1	146	148	PF00082	0.367
CLV_PCSK_KEX2_1	261	263	PF00082	0.302
CLV_PCSK_SKI1_1	129	133	PF00082	0.329
CLV_PCSK_SKI1_1	214	218	PF00082	0.319
CLV_PCSK_SKI1_1	34	38	PF00082	0.288
CLV_PCSK_SKI1_1	5	9	PF00082	0.456
DEG_SCF_FBW7_1	157	163	PF00400	0.395
DOC_CKS1_1	113	118	PF01111	0.310
DOC_CKS1_1	157	162	PF01111	0.395
DOC_MAPK_DCC_7	183	191	PF00069	0.310
DOC_MAPK_gen_1	84	93	PF00069	0.340
DOC_MAPK_MEF2A_6	183	191	PF00069	0.310
DOC_MAPK_MEF2A_6	281	288	PF00069	0.285
DOC_PP2B_LxvP_1	53	56	PF13499	0.395
DOC_USP7_MATH_1	142	146	PF00917	0.369
DOC_USP7_MATH_1	151	155	PF00917	0.313
DOC_USP7_MATH_1	182	186	PF00917	0.368
DOC_USP7_MATH_1	58	62	PF00917	0.370
DOC_USP7_MATH_1	80	84	PF00917	0.355
DOC_USP7_UBL2_3	297	301	PF12436	0.356
DOC_WW_Pin1_4	112	117	PF00397	0.266
DOC_WW_Pin1_4	156	161	PF00397	0.380
LIG_14-3-3_CanoR_1	229	235	PF00244	0.344
LIG_14-3-3_CanoR_1	5	12	PF00244	0.328
LIG_Actin_WH2_2	18	36	PF00022	0.181
LIG_APCC_ABBA_1	206	211	PF00400	0.356
LIG_APCC_ABBA_1	71	76	PF00400	0.395
LIG_BRCT_BRCA1_1	219	223	PF00533	0.266
LIG_FHA_1	122	128	PF00498	0.344
LIG_FHA_1	157	163	PF00498	0.380
LIG_FHA_2	26	32	PF00498	0.317
LIG_FHA_2	64	70	PF00498	0.395
LIG_LIR_Apic_2	111	116	PF02991	0.346
LIG_LIR_Gen_1	69	79	PF02991	0.346
LIG_LIR_Nem_3	114	120	PF02991	0.289
LIG_LIR_Nem_3	239	244	PF02991	0.287
LIG_LIR_Nem_3	265	271	PF02991	0.344
LIG_LIR_Nem_3	69	74	PF02991	0.346
LIG_LYPXL_yS_3	241	244	PF13949	0.285
LIG_PCNA_TLS_4	26	33	PF02747	0.395
LIG_PDZ_Class_2	323	328	PF00595	0.208
LIG_Pex14_1	226	230	PF04695	0.266
LIG_Pex14_2	219	223	PF04695	0.351
LIG_SH2_CRK	268	272	PF00017	0.310
LIG_SH2_NCK_1	113	117	PF00017	0.310
LIG_SH2_NCK_1	18	22	PF00017	0.395
LIG_SH2_SRC	77	80	PF00017	0.285
LIG_SH2_STAP1	232	236	PF00017	0.355
LIG_SH2_STAP1	321	325	PF00017	0.310
LIG_SH2_STAT3	234	237	PF00017	0.224
LIG_SH2_STAT5	161	164	PF00017	0.354
LIG_SH2_STAT5	232	235	PF00017	0.357
LIG_SH2_STAT5	270	273	PF00017	0.293
LIG_SH2_STAT5	32	35	PF00017	0.411
LIG_SH2_STAT5	77	80	PF00017	0.292
LIG_SH3_1	113	119	PF00018	0.255
LIG_SH3_2	116	121	PF14604	0.349
LIG_SH3_3	113	119	PF00018	0.255
LIG_SH3_3	202	208	PF00018	0.395
LIG_TRFH_1	92	96	PF08558	0.285
MOD_CK1_1	108	114	PF00069	0.395
MOD_CK1_1	145	151	PF00069	0.395
MOD_CK1_1	317	323	PF00069	0.271
MOD_CK1_1	63	69	PF00069	0.266
MOD_CK1_1	83	89	PF00069	0.341
MOD_CK2_1	108	114	PF00069	0.395
MOD_CK2_1	63	69	PF00069	0.395
MOD_CK2_1	83	89	PF00069	0.336
MOD_GlcNHglycan	106	110	PF01048	0.286
MOD_GlcNHglycan	5	8	PF01048	0.502
MOD_GlcNHglycan	62	65	PF01048	0.266
MOD_GSK3_1	108	115	PF00069	0.395
MOD_GSK3_1	156	163	PF00069	0.375
MOD_GSK3_1	170	177	PF00069	0.420
MOD_GSK3_1	270	277	PF00069	0.232
MOD_GSK3_1	310	317	PF00069	0.260
MOD_N-GLC_2	309	311	PF02516	0.266
MOD_NEK2_1	230	235	PF00069	0.344
MOD_NEK2_1	271	276	PF00069	0.285
MOD_NEK2_1	3	8	PF00069	0.299
MOD_NEK2_1	60	65	PF00069	0.344
MOD_PIKK_1	174	180	PF00454	0.181
MOD_PIKK_1	236	242	PF00454	0.224
MOD_PIKK_1	303	309	PF00454	0.300
MOD_PK_1	310	316	PF00069	0.379
MOD_PKA_2	145	151	PF00069	0.288
MOD_PKA_2	182	188	PF00069	0.288
MOD_PKA_2	228	234	PF00069	0.399
MOD_PKA_2	271	277	PF00069	0.301
MOD_Plk_1	151	157	PF00069	0.287
MOD_Plk_1	314	320	PF00069	0.269
MOD_Plk_2-3	123	129	PF00069	0.279
MOD_Plk_4	182	188	PF00069	0.310
MOD_Plk_4	244	250	PF00069	0.395
MOD_ProDKin_1	112	118	PF00069	0.266
MOD_ProDKin_1	156	162	PF00069	0.380
TRG_ENDOCYTIC_2	18	21	PF00928	0.395
TRG_ENDOCYTIC_2	241	244	PF00928	0.285
TRG_ENDOCYTIC_2	268	271	PF00928	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG9	Leptomonas seymouri	71%	100%
A0A1X0P836	Trypanosomatidae	49%	100%
A0A3Q8IIU9	Leishmania donovani	84%	89%
A0A422NTW6	Trypanosoma rangeli	49%	100%
A1RTJ4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	23%	100%
A3MS51	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	24%	100%
A4FWD2	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	24%	100%
A4ICL8	Leishmania infantum	84%	89%
A4WH12	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	24%	100%
A4YIM6	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	22%	100%
A5UN65	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	27%	100%
A6UQ31	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	26%	100%
A6VGX3	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	24%	100%
A8AB69	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	25%	100%
A8M9U2	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	23%	100%
A9A2Y3	Nitrosopumilus maritimus (strain SCM1)	23%	100%
A9A9S6	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	24%	100%
B6YST0	Thermococcus onnurineus (strain NA1)	25%	100%
B8D6F2	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	24%	100%
B9K748	Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)	23%	100%
C3MJQ3	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	25%	100%
C3MZ11	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	25%	100%
C3N060	Sulfolobus islandicus (strain M.16.27)	25%	100%
C3N8S4	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	25%	100%
C3NMP4	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	25%	100%
C4KJ99	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	25%	100%
C5A7L6	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	25%	100%
D0A2U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ASN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	89%
O26151	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	24%	100%
O27974	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	25%	100%
O59292	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	25%	100%
O67039	Aquifex aeolicus (strain VF5)	23%	100%
P47085	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	97%
P61652	Methanococcus maripaludis (strain S2 / LL)	25%	100%
P95994	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	100%
Q10212	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q22915	Caenorhabditis elegans	36%	94%
Q2HJH7	Bos taurus	34%	100%
Q46CL1	Methanosarcina barkeri (strain Fusaro / DSM 804)	24%	100%
Q4JCG3	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	100%
Q4Q1W0	Leishmania major	83%	100%
Q4QQR9	Rattus norvegicus	34%	100%
Q4R6D9	Macaca fascicularis	34%	100%
Q54NZ1	Dictyostelium discoideum	35%	100%
Q57846	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5JJC3	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	25%	100%
Q6DJ03	Xenopus tropicalis	35%	100%
Q6GNT9	Xenopus laevis	36%	100%
Q803S3	Danio rerio	35%	100%
Q8PW40	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	23%	100%
Q8TT38	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	22%	100%
Q8TWR9	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	26%	100%
Q8U0F2	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	24%	100%
Q8ZYE1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	25%	100%
Q91VH6	Mus musculus	34%	100%
Q96YW6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	100%
Q978N2	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	24%	100%
Q9HLJ1	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	24%	100%
Q9V189	Pyrococcus abyssi (strain GE5 / Orsay)	22%	100%
Q9Y316	Homo sapiens	34%	100%
V5DRI1	Trypanosoma cruzi	53%	100%