Putative endonuclease/exonuclease/phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease/exonuclease/phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNX5_LEIBR

TriTrypDb:

LbrM.35.1280 , LBRM2903_350018600

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	6
GO:0006644	phospholipid metabolic process	4	6
GO:0006650	glycerophospholipid metabolic process	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016311	dephosphorylation	5	6
GO:0019637	organophosphate metabolic process	3	6
GO:0030258	lipid modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044255	cellular lipid metabolic process	3	6
GO:0046486	glycerolipid metabolic process	4	6
GO:0046488	phosphatidylinositol metabolic process	6	6
GO:0046839	phospholipid dephosphorylation	5	6
GO:0046856	phosphatidylinositol dephosphorylation	6	6
GO:0071704	organic substance metabolic process	2	6
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0009056	catabolic process	2	1
GO:0019751	polyol metabolic process	4	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004518	nuclease activity	4	6
GO:0004519	endonuclease activity	5	6
GO:0004527	exonuclease activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.613
CLV_C14_Caspase3-7	591	595	PF00656	0.692
CLV_NRD_NRD_1	103	105	PF00675	0.574
CLV_NRD_NRD_1	209	211	PF00675	0.636
CLV_NRD_NRD_1	213	215	PF00675	0.614
CLV_NRD_NRD_1	418	420	PF00675	0.513
CLV_NRD_NRD_1	452	454	PF00675	0.447
CLV_NRD_NRD_1	642	644	PF00675	0.511
CLV_NRD_NRD_1	711	713	PF00675	0.422
CLV_NRD_NRD_1	715	717	PF00675	0.428
CLV_NRD_NRD_1	725	727	PF00675	0.391
CLV_NRD_NRD_1	772	774	PF00675	0.618
CLV_NRD_NRD_1	776	778	PF00675	0.439
CLV_NRD_NRD_1	799	801	PF00675	0.603
CLV_PCSK_KEX2_1	103	105	PF00082	0.574
CLV_PCSK_KEX2_1	381	383	PF00082	0.453
CLV_PCSK_KEX2_1	418	420	PF00082	0.457
CLV_PCSK_KEX2_1	451	453	PF00082	0.443
CLV_PCSK_KEX2_1	641	643	PF00082	0.500
CLV_PCSK_KEX2_1	711	713	PF00082	0.435
CLV_PCSK_KEX2_1	725	727	PF00082	0.379
CLV_PCSK_KEX2_1	776	778	PF00082	0.454
CLV_PCSK_KEX2_1	882	884	PF00082	0.475
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.429
CLV_PCSK_PC1ET2_1	882	884	PF00082	0.475
CLV_PCSK_SKI1_1	235	239	PF00082	0.599
CLV_PCSK_SKI1_1	419	423	PF00082	0.323
CLV_PCSK_SKI1_1	716	720	PF00082	0.473
CLV_PCSK_SKI1_1	726	730	PF00082	0.450
CLV_PCSK_SKI1_1	777	781	PF00082	0.448
CLV_PCSK_SKI1_1	814	818	PF00082	0.478
CLV_PCSK_SKI1_1	84	88	PF00082	0.558
DEG_APCC_DBOX_1	348	356	PF00400	0.417
DEG_Nend_UBRbox_1	1	4	PF02207	0.581
DEG_SCF_FBW7_2	511	517	PF00400	0.535
DEG_SCF_SKP2-CKS1_1	664	671	PF00560	0.547
DEG_SPOP_SBC_1	221	225	PF00917	0.549
DEG_SPOP_SBC_1	519	523	PF00917	0.540
DOC_ANK_TNKS_1	589	596	PF00023	0.588
DOC_CKS1_1	511	516	PF01111	0.536
DOC_CKS1_1	583	588	PF01111	0.558
DOC_CYCLIN_RxL_1	126	137	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.534
DOC_MAPK_gen_1	418	429	PF00069	0.398
DOC_MAPK_MEF2A_6	479	488	PF00069	0.412
DOC_PP2B_LxvP_1	131	134	PF13499	0.565
DOC_PP2B_LxvP_1	21	24	PF13499	0.553
DOC_PP2B_LxvP_1	247	250	PF13499	0.535
DOC_PP2B_LxvP_1	761	764	PF13499	0.644
DOC_PP4_FxxP_1	345	348	PF00568	0.553
DOC_USP7_MATH_1	134	138	PF00917	0.656
DOC_USP7_MATH_1	150	154	PF00917	0.551
DOC_USP7_MATH_1	162	166	PF00917	0.577
DOC_USP7_MATH_1	221	225	PF00917	0.654
DOC_USP7_MATH_1	262	266	PF00917	0.539
DOC_USP7_MATH_1	286	290	PF00917	0.570
DOC_USP7_MATH_1	295	299	PF00917	0.603
DOC_USP7_MATH_1	55	59	PF00917	0.560
DOC_USP7_MATH_1	559	563	PF00917	0.566
DOC_USP7_MATH_1	764	768	PF00917	0.641
DOC_USP7_MATH_1	97	101	PF00917	0.590
DOC_USP7_UBL2_3	211	215	PF12436	0.556
DOC_WW_Pin1_4	110	115	PF00397	0.657
DOC_WW_Pin1_4	16	21	PF00397	0.632
DOC_WW_Pin1_4	253	258	PF00397	0.691
DOC_WW_Pin1_4	300	305	PF00397	0.584
DOC_WW_Pin1_4	488	493	PF00397	0.478
DOC_WW_Pin1_4	49	54	PF00397	0.543
DOC_WW_Pin1_4	510	515	PF00397	0.549
DOC_WW_Pin1_4	523	528	PF00397	0.610
DOC_WW_Pin1_4	531	536	PF00397	0.629
DOC_WW_Pin1_4	537	542	PF00397	0.563
DOC_WW_Pin1_4	564	569	PF00397	0.523
DOC_WW_Pin1_4	582	587	PF00397	0.512
DOC_WW_Pin1_4	595	600	PF00397	0.532
DOC_WW_Pin1_4	613	618	PF00397	0.763
DOC_WW_Pin1_4	665	670	PF00397	0.642
DOC_WW_Pin1_4	756	761	PF00397	0.525
LIG_14-3-3_CanoR_1	103	107	PF00244	0.663
LIG_14-3-3_CanoR_1	170	178	PF00244	0.610
LIG_14-3-3_CanoR_1	210	218	PF00244	0.591
LIG_14-3-3_CanoR_1	239	243	PF00244	0.534
LIG_14-3-3_CanoR_1	244	248	PF00244	0.558
LIG_14-3-3_CanoR_1	419	425	PF00244	0.314
LIG_14-3-3_CanoR_1	505	515	PF00244	0.523
LIG_14-3-3_CanoR_1	623	628	PF00244	0.647
LIG_14-3-3_CanoR_1	84	91	PF00244	0.566
LIG_14-3-3_CanoR_1	883	891	PF00244	0.470
LIG_14-3-3_CanoR_1	894	902	PF00244	0.347
LIG_14-3-3_CanoR_1	903	911	PF00244	0.252
LIG_14-3-3_CterR_2	919	923	PF00244	0.538
LIG_APCC_ABBA_1	893	898	PF00400	0.446
LIG_eIF4E_1	350	356	PF01652	0.414
LIG_EVH1_1	23	27	PF00568	0.529
LIG_EVH1_2	114	118	PF00568	0.553
LIG_FHA_1	173	179	PF00498	0.558
LIG_FHA_1	200	206	PF00498	0.612
LIG_FHA_1	342	348	PF00498	0.556
LIG_FHA_1	462	468	PF00498	0.474
LIG_FHA_1	506	512	PF00498	0.540
LIG_FHA_1	531	537	PF00498	0.537
LIG_FHA_1	596	602	PF00498	0.603
LIG_FHA_1	622	628	PF00498	0.519
LIG_FHA_1	681	687	PF00498	0.422
LIG_FHA_1	73	79	PF00498	0.572
LIG_FHA_2	155	161	PF00498	0.557
LIG_FHA_2	322	328	PF00498	0.643
LIG_FHA_2	489	495	PF00498	0.497
LIG_FHA_2	520	526	PF00498	0.606
LIG_FHA_2	583	589	PF00498	0.558
LIG_FHA_2	856	862	PF00498	0.505
LIG_GBD_Chelix_1	482	490	PF00786	0.417
LIG_HP1_1	909	913	PF01393	0.419
LIG_Integrin_isoDGR_2	82	84	PF01839	0.557
LIG_LIR_Apic_2	343	348	PF02991	0.555
LIG_LIR_Apic_2	580	586	PF02991	0.549
LIG_LIR_Gen_1	116	126	PF02991	0.559
LIG_LIR_Gen_1	673	684	PF02991	0.465
LIG_LIR_Gen_1	699	707	PF02991	0.320
LIG_LIR_Nem_3	116	121	PF02991	0.570
LIG_LIR_Nem_3	160	166	PF02991	0.568
LIG_LIR_Nem_3	268	273	PF02991	0.639
LIG_LIR_Nem_3	565	569	PF02991	0.559
LIG_LIR_Nem_3	612	618	PF02991	0.541
LIG_LIR_Nem_3	673	679	PF02991	0.497
LIG_LIR_Nem_3	699	703	PF02991	0.446
LIG_LYPXL_yS_3	163	166	PF13949	0.568
LIG_NRBOX	351	357	PF00104	0.411
LIG_Pex14_2	783	787	PF04695	0.337
LIG_Rb_pABgroove_1	908	916	PF01858	0.419
LIG_SH2_CRK	566	570	PF00017	0.544
LIG_SH2_CRK	583	587	PF00017	0.621
LIG_SH2_CRK	676	680	PF00017	0.452
LIG_SH2_NCK_1	433	437	PF00017	0.379
LIG_SH2_NCK_1	896	900	PF00017	0.432
LIG_SH2_SRC	106	109	PF00017	0.561
LIG_SH2_SRC	410	413	PF00017	0.353
LIG_SH2_STAP1	700	704	PF00017	0.317
LIG_SH2_STAP1	849	853	PF00017	0.478
LIG_SH2_STAT5	271	274	PF00017	0.524
LIG_SH2_STAT5	350	353	PF00017	0.413
LIG_SH2_STAT5	373	376	PF00017	0.410
LIG_SH2_STAT5	391	394	PF00017	0.292
LIG_SH2_STAT5	410	413	PF00017	0.415
LIG_SH2_STAT5	458	461	PF00017	0.460
LIG_SH2_STAT5	805	808	PF00017	0.476
LIG_SH2_STAT5	874	877	PF00017	0.408
LIG_SH2_STAT5	896	899	PF00017	0.429
LIG_SH3_2	365	370	PF14604	0.451
LIG_SH3_3	105	111	PF00018	0.664
LIG_SH3_3	120	126	PF00018	0.551
LIG_SH3_3	158	164	PF00018	0.579
LIG_SH3_3	190	196	PF00018	0.552
LIG_SH3_3	21	27	PF00018	0.558
LIG_SH3_3	362	368	PF00018	0.468
LIG_SH3_3	535	541	PF00018	0.642
LIG_SH3_3	548	554	PF00018	0.660
LIG_SH3_3	611	617	PF00018	0.765
LIG_SUMO_SIM_anti_2	116	124	PF11976	0.565
LIG_SUMO_SIM_par_1	398	404	PF11976	0.414
LIG_SUMO_SIM_par_1	486	491	PF11976	0.433
LIG_SUMO_SIM_par_1	533	540	PF11976	0.535
LIG_SUMO_SIM_par_1	909	915	PF11976	0.420
LIG_TRAF2_1	732	735	PF00917	0.525
LIG_TYR_ITIM	161	166	PF00017	0.569
LIG_UBA3_1	471	479	PF00899	0.545
LIG_UBA3_1	511	518	PF00899	0.536
LIG_WRC_WIRS_1	627	632	PF05994	0.497
LIG_WW_2	24	27	PF00397	0.516
MOD_CDK_SPK_2	488	493	PF00069	0.465
MOD_CDK_SPxK_1	523	529	PF00069	0.627
MOD_CDK_SPxK_1	665	671	PF00069	0.544
MOD_CDK_SPxK_1	756	762	PF00069	0.534
MOD_CK1_1	102	108	PF00069	0.594
MOD_CK1_1	117	123	PF00069	0.546
MOD_CK1_1	135	141	PF00069	0.563
MOD_CK1_1	15	21	PF00069	0.681
MOD_CK1_1	172	178	PF00069	0.565
MOD_CK1_1	220	226	PF00069	0.646
MOD_CK1_1	265	271	PF00069	0.586
MOD_CK1_1	298	304	PF00069	0.666
MOD_CK1_1	380	386	PF00069	0.348
MOD_CK1_1	534	540	PF00069	0.554
MOD_CK1_1	562	568	PF00069	0.606
MOD_CK1_1	597	603	PF00069	0.553
MOD_CK1_1	613	619	PF00069	0.573
MOD_CK1_1	626	632	PF00069	0.575
MOD_CK2_1	110	116	PF00069	0.540
MOD_CK2_1	220	226	PF00069	0.550
MOD_CK2_1	300	306	PF00069	0.611
MOD_CK2_1	626	632	PF00069	0.540
MOD_CK2_1	855	861	PF00069	0.513
MOD_Cter_Amidation	709	712	PF01082	0.427
MOD_GlcNHglycan	137	140	PF01048	0.604
MOD_GlcNHglycan	145	148	PF01048	0.568
MOD_GlcNHglycan	219	222	PF01048	0.556
MOD_GlcNHglycan	264	267	PF01048	0.713
MOD_GlcNHglycan	297	300	PF01048	0.542
MOD_GlcNHglycan	331	334	PF01048	0.532
MOD_GlcNHglycan	387	391	PF01048	0.474
MOD_GlcNHglycan	41	44	PF01048	0.555
MOD_GlcNHglycan	557	560	PF01048	0.578
MOD_GlcNHglycan	766	769	PF01048	0.589
MOD_GlcNHglycan	850	854	PF01048	0.505
MOD_GlcNHglycan	885	888	PF01048	0.456
MOD_GSK3_1	110	117	PF00069	0.624
MOD_GSK3_1	12	19	PF00069	0.686
MOD_GSK3_1	150	157	PF00069	0.551
MOD_GSK3_1	162	169	PF00069	0.540
MOD_GSK3_1	209	216	PF00069	0.558
MOD_GSK3_1	217	224	PF00069	0.533
MOD_GSK3_1	231	238	PF00069	0.601
MOD_GSK3_1	249	256	PF00069	0.548
MOD_GSK3_1	265	272	PF00069	0.516
MOD_GSK3_1	280	287	PF00069	0.524
MOD_GSK3_1	308	315	PF00069	0.616
MOD_GSK3_1	334	341	PF00069	0.569
MOD_GSK3_1	35	42	PF00069	0.682
MOD_GSK3_1	457	464	PF00069	0.491
MOD_GSK3_1	495	502	PF00069	0.471
MOD_GSK3_1	506	513	PF00069	0.523
MOD_GSK3_1	51	58	PF00069	0.527
MOD_GSK3_1	519	526	PF00069	0.566
MOD_GSK3_1	530	537	PF00069	0.554
MOD_GSK3_1	555	562	PF00069	0.541
MOD_GSK3_1	60	67	PF00069	0.625
MOD_GSK3_1	619	626	PF00069	0.642
MOD_GSK3_1	661	668	PF00069	0.576
MOD_GSK3_1	68	75	PF00069	0.554
MOD_GSK3_1	752	759	PF00069	0.508
MOD_GSK3_1	915	922	PF00069	0.474
MOD_N-GLC_1	595	600	PF02516	0.684
MOD_N-GLC_1	619	624	PF02516	0.592
MOD_N-GLC_1	64	69	PF02516	0.659
MOD_N-GLC_1	796	801	PF02516	0.471
MOD_N-GLC_1	862	867	PF02516	0.524
MOD_N-GLC_2	279	281	PF02516	0.522
MOD_NEK2_1	149	154	PF00069	0.568
MOD_NEK2_1	219	224	PF00069	0.553
MOD_NEK2_1	243	248	PF00069	0.684
MOD_NEK2_1	486	491	PF00069	0.433
MOD_NEK2_1	680	685	PF00069	0.422
MOD_NEK2_1	783	788	PF00069	0.406
MOD_NEK2_1	914	919	PF00069	0.310
MOD_OFUCOSY	62	69	PF10250	0.587
MOD_PIKK_1	132	138	PF00454	0.558
MOD_PIKK_1	177	183	PF00454	0.643
MOD_PIKK_1	4	10	PF00454	0.692
MOD_PIKK_1	401	407	PF00454	0.423
MOD_PIKK_1	422	428	PF00454	0.393
MOD_PIKK_1	495	501	PF00454	0.457
MOD_PIKK_1	648	654	PF00454	0.631
MOD_PKA_1	882	888	PF00069	0.464
MOD_PKA_2	102	108	PF00069	0.580
MOD_PKA_2	143	149	PF00069	0.593
MOD_PKA_2	169	175	PF00069	0.609
MOD_PKA_2	209	215	PF00069	0.578
MOD_PKA_2	238	244	PF00069	0.538
MOD_PKA_2	341	347	PF00069	0.566
MOD_PKA_2	843	849	PF00069	0.424
MOD_PKA_2	882	888	PF00069	0.464
MOD_PKA_2	902	908	PF00069	0.257
MOD_Plk_1	172	178	PF00069	0.563
MOD_Plk_1	321	327	PF00069	0.599
MOD_Plk_1	334	340	PF00069	0.489
MOD_Plk_1	386	392	PF00069	0.366
MOD_Plk_1	610	616	PF00069	0.530
MOD_Plk_1	783	789	PF00069	0.405
MOD_Plk_1	97	103	PF00069	0.559
MOD_Plk_2-3	588	594	PF00069	0.581
MOD_Plk_2-3	655	661	PF00069	0.578
MOD_Plk_2-3	821	827	PF00069	0.428
MOD_Plk_4	114	120	PF00069	0.567
MOD_Plk_4	238	244	PF00069	0.596
MOD_Plk_4	326	332	PF00069	0.545
MOD_Plk_4	597	603	PF00069	0.630
MOD_Plk_4	610	616	PF00069	0.598
MOD_Plk_4	675	681	PF00069	0.461
MOD_Plk_4	783	789	PF00069	0.405
MOD_ProDKin_1	110	116	PF00069	0.661
MOD_ProDKin_1	16	22	PF00069	0.631
MOD_ProDKin_1	253	259	PF00069	0.693
MOD_ProDKin_1	300	306	PF00069	0.588
MOD_ProDKin_1	488	494	PF00069	0.493
MOD_ProDKin_1	49	55	PF00069	0.542
MOD_ProDKin_1	510	516	PF00069	0.550
MOD_ProDKin_1	523	529	PF00069	0.611
MOD_ProDKin_1	531	537	PF00069	0.628
MOD_ProDKin_1	564	570	PF00069	0.524
MOD_ProDKin_1	582	588	PF00069	0.515
MOD_ProDKin_1	595	601	PF00069	0.532
MOD_ProDKin_1	613	619	PF00069	0.763
MOD_ProDKin_1	665	671	PF00069	0.640
MOD_ProDKin_1	756	762	PF00069	0.527
MOD_SUMO_rev_2	208	216	PF00179	0.559
MOD_SUMO_rev_2	353	362	PF00179	0.539
TRG_DiLeu_BaEn_1	173	178	PF01217	0.565
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.536
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.527
TRG_ENDOCYTIC_2	163	166	PF00928	0.568
TRG_ENDOCYTIC_2	433	436	PF00928	0.432
TRG_ENDOCYTIC_2	566	569	PF00928	0.546
TRG_ENDOCYTIC_2	676	679	PF00928	0.458
TRG_ENDOCYTIC_2	700	703	PF00928	0.450
TRG_ENDOCYTIC_2	715	718	PF00928	0.349
TRG_ENDOCYTIC_2	896	899	PF00928	0.429
TRG_ER_diArg_1	382	385	PF00400	0.368
TRG_ER_diArg_1	418	420	PF00400	0.461
TRG_ER_diArg_1	451	453	PF00400	0.442
TRG_ER_diArg_1	641	643	PF00400	0.500
TRG_ER_diArg_1	693	696	PF00400	0.415
TRG_ER_diArg_1	775	777	PF00400	0.501
TRG_NLS_Bipartite_1	867	885	PF00514	0.454
TRG_NLS_MonoExtC_3	772	777	PF00514	0.568
TRG_NLS_MonoExtN_4	771	777	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	590	594	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAJ4	Leishmania donovani	54%	99%
A4ICL9	Leishmania infantum	54%	73%
E9ASN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4Q1W1	Leishmania major	54%	100%