Putative short chain 3-hydroxyacyl-CoA dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain 3-hydroxyacyl-CoA dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNX4_LEIBR

TriTrypDb:

LbrM.35.1270 , LBRM2903_350018500

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0006635	fatty acid beta-oxidation	6	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0030258	lipid modification	4	1
GO:0034440	lipid oxidation	5	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	6
GO:0005488	binding	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0051287	NAD binding	4	10
GO:0070403	NAD+ binding	4	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.239
CLV_C14_Caspase3-7	243	247	PF00656	0.253
CLV_NRD_NRD_1	49	51	PF00675	0.308
CLV_PCSK_SKI1_1	111	115	PF00082	0.335
CLV_Separin_Metazoa	165	169	PF03568	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DOC_CYCLIN_RxL_1	108	118	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.308
DOC_MAPK_gen_1	145	154	PF00069	0.308
DOC_MAPK_gen_1	185	192	PF00069	0.424
DOC_MAPK_RevD_3	96	111	PF00069	0.424
DOC_MIT_MIM_1	112	120	PF04212	0.226
DOC_PP2B_LxvP_1	205	208	PF13499	0.308
DOC_PP4_FxxP_1	154	157	PF00568	0.308
DOC_USP7_UBL2_3	185	189	PF12436	0.367
DOC_USP7_UBL2_3	284	288	PF12436	0.308
DOC_USP7_UBL2_3	295	299	PF12436	0.426
DOC_WW_Pin1_4	153	158	PF00397	0.308
DOC_WW_Pin1_4	194	199	PF00397	0.339
DOC_WW_Pin1_4	2	7	PF00397	0.473
DOC_WW_Pin1_4	270	275	PF00397	0.383
LIG_14-3-3_CanoR_1	123	127	PF00244	0.288
LIG_14-3-3_CanoR_1	219	225	PF00244	0.367
LIG_BRCT_BRCA1_1	123	127	PF00533	0.424
LIG_BRCT_BRCA1_1	6	10	PF00533	0.492
LIG_EH1_1	199	207	PF00400	0.308
LIG_eIF4E_1	264	270	PF01652	0.448
LIG_FHA_1	129	135	PF00498	0.300
LIG_FHA_1	167	173	PF00498	0.424
LIG_FHA_2	142	148	PF00498	0.362
LIG_FHA_2	221	227	PF00498	0.332
LIG_FHA_2	35	41	PF00498	0.308
LIG_FHA_2	72	78	PF00498	0.333
LIG_FHA_2	84	90	PF00498	0.295
LIG_LIR_Gen_1	112	122	PF02991	0.303
LIG_LIR_Gen_1	223	231	PF02991	0.403
LIG_LIR_Gen_1	258	268	PF02991	0.299
LIG_LIR_Nem_3	112	117	PF02991	0.367
LIG_LIR_Nem_3	146	152	PF02991	0.240
LIG_LIR_Nem_3	223	227	PF02991	0.424
LIG_LIR_Nem_3	291	296	PF02991	0.308
LIG_LIR_Nem_3	7	13	PF02991	0.512
LIG_Pex14_1	260	264	PF04695	0.383
LIG_SH3_3	235	241	PF00018	0.308
LIG_SH3_3	262	268	PF00018	0.308
LIG_SUMO_SIM_par_1	34	40	PF11976	0.317
LIG_UBA3_1	113	119	PF00899	0.367
LIG_UBA3_1	57	64	PF00899	0.383
LIG_WRC_WIRS_1	221	226	PF05994	0.424
LIG_WRC_WIRS_1	72	77	PF05994	0.362
MOD_CK1_1	129	135	PF00069	0.317
MOD_CK1_1	141	147	PF00069	0.383
MOD_CK1_1	81	87	PF00069	0.308
MOD_CK2_1	132	138	PF00069	0.406
MOD_CK2_1	141	147	PF00069	0.226
MOD_CK2_1	34	40	PF00069	0.367
MOD_CK2_1	83	89	PF00069	0.308
MOD_Cter_Amidation	285	288	PF01082	0.308
MOD_GlcNHglycan	6	9	PF01048	0.623
MOD_GSK3_1	122	129	PF00069	0.327
MOD_GSK3_1	130	137	PF00069	0.321
MOD_GSK3_1	67	74	PF00069	0.454
MOD_GSK3_1	81	88	PF00069	0.289
MOD_N-GLC_1	129	134	PF02516	0.308
MOD_NEK2_1	244	249	PF00069	0.308
MOD_NEK2_1	46	51	PF00069	0.332
MOD_NEK2_1	75	80	PF00069	0.383
MOD_NEK2_1	9	14	PF00069	0.391
MOD_NEK2_2	122	127	PF00069	0.424
MOD_PKA_2	122	128	PF00069	0.241
MOD_Plk_1	129	135	PF00069	0.308
MOD_Plk_1	53	59	PF00069	0.308
MOD_Plk_4	122	128	PF00069	0.392
MOD_Plk_4	34	40	PF00069	0.308
MOD_Plk_4	53	59	PF00069	0.308
MOD_Plk_4	71	77	PF00069	0.262
MOD_ProDKin_1	153	159	PF00069	0.308
MOD_ProDKin_1	194	200	PF00069	0.339
MOD_ProDKin_1	2	8	PF00069	0.465
MOD_ProDKin_1	270	276	PF00069	0.383
MOD_SUMO_for_1	109	112	PF00179	0.424
MOD_SUMO_for_1	172	175	PF00179	0.271
MOD_SUMO_rev_2	165	174	PF00179	0.303
MOD_SUMO_rev_2	66	72	PF00179	0.260
TRG_DiLeu_BaEn_1	212	217	PF01217	0.332
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.308
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.383
TRG_NES_CRM1_1	246	258	PF08389	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX2	Leptomonas seymouri	74%	100%
A0A0S4JB86	Bodo saltans	61%	100%
A0A1X0P8Y1	Trypanosomatidae	60%	100%
A0A3Q8IQN1	Leishmania donovani	88%	100%
A4ICM0	Leishmania infantum	87%	100%
B1VLT7	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	29%	91%
D7URM0	Pseudomonas sp.	28%	95%
E9ASN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P00348	Sus scrofa	55%	97%
P14755	Oryctolagus cuniculus	28%	96%
P34439	Caenorhabditis elegans	46%	100%
P41938	Caenorhabditis elegans	52%	99%
P45364	Clostridioides difficile	38%	100%
P45856	Bacillus subtilis (strain 168)	41%	100%
P52041	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	39%	100%
P77851	Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032)	41%	100%
P83589	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	29%	88%
P9WNP6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	42%	100%
P9WNP7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	42%	100%
Q0AVM2	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	40%	100%
Q16836	Homo sapiens	55%	97%
Q45223	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	38%	100%
Q4Q1W2	Leishmania major	86%	100%
Q4V182	Bacillus cereus (strain ZK / E33L)	28%	94%
Q5RDZ2	Pongo abelii	28%	96%
Q61425	Mus musculus	56%	97%
Q811X6	Rattus norvegicus	27%	96%
Q88R32	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	30%	95%
Q8SPX7	Bos taurus	27%	95%
Q8SQ26	Sus scrofa	28%	95%
Q93RX5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	28%	96%
Q988C8	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	30%	99%
Q99KP3	Mus musculus	28%	96%
Q9RVG1	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	41%	100%
Q9WVK7	Rattus norvegicus	56%	97%
Q9Y2S2	Homo sapiens	28%	96%
V5BPS0	Trypanosoma cruzi	63%	95%
W7MSH6	Gibberella moniliformis (strain M3125 / FGSC 7600)	27%	95%