Ch36-1990 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Ch36-1990 protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HNX3_LEIBR

TriTrypDb:

LbrM.35.1260 , LBRM2903_350018400

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.347
CLV_C14_Caspase3-7	210	214	PF00656	0.695
CLV_C14_Caspase3-7	40	44	PF00656	0.516
CLV_NRD_NRD_1	270	272	PF00675	0.522
CLV_PCSK_KEX2_1	270	272	PF00082	0.525
CLV_PCSK_SKI1_1	234	238	PF00082	0.522
CLV_PCSK_SKI1_1	392	396	PF00082	0.572
CLV_PCSK_SKI1_1	89	93	PF00082	0.632
DEG_APCC_DBOX_1	233	241	PF00400	0.566
DEG_COP1_1	21	30	PF00400	0.346
DEG_Nend_UBRbox_2	1	3	PF02207	0.504
DEG_SPOP_SBC_1	224	228	PF00917	0.404
DOC_CDC14_PxL_1	135	143	PF14671	0.569
DOC_CYCLIN_yClb5_NLxxxL_5	194	201	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.563
DOC_MAPK_DCC_7	194	202	PF00069	0.559
DOC_MAPK_gen_1	315	324	PF00069	0.349
DOC_MAPK_MEF2A_6	194	202	PF00069	0.559
DOC_MAPK_MEF2A_6	315	324	PF00069	0.343
DOC_PP2B_LxvP_1	91	94	PF13499	0.597
DOC_PP4_FxxP_1	177	180	PF00568	0.550
DOC_PP4_FxxP_1	30	33	PF00568	0.499
DOC_USP7_MATH_1	148	152	PF00917	0.592
DOC_USP7_MATH_1	224	228	PF00917	0.505
DOC_USP7_MATH_1	53	57	PF00917	0.615
DOC_WW_Pin1_4	150	155	PF00397	0.521
DOC_WW_Pin1_4	80	85	PF00397	0.570
LIG_14-3-3_CanoR_1	163	172	PF00244	0.490
LIG_14-3-3_CanoR_1	188	198	PF00244	0.522
LIG_14-3-3_CanoR_1	36	45	PF00244	0.333
LIG_14-3-3_CanoR_1	5	11	PF00244	0.698
LIG_APCC_ABBA_1	320	325	PF00400	0.303
LIG_BRCT_BRCA1_1	160	164	PF00533	0.421
LIG_BRCT_BRCA1_1	213	217	PF00533	0.487
LIG_Clathr_ClatBox_1	360	364	PF01394	0.476
LIG_EH1_1	272	280	PF00400	0.595
LIG_eIF4E_1	233	239	PF01652	0.318
LIG_eIF4E_1	273	279	PF01652	0.513
LIG_FHA_1	117	123	PF00498	0.563
LIG_FHA_1	243	249	PF00498	0.500
LIG_FHA_1	274	280	PF00498	0.344
LIG_FHA_1	340	346	PF00498	0.361
LIG_FHA_2	190	196	PF00498	0.551
LIG_FHA_2	38	44	PF00498	0.478
LIG_FHA_2	81	87	PF00498	0.696
LIG_GBD_Chelix_1	343	351	PF00786	0.318
LIG_LIR_Apic_2	29	33	PF02991	0.504
LIG_LIR_Gen_1	214	224	PF02991	0.637
LIG_LIR_Gen_1	384	394	PF02991	0.499
LIG_LIR_LC3C_4	12	17	PF02991	0.319
LIG_LIR_LC3C_4	359	362	PF02991	0.542
LIG_LIR_Nem_3	167	173	PF02991	0.475
LIG_LIR_Nem_3	214	220	PF02991	0.509
LIG_LIR_Nem_3	29	34	PF02991	0.593
LIG_LIR_Nem_3	373	377	PF02991	0.600
LIG_LIR_Nem_3	384	390	PF02991	0.411
LIG_LYPXL_yS_3	138	141	PF13949	0.499
LIG_Pex14_2	399	403	PF04695	0.596
LIG_SH2_CRK	397	401	PF00017	0.476
LIG_SH2_GRB2like	396	399	PF00017	0.443
LIG_SH2_STAT5	146	149	PF00017	0.433
LIG_SH2_STAT5	152	155	PF00017	0.434
LIG_SH2_STAT5	157	160	PF00017	0.391
LIG_SH2_STAT5	374	377	PF00017	0.515
LIG_SH3_3	133	139	PF00018	0.510
LIG_SH3_3	308	314	PF00018	0.555
LIG_SH3_3	439	445	PF00018	0.692
LIG_Sin3_3	199	206	PF02671	0.315
LIG_SUMO_SIM_anti_2	359	364	PF11976	0.482
LIG_SUMO_SIM_par_1	359	364	PF11976	0.445
LIG_TRAF2_1	286	289	PF00917	0.486
LIG_UBA3_1	200	205	PF00899	0.369
LIG_UBA3_1	350	357	PF00899	0.342
LIG_UBA3_1	386	395	PF00899	0.574
LIG_WRC_WIRS_1	27	32	PF05994	0.452
MOD_CK1_1	112	118	PF00069	0.501
MOD_CK1_1	227	233	PF00069	0.435
MOD_CK1_1	55	61	PF00069	0.423
MOD_CK2_1	229	235	PF00069	0.546
MOD_CK2_1	444	450	PF00069	0.679
MOD_CK2_1	80	86	PF00069	0.682
MOD_GlcNHglycan	116	119	PF01048	0.555
MOD_GlcNHglycan	23	26	PF01048	0.560
MOD_GlcNHglycan	328	332	PF01048	0.545
MOD_GlcNHglycan	403	406	PF01048	0.497
MOD_GlcNHglycan	423	427	PF01048	0.326
MOD_GlcNHglycan	446	449	PF01048	0.694
MOD_GlcNHglycan	69	72	PF01048	0.630
MOD_GSK3_1	105	112	PF00069	0.520
MOD_GSK3_1	146	153	PF00069	0.449
MOD_GSK3_1	223	230	PF00069	0.466
MOD_GSK3_1	238	245	PF00069	0.526
MOD_GSK3_1	323	330	PF00069	0.562
MOD_N-GLC_1	180	185	PF02516	0.518
MOD_N-GLC_1	189	194	PF02516	0.522
MOD_N-GLC_1	36	41	PF02516	0.331
MOD_NEK2_1	107	112	PF00069	0.396
MOD_NEK2_1	158	163	PF00069	0.464
MOD_NEK2_1	238	243	PF00069	0.434
MOD_NEK2_1	8	13	PF00069	0.571
MOD_PIKK_1	273	279	PF00454	0.567
MOD_Plk_1	180	186	PF00069	0.496
MOD_Plk_4	180	186	PF00069	0.475
MOD_Plk_4	26	32	PF00069	0.333
MOD_Plk_4	356	362	PF00069	0.557
MOD_Plk_4	58	64	PF00069	0.531
MOD_ProDKin_1	150	156	PF00069	0.515
MOD_ProDKin_1	80	86	PF00069	0.583
MOD_SUMO_for_1	420	423	PF00179	0.519
MOD_SUMO_for_1	436	439	PF00179	0.668
TRG_DiLeu_BaEn_2	234	240	PF01217	0.495
TRG_DiLeu_BaEn_2	258	264	PF01217	0.369
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.452
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.304
TRG_ENDOCYTIC_2	138	141	PF00928	0.430
TRG_ENDOCYTIC_2	157	160	PF00928	0.469
TRG_ENDOCYTIC_2	374	377	PF00928	0.493
TRG_ENDOCYTIC_2	396	399	PF00928	0.490
TRG_ER_diArg_1	270	272	PF00400	0.522
TRG_NLS_MonoExtN_4	314	319	PF00514	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q9	Leptomonas seymouri	53%	88%
A0A0S4JAW3	Bodo saltans	25%	100%
A4ICM1	Leishmania infantum	77%	100%
E9ASN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
H2ALR9	Leishmania donovani	77%	100%
Q4Q1W3	Leishmania major	76%	100%