Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNX2_LEIBR

TriTrypDb:

LbrM.35.1250 , LBRM2903_350018300

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HNX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.391
CLV_NRD_NRD_1	15	17	PF00675	0.362
CLV_NRD_NRD_1	3	5	PF00675	0.384
CLV_NRD_NRD_1	40	42	PF00675	0.675
CLV_PCSK_KEX2_1	15	17	PF00082	0.362
CLV_PCSK_KEX2_1	3	5	PF00082	0.384
CLV_PCSK_KEX2_1	40	42	PF00082	0.650
CLV_PCSK_PC7_1	11	17	PF00082	0.384
CLV_PCSK_SKI1_1	182	186	PF00082	0.586
CLV_PCSK_SKI1_1	74	78	PF00082	0.652
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_SPOP_SBC_1	29	33	PF00917	0.377
DOC_CKS1_1	124	129	PF01111	0.439
DOC_CYCLIN_RxL_1	178	189	PF00134	0.382
DOC_MAPK_FxFP_2	163	166	PF00069	0.369
DOC_MAPK_MEF2A_6	281	288	PF00069	0.561
DOC_PP1_RVXF_1	258	264	PF00149	0.473
DOC_PP4_FxxP_1	163	166	PF00568	0.397
DOC_PP4_FxxP_1	303	306	PF00568	0.588
DOC_PP4_FxxP_1	307	310	PF00568	0.573
DOC_USP7_MATH_1	291	295	PF00917	0.579
DOC_USP7_MATH_1	30	34	PF00917	0.385
DOC_USP7_UBL2_3	225	229	PF12436	0.447
DOC_USP7_UBL2_3	311	315	PF12436	0.613
DOC_WW_Pin1_4	123	128	PF00397	0.427
LIG_14-3-3_CanoR_1	16	26	PF00244	0.623
LIG_14-3-3_CanoR_1	187	191	PF00244	0.380
LIG_14-3-3_CanoR_1	208	213	PF00244	0.434
LIG_14-3-3_CanoR_1	252	261	PF00244	0.380
LIG_14-3-3_CanoR_1	281	287	PF00244	0.629
LIG_14-3-3_CanoR_1	290	299	PF00244	0.615
LIG_14-3-3_CanoR_1	3	9	PF00244	0.765
LIG_BRCT_BRCA1_1	30	34	PF00533	0.301
LIG_deltaCOP1_diTrp_1	156	163	PF00928	0.370
LIG_deltaCOP1_diTrp_1	168	177	PF00928	0.380
LIG_deltaCOP1_diTrp_1	312	320	PF00928	0.596
LIG_deltaCOP1_diTrp_1	331	341	PF00928	0.583
LIG_FHA_1	273	279	PF00498	0.353
LIG_FHA_2	196	202	PF00498	0.451
LIG_FHA_2	64	70	PF00498	0.429
LIG_LIR_Apic_2	137	142	PF02991	0.394
LIG_LIR_Apic_2	161	166	PF02991	0.410
LIG_LIR_Apic_2	215	219	PF02991	0.445
LIG_LIR_Apic_2	302	306	PF02991	0.621
LIG_LIR_Gen_1	198	207	PF02991	0.467
LIG_LIR_Gen_1	85	93	PF02991	0.435
LIG_LIR_Nem_3	134	139	PF02991	0.424
LIG_LIR_Nem_3	198	203	PF02991	0.460
LIG_LIR_Nem_3	246	251	PF02991	0.359
LIG_LIR_Nem_3	42	46	PF02991	0.375
LIG_LIR_Nem_3	85	89	PF02991	0.445
LIG_PCNA_PIPBox_1	270	279	PF02747	0.258
LIG_Pex14_1	54	58	PF04695	0.453
LIG_Pex14_2	303	307	PF04695	0.543
LIG_PTB_Apo_2	69	76	PF02174	0.406
LIG_REV1ctd_RIR_1	73	79	PF16727	0.472
LIG_SH2_CRK	139	143	PF00017	0.397
LIG_SH2_GRB2like	343	346	PF00017	0.603
LIG_SH2_NCK_1	139	143	PF00017	0.397
LIG_SH2_SRC	277	280	PF00017	0.197
LIG_SH2_STAT3	346	349	PF00017	0.666
LIG_SH2_STAT5	135	138	PF00017	0.432
LIG_SH2_STAT5	139	142	PF00017	0.407
LIG_SH2_STAT5	233	236	PF00017	0.496
LIG_SH2_STAT5	277	280	PF00017	0.362
LIG_SH2_STAT5	343	346	PF00017	0.545
LIG_SH3_3	11	17	PF00018	0.652
LIG_SH3_3	211	217	PF00018	0.450
LIG_SH3_3	24	30	PF00018	0.404
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.534
LIG_TRAF2_1	323	326	PF00917	0.588
LIG_TRAF2_1	66	69	PF00917	0.442
LIG_WRC_WIRS_1	48	53	PF05994	0.509
LIG_WW_1	127	130	PF00397	0.362
LIG_WW_1	218	221	PF00397	0.435
MOD_CDK_SPxK_1	123	129	PF00069	0.458
MOD_CK1_1	123	129	PF00069	0.511
MOD_CK2_1	240	246	PF00069	0.402
MOD_CK2_1	63	69	PF00069	0.454
MOD_CK2_1	92	98	PF00069	0.466
MOD_CMANNOS	190	193	PF00535	0.559
MOD_GSK3_1	191	198	PF00069	0.447
MOD_GSK3_1	250	257	PF00069	0.425
MOD_GSK3_1	59	66	PF00069	0.501
MOD_N-GLC_1	115	120	PF02516	0.663
MOD_NEK2_1	272	277	PF00069	0.342
MOD_NEK2_1	284	289	PF00069	0.567
MOD_PIKK_1	92	98	PF00454	0.525
MOD_PKA_1	15	21	PF00069	0.555
MOD_PKA_1	3	9	PF00069	0.579
MOD_PKA_2	15	21	PF00069	0.743
MOD_PKA_2	186	192	PF00069	0.372
MOD_PKA_2	3	9	PF00069	0.786
MOD_PKA_2	63	69	PF00069	0.462
MOD_Plk_1	114	120	PF00069	0.549
MOD_Plk_4	186	192	PF00069	0.372
MOD_Plk_4	272	278	PF00069	0.342
MOD_Plk_4	284	290	PF00069	0.572
MOD_ProDKin_1	123	129	PF00069	0.427
TRG_DiLeu_BaEn_1	237	242	PF01217	0.429
TRG_DiLeu_BaEn_2	264	270	PF01217	0.410
TRG_ENDOCYTIC_2	133	136	PF00928	0.460
TRG_ENDOCYTIC_2	233	236	PF00928	0.529
TRG_ENDOCYTIC_2	248	251	PF00928	0.321
TRG_ENDOCYTIC_2	43	46	PF00928	0.430
TRG_ENDOCYTIC_2	86	89	PF00928	0.437
TRG_ER_diArg_1	14	16	PF00400	0.563
TRG_ER_diArg_1	172	175	PF00400	0.420
TRG_ER_diArg_1	2	4	PF00400	0.591
TRG_ER_diArg_1	207	210	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P652	Leptomonas seymouri	83%	100%
A0A0S4JBL9	Bodo saltans	62%	100%
A0A1X0P846	Trypanosomatidae	70%	100%
A0A3S7XAH0	Leishmania donovani	86%	100%
A4ICM2	Leishmania infantum	86%	100%
D0A2T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ASN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1W4	Leishmania major	88%	100%
V5BZU2	Trypanosoma cruzi	72%	99%