HORMA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HORMA domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNX1_LEIBR

TriTrypDb:

LbrM.35.1240 , LBRM2903_350018200

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.443
CLV_NRD_NRD_1	144	146	PF00675	0.326
CLV_NRD_NRD_1	147	149	PF00675	0.299
CLV_NRD_NRD_1	519	521	PF00675	0.665
CLV_NRD_NRD_1	540	542	PF00675	0.586
CLV_PCSK_FUR_1	145	149	PF00082	0.312
CLV_PCSK_KEX2_1	110	112	PF00082	0.231
CLV_PCSK_KEX2_1	146	148	PF00082	0.316
CLV_PCSK_KEX2_1	519	521	PF00082	0.665
CLV_PCSK_KEX2_1	542	544	PF00082	0.600
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.231
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.388
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.598
CLV_PCSK_PC7_1	515	521	PF00082	0.542
CLV_PCSK_SKI1_1	179	183	PF00082	0.312
CLV_PCSK_SKI1_1	312	316	PF00082	0.531
CLV_PCSK_SKI1_1	43	47	PF00082	0.311
CLV_PCSK_SKI1_1	69	73	PF00082	0.312
CLV_PCSK_SKI1_1	93	97	PF00082	0.334
DEG_APCC_DBOX_1	218	226	PF00400	0.231
DEG_APCC_DBOX_1	76	84	PF00400	0.312
DOC_CKS1_1	116	121	PF01111	0.248
DOC_CKS1_1	268	273	PF01111	0.591
DOC_CKS1_1	457	462	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	236	242	PF00134	0.312
DOC_MAPK_gen_1	110	116	PF00069	0.231
DOC_MAPK_gen_1	146	158	PF00069	0.231
DOC_MAPK_MEF2A_6	151	158	PF00069	0.231
DOC_MAPK_MEF2A_6	237	244	PF00069	0.337
DOC_MAPK_MEF2A_6	43	50	PF00069	0.311
DOC_PP2B_LxvP_1	46	49	PF13499	0.307
DOC_USP7_MATH_1	23	27	PF00917	0.294
DOC_USP7_MATH_1	274	278	PF00917	0.603
DOC_USP7_MATH_1	294	298	PF00917	0.478
DOC_USP7_MATH_1	480	484	PF00917	0.330
DOC_USP7_MATH_1	6	10	PF00917	0.471
DOC_WW_Pin1_4	115	120	PF00397	0.248
DOC_WW_Pin1_4	189	194	PF00397	0.312
DOC_WW_Pin1_4	267	272	PF00397	0.569
DOC_WW_Pin1_4	398	403	PF00397	0.307
DOC_WW_Pin1_4	456	461	PF00397	0.681
DOC_WW_Pin1_4	466	471	PF00397	0.712
LIG_14-3-3_CanoR_1	111	117	PF00244	0.312
LIG_14-3-3_CanoR_1	179	184	PF00244	0.314
LIG_14-3-3_CanoR_1	22	30	PF00244	0.307
LIG_14-3-3_CanoR_1	262	271	PF00244	0.742
LIG_14-3-3_CanoR_1	306	315	PF00244	0.573
LIG_14-3-3_CanoR_1	32	40	PF00244	0.311
LIG_14-3-3_CanoR_1	335	340	PF00244	0.643
LIG_14-3-3_CanoR_1	408	416	PF00244	0.411
LIG_14-3-3_CanoR_1	439	446	PF00244	0.546
LIG_14-3-3_CterR_2	541	546	PF00244	0.608
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.312
LIG_FHA_1	126	132	PF00498	0.388
LIG_FHA_1	157	163	PF00498	0.312
LIG_FHA_1	180	186	PF00498	0.312
LIG_FHA_1	387	393	PF00498	0.426
LIG_FHA_1	457	463	PF00498	0.606
LIG_FHA_1	493	499	PF00498	0.418
LIG_FHA_1	56	62	PF00498	0.312
LIG_FHA_1	9	15	PF00498	0.409
LIG_FHA_2	148	154	PF00498	0.315
LIG_FHA_2	184	190	PF00498	0.312
LIG_FHA_2	268	274	PF00498	0.755
LIG_FHA_2	315	321	PF00498	0.527
LIG_FHA_2	410	416	PF00498	0.359
LIG_FHA_2	474	480	PF00498	0.331
LIG_FHA_2	60	66	PF00498	0.312
LIG_LIR_Apic_2	195	199	PF02991	0.448
LIG_LIR_Gen_1	186	196	PF02991	0.312
LIG_LIR_Gen_1	387	398	PF02991	0.350
LIG_LIR_Nem_3	186	191	PF02991	0.312
LIG_LIR_Nem_3	387	393	PF02991	0.350
LIG_NRBOX	387	393	PF00104	0.350
LIG_NRBOX	493	499	PF00104	0.438
LIG_NRP_CendR_1	543	546	PF00754	0.616
LIG_PTB_Apo_2	95	102	PF02174	0.219
LIG_SH2_NCK_1	188	192	PF00017	0.324
LIG_SH2_PTP2	510	513	PF00017	0.338
LIG_SH2_SRC	188	191	PF00017	0.290
LIG_SH2_SRC	196	199	PF00017	0.357
LIG_SH2_STAT5	105	108	PF00017	0.312
LIG_SH2_STAT5	390	393	PF00017	0.417
LIG_SH2_STAT5	510	513	PF00017	0.417
LIG_SH2_STAT5	79	82	PF00017	0.312
LIG_SH2_STAT5	99	102	PF00017	0.183
LIG_SH3_2	271	276	PF14604	0.684
LIG_SH3_3	136	142	PF00018	0.364
LIG_SH3_3	265	271	PF00018	0.613
LIG_SH3_3	474	480	PF00018	0.549
LIG_SUMO_SIM_anti_2	481	486	PF11976	0.308
LIG_TRAF2_1	150	153	PF00917	0.312
LIG_TRAF2_1	328	331	PF00917	0.671
LIG_TRAF2_1	514	517	PF00917	0.507
LIG_TYR_ITIM	508	513	PF00017	0.319
LIG_TYR_ITSM	184	191	PF00017	0.312
LIG_UBA3_1	392	400	PF00899	0.272
MOD_CDK_SPK_2	456	461	PF00069	0.579
MOD_CDK_SPxxK_3	398	405	PF00069	0.327
MOD_CDK_SPxxK_3	466	473	PF00069	0.739
MOD_CK1_1	132	138	PF00069	0.394
MOD_CK1_1	224	230	PF00069	0.312
MOD_CK1_1	246	252	PF00069	0.467
MOD_CK1_1	26	32	PF00069	0.310
MOD_CK1_1	281	287	PF00069	0.561
MOD_CK1_1	466	472	PF00069	0.624
MOD_CK1_1	478	484	PF00069	0.419
MOD_CK2_1	147	153	PF00069	0.312
MOD_CK2_1	274	280	PF00069	0.613
MOD_CK2_1	314	320	PF00069	0.562
MOD_CK2_1	325	331	PF00069	0.616
MOD_CK2_1	335	341	PF00069	0.621
MOD_CK2_1	373	379	PF00069	0.599
MOD_CK2_1	53	59	PF00069	0.312
MOD_Cter_Amidation	108	111	PF01082	0.231
MOD_GlcNHglycan	134	137	PF01048	0.388
MOD_GlcNHglycan	264	267	PF01048	0.675
MOD_GlcNHglycan	276	279	PF01048	0.638
MOD_GlcNHglycan	290	293	PF01048	0.535
MOD_GlcNHglycan	296	299	PF01048	0.480
MOD_GlcNHglycan	402	405	PF01048	0.523
MOD_GlcNHglycan	427	431	PF01048	0.488
MOD_GSK3_1	125	132	PF00069	0.375
MOD_GSK3_1	179	186	PF00069	0.320
MOD_GSK3_1	202	209	PF00069	0.474
MOD_GSK3_1	221	228	PF00069	0.292
MOD_GSK3_1	274	281	PF00069	0.604
MOD_GSK3_1	396	403	PF00069	0.455
MOD_GSK3_1	492	499	PF00069	0.419
MOD_GSK3_1	53	60	PF00069	0.308
MOD_GSK3_1	533	540	PF00069	0.559
MOD_GSK3_1	6	13	PF00069	0.315
MOD_N-GLC_1	103	108	PF02516	0.312
MOD_N-GLC_1	335	340	PF02516	0.523
MOD_N-GLC_2	98	100	PF02516	0.219
MOD_NEK2_1	1	6	PF00069	0.530
MOD_NEK2_1	131	136	PF00069	0.382
MOD_NEK2_1	156	161	PF00069	0.380
MOD_NEK2_1	183	188	PF00069	0.335
MOD_NEK2_1	225	230	PF00069	0.279
MOD_NEK2_1	279	284	PF00069	0.528
MOD_NEK2_1	396	401	PF00069	0.382
MOD_NEK2_1	426	431	PF00069	0.387
MOD_NEK2_2	346	351	PF00069	0.619
MOD_PIKK_1	129	135	PF00454	0.375
MOD_PIKK_1	243	249	PF00454	0.399
MOD_PIKK_1	6	12	PF00454	0.414
MOD_PKA_1	147	153	PF00069	0.312
MOD_PKA_2	147	153	PF00069	0.312
MOD_PKA_2	183	189	PF00069	0.320
MOD_PKA_2	21	27	PF00069	0.376
MOD_PKA_2	307	313	PF00069	0.533
MOD_PKA_2	438	444	PF00069	0.480
MOD_PKA_2	532	538	PF00069	0.730
MOD_PKB_1	145	153	PF00069	0.312
MOD_Plk_1	126	132	PF00069	0.303
MOD_Plk_1	279	285	PF00069	0.613
MOD_Plk_1	335	341	PF00069	0.525
MOD_Plk_1	386	392	PF00069	0.433
MOD_Plk_1	473	479	PF00069	0.348
MOD_Plk_1	81	87	PF00069	0.312
MOD_Plk_2-3	325	331	PF00069	0.528
MOD_Plk_2-3	59	65	PF00069	0.312
MOD_Plk_4	157	163	PF00069	0.388
MOD_Plk_4	183	189	PF00069	0.314
MOD_Plk_4	296	302	PF00069	0.526
MOD_Plk_4	386	392	PF00069	0.387
MOD_Plk_4	480	486	PF00069	0.389
MOD_ProDKin_1	115	121	PF00069	0.248
MOD_ProDKin_1	189	195	PF00069	0.312
MOD_ProDKin_1	267	273	PF00069	0.570
MOD_ProDKin_1	398	404	PF00069	0.312
MOD_ProDKin_1	456	462	PF00069	0.681
MOD_ProDKin_1	466	472	PF00069	0.699
MOD_SUMO_rev_2	107	112	PF00179	0.385
TRG_DiLeu_BaEn_1	153	158	PF01217	0.388
TRG_DiLeu_BaEn_1	387	392	PF01217	0.352
TRG_DiLeu_BaEn_1	91	96	PF01217	0.225
TRG_DiLeu_BaEn_2	40	46	PF01217	0.307
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.334
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.387
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.410
TRG_ENDOCYTIC_2	188	191	PF00928	0.324
TRG_ENDOCYTIC_2	390	393	PF00928	0.417
TRG_ENDOCYTIC_2	510	513	PF00928	0.338
TRG_ER_diArg_1	144	147	PF00400	0.312
TRG_ER_diArg_1	419	422	PF00400	0.380
TRG_ER_diArg_1	541	544	PF00400	0.566
TRG_NLS_MonoCore_2	144	149	PF00514	0.388
TRG_NLS_MonoExtN_4	142	149	PF00514	0.388
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U4	Leptomonas seymouri	52%	100%
A0A3S7XAH4	Leishmania donovani	73%	100%
A4ICM3	Leishmania infantum	73%	100%
E9ASN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q1W5	Leishmania major	73%	100%