Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNW8_LEIBR

TriTrypDb:

LbrM.35.1210 , LBRM2903_350017900

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HNW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.401
CLV_C14_Caspase3-7	526	530	PF00656	0.437
CLV_NRD_NRD_1	128	130	PF00675	0.623
CLV_NRD_NRD_1	14	16	PF00675	0.514
CLV_NRD_NRD_1	169	171	PF00675	0.656
CLV_NRD_NRD_1	309	311	PF00675	0.717
CLV_NRD_NRD_1	317	319	PF00675	0.601
CLV_NRD_NRD_1	573	575	PF00675	0.505
CLV_PCSK_FUR_1	571	575	PF00082	0.446
CLV_PCSK_KEX2_1	128	130	PF00082	0.614
CLV_PCSK_KEX2_1	14	16	PF00082	0.514
CLV_PCSK_KEX2_1	168	170	PF00082	0.693
CLV_PCSK_KEX2_1	308	310	PF00082	0.743
CLV_PCSK_KEX2_1	317	319	PF00082	0.616
CLV_PCSK_KEX2_1	571	573	PF00082	0.508
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.743
CLV_PCSK_SKI1_1	170	174	PF00082	0.498
CLV_PCSK_SKI1_1	193	197	PF00082	0.542
CLV_PCSK_SKI1_1	216	220	PF00082	0.655
CLV_PCSK_SKI1_1	242	246	PF00082	0.657
CLV_PCSK_SKI1_1	309	313	PF00082	0.736
CLV_PCSK_SKI1_1	387	391	PF00082	0.626
CLV_PCSK_SKI1_1	63	67	PF00082	0.637
DEG_APCC_DBOX_1	386	394	PF00400	0.452
DEG_MDM2_SWIB_1	394	402	PF02201	0.455
DEG_SPOP_SBC_1	2	6	PF00917	0.815
DEG_SPOP_SBC_1	530	534	PF00917	0.444
DEG_SPOP_SBC_1	535	539	PF00917	0.423
DOC_CKS1_1	243	248	PF01111	0.318
DOC_CKS1_1	53	58	PF01111	0.406
DOC_CYCLIN_RxL_1	384	392	PF00134	0.457
DOC_CYCLIN_RxL_1	60	70	PF00134	0.427
DOC_CYCLIN_yClb5_NLxxxL_5	384	393	PF00134	0.280
DOC_MAPK_gen_1	168	175	PF00069	0.394
DOC_MAPK_gen_1	252	261	PF00069	0.328
DOC_MAPK_gen_1	52	60	PF00069	0.586
DOC_MAPK_MEF2A_6	78	86	PF00069	0.381
DOC_PP2B_LxvP_1	520	523	PF13499	0.435
DOC_PP2B_LxvP_1	82	85	PF13499	0.471
DOC_PP4_FxxP_1	555	558	PF00568	0.411
DOC_USP7_MATH_1	108	112	PF00917	0.443
DOC_USP7_MATH_1	195	199	PF00917	0.470
DOC_USP7_MATH_1	2	6	PF00917	0.638
DOC_USP7_MATH_1	228	232	PF00917	0.397
DOC_USP7_MATH_1	272	276	PF00917	0.452
DOC_USP7_MATH_1	373	377	PF00917	0.400
DOC_USP7_MATH_1	530	534	PF00917	0.579
DOC_USP7_MATH_1	536	540	PF00917	0.579
DOC_USP7_MATH_2	432	438	PF00917	0.307
DOC_WW_Pin1_4	180	185	PF00397	0.377
DOC_WW_Pin1_4	242	247	PF00397	0.324
DOC_WW_Pin1_4	348	353	PF00397	0.308
DOC_WW_Pin1_4	453	458	PF00397	0.462
DOC_WW_Pin1_4	464	469	PF00397	0.436
DOC_WW_Pin1_4	497	502	PF00397	0.452
DOC_WW_Pin1_4	510	515	PF00397	0.454
DOC_WW_Pin1_4	52	57	PF00397	0.514
DOC_WW_Pin1_4	67	72	PF00397	0.512
LIG_14-3-3_CanoR_1	168	173	PF00244	0.330
LIG_14-3-3_CanoR_1	207	212	PF00244	0.408
LIG_14-3-3_CanoR_1	283	287	PF00244	0.351
LIG_14-3-3_CanoR_1	463	469	PF00244	0.450
LIG_APCC_ABBA_1	338	343	PF00400	0.303
LIG_APCC_ABBA_1	455	460	PF00400	0.353
LIG_APCC_ABBAyCdc20_2	308	314	PF00400	0.459
LIG_Clathr_ClatBox_1	354	358	PF01394	0.452
LIG_Dynein_DLC8_1	461	467	PF01221	0.359
LIG_EVH1_2	56	60	PF00568	0.597
LIG_FHA_1	181	187	PF00498	0.474
LIG_FHA_1	194	200	PF00498	0.374
LIG_FHA_1	213	219	PF00498	0.347
LIG_FHA_1	30	36	PF00498	0.411
LIG_FHA_1	328	334	PF00498	0.321
LIG_FHA_1	469	475	PF00498	0.367
LIG_FHA_1	486	492	PF00498	0.395
LIG_FHA_1	530	536	PF00498	0.527
LIG_FHA_1	564	570	PF00498	0.660
LIG_FHA_1	68	74	PF00498	0.531
LIG_FHA_1	78	84	PF00498	0.470
LIG_FHA_2	153	159	PF00498	0.473
LIG_FHA_2	295	301	PF00498	0.379
LIG_FHA_2	344	350	PF00498	0.343
LIG_FHA_2	59	65	PF00498	0.431
LIG_GBD_Chelix_1	27	35	PF00786	0.492
LIG_LIR_Apic_2	453	457	PF02991	0.459
LIG_LIR_Apic_2	50	56	PF02991	0.397
LIG_LIR_Gen_1	135	142	PF02991	0.459
LIG_LIR_Gen_1	219	228	PF02991	0.314
LIG_LIR_Gen_1	266	273	PF02991	0.306
LIG_LIR_LC3C_4	80	84	PF02991	0.473
LIG_LIR_Nem_3	135	140	PF02991	0.455
LIG_LIR_Nem_3	219	224	PF02991	0.315
LIG_LIR_Nem_3	266	270	PF02991	0.405
LIG_LIR_Nem_3	325	331	PF02991	0.405
LIG_LIR_Nem_3	41	47	PF02991	0.398
LIG_LIR_Nem_3	503	508	PF02991	0.499
LIG_LIR_Nem_3	67	72	PF02991	0.408
LIG_MAD2	242	250	PF02301	0.336
LIG_NRBOX	480	486	PF00104	0.470
LIG_PCNA_PIPBox_1	408	417	PF02747	0.288
LIG_PCNA_yPIPBox_3	463	473	PF02747	0.474
LIG_Pex14_2	221	225	PF04695	0.383
LIG_Pex14_2	394	398	PF04695	0.457
LIG_SH2_CRK	137	141	PF00017	0.465
LIG_SH2_CRK	415	419	PF00017	0.372
LIG_SH2_CRK	53	57	PF00017	0.406
LIG_SH2_PTP2	454	457	PF00017	0.380
LIG_SH2_STAP1	137	141	PF00017	0.465
LIG_SH2_STAT3	185	188	PF00017	0.475
LIG_SH2_STAT5	185	188	PF00017	0.475
LIG_SH2_STAT5	345	348	PF00017	0.333
LIG_SH2_STAT5	370	373	PF00017	0.388
LIG_SH2_STAT5	454	457	PF00017	0.456
LIG_SH2_STAT5	47	50	PF00017	0.402
LIG_SH2_STAT5	554	557	PF00017	0.405
LIG_SH2_STAT5	94	97	PF00017	0.545
LIG_SH3_1	254	260	PF00018	0.329
LIG_SH3_3	102	108	PF00018	0.338
LIG_SH3_3	240	246	PF00018	0.352
LIG_SH3_3	254	260	PF00018	0.350
LIG_SH3_3	36	42	PF00018	0.306
LIG_SH3_3	377	383	PF00018	0.363
LIG_SUMO_SIM_anti_2	330	335	PF11976	0.320
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.476
LIG_SUMO_SIM_par_1	129	135	PF11976	0.352
LIG_SUMO_SIM_par_1	31	36	PF11976	0.411
LIG_SUMO_SIM_par_1	470	475	PF11976	0.375
LIG_SUMO_SIM_par_1	70	75	PF11976	0.474
LIG_TRAF2_1	432	435	PF00917	0.326
LIG_TRAF2_1	515	518	PF00917	0.400
LIG_TRFH_1	554	558	PF08558	0.411
LIG_TYR_ITIM	265	270	PF00017	0.370
LIG_UBA3_1	484	490	PF00899	0.563
LIG_Vh1_VBS_1	535	553	PF01044	0.619
MOD_CDK_SPxxK_3	497	504	PF00069	0.555
MOD_CK1_1	177	183	PF00069	0.474
MOD_CK1_1	198	204	PF00069	0.458
MOD_CK1_1	281	287	PF00069	0.514
MOD_CK1_1	323	329	PF00069	0.457
MOD_CK1_1	361	367	PF00069	0.560
MOD_CK1_1	462	468	PF00069	0.502
MOD_CK1_1	537	543	PF00069	0.515
MOD_CK2_1	152	158	PF00069	0.586
MOD_CK2_1	294	300	PF00069	0.452
MOD_CK2_1	497	503	PF00069	0.559
MOD_CK2_1	58	64	PF00069	0.556
MOD_Cter_Amidation	12	15	PF01082	0.750
MOD_DYRK1A_RPxSP_1	242	246	PF00069	0.373
MOD_GlcNHglycan	110	113	PF01048	0.626
MOD_GlcNHglycan	137	140	PF01048	0.576
MOD_GlcNHglycan	176	179	PF01048	0.590
MOD_GlcNHglycan	322	325	PF01048	0.638
MOD_GlcNHglycan	360	363	PF01048	0.496
MOD_GlcNHglycan	375	378	PF01048	0.556
MOD_GlcNHglycan	49	52	PF01048	0.677
MOD_GlcNHglycan	508	511	PF01048	0.396
MOD_GlcNHglycan	539	542	PF01048	0.611
MOD_GlcNHglycan	90	93	PF01048	0.541
MOD_GSK3_1	120	127	PF00069	0.658
MOD_GSK3_1	149	156	PF00069	0.648
MOD_GSK3_1	159	166	PF00069	0.814
MOD_GSK3_1	2	9	PF00069	0.774
MOD_GSK3_1	206	213	PF00069	0.745
MOD_GSK3_1	278	285	PF00069	0.428
MOD_GSK3_1	29	36	PF00069	0.411
MOD_GSK3_1	290	297	PF00069	0.351
MOD_GSK3_1	318	325	PF00069	0.493
MOD_GSK3_1	389	396	PF00069	0.458
MOD_GSK3_1	43	50	PF00069	0.603
MOD_GSK3_1	446	453	PF00069	0.539
MOD_GSK3_1	464	471	PF00069	0.621
MOD_GSK3_1	506	513	PF00069	0.531
MOD_GSK3_1	525	532	PF00069	0.688
MOD_N-GLC_1	147	152	PF02516	0.550
MOD_N-GLC_1	318	323	PF02516	0.599
MOD_N-GLC_1	445	450	PF02516	0.567
MOD_N-GLC_2	422	424	PF02516	0.380
MOD_N-GLC_2	568	570	PF02516	0.706
MOD_NEK2_1	273	278	PF00069	0.552
MOD_NEK2_1	29	34	PF00069	0.411
MOD_NEK2_1	3	8	PF00069	0.539
MOD_NEK2_1	341	346	PF00069	0.615
MOD_NEK2_1	389	394	PF00069	0.557
MOD_NEK2_1	420	425	PF00069	0.623
MOD_NEK2_1	450	455	PF00069	0.591
MOD_NEK2_1	459	464	PF00069	0.629
MOD_NEK2_1	485	490	PF00069	0.366
MOD_NEK2_1	506	511	PF00069	0.526
MOD_NEK2_1	563	568	PF00069	0.597
MOD_NEK2_2	195	200	PF00069	0.430
MOD_NEK2_2	282	287	PF00069	0.347
MOD_OFUCOSY	176	181	PF10250	0.494
MOD_PIKK_1	147	153	PF00454	0.803
MOD_PIKK_1	294	300	PF00454	0.410
MOD_PIKK_1	462	468	PF00454	0.444
MOD_PIKK_1	563	569	PF00454	0.455
MOD_PK_1	168	174	PF00069	0.598
MOD_PKA_1	168	174	PF00069	0.557
MOD_PKA_2	168	174	PF00069	0.557
MOD_PKA_2	206	212	PF00069	0.634
MOD_PKA_2	282	288	PF00069	0.535
MOD_PKA_2	462	468	PF00069	0.521
MOD_PKB_1	214	222	PF00069	0.565
MOD_Plk_1	318	324	PF00069	0.449
MOD_Plk_1	341	347	PF00069	0.402
MOD_Plk_1	434	440	PF00069	0.408
MOD_Plk_1	445	451	PF00069	0.504
MOD_Plk_2-3	343	349	PF00069	0.377
MOD_Plk_4	22	28	PF00069	0.426
MOD_Plk_4	290	296	PF00069	0.644
MOD_Plk_4	33	39	PF00069	0.395
MOD_Plk_4	389	395	PF00069	0.556
MOD_Plk_4	402	408	PF00069	0.343
MOD_Plk_4	43	49	PF00069	0.640
MOD_Plk_4	446	452	PF00069	0.545
MOD_Plk_4	468	474	PF00069	0.359
MOD_Plk_4	77	83	PF00069	0.574
MOD_ProDKin_1	180	186	PF00069	0.454
MOD_ProDKin_1	242	248	PF00069	0.381
MOD_ProDKin_1	348	354	PF00069	0.352
MOD_ProDKin_1	453	459	PF00069	0.570
MOD_ProDKin_1	464	470	PF00069	0.528
MOD_ProDKin_1	497	503	PF00069	0.559
MOD_ProDKin_1	510	516	PF00069	0.569
MOD_ProDKin_1	52	58	PF00069	0.646
MOD_ProDKin_1	67	73	PF00069	0.641
MOD_SUMO_rev_2	526	533	PF00179	0.542
TRG_DiLeu_BaEn_2	543	549	PF01217	0.389
TRG_ENDOCYTIC_2	137	140	PF00928	0.576
TRG_ENDOCYTIC_2	267	270	PF00928	0.394
TRG_ENDOCYTIC_2	415	418	PF00928	0.447
TRG_ENDOCYTIC_2	554	557	PF00928	0.413
TRG_ER_diArg_1	128	130	PF00400	0.472
TRG_ER_diArg_1	14	16	PF00400	0.647
TRG_ER_diArg_1	168	170	PF00400	0.617
TRG_ER_diArg_1	214	217	PF00400	0.572
TRG_ER_diArg_1	309	311	PF00400	0.663
TRG_ER_diArg_1	316	318	PF00400	0.637
TRG_ER_diArg_1	571	574	PF00400	0.635
TRG_NES_CRM1_1	401	413	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	309	314	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I575	Leptomonas seymouri	34%	99%
A0A3Q8IKB7	Leishmania donovani	66%	100%
A4ICM6	Leishmania infantum	66%	100%
E9ASM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q1W8	Leishmania major	65%	100%