LeishMANIAdb
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RNA editing complex protein MP61

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA editing complex protein MP61
Gene product:
RNA editing complex protein MP61
Species:
Leishmania braziliensis
UniProt:
A4HNW5_LEIBR
TriTrypDb:
LbrM.35.1180 , LBRM2903_350017600
Length:
598

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HNW5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNW5

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004518 nuclease activity 4 11
GO:0004519 endonuclease activity 5 11
GO:0004521 RNA endonuclease activity 5 11
GO:0004525 ribonuclease III activity 6 11
GO:0004540 RNA nuclease activity 4 11
GO:0016787 hydrolase activity 2 11
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6 11
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 11
GO:0032296 double-stranded RNA-specific ribonuclease activity 5 11
GO:0140098 catalytic activity, acting on RNA 3 11
GO:0140640 catalytic activity, acting on a nucleic acid 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 316 320 PF00656 0.360
CLV_C14_Caspase3-7 86 90 PF00656 0.477
CLV_NRD_NRD_1 130 132 PF00675 0.482
CLV_NRD_NRD_1 155 157 PF00675 0.450
CLV_NRD_NRD_1 236 238 PF00675 0.331
CLV_NRD_NRD_1 239 241 PF00675 0.343
CLV_NRD_NRD_1 24 26 PF00675 0.768
CLV_NRD_NRD_1 538 540 PF00675 0.631
CLV_NRD_NRD_1 96 98 PF00675 0.649
CLV_NRD_NRD_1 99 101 PF00675 0.670
CLV_PCSK_FUR_1 237 241 PF00082 0.352
CLV_PCSK_FUR_1 97 101 PF00082 0.646
CLV_PCSK_KEX2_1 130 132 PF00082 0.623
CLV_PCSK_KEX2_1 155 157 PF00082 0.441
CLV_PCSK_KEX2_1 167 169 PF00082 0.282
CLV_PCSK_KEX2_1 238 240 PF00082 0.355
CLV_PCSK_KEX2_1 24 26 PF00082 0.766
CLV_PCSK_KEX2_1 500 502 PF00082 0.496
CLV_PCSK_KEX2_1 96 98 PF00082 0.649
CLV_PCSK_KEX2_1 99 101 PF00082 0.670
CLV_PCSK_PC1ET2_1 167 169 PF00082 0.346
CLV_PCSK_PC1ET2_1 238 240 PF00082 0.372
CLV_PCSK_PC1ET2_1 500 502 PF00082 0.496
CLV_PCSK_SKI1_1 100 104 PF00082 0.534
CLV_PCSK_SKI1_1 155 159 PF00082 0.503
CLV_PCSK_SKI1_1 239 243 PF00082 0.410
CLV_PCSK_SKI1_1 246 250 PF00082 0.347
CLV_PCSK_SKI1_1 251 255 PF00082 0.349
CLV_PCSK_SKI1_1 286 290 PF00082 0.319
CLV_Separin_Metazoa 197 201 PF03568 0.369
CLV_Separin_Metazoa 579 583 PF03568 0.600
DEG_APCC_DBOX_1 238 246 PF00400 0.468
DEG_APCC_DBOX_1 514 522 PF00400 0.639
DEG_SPOP_SBC_1 150 154 PF00917 0.490
DEG_SPOP_SBC_1 41 45 PF00917 0.476
DOC_ANK_TNKS_1 500 507 PF00023 0.627
DOC_ANK_TNKS_1 84 91 PF00023 0.475
DOC_CDC14_PxL_1 223 231 PF14671 0.362
DOC_CKS1_1 114 119 PF01111 0.614
DOC_CKS1_1 77 82 PF01111 0.580
DOC_CYCLIN_yClb1_LxF_4 415 421 PF00134 0.510
DOC_MAPK_gen_1 237 247 PF00069 0.329
DOC_MAPK_gen_1 411 420 PF00069 0.415
DOC_MAPK_gen_1 575 585 PF00069 0.484
DOC_MAPK_HePTP_8 138 150 PF00069 0.439
DOC_MAPK_MEF2A_6 141 150 PF00069 0.553
DOC_MAPK_MEF2A_6 191 198 PF00069 0.338
DOC_MAPK_MEF2A_6 578 585 PF00069 0.495
DOC_MAPK_NFAT4_5 191 199 PF00069 0.342
DOC_PP1_RVXF_1 274 280 PF00149 0.338
DOC_PP2B_LxvP_1 111 114 PF13499 0.643
DOC_PP2B_LxvP_1 583 586 PF13499 0.548
DOC_PP4_FxxP_1 77 80 PF00568 0.574
DOC_USP7_MATH_1 140 144 PF00917 0.445
DOC_USP7_MATH_1 52 56 PF00917 0.655
DOC_WW_Pin1_4 113 118 PF00397 0.699
DOC_WW_Pin1_4 202 207 PF00397 0.385
DOC_WW_Pin1_4 23 28 PF00397 0.498
DOC_WW_Pin1_4 29 34 PF00397 0.497
DOC_WW_Pin1_4 366 371 PF00397 0.607
DOC_WW_Pin1_4 76 81 PF00397 0.591
LIG_14-3-3_CanoR_1 216 223 PF00244 0.336
LIG_14-3-3_CanoR_1 582 586 PF00244 0.670
LIG_14-3-3_CanoR_1 8 15 PF00244 0.659
LIG_AP2alpha_1 157 161 PF02296 0.257
LIG_APCC_ABBA_1 158 163 PF00400 0.334
LIG_APCC_ABBA_1 81 86 PF00400 0.454
LIG_BIR_II_1 1 5 PF00653 0.449
LIG_BRCT_BRCA1_1 270 274 PF00533 0.369
LIG_BRCT_BRCA1_1 293 297 PF00533 0.389
LIG_eIF4E_1 380 386 PF01652 0.402
LIG_FHA_1 181 187 PF00498 0.313
LIG_FHA_1 255 261 PF00498 0.400
LIG_FHA_1 366 372 PF00498 0.635
LIG_FHA_1 374 380 PF00498 0.585
LIG_FHA_1 467 473 PF00498 0.607
LIG_FHA_1 531 537 PF00498 0.496
LIG_FHA_2 203 209 PF00498 0.374
LIG_FHA_2 360 366 PF00498 0.468
LIG_FHA_2 492 498 PF00498 0.584
LIG_FHA_2 77 83 PF00498 0.496
LIG_FXI_DFP_1 161 165 PF00024 0.343
LIG_GBD_Chelix_1 347 355 PF00786 0.284
LIG_IRF3_LxIS_1 562 569 PF10401 0.461
LIG_LIR_Gen_1 154 164 PF02991 0.379
LIG_LIR_Gen_1 211 222 PF02991 0.402
LIG_LIR_Gen_1 271 280 PF02991 0.400
LIG_LIR_Gen_1 309 315 PF02991 0.514
LIG_LIR_Gen_1 349 359 PF02991 0.368
LIG_LIR_Gen_1 493 504 PF02991 0.649
LIG_LIR_Nem_3 132 136 PF02991 0.572
LIG_LIR_Nem_3 159 164 PF02991 0.341
LIG_LIR_Nem_3 211 217 PF02991 0.366
LIG_LIR_Nem_3 271 277 PF02991 0.408
LIG_LIR_Nem_3 309 314 PF02991 0.523
LIG_LIR_Nem_3 349 355 PF02991 0.329
LIG_LIR_Nem_3 493 499 PF02991 0.584
LIG_NRBOX 240 246 PF00104 0.324
LIG_PCNA_yPIPBox_3 406 414 PF02747 0.380
LIG_PDZ_Class_3 593 598 PF00595 0.507
LIG_Pex14_1 546 550 PF04695 0.411
LIG_Pex14_2 129 133 PF04695 0.551
LIG_Pex14_2 157 161 PF04695 0.339
LIG_PTB_Apo_2 170 177 PF02174 0.350
LIG_SH2_CRK 460 464 PF00017 0.674
LIG_SH2_GRB2like 404 407 PF00017 0.236
LIG_SH2_GRB2like 496 499 PF00017 0.515
LIG_SH2_GRB2like 74 77 PF00017 0.631
LIG_SH2_NCK_1 550 554 PF00017 0.400
LIG_SH2_SRC 404 407 PF00017 0.236
LIG_SH2_STAP1 136 140 PF00017 0.414
LIG_SH2_STAP1 380 384 PF00017 0.489
LIG_SH2_STAP1 391 395 PF00017 0.415
LIG_SH2_STAP1 550 554 PF00017 0.400
LIG_SH2_STAT5 202 205 PF00017 0.402
LIG_SH2_STAT5 243 246 PF00017 0.330
LIG_SH2_STAT5 287 290 PF00017 0.315
LIG_SH2_STAT5 358 361 PF00017 0.412
LIG_SH2_STAT5 380 383 PF00017 0.461
LIG_SH2_STAT5 404 407 PF00017 0.327
LIG_SH3_1 460 466 PF00018 0.566
LIG_SH3_3 111 117 PF00018 0.606
LIG_SH3_3 30 36 PF00018 0.518
LIG_SH3_3 460 466 PF00018 0.711
LIG_SUMO_SIM_anti_2 469 474 PF11976 0.467
LIG_SUMO_SIM_anti_2 516 522 PF11976 0.641
LIG_SUMO_SIM_par_1 146 154 PF11976 0.543
LIG_TRAF2_1 205 208 PF00917 0.284
LIG_TRAF2_1 514 517 PF00917 0.458
LIG_UBA3_1 241 249 PF00899 0.330
LIG_WRC_WIRS_1 255 260 PF05994 0.402
MOD_CK1_1 134 140 PF00069 0.701
MOD_CK1_1 149 155 PF00069 0.521
MOD_CK1_1 2 8 PF00069 0.619
MOD_CK1_1 265 271 PF00069 0.512
MOD_CK1_1 291 297 PF00069 0.333
MOD_CK1_1 43 49 PF00069 0.648
MOD_CK1_1 530 536 PF00069 0.527
MOD_CK1_1 55 61 PF00069 0.645
MOD_CK2_1 202 208 PF00069 0.460
MOD_Cter_Amidation 67 70 PF01082 0.605
MOD_GlcNHglycan 138 141 PF01048 0.652
MOD_GlcNHglycan 15 18 PF01048 0.481
MOD_GlcNHglycan 267 270 PF01048 0.491
MOD_GlcNHglycan 551 554 PF01048 0.412
MOD_GlcNHglycan 568 571 PF01048 0.646
MOD_GlcNHglycan 58 61 PF01048 0.624
MOD_GlcNHglycan 66 69 PF01048 0.574
MOD_GSK3_1 136 143 PF00069 0.639
MOD_GSK3_1 146 153 PF00069 0.555
MOD_GSK3_1 254 261 PF00069 0.423
MOD_GSK3_1 338 345 PF00069 0.392
MOD_GSK3_1 36 43 PF00069 0.730
MOD_GSK3_1 52 59 PF00069 0.612
MOD_GSK3_1 545 552 PF00069 0.574
MOD_N-GLC_1 172 177 PF02516 0.363
MOD_N-GLC_1 258 263 PF02516 0.561
MOD_N-GLC_2 218 220 PF02516 0.407
MOD_NEK2_1 254 259 PF00069 0.388
MOD_NEK2_1 333 338 PF00069 0.447
MOD_NEK2_1 359 364 PF00069 0.526
MOD_NEK2_1 440 445 PF00069 0.556
MOD_NEK2_1 490 495 PF00069 0.677
MOD_NEK2_1 549 554 PF00069 0.656
MOD_NEK2_1 566 571 PF00069 0.734
MOD_NEK2_2 306 311 PF00069 0.453
MOD_NEK2_2 532 537 PF00069 0.537
MOD_NEK2_2 545 550 PF00069 0.463
MOD_PIKK_1 140 146 PF00454 0.450
MOD_PIKK_1 174 180 PF00454 0.300
MOD_PIKK_1 260 266 PF00454 0.385
MOD_PIKK_1 359 365 PF00454 0.542
MOD_PIKK_1 474 480 PF00454 0.553
MOD_PIKK_1 8 14 PF00454 0.452
MOD_PKA_2 140 146 PF00069 0.541
MOD_PKA_2 36 42 PF00069 0.582
MOD_PKA_2 581 587 PF00069 0.694
MOD_PKA_2 64 70 PF00069 0.530
MOD_Plk_1 134 140 PF00069 0.414
MOD_Plk_1 172 178 PF00069 0.367
MOD_Plk_1 452 458 PF00069 0.484
MOD_Plk_1 516 522 PF00069 0.655
MOD_Plk_4 288 294 PF00069 0.326
MOD_Plk_4 347 353 PF00069 0.293
MOD_Plk_4 468 474 PF00069 0.705
MOD_Plk_4 516 522 PF00069 0.546
MOD_Plk_4 545 551 PF00069 0.663
MOD_Plk_4 59 65 PF00069 0.568
MOD_ProDKin_1 113 119 PF00069 0.696
MOD_ProDKin_1 202 208 PF00069 0.386
MOD_ProDKin_1 23 29 PF00069 0.499
MOD_ProDKin_1 366 372 PF00069 0.612
MOD_ProDKin_1 76 82 PF00069 0.593
MOD_SUMO_for_1 588 591 PF00179 0.637
TRG_AP2beta_CARGO_1 159 168 PF09066 0.351
TRG_DiLeu_BaEn_2 274 280 PF01217 0.471
TRG_DiLeu_BaLyEn_6 237 242 PF01217 0.395
TRG_DiLeu_LyEn_5 106 111 PF01217 0.503
TRG_ENDOCYTIC_2 325 328 PF00928 0.405
TRG_ENDOCYTIC_2 496 499 PF00928 0.551
TRG_ENDOCYTIC_2 74 77 PF00928 0.631
TRG_ER_diArg_1 129 131 PF00400 0.632
TRG_ER_diArg_1 155 157 PF00400 0.449
TRG_ER_diArg_1 23 25 PF00400 0.773
TRG_ER_diArg_1 237 240 PF00400 0.346
TRG_ER_diArg_1 96 99 PF00400 0.660
TRG_NLS_Bipartite_1 155 171 PF00514 0.348
TRG_NLS_MonoExtN_4 237 242 PF00514 0.330
TRG_Pf-PMV_PEXEL_1 383 387 PF00026 0.445
TRG_Pf-PMV_PEXEL_1 8 12 PF00026 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V7 Leptomonas seymouri 48% 100%
A0A1X0P9H0 Trypanosomatidae 48% 100%
A0A3R7KSN8 Trypanosoma rangeli 45% 100%
A0A3S7XAI5 Leishmania donovani 77% 100%
A4ICM9 Leishmania infantum 77% 100%
D0A2T3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9ASM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
Q6T449 Leishmania major 76% 98%
V5BZU7 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS