Flagellar C1a complex subunit C1a-32

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellar C1a complex subunit C1a-32, putative

Species:

Leishmania braziliensis

UniProt:

A4HNW4_LEIBR

TriTrypDb:

LbrM.35.1170 , LBRM2903_350017500

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	3
GO:0031514	motile cilium	5	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

A4HNW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.491
CLV_NRD_NRD_1	284	286	PF00675	0.628
CLV_PCSK_KEX2_1	218	220	PF00082	0.569
CLV_PCSK_KEX2_1	284	286	PF00082	0.614
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.434
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.630
DEG_APCC_DBOX_1	232	240	PF00400	0.449
DOC_MAPK_gen_1	245	253	PF00069	0.350
DOC_MAPK_MEF2A_6	48	57	PF00069	0.517
DOC_USP7_MATH_1	51	55	PF00917	0.339
DOC_USP7_MATH_1	67	71	PF00917	0.413
DOC_USP7_UBL2_3	280	284	PF12436	0.591
DOC_WW_Pin1_4	70	75	PF00397	0.376
LIG_14-3-3_CanoR_1	111	115	PF00244	0.297
LIG_14-3-3_CanoR_1	116	126	PF00244	0.202
LIG_14-3-3_CanoR_1	194	199	PF00244	0.556
LIG_14-3-3_CanoR_1	98	103	PF00244	0.345
LIG_Actin_WH2_2	145	162	PF00022	0.449
LIG_Actin_WH2_2	15	30	PF00022	0.476
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_DLG_GKlike_1	98	105	PF00625	0.413
LIG_eIF4E_1	60	66	PF01652	0.449
LIG_FHA_1	159	165	PF00498	0.614
LIG_FHA_1	246	252	PF00498	0.350
LIG_FHA_1	4	10	PF00498	0.438
LIG_FHA_1	75	81	PF00498	0.425
LIG_FHA_2	195	201	PF00498	0.571
LIG_FHA_2	257	263	PF00498	0.547
LIG_LIR_Gen_1	101	110	PF02991	0.334
LIG_LIR_Gen_1	6	11	PF02991	0.535
LIG_LIR_LC3C_4	107	110	PF02991	0.475
LIG_LIR_Nem_3	101	105	PF02991	0.384
LIG_LIR_Nem_3	138	144	PF02991	0.332
LIG_LIR_Nem_3	58	63	PF02991	0.445
LIG_LIR_Nem_3	6	10	PF02991	0.417
LIG_LIR_Nem_3	70	75	PF02991	0.413
LIG_SH2_CRK	102	106	PF00017	0.413
LIG_SH2_CRK	149	153	PF00017	0.363
LIG_SH2_STAP1	119	123	PF00017	0.449
LIG_SH2_STAT5	147	150	PF00017	0.366
LIG_SH3_3	111	117	PF00018	0.315
LIG_SH3_3	165	171	PF00018	0.533
LIG_SUMO_SIM_anti_2	247	256	PF11976	0.570
LIG_SUMO_SIM_par_1	160	167	PF11976	0.643
LIG_TRAF2_1	197	200	PF00917	0.534
MOD_CDC14_SPxK_1	73	76	PF00782	0.376
MOD_CDK_SPxK_1	70	76	PF00069	0.376
MOD_CK1_1	244	250	PF00069	0.547
MOD_CK1_1	270	276	PF00069	0.639
MOD_CK1_1	279	285	PF00069	0.684
MOD_CK1_1	70	76	PF00069	0.449
MOD_CK2_1	122	128	PF00069	0.320
MOD_CK2_1	194	200	PF00069	0.540
MOD_CK2_1	256	262	PF00069	0.548
MOD_GlcNHglycan	178	181	PF01048	0.610
MOD_GlcNHglycan	219	222	PF01048	0.601
MOD_GlcNHglycan	269	272	PF01048	0.637
MOD_GlcNHglycan	44	47	PF01048	0.558
MOD_GSK3_1	118	125	PF00069	0.418
MOD_GSK3_1	131	138	PF00069	0.414
MOD_GSK3_1	194	201	PF00069	0.545
MOD_GSK3_1	207	214	PF00069	0.600
MOD_GSK3_1	241	248	PF00069	0.607
MOD_GSK3_1	275	282	PF00069	0.676
MOD_GSK3_1	42	49	PF00069	0.551
MOD_GSK3_1	70	77	PF00069	0.361
MOD_GSK3_1	94	101	PF00069	0.359
MOD_N-GLC_1	164	169	PF02516	0.668
MOD_NEK2_1	122	127	PF00069	0.459
MOD_NEK2_1	136	141	PF00069	0.328
MOD_NEK2_1	75	80	PF00069	0.378
MOD_PIKK_1	67	73	PF00454	0.418
MOD_PKA_1	245	251	PF00069	0.350
MOD_PKA_2	110	116	PF00069	0.413
MOD_PKA_2	12	18	PF00069	0.530
MOD_PKA_2	275	281	PF00069	0.754
MOD_PKA_2	94	100	PF00069	0.376
MOD_PKB_1	274	282	PF00069	0.759
MOD_Plk_1	164	170	PF00069	0.463
MOD_Plk_1	88	94	PF00069	0.413
MOD_Plk_2-3	211	217	PF00069	0.400
MOD_Plk_4	118	124	PF00069	0.477
MOD_Plk_4	131	137	PF00069	0.389
MOD_Plk_4	51	57	PF00069	0.410
MOD_Plk_4	76	82	PF00069	0.342
MOD_ProDKin_1	70	76	PF00069	0.376
MOD_SUMO_rev_2	210	220	PF00179	0.410
MOD_SUMO_rev_2	249	259	PF00179	0.495
TRG_ENDOCYTIC_2	102	105	PF00928	0.328
TRG_ENDOCYTIC_2	119	122	PF00928	0.328
TRG_ENDOCYTIC_2	149	152	PF00928	0.357
TRG_ENDOCYTIC_2	60	63	PF00928	0.442
TRG_ER_diArg_1	274	277	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE82	Leptomonas seymouri	68%	100%
A0A0S4JAR9	Bodo saltans	36%	95%
A0A1X0P8D5	Trypanosomatidae	41%	100%
A0A3Q8IVT9	Leishmania donovani	84%	100%
A0A3R7MW02	Trypanosoma rangeli	42%	100%
A4ICN0	Leishmania infantum	84%	100%
D0A2T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1X2	Leishmania major	83%	100%
V5BQE4	Trypanosoma cruzi	46%	100%