Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNW2_LEIBR

TriTrypDb:

LbrM.35.1150 , LBRM2903_350017300

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HNW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.392
CLV_NRD_NRD_1	139	141	PF00675	0.579
CLV_NRD_NRD_1	145	147	PF00675	0.579
CLV_NRD_NRD_1	355	357	PF00675	0.561
CLV_NRD_NRD_1	441	443	PF00675	0.434
CLV_NRD_NRD_1	529	531	PF00675	0.387
CLV_NRD_NRD_1	542	544	PF00675	0.414
CLV_PCSK_FUR_1	439	443	PF00082	0.459
CLV_PCSK_KEX2_1	138	140	PF00082	0.560
CLV_PCSK_KEX2_1	322	324	PF00082	0.554
CLV_PCSK_KEX2_1	327	329	PF00082	0.522
CLV_PCSK_KEX2_1	355	357	PF00082	0.539
CLV_PCSK_KEX2_1	441	443	PF00082	0.406
CLV_PCSK_KEX2_1	529	531	PF00082	0.387
CLV_PCSK_KEX2_1	541	543	PF00082	0.414
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.591
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.580
CLV_PCSK_PC7_1	135	141	PF00082	0.605
CLV_PCSK_PC7_1	323	329	PF00082	0.468
CLV_PCSK_PC7_1	437	443	PF00082	0.404
CLV_PCSK_SKI1_1	220	224	PF00082	0.480
CLV_PCSK_SKI1_1	327	331	PF00082	0.558
CLV_PCSK_SKI1_1	529	533	PF00082	0.364
CLV_PCSK_SKI1_1	543	547	PF00082	0.443
DEG_APCC_DBOX_1	322	330	PF00400	0.381
DEG_Nend_UBRbox_1	1	4	PF02207	0.399
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.310
DOC_MAPK_JIP1_4	503	509	PF00069	0.240
DOC_MAPK_MEF2A_6	220	229	PF00069	0.274
DOC_MAPK_MEF2A_6	462	470	PF00069	0.487
DOC_MAPK_MEF2A_6	503	511	PF00069	0.231
DOC_MAPK_NFAT4_5	220	228	PF00069	0.259
DOC_PP1_RVXF_1	487	494	PF00149	0.258
DOC_PP2B_LxvP_1	223	226	PF13499	0.368
DOC_PP2B_LxvP_1	473	476	PF13499	0.348
DOC_SPAK_OSR1_1	492	496	PF12202	0.246
DOC_USP7_MATH_1	209	213	PF00917	0.460
DOC_USP7_MATH_1	258	262	PF00917	0.465
DOC_USP7_MATH_1	321	325	PF00917	0.384
DOC_USP7_MATH_1	387	391	PF00917	0.329
DOC_USP7_MATH_2	63	69	PF00917	0.313
DOC_USP7_UBL2_3	327	331	PF12436	0.349
DOC_WW_Pin1_4	446	451	PF00397	0.602
DOC_WW_Pin1_4	533	538	PF00397	0.555
LIG_14-3-3_CanoR_1	146	151	PF00244	0.448
LIG_14-3-3_CanoR_1	30	35	PF00244	0.517
LIG_14-3-3_CterR_2	543	548	PF00244	0.572
LIG_Actin_WH2_2	237	253	PF00022	0.317
LIG_Actin_WH2_2	476	491	PF00022	0.197
LIG_APCC_ABBA_1	233	238	PF00400	0.351
LIG_BRCT_BRCA1_1	512	516	PF00533	0.268
LIG_deltaCOP1_diTrp_1	56	61	PF00928	0.495
LIG_DLG_GKlike_1	146	153	PF00625	0.316
LIG_EH1_1	492	500	PF00400	0.235
LIG_eIF4E_1	465	471	PF01652	0.197
LIG_FHA_1	31	37	PF00498	0.500
LIG_FHA_1	392	398	PF00498	0.379
LIG_FHA_1	452	458	PF00498	0.638
LIG_FHA_1	506	512	PF00498	0.184
LIG_FHA_2	102	108	PF00498	0.464
LIG_FHA_2	272	278	PF00498	0.432
LIG_FHA_2	286	292	PF00498	0.437
LIG_FHA_2	312	318	PF00498	0.463
LIG_LIR_Gen_1	344	354	PF02991	0.301
LIG_LIR_Gen_1	420	430	PF02991	0.319
LIG_LIR_LC3C_4	472	475	PF02991	0.355
LIG_LIR_Nem_3	188	194	PF02991	0.345
LIG_LIR_Nem_3	344	349	PF02991	0.410
LIG_LIR_Nem_3	420	426	PF02991	0.336
LIG_MYND_1	476	480	PF01753	0.322
LIG_NRBOX	325	331	PF00104	0.377
LIG_NRBOX	466	472	PF00104	0.419
LIG_PAM2_1	358	370	PF00658	0.386
LIG_PCNA_yPIPBox_3	521	530	PF02747	0.197
LIG_Pex14_1	57	61	PF04695	0.490
LIG_SH2_CRK	346	350	PF00017	0.332
LIG_SH2_CRK	465	469	PF00017	0.197
LIG_SH2_NCK_1	346	350	PF00017	0.257
LIG_SH2_STAP1	346	350	PF00017	0.326
LIG_SH2_STAT5	131	134	PF00017	0.414
LIG_SH2_STAT5	522	525	PF00017	0.437
LIG_SH3_1	213	219	PF00018	0.347
LIG_SH3_3	213	219	PF00018	0.347
LIG_SH3_3	390	396	PF00018	0.445
LIG_SH3_3	406	412	PF00018	0.344
LIG_SH3_3	444	450	PF00018	0.671
LIG_SH3_3	471	477	PF00018	0.414
LIG_SH3_5	127	131	PF00018	0.282
LIG_SUMO_SIM_anti_2	469	475	PF11976	0.355
LIG_SUMO_SIM_anti_2	497	503	PF11976	0.219
LIG_SUMO_SIM_par_1	225	230	PF11976	0.371
LIG_SUMO_SIM_par_1	31	37	PF11976	0.470
LIG_SUMO_SIM_par_1	466	472	PF11976	0.437
LIG_TRAF2_1	63	66	PF00917	0.456
LIG_UBA3_1	366	374	PF00899	0.399
LIG_WRC_WIRS_1	58	63	PF05994	0.407
MOD_CK1_1	183	189	PF00069	0.593
MOD_CK1_1	26	32	PF00069	0.646
MOD_CK1_1	303	309	PF00069	0.445
MOD_CK1_1	68	74	PF00069	0.354
MOD_CK2_1	101	107	PF00069	0.631
MOD_CK2_1	151	157	PF00069	0.406
MOD_CK2_1	258	264	PF00069	0.586
MOD_CK2_1	271	277	PF00069	0.521
MOD_CK2_1	285	291	PF00069	0.365
MOD_CK2_1	311	317	PF00069	0.560
MOD_CK2_1	466	472	PF00069	0.355
MOD_CMANNOS	80	83	PF00535	0.536
MOD_GlcNHglycan	110	114	PF01048	0.568
MOD_GlcNHglycan	206	209	PF01048	0.561
MOD_GlcNHglycan	381	384	PF01048	0.536
MOD_GlcNHglycan	512	515	PF01048	0.380
MOD_GlcNHglycan	73	77	PF01048	0.335
MOD_GSK3_1	176	183	PF00069	0.498
MOD_GSK3_1	197	204	PF00069	0.528
MOD_GSK3_1	26	33	PF00069	0.698
MOD_GSK3_1	272	279	PF00069	0.381
MOD_GSK3_1	281	288	PF00069	0.397
MOD_GSK3_1	296	303	PF00069	0.534
MOD_GSK3_1	311	318	PF00069	0.479
MOD_GSK3_1	387	394	PF00069	0.470
MOD_GSK3_1	451	458	PF00069	0.496
MOD_GSK3_1	65	72	PF00069	0.365
MOD_N-GLC_1	151	156	PF02516	0.517
MOD_N-GLC_1	183	188	PF02516	0.379
MOD_N-GLC_1	204	209	PF02516	0.490
MOD_N-GLC_1	379	384	PF02516	0.456
MOD_NEK2_1	176	181	PF00069	0.539
MOD_NEK2_1	199	204	PF00069	0.460
MOD_NEK2_1	271	276	PF00069	0.476
MOD_NEK2_1	391	396	PF00069	0.450
MOD_NEK2_1	453	458	PF00069	0.575
MOD_NEK2_1	466	471	PF00069	0.468
MOD_NEK2_2	20	25	PF00069	0.426
MOD_NEK2_2	362	367	PF00069	0.421
MOD_PIKK_1	264	270	PF00454	0.451
MOD_PK_1	331	337	PF00069	0.335
MOD_PKA_1	146	152	PF00069	0.407
MOD_PKA_2	100	106	PF00069	0.636
MOD_PKA_2	339	345	PF00069	0.548
MOD_PKB_1	144	152	PF00069	0.364
MOD_PKB_1	49	57	PF00069	0.428
MOD_Plk_1	362	368	PF00069	0.445
MOD_Plk_1	65	71	PF00069	0.412
MOD_Plk_4	14	20	PF00069	0.411
MOD_Plk_4	146	152	PF00069	0.476
MOD_Plk_4	285	291	PF00069	0.379
MOD_Plk_4	296	302	PF00069	0.422
MOD_Plk_4	331	337	PF00069	0.367
MOD_Plk_4	362	368	PF00069	0.340
MOD_Plk_4	419	425	PF00069	0.265
MOD_Plk_4	494	500	PF00069	0.345
MOD_Plk_4	535	541	PF00069	0.509
MOD_Plk_4	65	71	PF00069	0.466
MOD_ProDKin_1	446	452	PF00069	0.500
MOD_ProDKin_1	533	539	PF00069	0.440
MOD_SUMO_rev_2	273	282	PF00179	0.312
MOD_SUMO_rev_2	316	324	PF00179	0.530
TRG_DiLeu_BaEn_1	190	195	PF01217	0.462
TRG_DiLeu_BaEn_1	325	330	PF01217	0.507
TRG_DiLeu_BaEn_2	231	237	PF01217	0.365
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.473
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.421
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.448
TRG_DiLeu_LyEn_5	325	330	PF01217	0.307
TRG_ENDOCYTIC_2	346	349	PF00928	0.500
TRG_ENDOCYTIC_2	350	353	PF00928	0.481
TRG_ENDOCYTIC_2	465	468	PF00928	0.210
TRG_ER_diArg_1	137	140	PF00400	0.472
TRG_ER_diArg_1	354	356	PF00400	0.413
TRG_ER_diArg_1	438	441	PF00400	0.526
TRG_ER_diArg_1	49	52	PF00400	0.517
TRG_ER_diArg_1	528	530	PF00400	0.468
TRG_ER_diArg_1	540	543	PF00400	0.553
TRG_ER_diArg_1	93	96	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R2	Leptomonas seymouri	43%	99%
A0A1X0P8Z7	Trypanosomatidae	24%	97%
A0A3Q8INF1	Leishmania donovani	67%	100%
A0A3R7NN64	Trypanosoma rangeli	26%	97%
A4ICN2	Leishmania infantum	67%	100%
D0A2T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
E9ASM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q1X4	Leishmania major	67%	100%
V5BV13	Trypanosoma cruzi	25%	85%