Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HNV5_LEIBR

TriTrypDb:

LbrM.35.1080 , LBRM2903_350016600

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HNV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.585
CLV_C14_Caspase3-7	514	518	PF00656	0.572
CLV_C14_Caspase3-7	519	523	PF00656	0.585
CLV_C14_Caspase3-7	652	656	PF00656	0.635
CLV_NRD_NRD_1	366	368	PF00675	0.453
CLV_NRD_NRD_1	405	407	PF00675	0.461
CLV_NRD_NRD_1	431	433	PF00675	0.378
CLV_NRD_NRD_1	443	445	PF00675	0.388
CLV_NRD_NRD_1	576	578	PF00675	0.473
CLV_NRD_NRD_1	599	601	PF00675	0.342
CLV_NRD_NRD_1	705	707	PF00675	0.379
CLV_PCSK_FUR_1	574	578	PF00082	0.448
CLV_PCSK_KEX2_1	366	368	PF00082	0.453
CLV_PCSK_KEX2_1	405	407	PF00082	0.465
CLV_PCSK_KEX2_1	431	433	PF00082	0.378
CLV_PCSK_KEX2_1	443	445	PF00082	0.388
CLV_PCSK_KEX2_1	576	578	PF00082	0.476
CLV_PCSK_KEX2_1	705	707	PF00082	0.379
CLV_PCSK_SKI1_1	232	236	PF00082	0.206
CLV_PCSK_SKI1_1	431	435	PF00082	0.398
CLV_PCSK_SKI1_1	476	480	PF00082	0.333
DEG_APCC_DBOX_1	695	703	PF00400	0.628
DEG_SCF_FBW7_1	153	159	PF00400	0.343
DOC_ANK_TNKS_1	78	85	PF00023	0.372
DOC_CKS1_1	153	158	PF01111	0.339
DOC_CKS1_1	215	220	PF01111	0.565
DOC_CKS1_1	291	296	PF01111	0.332
DOC_CKS1_1	410	415	PF01111	0.567
DOC_CYCLIN_RxL_1	222	233	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	410	416	PF00134	0.565
DOC_PP1_RVXF_1	449	456	PF00149	0.554
DOC_PP4_FxxP_1	482	485	PF00568	0.575
DOC_PP4_FxxP_1	681	684	PF00568	0.715
DOC_USP7_MATH_1	124	128	PF00917	0.358
DOC_USP7_MATH_1	382	386	PF00917	0.626
DOC_USP7_MATH_1	404	408	PF00917	0.585
DOC_USP7_MATH_1	419	423	PF00917	0.533
DOC_USP7_MATH_1	542	546	PF00917	0.576
DOC_USP7_MATH_1	582	586	PF00917	0.621
DOC_USP7_MATH_1	633	637	PF00917	0.673
DOC_USP7_MATH_1	64	68	PF00917	0.392
DOC_USP7_MATH_1	692	696	PF00917	0.602
DOC_WW_Pin1_4	152	157	PF00397	0.387
DOC_WW_Pin1_4	214	219	PF00397	0.717
DOC_WW_Pin1_4	290	295	PF00397	0.334
DOC_WW_Pin1_4	409	414	PF00397	0.606
DOC_WW_Pin1_4	481	486	PF00397	0.528
DOC_WW_Pin1_4	578	583	PF00397	0.663
DOC_WW_Pin1_4	680	685	PF00397	0.602
LIG_14-3-3_CanoR_1	229	235	PF00244	0.471
LIG_14-3-3_CanoR_1	300	306	PF00244	0.266
LIG_14-3-3_CanoR_1	405	410	PF00244	0.647
LIG_14-3-3_CanoR_1	418	424	PF00244	0.613
LIG_14-3-3_CanoR_1	541	551	PF00244	0.555
LIG_14-3-3_CanoR_1	56	63	PF00244	0.281
LIG_14-3-3_CanoR_1	564	573	PF00244	0.582
LIG_14-3-3_CanoR_1	574	580	PF00244	0.639
LIG_14-3-3_CanoR_1	621	625	PF00244	0.594
LIG_14-3-3_CanoR_1	696	700	PF00244	0.583
LIG_Actin_WH2_2	217	233	PF00022	0.515
LIG_BRCT_BRCA1_1	635	639	PF00533	0.664
LIG_BRCT_BRCA1_1	94	98	PF00533	0.270
LIG_deltaCOP1_diTrp_1	596	602	PF00928	0.540
LIG_EH1_1	185	193	PF00400	0.215
LIG_eIF4E_1	301	307	PF01652	0.260
LIG_FHA_1	20	26	PF00498	0.525
LIG_FHA_1	210	216	PF00498	0.587
LIG_FHA_1	244	250	PF00498	0.265
LIG_FHA_1	291	297	PF00498	0.303
LIG_FHA_1	302	308	PF00498	0.228
LIG_FHA_1	507	513	PF00498	0.621
LIG_FHA_1	605	611	PF00498	0.542
LIG_FHA_1	98	104	PF00498	0.378
LIG_FHA_2	410	416	PF00498	0.565
LIG_FHA_2	517	523	PF00498	0.688
LIG_FHA_2	567	573	PF00498	0.627
LIG_LIR_Apic_2	480	485	PF02991	0.538
LIG_LIR_Apic_2	642	648	PF02991	0.629
LIG_LIR_Apic_2	679	684	PF02991	0.638
LIG_LIR_Gen_1	22	32	PF02991	0.404
LIG_LIR_Gen_1	233	244	PF02991	0.233
LIG_LIR_Gen_1	303	312	PF02991	0.282
LIG_LIR_Gen_1	655	663	PF02991	0.601
LIG_LIR_Gen_1	95	103	PF02991	0.302
LIG_LIR_Nem_3	22	27	PF02991	0.496
LIG_LIR_Nem_3	233	239	PF02991	0.256
LIG_LIR_Nem_3	278	283	PF02991	0.307
LIG_LIR_Nem_3	303	308	PF02991	0.282
LIG_LIR_Nem_3	428	433	PF02991	0.666
LIG_LIR_Nem_3	655	660	PF02991	0.600
LIG_LIR_Nem_3	86	92	PF02991	0.357
LIG_LIR_Nem_3	95	101	PF02991	0.324
LIG_PCNA_PIPBox_1	498	507	PF02747	0.550
LIG_PCNA_yPIPBox_3	495	505	PF02747	0.552
LIG_Pex14_1	24	28	PF04695	0.417
LIG_Pex14_1	598	602	PF04695	0.540
LIG_Pex14_2	477	481	PF04695	0.525
LIG_Pex14_2	681	685	PF04695	0.603
LIG_RPA_C_Fungi	362	374	PF08784	0.447
LIG_RPA_C_Fungi	381	393	PF08784	0.450
LIG_RPA_C_Fungi	701	713	PF08784	0.447
LIG_SH2_CRK	236	240	PF00017	0.218
LIG_SH2_CRK	430	434	PF00017	0.484
LIG_SH2_CRK	645	649	PF00017	0.475
LIG_SH2_GRB2like	63	66	PF00017	0.444
LIG_SH2_NCK_1	140	144	PF00017	0.411
LIG_SH2_NCK_1	281	285	PF00017	0.393
LIG_SH2_PTP2	43	46	PF00017	0.305
LIG_SH2_SRC	140	143	PF00017	0.415
LIG_SH2_SRC	609	612	PF00017	0.412
LIG_SH2_STAP1	236	240	PF00017	0.215
LIG_SH2_STAP1	297	301	PF00017	0.305
LIG_SH2_STAP1	641	645	PF00017	0.481
LIG_SH2_STAT3	641	644	PF00017	0.480
LIG_SH2_STAT5	147	150	PF00017	0.448
LIG_SH2_STAT5	219	222	PF00017	0.416
LIG_SH2_STAT5	305	308	PF00017	0.321
LIG_SH2_STAT5	43	46	PF00017	0.221
LIG_SH2_STAT5	505	508	PF00017	0.406
LIG_SH2_STAT5	609	612	PF00017	0.413
LIG_SH3_2	130	135	PF14604	0.378
LIG_SH3_3	127	133	PF00018	0.399
LIG_SH3_3	210	216	PF00018	0.462
LIG_SH3_3	288	294	PF00018	0.403
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.319
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.215
LIG_SUMO_SIM_anti_2	315	321	PF11976	0.196
LIG_SUMO_SIM_par_1	211	217	PF11976	0.422
LIG_SUMO_SIM_par_1	31	37	PF11976	0.214
LIG_TRAF2_1	139	142	PF00917	0.422
LIG_TRAF2_1	438	441	PF00917	0.510
LIG_TYR_ITIM	234	239	PF00017	0.215
LIG_TYR_ITIM	41	46	PF00017	0.213
LIG_WW_2	130	133	PF00397	0.371
MOD_CDC14_SPxK_1	683	686	PF00782	0.487
MOD_CDK_SPK_2	290	295	PF00069	0.394
MOD_CDK_SPxK_1	680	686	PF00069	0.490
MOD_CK1_1	111	117	PF00069	0.493
MOD_CK1_1	175	181	PF00069	0.281
MOD_CK1_1	315	321	PF00069	0.317
MOD_CK1_1	36	42	PF00069	0.321
MOD_CK1_1	408	414	PF00069	0.457
MOD_CK1_1	578	584	PF00069	0.468
MOD_CK1_1	637	643	PF00069	0.594
MOD_CK1_1	653	659	PF00069	0.544
MOD_CK1_1	695	701	PF00069	0.487
MOD_CK1_1	71	77	PF00069	0.556
MOD_CK2_1	366	372	PF00069	0.447
MOD_CK2_1	566	572	PF00069	0.521
MOD_CK2_1	580	586	PF00069	0.439
MOD_GlcNHglycan	113	116	PF01048	0.573
MOD_GlcNHglycan	174	177	PF01048	0.344
MOD_GlcNHglycan	236	239	PF01048	0.357
MOD_GlcNHglycan	314	317	PF01048	0.321
MOD_GlcNHglycan	338	341	PF01048	0.426
MOD_GlcNHglycan	368	371	PF01048	0.466
MOD_GlcNHglycan	38	41	PF01048	0.321
MOD_GlcNHglycan	672	675	PF01048	0.594
MOD_GlcNHglycan	707	711	PF01048	0.509
MOD_GlcNHglycan	75	78	PF01048	0.529
MOD_GSK3_1	152	159	PF00069	0.465
MOD_GSK3_1	16	23	PF00069	0.470
MOD_GSK3_1	230	237	PF00069	0.242
MOD_GSK3_1	285	292	PF00069	0.394
MOD_GSK3_1	346	353	PF00069	0.472
MOD_GSK3_1	373	380	PF00069	0.511
MOD_GSK3_1	382	389	PF00069	0.469
MOD_GSK3_1	404	411	PF00069	0.463
MOD_GSK3_1	51	58	PF00069	0.539
MOD_GSK3_1	513	520	PF00069	0.447
MOD_GSK3_1	558	565	PF00069	0.542
MOD_GSK3_1	578	585	PF00069	0.514
MOD_GSK3_1	633	640	PF00069	0.592
MOD_GSK3_1	64	71	PF00069	0.437
MOD_GSK3_1	649	656	PF00069	0.531
MOD_GSK3_1	668	675	PF00069	0.476
MOD_GSK3_1	97	104	PF00069	0.368
MOD_LATS_1	666	672	PF00433	0.501
MOD_N-GLC_1	258	263	PF02516	0.412
MOD_N-GLC_1	289	294	PF02516	0.439
MOD_N-GLC_1	633	638	PF02516	0.483
MOD_N-GLC_1	64	69	PF02516	0.511
MOD_N-GLC_1	71	76	PF02516	0.543
MOD_NEK2_1	1	6	PF00069	0.487
MOD_NEK2_1	108	113	PF00069	0.452
MOD_NEK2_1	186	191	PF00069	0.267
MOD_NEK2_1	230	235	PF00069	0.369
MOD_NEK2_1	243	248	PF00069	0.275
MOD_NEK2_1	258	263	PF00069	0.384
MOD_NEK2_1	283	288	PF00069	0.434
MOD_NEK2_1	289	294	PF00069	0.503
MOD_NEK2_1	312	317	PF00069	0.436
MOD_NEK2_1	377	382	PF00069	0.566
MOD_NEK2_1	42	47	PF00069	0.207
MOD_NEK2_1	511	516	PF00069	0.498
MOD_NEK2_1	562	567	PF00069	0.531
MOD_NEK2_1	575	580	PF00069	0.465
MOD_NEK2_1	639	644	PF00069	0.504
MOD_NEK2_1	649	654	PF00069	0.663
MOD_NEK2_1	672	677	PF00069	0.509
MOD_NEK2_1	92	97	PF00069	0.323
MOD_NEK2_2	620	625	PF00069	0.468
MOD_PIKK_1	142	148	PF00454	0.509
MOD_PIKK_1	542	548	PF00454	0.440
MOD_PIKK_1	55	61	PF00454	0.402
MOD_PIKK_1	640	646	PF00454	0.482
MOD_PKA_1	366	372	PF00069	0.553
MOD_PKA_1	405	411	PF00069	0.463
MOD_PKA_2	366	372	PF00069	0.553
MOD_PKA_2	404	410	PF00069	0.522
MOD_PKA_2	55	61	PF00069	0.313
MOD_PKA_2	563	569	PF00069	0.474
MOD_PKA_2	575	581	PF00069	0.563
MOD_PKA_2	620	626	PF00069	0.547
MOD_PKA_2	653	659	PF00069	0.483
MOD_PKA_2	695	701	PF00069	0.487
MOD_Plk_1	197	203	PF00069	0.353
MOD_Plk_1	64	70	PF00069	0.519
MOD_Plk_2-3	517	523	PF00069	0.470
MOD_Plk_4	175	181	PF00069	0.282
MOD_Plk_4	20	26	PF00069	0.420
MOD_Plk_4	230	236	PF00069	0.255
MOD_Plk_4	238	244	PF00069	0.273
MOD_Plk_4	301	307	PF00069	0.357
MOD_Plk_4	315	321	PF00069	0.282
MOD_Plk_4	405	411	PF00069	0.490
MOD_Plk_4	42	48	PF00069	0.222
MOD_Plk_4	653	659	PF00069	0.483
MOD_Plk_4	83	89	PF00069	0.464
MOD_ProDKin_1	152	158	PF00069	0.475
MOD_ProDKin_1	214	220	PF00069	0.650
MOD_ProDKin_1	290	296	PF00069	0.394
MOD_ProDKin_1	409	415	PF00069	0.490
MOD_ProDKin_1	481	487	PF00069	0.390
MOD_ProDKin_1	578	584	PF00069	0.571
MOD_ProDKin_1	680	686	PF00069	0.490
TRG_DiLeu_BaEn_1	83	88	PF01217	0.457
TRG_DiLeu_BaLyEn_6	645	650	PF01217	0.476
TRG_ENDOCYTIC_2	236	239	PF00928	0.218
TRG_ENDOCYTIC_2	305	308	PF00928	0.321
TRG_ENDOCYTIC_2	43	46	PF00928	0.273
TRG_ENDOCYTIC_2	430	433	PF00928	0.600
TRG_ER_diArg_1	331	334	PF00400	0.385
TRG_ER_diArg_1	430	432	PF00400	0.460
TRG_ER_diArg_1	443	445	PF00400	0.469
TRG_ER_diArg_1	573	576	PF00400	0.578
TRG_NES_CRM1_1	469	480	PF08389	0.420
TRG_NES_CRM1_1	604	617	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X5	Leptomonas seymouri	31%	93%
A0A3S7XAF2	Leishmania donovani	50%	78%
A4ICN8	Leishmania infantum	50%	78%
E9ASL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	78%
Q4Q1Y0	Leishmania major	50%	100%